检索结果-南通市图书馆

Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第2期7卷 137-144页

作者： Yong mei Li Chen Peng-Fei Zeng Ci-Jun Peng Jun Wang Wen-Ping Li Chao Du Kun Xiong Kai Leng Chun-Lin Feng Ji-hu Jia Department of Hepatopancreatobiliary Surgery the Third Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Diagnostics Laboratory Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Hepatopancreatobiliary Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Gamma-glutamyltransferase(GGT) is one of the most important laboratory tests for the evaluation of liver damage. Through a long-term clinical observation of patients with secondary asymptomatic choledocholithiasis, we found that most patients had abnormal GGT serum *** To investigate the combination of serum GGT and alkaline phosphatase(ALP) in predicting the diagnosis of asymptomatic choledocholithiasis secondary to *** In this retrospective cohort study, the clinical data of 829 patients with cholecystolithiasis admitted to the Third Affiliated Hospital of Zunyi Medical College from August 2014 to August 2017 were collected. Among these patients,151 patients had secondary asymptomatic choledocholithiasis and served as the observation group, and the remaining 678 cholecystolithiasis patients served as the control group. Serum liver function indexes were detected in both groups,and the receiver operating characteristic(commonly known as ROC) curves were constructed for markers showing statistical significances. The cutoff value,sensitivity, and specificity of each marker were calculated according to the ROC *** The overall incidence of asymptomatic choledocholithiasis secondary to cholecystolithiasis was 18.2%. The results of liver function indexes including serum aspartate aminotransferase, alanine aminotransferase, direct bilirubin and total bilirubin levels showed no significant differences between the two groups(P> 0.05). However, the serum GGT and ALP levels were significantly higher in the observation group than in the control group(P < 0.05). The ROC curve analysis showed that the area under the curve was 0.881(95%CI: 0.830-0.932), 0.647(95%CI: 0.583-0.711) and 0.923(0.892-0.953) for GGT, ALP, and GGT + ALP,respectively. The corresponding cut-off values of GGT and ALP were 95.5 U/L and 151.5 U/L, sensitivity were 90.8% and 65.1%, and specificity were 83.6% and59.8%, respectively. The sensitivity and specifi

关键词： Asymptomatic choledocholithiasis Gamma-glutamyltransferase Cholecystolithiasis Alkaline phosphatase Diagnosis Screening

A novel homozygous frameshift mutation in MNS1 associated with severe oligoasthenoteratozoospermia in humans

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2021年第2期23卷 197-204页

作者： Yong Li wei-Li Wang Chao-Feng Tu Lan-Lan Meng Tong-Yao hu Juan Du Ge Lin Hong-Chuan Nie Yue-Qiu Tan Institute of Reproductive and Stem Cell Engineering School of Basic Medical ScienceCentral South UniversityChangsha 410078China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410078China Clinical Research Center for Reproduction and Genetics in hunan Province Changsha 410078China

Oligoasthenoteratozoospermia(OAT)refers to the combination of various sperm abnormalities,including a decreased sperm count,reduced motility,and abnormal sperm *** a few genetic causes have been shown to be associated with ***,we identified a novel homozygous frameshift mutation in meiosis-specific nuclear structural 1(MNS1;NM_018365:c.603_604insG:***202Glufs*6)by whole-exome sequencing in an OAT proband from a consanguineous Chinese *** variant screening identified four additional heterozygous MNS1 variants in 6/219 infertile individuals with oligoasthenospermia,but no MNS1 variants were observed among 223 fertile *** analysis showed MNS1 to be normally located in the whole-sperm flagella,but was absent in the proband's *** analysis by Western blot also confirmed that MNS1 was absent in the proband's *** flagellum morphology and ultrastructural disturbances in outer doublet microtubules were observed in the proband's sperm.A total of three intracytoplasmic sperm injection cycles were carried out for the proband's wife,but they all failed to lead to a successful ***,this is the first study to report a loss-of-function mutation in MNS1 causing OAT in a Han Chinese patient.

