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Nociceptors and Macrophages in Bacterial Meningitis:Partners in Crime?

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Neuroscience Bulletin 2024年第3期40卷 418-420页

作者： Fang Gao Hongzhen hu The Kimberly and Eric J.Waldman Department of Dermatology Icahn School of Medicine at Mount SinaiNew York NY10029USA The Nash Family Department of Neuroscience Icahn School of Medicine at Mount SinaiNew York NY10029USA The Mark Lebwohl Center for Neuroinfammation and Sensation Icahn School of Medicine at Mount SinaiNew York NY10029USA Friedman Brain Institute Icahn School of Medicine at Mount SinaiNew York NY10029USA

Bacterial meningitis is a serious and potentially life-threatening infection that affects the protective layers surrounding the brain and spinal cord,known as the *** types of bacteria,including Streptococcus pneumoniae,Neisseria meningitidis,and Haemophilus influenzae,can cause this *** populations,such as infants,children,immunocompromised adults,and the elderly,are particularly vulnerable to these *** of bacterial meningitis can manifest suddenly and may include high fever,severe and persistent headache,stiff neck,vomiting,sensitivity to light,and confusion or changes in mental state[1,2].Identifying these symptoms in infants can be more challenging and may lead to long-term disability or death[3].Despite the effectiveness of vaccines,it is crucial to understand how bacteria invade the brain and how our innate immune system responds to infection(Fig.1).

关键词： protective infection suddenly

Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

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Science China Chemistry 2024年第3期67卷 990-999页

作者： Cai-Qin Wu An-An Liu Xu Li Jia-wei Tu Juan Kong Ling-Ling Yang Jian-Hong Jia Chuan Wang Bin hu Zhi-Xiong Xie Dai-Wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

On secondary new particle formation in China

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Frontiers of Environmental Science & Engineering 2016年第5期10卷 191-200页

作者： Markku Kulmala Tuukka Petaja Veli-Matti Kerminen Joni Kujansuu Taina Ruuskanen Aijun Ding wei Nie Min hu Zhibin Wang Zhijun Wu Lin Wang Douglas R. Worsnop University of Helsinki P.O. Box 64 Helsinki 00014 Finland Joint Intemational Research Laboratory of Atmospheric and Earth System Sciences (JirLATEST) Nanjing University and University of Helsinki Nanjing 210093 China Institute for Climate and Global Change Research Nanjing University Nanjing 210000 China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering Peking University Beijing 100871 China Max Planck Institute for Chemistry Hahn-Meimer-Weg 1 Mainz DE 55128 Germany Department of Environmental Science & Engineering Fudan University Shanghai 200433 China Aerodyne Research Inc. Billerica MA 01821 USA

Formation of new atmospheric aerosol particles is a global phenomenon that has been observed to take place in even heavily-polluted environments. However, in all environments there appears to be a threshold value of the condensation sink （due to pre-existing aerosol particles） after which the formation rate of 3 nm particles is no longer detected. In China new particle production has been observed at very high pollution levels （condensation sink about 0.1 s-1 ） m several megaclt es, including Beijing, Shanghai and Nanjing as well as in Pearl River Delta （PRD）. Here we summarize the recent findings obtained from these studies and discuss the various implications these findings will have on future research and policy.

关键词： Aerosol particles Heavily-polluted environments Condensation sink New particle production Megacities

Modified Method for Estimating Organic Carbon Density in Discontinuous Karst Soil Using Ground-Penetrating Radar and Geostatistics

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Journal of Mountain Science 2015年第5期12卷 1229-1240页

作者： LI Lei XIA Yin-hang LIU Shu-juan ZHANG wei CHEN Xiang-bi ZHENG hua QIU hu-sen HE Xun-yang SU Yi-rong Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences huanjiang Observation and Research Station for Karst Eco-systems University of Chinese Academy of sciences Guangxi Institute of Subtropical Crops

The conventional method which assumes the soil distribution is continuous was unsuitable for estimating soil organic carbon density(SOCD) in Karst areas because of its discontinuous soil distribution. The accurate estimation of SOCD in Karst areas is essential for carbon sequestration assessment in China. In this study, a modified method,which considers the vertical proportion of soil area in the profile when calculating the SOCD, was developed to estimate the SOCD in a typical Karst peak-cluster depression area in southwest China. In the modified method, ground-penetrating radar(GPR) technology was used to detect the distribution and thickness of soil. The accuracy of the method was confirmed through comparison with the data obtained using a validation method, in which the soil thickness was measured by excavation. In comparison with the conventional method and average-soil-depth method,the SOCD estimated using the GPR method showed the minimum relative error with respect to that obtained using the validation method. At a regional scale, the average SOCDs at depths of 0-20 cm and 0-100 cm, which were interpolated by ordinary kriging,were 1.49(ranging from 0.03-5.65) and 2.26(0.09-11.60) kgm-2based on GPR method in our study area(covering 393.6 hm2), respectively. Therefore, the modified method can be applied on the accurate estimation of SOCD in discontinuous soil areas such as Karst regions.

