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The Study of IgG Subclass Profiles of Anti-HBc in Populations with Different Status of HBV Infection

Cellular & Molecular Immunology 2005年第5期2卷 393-398页

作者： Yu-Yen Yang Chien-Fu Huang James Cheng-Chung Wei mei-shang ho Lina Wang Shyh-Jye Lin Wei-Yu Tsai Chien-Chou Lin Fangling Xu Chi-Chiang Yang Department of Medical Research Show Chwan Memorial Hospital Changhua China Taiwan Department of Biological Science and Technology I-Shou UniversityKaoshiung China Taiwan Division of Allergy immunology and Rheumatology Chung Shan Medical University Hospital Taichung China Taiwan Institute of Biomedical Sciences Academia Sinica Taipei 11529 ChinaTaiwan School of Medical Laboratory and Biotechnology Chung Shan MedicalUniversity Taichung China Taiwan Division of Laboratory Research and Development Center for DiseaseControl Department of Health Kaoshiung China Taiwan Institute of Virology Medical College Wuhan University Wuhan 430071Hubei China

To study IgG subclasses for the hepatitis B virus （HBV） core antigen （anti-HBc） in different populations, a comparison was made between 104 chronic carriers （60 male and 44 female） and 434 recovered individuals （247 male and 192 female）. Biochemistry analyses of AST （aspartate aminotransferase） and ALT （alanine aminotransferase） were also performed. Among the 104 chronic carriers, 21 patients were found to be ALT and AST abnormal （〉 25 IU/ml）. After comparing these ALT and AST abnormal patients with other ALT and AST normal chronic carriers, no statistical difference was observed in the OD values of the anti-HBe （p 〉 0.05）. The ELISA results showed the anti-HBc IgG subclass pattern was IgG1 〉 IgG3 〉 IgG4 in chronic carriers and IgG3 〉 IgG1 〉 IgG4 in recovered individuals （p 〈 0.05）. This result suggests the IgG1/IgG3 ratio may be related with HBV status. however, in spite of the different anti-HBc IgG1/IgG3 patterns demonstrated in different populations, both anti-HBc IgG1 and IgG3 concentrations were significantly higher in chronic carriers （p 〈 0.05）. Therefore, both the anti-HBc IgG1/IgG3 ratio and their amounts differed. They may play a significant role in chronic carriers and recovered individuals. The anti-HBc IgG subclass profiles of chronic carriers were not changed regardless of liver inflammation, and were independent of sex and age.

关键词： anti-HBs anti-HBe anti-HBc ELISA HBV

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Expression,purification and characterization of enterovirus-71 virus-like particles

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World Journal of Gastroenterology 2006年第6期12卷 921-927页

作者： Yao-Chi Chung Jen-Huang Huang Chia-Wei Lai Heng-Chun Sheng Shin-Ru Shih mei-shang ho Yu-Chen Hu Department of Chemical Engineering National Tsing Hua University Hsinchu 300 Taiwan China School of Medical Technology Chang GungUniversity Taoyuan 333 Taiwan China Institute of Biomedical Sciences AcademiaSinica Taipei 11529 Taiwan China

AIM： Enterovirus 71 （EV71） has been implicated as the etiological agent responsible for the recent outbreaks of hand, foot and mouth disease associated with severe neurological diseases in the Asia-Pacific region. METhoDS： The assembly process was hypothesized to occur via an orchestrated proteolytic processing of the P1 precursor by the viral protease 3CD. To test this hypothesis, we constructed 3 recombinant baculoviruses： Bac-P1 expressing P1; Bac-3CD expressing 3CD; and Bac-P1-3CD co-expressing P1 and 3CD. RESULTS： Both single infection by Bac-P1-3CD and coinfection by Bac-P1 and Bac-3CD resulted in correct cleavage of P1 to yield individual proteins VP0, VP1 and VP3, while the former approach yielded higher VLP production. In the cells, the structural proteins selfassembled into clusters of virus-like particles （VLP） resembling the authentic EV71 particle aggregates. After ultracentrifugation purification, the dispersed VLPs were indistinguishable from the authentic virus in size, appearance, composition and surface epitopes, as determined by SDS-PAGE, Western blot, transmission electron microscopy and immunogold labeling. CONCLUSION： Our data, for the first time, suggest that in insect cells EV71 structural proteins adopt a processing and assembly pathway similar to poliovirus assembly. The preservation of particle morphology and composition suggest that the VLP may be a valuable vaccine candidate to prevent EV71 epidemics.