关键词： intracytoplasmic sperm injection male infertility meiosis-specific nuclear structural 1(MNS1) oligoasthenoteratozoospermia whole-exome sequencing

Highly effective and reproducible surface-enhanced Raman scattering substrates based on Ag pyramidal arrays

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2013年第3期6卷 159-166页

作者： Yandong Wang Nan Lu Wentao Wang Lingxiao Liu Lei Feng Zhoufang Zeng Haibo Li weiqing Xu Zijian Wu wei hu Yanqing Lu Lifeng Chi State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130012 China National Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China Physikalisches Institut and Center for Nanotechnology (CeNTech) Westfalische Wilhelms-Universitat D-48149 Munster Germany

Close-packed Ag pyramidal arrays have been fabricated by using inverted pyramidal pits on Si as a template and used to generate plentiful and homogeneous surface-enhanced Raman scattering （SERS） hot sites. The sharp nanotip and the four edges of the Ag pyramid result in strong electromagnetic field enhancement with an average enhancement factor （EF） of 2.84 × 10^7. Moreover, the features of the close-packed Ag pyramidal array can be well controlled, which allows SERS substrates with good reproducibility to be obtained. The relative standard deviation （RSD） was lower than 8.78% both across a single substrate and different batches of substrates.

关键词： SERS Ag pyramidal array reproducibility etching nanosphere lithography

Hepatitis B virus infection and intrahepatic cholangiocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第19期20卷 5721-5729页

作者： hua-Bang Zhou Jing-Yi hu He-Ping hu Department I of Hepatobiliary Diseases Eastern Hepatobiliary Surgery HospitalSecond Military Medical University School of Medicine Shanghai Jiao Tong University

Intrahepatic cholangiocarcinoma(ICC)is a devastating malignant tumor arising from the peripheral intrahepatic bile duct *** incidence and mortality of ICC is markedly increasing over the past two decades worldwide,though the cause for this rise in incidence is unclear,thus intensifying the search for alternative etiological agents and pathogenetic ***,primary sclerosing cholangitis,parasitic infection(Opisthorchis viverrini or Clonorchis sinensis),fibropolycystic liver disease,and chemical carcinogen exposure are thought to be the risk factors for ***,the majority of ICC patients do not have any of these risk factors,and none of the established risk factors can explain the recent increasing trend of ***,identifying other risk factors may lead to the prevention and early detection of *** hepatitis B virus(HBV)infection is the predominant cause of hepatocellular carcinoma in HBVendemic *** review discusses the evidence implicating chronic HBV infection as a likely etiology of ICC and the pathogenetic mechanisms that might be involved.

关键词： Hepatitis B virus Intrahepatic cholangiocarcinoma Epidemiology Etiopathogenesis

Long-term effect of Chinese herbal medicine Tianqi Capsule on the incidence ofdiabetes： an 8-year cohort study protocol

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2018年第4期3卷 166-172页

作者： Bing Pang Chun-Yong Han Qing-hu He Jing Liu Qing-wei Li Yu-Jiao Zheng Feng-mei Lian Xiao-LinTong Department of Endocrinology Guang'anmen Hospital of China Academy of Chinese Medical Sciences Beijing China Sinobioway Group Co. Ltd. Heilongjiang Tian Ren Pharmarceutical Co. Ltd Heilongjiang China hunan Universityof Traditional Chinese Medicine Hunan China