关键词： Discontinuous soil Organic carbondensity Soil distribution Estimation method Ground penetrating radar Karst Peak clusterdepression

Livelihood changes and evolution of upland ethnic communities driven by tourism:a case study in Guizhou Province,southwest China

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Journal of Mountain Science 2016年第7期13卷 1313-1332页

作者： LI Ya-juan VV hu CHEN Tian hu Jing CUI Hai-yang The College of Urban&Environmental Sciences Central China Normal UniversityWuhan 430079China Wuhan Branch of China Tourism Academy Wuhan 430079China Institute of Geographic Sciences and Natural Resources Research University of Chinese Academy of SciencesBeijing 100101China ASEAN(Association of Southeast Asian Nations)Research Center Guizhou UniversityGuiyang 550025China

As an effective livelihood approach to alleviate poverty without rural population migration, ethnic tourism has become the primary choice of economic development in ethnic areas worldwide in addition to traditional livelihood approaches. This article applies the theories of livelihood to study the community evolution driven by tourism livelihood and examine three mountainous tourism communities in different stages of tourist area life cycle. Drawing on the methods of GIS spatial analysis, semi-structured interviews and questionnaires, this article proposes a sustainable livelihood framework for ethnic tourism to explore the evolution of ethnic tourism communities by identifying changes in livelihood assets(natural, financial, social, cultural and human capitals) in the process of tourism development. The results show that the development of ethnic tourism has led to changes in the increase of building land, and the diversification of land use functions with a trend of shifting from meeting local villagers' living needs to satisfying tourists, income composition and uneven distribution of tourism income spatially. Ethnic tourism also led to the deterioration of traditional social management structure, collapse of neighboring relationship, the over- commercialization and staged authenticity of ethnic culture, as well as the gradual vanish of agricultural knowledge with a trend of increasing modern business knowledge and higher education. In addition, these changes, involving livelihood assets from natural, economic, human, social and cultural aspects are interrelated and interactive, which form new evolution characters of ethnic community. This study reveals the conflicts over livelihood approaches which have formed new vulnerabilities to impact on sustainable evolution of ethnic communities. This research provides implications for achieving the sustainable development of ethnic communities with the driving force of tourism livelihood.

关键词： Community evolution Tourism livelihood Livelihood assets Ethnic tourism Guizhou

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预制装配式RC框架结构抗震性能研究

振动与冲击 2022年第24期41卷 79-87页

作者：黄炜胡高兴西安建筑科技大学土木工程学院西安710055 安徽工程大学建筑工程学院安徽芜湖241000

针对预制装配式RC(reinforced concrete)梁柱节点连接及震损后修复的问题,提出一种可修复的梁柱节点连接形式。为验证其有效性和可行性,设计一个装配式节点足尺试件并进行拟静力加载测试,并与现浇节点试件试验结果进行对比分析。结果表... 详细信息

针对预制装配式RC(reinforced concrete)梁柱节点连接及震损后修复的问题,提出一种可修复的梁柱节点连接形式。为验证其有效性和可行性,设计一个装配式节点足尺试件并进行拟静力加载测试,并与现浇节点试件试验结果进行对比分析。结果表明,该装配式节点在承载力、延性、变形和耗能能力均显著优于现浇节点,且破坏主要集中在多缝耗能装置上,预制梁、柱构件基本处在弹性阶段,可以实现节点损伤可控以及震后快速修复的目的。在此基础上,建立装配式梁柱节点及结构的简化数值模型,通过非线性动力时程分析研究了此类装配式RC框架结构的抗震性能。研究结果表明,该装配式结构在各级水平地震作用下均表现较好,满足抗震规范设计要求,其整体抗震性能基本接近现浇结构。

关键词：装配式RC框架结构可修复连接节点抗震性能耗能能力多缝耗能装置

OsMADS32 interacts with PI-like proteins and regulates rice flower development

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Journal of Integrative Plant Biology 2015年第5期57卷 504-513页

