检索结果-南通市图书馆

Ancient DNA unravels species identification from Laosicheng site,Hunan Province,China,and provides insights into maternal genetic history of East Asian leopards

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第1期45卷 226-229页

作者： Ming Zhang Cai-Hui Wang Yu-Xin Zheng Qi-Gao Jiangzuo Ye-Mao Hou Peng cao Qing-Yan Dai Ruo-Wei Yang Feng Liu Xiao-Tian Feng Lin-Heng Mo Qiao-mei Fu China-Central Asia"the Belt and Road"Joint Laboratory on Human and Environment Research Key Laboratory of Cultural Heritage Research and ConservationSchool of Culture HeritageNorthwest UniversityXi’anShaanxi 710127China Shanghai Qi Zhi Institute Shanghai 200232China College of Life Sciences Northwest UniversityXi’anShaanxi 710127China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyCenter for Excellence in Life and PaleoenvironmentChinese Academy of SciencesBeijing 100044China Cultural Relics and Archaeology Institute of Hunan ChangshaHunan 410083China University of the Chinese Academy of Sciences Beijing 100049China

DEAR EDITOR,The Laosicheng site in Yongshun County,Hunan Province,China,plays an important role in elucidating the animal population composition of the region prior to the middle Qing Dynasty(approximately 300 years ago).This site has yielded a substantial number of animal bones,11960 of which have been identified to the species level,serving as direct evidence of ancient animal populations(Hunan Provincial Institute of Cultural Relics and Archaeology,2018).

关键词： Hunan Ancient insight

Pien Tze Huang Inhibits Proliferation of Colorectal Cancer Cells through Suppressing PNO1 Expression and Activating p53/p21 Signaling Pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 515-524页

作者： cao Liu-jing LIU Li-ya CHEN You-qin HAN Yu-ying WEI Li-hui YAO Meng-ying FANG Yi WU mei-zhu CHENG Ying Thomas J.Sferra LIU Hui-xin LI Li PENG Jun SHEN A-ling Clinical Research Institute the Second Affiliated Hospital&Academy of Integrative MedicineFujian University of Traditional Chinese MedicineFuzhou350122China Fujian Key Laboratory of Integrative Medicine in Geriatrics Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Pediatrics Case Western Reserve University School of MedicineUH Rainbow Babies and Children’s HospitalClevelandOH44106USA Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhou350122China Department of Health Management Fujian Provincial HospitalShengli Clinical College of Fujian Medical UniversityFuzhou000000China

ObjectiveTo explore the regulatory effect of Pien Tze Huang (PZH) on targeting partner of NOB1 (PNO1) and it’s down-stream mediators in colorectal cancer (CRC) *** polymerase chain reaction was performed to determine mRNA levels of PNO1, TP53, and CDKN1A. Western blotting was performed to determine protein levels of PNO1, p53, and p21. HCT-8 cells were transduced with a lentivirus over-expressing PNO1. Colony formation assay was used to detect cell survival in PNO1 overexpression of HCT-8 cells after PZH treatment. Cell-cycle distribution, cell viability and cell apoptosis were performed to identify the effect of PNO1 overexpression on cell proliferation and apoptosis of HCT-8 cells after PZH treatment. Xenograft BALB/c nude mice bearing HCT116 cells transduced with sh-PNO1 or sh-Ctrl lentivirus were evaluated. Western blot assay was performed to detect PNO1, p53, p21 and PCNA expression in tumor sections. Terminal deoxynucleotidyl transferase dUTP nick end labling (TUNEL) assay was used to determine the apoptotic cells in *** treatment decreased cell viability, down-regulated PNO1 expression, and up-regulated p53 and p21 expressions in HCT-8 cells (P<0.05). PNO1 overexpression attenuated the effects of PZH treatment, including the expression of p53 and p21, cell growth, cell viability, cell cycle arrest and cell apoptosis in vitro (P<0.05). PNO1 knockdown eliminated the effects of PZH treatment on tumor growth, inhibiting cell proliferation inhibition and apoptosis induction in vivo (P<0.05). Similarly, PNO1 knockdown attenuated the effects of PZH treatment on the down-regulation of PNO1 and up-regulation of p53 and p21 in vivo (P<0.05).ConclusionThe mechanism by which PZH induces its CRC anti-proliferative effect is at least in part by regulating the expression of PNO1 and its downstream targets p53 and p21.