Background： The rapid growth of type 2 diabetes mellitus （T2DM） remains a big challenge for clinicians *** Chinese medicine may bring a new approach for solving this problem. The Tianqi Capsule DiabetesPrevention Study （REDUCES Study） reported that 1 years of therapy with Tianqi capsule reduced the risk of diabetes by32.1% compared with the placebo. Here we aimed to assess the long-term effect of Tianqi capsule on prevention ofT2DM in people with impaired glucose tolerance after discontinuation of active intervention. Methods/design： 420subjects will be followed-up for 8 years to assess the long-term effect of Tianqi capsule intervention. The causes of deathand the status of living subjects will be investigated. Follow-up data for living subjects will be collected by personalinterview and clinical examination and medical record review to determine diabetes status. Questionnaires will be givento all the subjects to investigate the factors that probably affect the diabetes status during the 8-year of discontinuation ofintervention. The primary outcome is the incidence of T2DM, and the secondary outcomes are body mass index, bloodglucose, blood lipids and blood pressure. The Cox proportional hazards model will be used to estimate the hazard ratiofor diabetes incidence. Analyses will be done with SAS 8.2 software package. Discussion： Results from this study mayprovide evidence for the long-term efficacy of Tianqi capsule in patients with prediabetes. The findings will provide abasis for further confirmatory studies. Ethics： The protocol has been approved by the Medical Ethics Committee ofGuang’anmen Hospital of China Academy of Chinese Medical Sciences （approval number 2016-046-KY-01）. Studyregistration number： ***; NCT02848053.

关键词： Diabetes Prevention Tianqi capsule Long-term effect

Assessment of prospective hazards resulting from the 2017 earthquake at the world heritage site Jiuzhaigou Valley, Sichuan, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2018年第4期15卷 779-792页

作者： CHEN Xiao-qing CHEN Jian-gang CUI Peng YOU Yong hu Kai-heng YANG Zong-ji ZHANG wei-feng LI Xin-po WU Yong Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and Environment Chinese Academy of Sciences (CAS) Chengdu 610041 China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101 China Youth Innovation Promotion Association CAS Beijing 100029 China

On August 8, 2017, a Ms = 7.0 magnitude earthquake occurred in the Jiuzhaigou Valley, in Sichuan Province, China(N: 33.20°, E: 103.82°). Jiuzhaigou Valley is an area recognized and listed as a world heritage site by UNESCO in 1992. Data analysis and field survey were conducted on the landslide, collapse, and debris flow gully, to assess the coseismic geological hazards generated by the earthquake using an unmanned aerial vehicle(UAV), remote-sensing imaging, laser range finders, geological radars, and cameras. The results highlighted the occurrence of 13 landslides, 70 collapses, and 25 potential debris flow gullies following the earthquake. The hazards were classified on the basis of their size and the potential property loss attributable to them. Consequently, 14 large-scale hazards, 30 medium-sized hazards, and 64 small hazards accounting for 13%, 28%, and 59% of the total hazards, respectively, were identified. Based on the variation tendency of the geological hazards that ensued in areas affected by the Kanto earthquake(Japan), Chi-chi earthquake(Taiwan China), and Wenchuan earthquake(Sichuan China), the study predicts that, depending on the rain intensity cycle, the duration of geological hazard activities in the Jiuzhaigou Valley may last over ten years and will gradually decrease for the following five to ten yearsbefore returning to pre-earthquake levels. Thus,necessary monitoring and early warning systems must be implemented to ensure the safety of residents,workers and tourists during the construction of engineering projects and reopening of scenic sites to the public.

关键词： 2017 Jiuzhaigou earthquake Disaster risk Geological hazard Landslide World heritage site Jiuzhaigou Valley

Research on the knee region of cosmic ray by using a novel type of electron-neutron detector array

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2024年第4期19卷 13-24页

作者： Bing-Bing Li Xin-hua Ma Shu-Wang Cui Hao-Kun Chen Tian-Lu Chen Danzengluobu wei Gao Hai-Bing hu Denis Kuleshov Kirill Kurinov hu Liu Mao-Yuan Liu Ye Liu Da-Yu Peng Yao-hui Qi Oleg Shchegolev Yuri Stenkin Li-Qiao Yin Heng-Yu Zhang Liang-wei Zhang College of Physics Hebei Normal UniversityShijiazhuang 050024China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China TIANFU Cosmic Ray Research Center Chengdu 610000China College of Science Tibet UniversityLhasa 850000China Key Laboratory of Comic Rays Ministry of EducationTibet UniversityLhasa 850000China Institute for Nuclear Research of the Russian Academy of Sciences Moscow 117312Russia School of Physical Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Management Science and Engineering Hebei University of Economics and BusinessShijiazhuang 050061China Moscow Institute of Physics and Technology Moscow 141700Russia

