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Combined ATAC-seq,RNA-seq,and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster(Crassostrea ariakensis)

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Zoological Research 2024年第1期45卷 201-214页

作者： Biao Wu Xi Chen Jie Hu Zhen-Yuan Wang Yan Wang Da-You Xu Hao-Bing Guo Chang-Wei Shao Li-Qing Zhou Xiu-Jun Sun Tao Yu Xiao-mei Wang Yan-Xin Zheng Guang-yi Fan Zhi-Hong Liu State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdaoShandong 266071China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266426China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai 201306China Changdao Enhancement and Experiment Station Chinese Academy of Fishery SciencesYantaiShandong 265800China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhenGuangdong 518083China

Glycogen serves as the principal energy reserve for metabolic processes in aquatic shellfish and substantially contributes to the flavor and quality of *** Jinjiang oyster(Crassostrea ariakensis)is an economically and ecologically important species in *** the present study,RNA sequencing(RNA-seq)and assay for transposase-accessible chromatin using sequencing(ATAC-seq)were performed to investigate gene expression and chromatin accessibility variations in oysters with different glycogen *** identified 9483 differentially expressed genes(DEGs)and 7215 genes with significantly differential chromatin accessibility(DCAGs)were obtained,with an overlap of 2600 genes between ***,a significant proportion of these genes were enriched in pathways related to glycogen metabolism,including“Glycogen metabolic process”and“Starch and sucrose metabolism”.In addition,genome-wide association study(GWAS)identified 526 single nucleotide polymorphism(SNP)loci associated with glycogen *** loci corresponded to 241 genes,63 of which were categorized as both DEGs and *** study enriches basic research data and provides insights into the molecular mechanisms underlying the regulation of glycogen metabolism in ***.

关键词： Crassostrea ariakensis Glycogen Transcriptome ATAC GWAS

Multifunctional biodegradable nanoplatform based on oxaliplatin prodrug cross-linked mesoporous polydopamine for enhancing cancer synergetic therapy

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Chinese Chemical Letters 2024年第1期35卷 379-384页

作者： Ping Sun Zimu Li Dan Zhang Wenfeng Zeng yi Zheng Lin mei Hongzhong Chen Nansha Gao Xiaowei Zeng School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Central Laboratory University of Chinese Academy of Sciences-Shenzhen HospitalShenzhen 518106China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China

Due to the limitations of conventional chemotherapy including side effects,poor prognosis,and drug resistance,there is an urgent need for the development of a novel multi-functional combined therapy ***-modified oxaliplatin prodrug(OXA-DA)was successfully synthesized in this study to ameliorate the organ distribution of oxaliplatin for improving the drug efficacy and reducing toxic side effects,and OXA-DA was applied to develop a porous oxaliplatin cross-linked polydopamine nanoparticle for loading siPD-L1 to construct multifunctional *** multifunctional nanoplatform was modified with poly(2-ethyl-2-oxazoline)(PEOz),which occurred charge reversal in the tumor microenvironment,and exerted the lysosomal escape effect in tumor cells to improve the bioavailability of small interfering RNA targeting programmed cell death-ligand 1(siPD-L1).The pH-responsive charge reversal,photothermal,biodegradation,lysosomal escape ability,PD-L1 protein degradation,toxicity properties and multiple antitumor effects were comprehensively evaluated in vitro and in vivo *** findings indicated that OXA-DA-siPD-L1@PDA-PEOz excellently induced tumor cell necrosis and apoptosis as a result of the synergistic effect of chemo-photothermal therapy,and upregulated CD8+T cells produced interferon-γ(IFN-γ)to further attack the tumor *** conclusion,the novel nanoplatform-mediated chemo/photothermal/immunotherapy has promising clinical applications in the treatment of malignant tumors.

关键词： Oxaliplatin prodrug Mesoporous polydopamine Charge reversal Synergetic therapy Cancer nanotechnology

Prolonged course of Paxlovid administration in a centenarian with COVID-19:A case report

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World Journal of Radiology 2024年第9期16卷 489-496页

作者： yi-Xue Zhang Juan Tang Dan Zhu Chun-Yan Wu mei-Lan Liang Yuan-Tao Huang Department of Healthcare Haikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikou 570208Hainan ProvinceChina Department of Healthcare Hainan Chengmei HospitalHaikou 570000Hainan ProvinceChina