作者： huanhuan Wang Liang Zhang Qiang Cai Yun hu Zhenming Jin Xiangxiang Zhao wei Fan Qianming huang Zhijing Luo Mingjiao Chen Dabing Zhang Zheng Yuan State Key Laboratory of Hybrid Rice School of Life Sciences and BiotechnologyShanghai Jiao Tong University College of Life and Basic Sciences Sichuan Agricultural University Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake Huaiyin Normal University

OsMADS32 is a monocot specific MIKCc type MADS‐box gene that plays an important role in regulating rice floral meristem and organs identity, a crucial process for reproductive success and rice yield. However, its underlying mechanism of action remains to be clarified. Here, we characterized a hypomorphic mutant allele of OsMADS32/CFO1, cfo1‐3 and identified its function in controlling rice flower development by bioinformatics and protein‐protein interaction analysis. The cfo1‐3 mutant produces defective flowers, including loss of lodicule identity, formation of ectopic lodicule or hull‐like organs and decreased stamen number, mimicking phenotypes related to the mutation of B class genes. Molecular characterization indicated that mis‐splicing of OsMADS32 transcripts in the cfo1‐3 mutant resulted in an extra eight amino acids in the K‐domain of OsMADS32 protein. By yeast two hybrid and bimolecular fluorescence comple-mentation assays, we revealed that the insertion of eight amino acids or deletion of the internal region in the K1 subdomain of OsMADS32 affects the interaction between OsMADS32 with PISTILLATA （PI）‐like proteins OsMADS2 and OsMADS4. This work provides new insight into the mecha-nism by which OsMADS32 regulates rice lodicule and stamen identity, by interaction with two PI‐like proteins via its K domain.

关键词： Floral organ identity hypomorphic mutant K domain OsMADS32 protein interaction

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猪肚菇母种培养基的筛选

北方园艺 2012年第18期 176-178页

作者：胡梅河南科技大学林学院河南洛阳471003

以猪肚菇菌种为试材,研究了适合猪肚菇菌丝生长的最佳母种培养基。结果表明:在选用的9种培养基中,猪肚菇母种最适的培养基为:葡萄糖20g,麸皮100g,蛋白胨5g,KH2PO42g,MgSO41g,VB110mg/L,琼脂20g,H2O 1 000mL,pH 6.0～6.5。

关键词：猪肚菇母种培养基筛选

Application of Stable Strontium Isotope Geochemistry and Fluid Inclusion Microthermometry to Studies of Dolomitization of the Deeply Buried Cambrian Carbonate Successions in West-Central Tarim Basin, NW China

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Journal of Earth Science 2019年第1期30卷 176-193页

作者： Ngong Roger Ngia Mingyi hu Da Gao Zhonggui hu Chun-Yan Sun Sedimentary Basin Research Center Yangtze University hubei Cooperative Innovation Center for Unconventional Oil and Gas Key Laboratory of Exploration Technologies for Oil and Gas Resources of the Ministry of Education Yangtze University Department of Geology University of Buea

Detailed petrographic,geochemical(O-C-Sr isotopes)and fluid inclusion studies of the deeply buried Cambrian carbonates in the West-central Tarim Basin revealed three types of crystalline dolomites(fine-crystalline,nonplanar-a(s),dolomite(RD1),fine-to medium-crystalline,planar-e(s)dolomite(RD2),and medium-to coarse-crystalline,nonplanar-a dolomite(RD3)),medium-to coarsecrystalline,nonplanar-a saddle dolomite cement(CD)and early and later-stage calcite *** occurrence of RD1 along low-amplitude stylolites points to link with pressure dissolution by which minor Mg ions were likely released for replacive dolomitization during early-to intermediate-burial seawater *** increasing crystal sizes of RD2 and RD3 with irregular overgrowth rims suggests intense recrystallization and replacement upon the RD1 or remaining precursor limestones by dolomitizing fluids during late intermediate burial *** overlap ofδ^(18)O,δ^(13)C and ^(87)Sr/^(86)Sr values of RD1-RD3 and CD dolomite with coeval seawater values,suggests that the principal dolomitizing fluids that precipitated these dolomites was connate(Cambrian)seawater preserved in the host limestones/*** high ^(87)Sr/^(86)Sr ratios suggest influx of radiogenic strontium into the Cambrian *** regimes of fluid flow are recognized in the study area:firstly,influx of magnesium-rich higher-temperature basinal brines along deep-seated faults/fractures,resulting in cementation by CD ***,the incursion of meteoric waters,mixing with ascending highertemperature basinal brines,and an increase in Ca^(2+)/Mg^(2+)ratio in the fluids probably results in the precipitation of calcite cement in vugs and fractures.

关键词： Cambrian dolomites C-O-Sr isotopes burial dolomitization West-central Tarim Basin fluid flow regimes