By accurately measuring composition and energy spectrum of cosmic ray,the origin problem of so called“knee”region(energy>one PeV)can be ***,up to the present,the results of the spectrum in the knee region obtained by several previous experiments have shown obvious differences,so they cannot give effective evidence for judging the theoretical models on the origin of the ***,the Large High Altitude Air Shower Observatory(LHAASO)has reported several major breakthroughs and important results in astro-particle physics *** on its advantages of wide-sky survey,high altitude location and large area detector arrays,the research content of LHAASO experiment mainly includes ultra high-energy gamma-ray astronomy,measurement of cosmic ray spectra in the knee region,searching for dark matter and new phenomena of particle physics at higher *** electron and thermal neutron detector(EN-Detector)is a new scintillator detector which applies thermal neutron detection technology to measure cosmic ray extensive air shower(EAS).This technology is an extension of *** EN-Detector Array(ENDA)can highly efficiently measure thermal neutrons generated by secondary hadrons so called“skeleton”of *** this paper,we perform the optimization of ENDA configuration,and obtain expectations on the ENDA results,including thermal neutron distribution,trigger efficiency and capability of cosmic ray composition *** obtained real data results are consistent with those by the Monte Carlo simulation.

关键词： cosmic ray EAS knee region LHAASO ENDA

Brain injury in combination with tacrolimus promotes the regeneration of injured peripheral nerves

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第6期12卷 987-994页

作者： Xin-ze He Jian-jun Ma Hao-qi Wang Tie-min hu Bo Sun Yun-feng Gao Shi-bo Liu wei Wang Pei Wang Department of Hand and Foot Surgery Affiliated Hospital of Chengde Medical College Binzhou Central Hospital Postgraduate School Chengde Medical College Department of Neurosurgery Affiliated Hospital of Chengde Medical College Department of Hand and Foot Surgery the First Hospital of Qinhuangdao

Both brain injury and tacrolimus have been reported to promote the regeneration of injured peripheral nerves. In this study, before transection of rat sciatic nerve, moderate brain contusion was（or was not） induced. After sciatic nerve injury, tacrolimus, an immunosuppressant, was（or was not） intraperitoneally administered. At 4, 8 and 12 weeks after surgery, Masson＇s trichrome, hematoxylin-eosin, and toluidine blue staining results revealed that brain injury or tacrolimus alone or their combination alleviated gastrocnemius muscle atrophy and sciatic nerve fiber impairment on the experimental side, simultaneously improved sciatic nerve function, and increased gastrocnemius muscle wet weight on the experimental side. At 8 and 12 weeks after surgery, brain injury induction and/or tacrolimus treatment increased action potential amplitude in the sciatic nerve trunk. Horseradish peroxidase retrograde tracing revealed that the number of horseradish peroxidase-positive neurons in the anterior horn of the spinal cord was greatly increased. Brain injury in combination with tacrolimus exhibited better effects on repair of injured peripheral nerves than brain injury or tacrolimus alone. This result suggests that brain injury in combination with tacrolimus promotes repair of peripheral nerve injury.

关键词： tacrolimus injured nerves regeneration alone axonal hematoxylin peroxidase tracing Schwann

On the Diophantine Equation x^2-kxy+y^2+lx=0

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2013年第5期34卷 715-718页

作者： Yongzhong hu Maohua LE Department of Mathematics Foshan University Institute of Mathematics Zhanjiang Normal College

Let l be a given nonzero integer. The authors give an explicit characterization of the positive integer k that makes the Diophantine equation x2 - kxy ＋ y2 ＋ 1x = 0 have infinitely many positive integer solutions （... 详细信息

关键词： Quadratic Diophantine equation Solvability Counting solutions