关键词： Enterovirus 71 Virus-like particle VLP Vaccine Baculovirus Insect cell

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Efficient photocatalytic reduction of chromium(Ⅵ) using photoreduced graphene oxide as photocatalyst under visible light irradiation

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Journal of Materials Science & Technology 2021年第32期91卷 17-27页

作者： mei Yu Jing shang Yu Kuang Department of Environment and Health State Key Joint Laboratory of Environmental Simulation and Pollution ControlCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China

Graphene oxide(GO),a new and promising material,has been widely used as a co-catalyst in photocatalytic reactions;however,its capacity as a sole photocatalyst has rarely been *** this study,ultraviolet(UV) light irradiation was used as a modification method to obtain reduced GO(rGO) *** samples were used as photocatalysts to examine their visible light photocatalytic activity toward hexavalent chromium(Cr(Ⅵ)) *** force microscopy(AFM),X-ray diffraction(XRD),UV-vis spectrophotometry,Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),and electron spin resonance(ESR) spectroscopy were applied to interpret the surface and structure changes with UV *** oxygen-containing functional groups(OFGs) on the GO surface were reduced to defective carbons andπ-conjugated C=C(sp^(2) domains) under UV light;this led to a decrease in the interlayer distance between GO sheets,GO fragmentation,and increased disorder on the GO *** restoration of sp^(2) domains led to a narrower band gap of GO,which favored the rGO excitation by visible light to generate electron-hole *** rGO pre-irradiated with UV for 1 h(rGO-1),possessing the highest defect density and electron generation efficiency,exhibited the best Cr(Ⅵ) reduction efficiency,which was about three times that of the GO sample;moreover,it outperformed most of the reported GO-based *** addition,low pH and the addition of citric acid as a hole scavenger could further improve the photocatalytic *** study proves that GO or rGO can be used as a sole photocatalyst under visible light to remove environmental pollutants such as heavy-metal ions,and it paves the way for the development of this kind of material and its UV-irradiation modification for further applications.

关键词： Graphene oxide Chromium(Ⅵ) Defect density UV-irradiation modification Photocatalytic reduction

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On RNN-Based k-WTA Models With Time-Dependent Inputs

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IEEE/CAA Journal of Automatica Sinica 2022年第11期9卷 2034-2036页

作者： mei Liu Mingsheng shang the Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714 the Chongqing School University of Chinese Academy of SciencesChongqing 400714China

Dear editor,This letter identifies two weaknesses of state-of-the-art k-winnerstake-all(k-WTA)models based on recurrent neural networks(RNNs)when considering time-dependent inputs,i.e.,the lagging error and the infeas... 详细信息

关键词： letter convergence finite

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Gradient-Based Differential kWTA Network With Application to Competitive Coordination of Multiple Robots

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IEEE/CAA Journal of Automatica Sinica 2022年第8期9卷 1452-1463页

作者： mei Liu Xiaoyan Zhang Mingsheng shang Long Jin School of Information Science and Engineering Lanzhou UniversityLanzhou 730000 State Key Laboratory of Tibetan Intelligent Information Processing and Application Xining 810016China Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Shenzhen Research Institute Lanzhou UniversityShenzhen 518063China

Aiming at the k-winners-take-all(kWTA)operation,this paper proposes a gradient-based differential kWTA(GDk WTA)*** obtaining the network,theorems and related proofs are provided to guarantee the exponential convergence and noise resistance of the proposed GD-kWTA ***,numerical simulations are conducted to substantiate the preferable performance of the proposed network as compared with the traditional ***,the GD-k WTA network,backed with a consensus filter,is utilized as a robust control scheme for modeling the competition behavior in the multi-robot coordination,thereby further demonstrating its effectiveness and feasibility.

关键词： Consensus filter k-winners-take-all(kWTA) multirobot coordination noise resistance

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Well-posedness and Stability for an Elliptic-parabolic Free Boundary Problem Modeling the Growth of Multi-layer Tumors

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Acta Mathematicae Applicatae Sinica 2009年第4期25卷 547-560页

作者： Xiu-mei hou shang-bin Cui Department of Mathematics Sun Yat-sen University Guangzhou 510275 China

In this paper we study a free boundary problem modeling the growth of multi-layer tumors. This free boundary problem contains one parabolic equation and one elliptic equation, defined on an unbounded domain in R2 of the form 0 〈 y 〈p（x,t）, where p（x,t） is an unknown function. Unlike previous works on this tumor model where unknown functions are assumed to be periodic and only elliptic equations are evolved in the model, in this paper we consider the case where unknown functions are not periodic functions and both elliptic and parabolic equations appear in the model. It turns out that this problem is more difficult to analyze rigorously. We first prove that this problem is locally well-posed in little H61der spaces. Next we investigate asymptotic behavior of the solution. By using the principle of linearized stability, we prove that if the surface tension coefficient y is larger than a threshold value y〉0, then the unique flat equilibrium is asymptotically stable provided that the constant c representing the ratio between the nutrient diffusion time and the tumor-cell doubling time is sufficiently small.