BACKGROUND According to the population statistics in 2023,there were 110000 people aged over 100 years in China,and the experience of using Paxlovid(nirmatrelvir/ritonavir)for centenarians is particularly *** article reports our experience of using Paxlovid in a centenarian with the novel coronavirus disease 2019(COVID-19)*** SUMMARY A 103-year-old female with mild COVID-19 and renal insufficiency was given sufficient Paxlovid for 2 days and a half dose for 3 *** treatment,the patient was complicated with lung infection and heart failure,and nucleic acid remained *** expert consultation,a full dose of Paxlovid was given again on the 9th day of admission for 2 days and a half dose for 3 ***,anti-heart failure and antibiotics were administered;the heart failure and pulmonary infection were ***,on the 33^(th) day of admission,nucleic acid turned negative,body temperature returned to normal,cough and sputum,fatigue,poor appetite and other symptoms basically *** patient was given Paxlovid via nasal feeding for 2 courses without deterioration of liver and kidney function,diarrhea,nausea and vomiting,myalgia,chest tightness and other side effects,and was discharged from hospital with good *** This case suggests that Paxlovid can be used cautiously in centenarians with renal insufficiency and two courses of treatment can be considered in patients with persistent positive nucleic acid.

关键词： COVID-19 Paxlovid Centenarians Renal insufficiency Heart failure Lung infection Case report

The evolution and significance of medicine and food homology

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Acupuncture and Herbal Medicine 2024年第1期4卷 19-35页

作者： Huan Zhong Zhi-Qing Tang yi-Fang Li mei Wang Wan-Yang Sun Rong-Rong He Guangdong Engineering Research Center of Traditional Chinese Medicine&Disease Susceptibility/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhouChina Naturalis Biodiversity Center Darwinweg RA Leidenthe Netherlands SU BioMedicine BD Leidenthe Netherlands School of Pharmacy Shenyang Pharmaceutical UniversityShenyangChina State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization Yunnan University of Chinese MedicineKunmingChina

Historical insights into medicine and food homology(MFH)Evolution of the MFH theory MFH,a basic concept in traditional Chinese medicine(TCM),suggests that many materials function as both food and medicine,providing nourishment and simultaneously treating *** concept has evolved significantly throughout TCM history^([1]).Integral to this evolution was the discovery of certain materials with dual purposes during early searches for *** materials not only offer sustenance and nutrition but are also capable of treating simple illnesses^([2]).

关键词： evolution insight medicine

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入口颗粒对旋流除砂器壁面磨损的影响研究

石油化工设备 2024年第2期53卷 18-22页

作者：梅毅刘杨罗元刘祎汉正检测技术有限公司四川广汉618300

基于计算流体动力学方法,采用Fluent软件中的雷诺应力模型和颗粒随机轨道模型,选取旋流除砂器常见工作状态,数值模拟研究了颗粒入口速度在5~15 m/s、质量浓度在10~30 kg/m^(3)变化时对旋流除砂器壁面磨损的影响,得到了旋流除砂器内壁磨... 详细信息

基于计算流体动力学方法,采用Fluent软件中的雷诺应力模型和颗粒随机轨道模型,选取旋流除砂器常见工作状态,数值模拟研究了颗粒入口速度在5~15 m/s、质量浓度在10~30 kg/m^(3)变化时对旋流除砂器壁面磨损的影响,得到了旋流除砂器内壁磨损分布规律。模拟结果表明,旋流除砂器壁面磨损分布并不均匀,入口环形空间以及底流口附近磨损率较大。颗粒入口速度和质量浓度的变化对旋流除砂器壁面磨损整体分布影响较小,但入口速度的变化会改变各磨损区域内磨损最严重点的位置,入口环形空间壁面磨损位置变化最为明显,而颗粒质量浓度的变化则对壁面磨损最严重点的位置影响较小。颗粒入口速度和质量浓度的增大都会使旋流除砂器最大磨损率增大,入口速度对旋流除砂器最大磨损率的影响比质量浓度更大。

关键词：旋流除砂器磨损颗粒入口速度质量浓度数值模拟

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成骨不全症儿童的骨骼表型影像测量研究进展

中华骨质疏松和骨矿盐疾病杂志 2024年第3期17卷 266-271页

作者：刘家怡李梅中国医学科学院、北京协和医学院、北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室北京100730

成骨不全症(osteogenesis imperfecta,OI)是最常见的单基因遗传性骨病,以反复骨折、骨骼畸形和身材矮小为特点。准确定量评估骨骼表型对判断OI严重程度、制定治疗方案和预测预后有重要意义。目前常用OI表型评估方法,如X线检查、双能X射... 详细信息

成骨不全症(osteogenesis imperfecta,OI)是最常见的单基因遗传性骨病,以反复骨折、骨骼畸形和身材矮小为特点。准确定量评估骨骼表型对判断OI严重程度、制定治疗方案和预测预后有重要意义。目前常用OI表型评估方法,如X线检查、双能X射线吸收测量仪等,难以全面反映骨微结构和骨骼生物力学性能。近年来,多种新型影像测量技术,包括骨小梁评分、高分辨外周骨定量计算机体层成像、磁共振成像等,能够定量评估骨微结构、骨骼生物力学性能,有助于全面了解OI骨骼表型信息、预测骨折风险,值得关注及应用。

关键词：成骨不全骨小梁评分高分辨外周骨定量计算机体层成像磁共振成像

Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1665-1674页

作者： Jie Xiong Shu Cheng Xiao Gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-Fu Wang Hong-mei yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nuclear Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Shanghai Rujin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiation Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology Navy Medical Center of PLAShanghaiChina Pole de Recherches Sino-Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghaiChina

Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive *** explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 *** complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),*** a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),*** most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of *** proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab *** conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage *** lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.

关键词： killer metabolism lymphoma

CAR-T细胞免疫疗法在B细胞非霍奇金淋巴瘤中的应用进展

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中国实验血液学杂志 2024年第3期32卷 970-973页

作者：王美懿田晨天津医科大学肿瘤医院血液科国家恶性肿瘤临床医学研究中心天津市恶性肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津300060 新疆和田地区人民医院肿瘤科新疆和田848000

嵌合抗原受体T(CAR-T)细胞疗法是近年来迅速发展的免疫治疗新方法。相对于其他疗法,CAR-T疗法在高危及复发/难治性B细胞非霍奇金淋巴瘤(B-NHL)患者中具有显著优势。目前多种抗CD-19 CAR-T细胞已被FDA批准用于B-NHL的治疗,如阿基仑赛、... 详细信息

嵌合抗原受体T(CAR-T)细胞疗法是近年来迅速发展的免疫治疗新方法。相对于其他疗法,CAR-T疗法在高危及复发/难治性B细胞非霍奇金淋巴瘤(B-NHL)患者中具有显著优势。目前多种抗CD-19 CAR-T细胞已被FDA批准用于B-NHL的治疗,如阿基仑赛、司利弗明、利基迈仑赛、贝林妥欧单抗。除此之外,许多研究正在积极探索和开发不同靶点的CAR-T细胞,它们在B-NHL的治疗中表现出巨大的潜力。本文就CAR-T在常见B-NHL中的最新应用研究进展作一综述。

关键词： B细胞非霍奇金淋巴瘤 CAR-T 免疫疗法

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer

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World Journal of Gastroenterology 2024年第29期30卷 3511-3533页

作者： Zhen Huang Fan-ying Meng Lin-Zhu Lu Qian-Qian Guo Chang-Jun Lv Nian-Hua Tan Zhe Deng Jun-yi Chen Zi-Shu Zhang Bo Zou Hong-Ping Long Qing Zhou Sha Tian Si mei Xue-Fei Tian College of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine for Mechanism of Tumor Prevention and Treatment Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Clinical College of Traditional Chinese Medicine Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Hepatology Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Faculty of Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Calculus bovis(CB),used in traditional Chinese medicine,exhibits anti-tumor effects in various cancer *** also constitutes an integral component of a compound formulation known as Pien Tze Huang,which is indicated for the treatment of liver ***,its impact on the liver cancer tumor microenvironment,particularly on tumor-associated macrophages(TAMs),is not well *** To elucidate the anti-liver cancer effect of CB by inhibiting M2-TAM polarization via Wnt/β-catenin pathway *** This study identified the active components of CB using UPLC-Q-TOF-MS,evaluated its anti-neoplastic effects in a nude mouse model,and elucidated the underlying mechanisms via network pharmacology,transcriptomics,and molecular *** vitro assays were used to investigate the effects of CB-containing serum on HepG2 cells and M2-TAMs,and Wnt pathway modulation was validated by real-time reverse transcriptase-polymerase chain reaction and Western blot *** This study identified 22 active components in CB,11 of which were detected in the *** investigations have demonstrated the ability of CB to effectively inhibit liver tumor *** integrated approach employing network pharmacology,transcriptomics,and molecular docking implicated the Wnt signaling pathway as a target of the antineoplastic activity of CB by suppressing M2-TAM *** vitro and in vivo experiments further confirmed that CB significantly hinders M2-TAM polarization and suppresses Wnt/β-catenin pathway *** inhibitory effect of CB on M2-TAMs was reversed when treated with the Wnt agonist SKL2001,confirming its pathway *** This study demonstrated that CB mediates inhibition of M2-TAM polarization through the Wnt/β-catenin pathway,contributing to the suppression of liver cancer growth.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway Tumor microenvironment