关键词： Free boundary problem multi-layer tumors well-posedness asymptotic behavior

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Neighbor Connectivity of Two Kinds of Cayley Graphs

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Acta Mathematicae Applicatae Sinica 2018年第2期34卷 386-397页

作者： Yi-jie shang Rong-xia HAO mei-mei GU Mathematics Beijing Jiaotong University

In this paper, we determine the neighbor connectivity κNB of two kinds of Cayley graphs： alter- nating group networks ANn and star graphs Sn; and give the exact values of edge neighbor connectivity λNB of ANn and Cayley graphs generated by transposition trees Fn. Those are κNB（ANn） = n-1, λNB（ANn） = n-2 and κNB（Sn） = λNB（Гn） = n - 1.

关键词： neighbor connectivity edge neighbor connectivity Cayley graphs

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Conservation Laws of Differential Equations in Finance

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Communications in Theoretical Physics 2005年第6X期44卷 967-968页

作者： QIN Mao-Chang mei Feng-Xiang shang mei School of Science Chongqing Technology and Business University Chongqing 400067 China School of Science Beijing Institute of Technology Beijing 100081 China

Conservation laws of some differential equations in fiance are studied in this paper. This method does not involve the use or existence of a variational principle. As an alternative, linearize the given equation and find adjoint equation of the linearized equation, the conservation laws can be constructed directly from the symmetries and adjoint symmetries of the associated linearized equation and its adjoint equation.

关键词： conservation law adjoint equation finance

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Mg doping and native N vacancy effect on electronic and transport properties of AlN nanowires

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Science China(Technological Sciences) 2015年第5期58卷 832-841页

作者： QIN mei shang Yan WANG Xiao ZHANG GuiLing Innovative Research Team of Green Chemical Technology in University of Heilongjiang Province College of Chemical and Environmental Engineering Harbin University of Science and Technology

The effects of Mg doping(MgAl) and native N vacancy(VN) on the electronic structures and transport properties of Al N nanowire(Al NNW) were theoretically investigated by using density functional theory. Either the MgAl defect or the VN defect prefers to be formed on the Al NNW surfaces. Both MgAl and VN defects could increase the conductivity owing to introducing a defect band inside the band gap of Al N and split the Al N band gap into two subgaps. The defect concentration has little influence on the magnitude of the subgaps. The MgAl serves as a shallow acceptor rendering the nanowire a p-type conductor. The VN introduces a deep donor state enabling the nanowire an n-type conductor. The MgAl systems exhibit higher conductivity than the VN ones owing to the narrow subgaps of MgAl systems. The conductivity is roughly proportional to the defect concentration in the MgAl and VN defect systems. When the MgAl and VN coexist, the hole state of the MgAl defect and the electron state of the VN defect will compensate each other and their coupling state appears just above the valence-band maximum leading to a little decrease of the band gap compared with the pure Al NNW, which is unfavorable for the enhancing of the conductivity.

关键词： doping enabling rendering compensate introducing valence magnitude defects narrow nanotubes

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Development of chromatographic technologies for the quality control of Traditional Chinese Medicine in the Chinese Pharmacopoeia

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Journal of Pharmaceutical Analysis 2021年第2期11卷 155-162页

作者： Ming-Rui Shen Yi He shang-mei Shi Chinese Pharmacopoeia Commission No.11 Fahua NanliBeijing100061China

As an important branch of medicine, Traditional Chinese Medicine(TCM) has been applied for the treatment of diseases for thousands of years in China and other countries in East Asia. The Chinese Pharmacopoeia(ChP) is a drug code formulated by the Chinese government, and it includes a special volume for the monographs of TCM, which plays an important role in ensuring the quality of drugs. The use of quality control technology has always been a complex and important factor in TCM. Owing to the chemical diversity of TCM, chromatography technology has been proven to be a comprehensive strategy for the assessment of the overall quality of TCM and has become the main analytical method in the *** article provides an overview of the classical and modern chromatographic technologies applied in the ChP, and summarizes the advantages and disadvantages of each technique in the TCM *** 2020, the new edition of the Ch P(the 2020 edition) has been implemented at the end of 2020. This paper also contains a brief introduction about the application of chromatographic technologies in the new edition of the ChP.

关键词： Traditional Chinese medicine Chinese pharmacopoeia Chromatographic technology Quality control

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