关键词： colorectal cancer Pien Tze Huang Chinese medicine partner of NOB1 proliferation p53/p21 pathway

Clinical observation of endometrial prescription combined with TAM on FET of thin endometrial patients with kidney deficiency and blood stasis

在线全文

学校读者我要写书评

暂无评论

Clinical Research Communications 2024年第2期7卷 18-22页

作者： Wen-Ming cao Nan Jiang mei-Hua Wu Xiao-Lei Song Na Yu Shu-Ling Zhang Kui-mei Zhang Gynecology department Shenzhen Hospital of Integrated Traditional Chinese and Western MedicineShenzhen 518104China Gynecology department Shandong Maternal and Child Health HospitalJinan 2500013China Gynecology department Shandong Changle People’s HospitalWeifang 262400China.

Objective:To explore the best endometrial preparation scheme of freeze-thawed embryo transfer(FET)for patients with thin endometrium with kidney deficiency and blood stasis by comparing the clinical outcomes of three endometrial preparation schemes of estradiol valerate tablets Hormone Replacement(HRT),Tamoxifen(TAM)and Endometrial Prescription combined with TAM(EP-TAM group).Method:Retrospective analysis of 318 patients with thin endometrium with kidney deficiency and blood stasis who underwent FET in Changle People's Hospital of Shandong Province,Shandong Maternal and Child Health Hospital,and Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from September 2018 to March 2023,including 101 patients in HRT group(estradiol valerate tablets);108 patients in TAM group;109 patients in EP-TAM *** cycle cancellation rate,intimal thickness,clinical pregnancy rate,embryo implantation rate,early abortion rate and ectopic pregnancy rate were compared among the three ***:Cycle cancellation rates of TAM group and EP-TAM group were significantly lower than HRT group(8.3%,9.2%vs 17.8%,P<0.05).The intimal thickness of TAM group[(8.11±0.36)mm]and EP-TAM group[(8.21±0.40)mm]was significantly thicker than HRT group[(7.11±0.43)mm](P<0.05).The clinical pregnancy rate and implantation rate of TAM group and EP-TAM group were higher than HRT group,the early abortion rate and ectopic pregnancy rate were lower than HRT group,and EP-TAM group was more significant(P<0.05).Conclusion:Patients with thin endometrium underwent FET can try Endometrium Prescription combined with TAM(EP-TAM)to prepare the endometrium.

关键词： endometrium prescription estradiol valerate tablets tamoxifen hormone replacement thin endometrium freeze-thawed embryo transfer

基于语义分析的政府开放数据平台隐私政策量化评价研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

图书情报工作 2024年第1期68卷 65-76页

作者：陈美曹语嫣中南财经政法大学公共管理学院武汉430073

[目的/意义]在政府开放数据持续推进的过程中,如何确保个人隐私的安全性成为重要课题。系统梳理政府开放数据平台隐私政策,为推动政府开放数据和隐私保护的平衡发展提供参考和借鉴。[方法/过程]以15个省级政府开放数据平台隐私政策(211... 详细信息

[目的/意义]在政府开放数据持续推进的过程中,如何确保个人隐私的安全性成为重要课题。系统梳理政府开放数据平台隐私政策,为推动政府开放数据和隐私保护的平衡发展提供参考和借鉴。[方法/过程]以15个省级政府开放数据平台隐私政策(211条政策细则)为研究样本,综合运用LDA2Vce主题模型、命名实体识别以及PMC指数模型,从“政策主题—政策客体—政策效力”3个维度对各省政府开放数据平台隐私政策进行系统性梳理和量化评价。[结果/结论]我国政府数据开放平台隐私政策存在政策主题有待细化、政策客体参与失衡、政策效力仍需提升等问题,并提出相应的对策建议。

关键词：开放政府数据隐私保护 LDA2Vec主题模型命名实体识别 PMC指数模型

在线全文

学校读者我要写书评

暂无评论

管理者权力对短视主义波动的影响研究

管理评论 2024年第2期36卷 181-193页

作者：任声策杜梅操友根同济大学上海国际知识产权学院上海200092

疫情背景下企业该何去何从?作为企业重要决策人员的管理者,陷入短期获益和长期发展平衡的两难之中,短视主义波动越发明显。基于管理者认知和资源依赖理论,构建管理者短视主义波动指标,并以上海证券交易所、深圳证券交易所2019—2020年所... 详细信息

疫情背景下企业该何去何从?作为企业重要决策人员的管理者,陷入短期获益和长期发展平衡的两难之中,短视主义波动越发明显。基于管理者认知和资源依赖理论,构建管理者短视主义波动指标,并以上海证券交易所、深圳证券交易所2019—2020年所有A股上市公司为研究对象,探究疫情背景下管理者权力对短视主义波动的影响以及所有权性质、冗余资源和管理者任期在其间的调节作用。结果发现:管理者权力对短视主义波动有显著的负向作用;所有权性质和冗余资源在管理者权力与短视主义波动关系中起到显著的负向调节作用,而管理者任期在管理者权力与短视主义波动关系中起到显著的正向调节作用。研究结论拓展了管理者认知和资源依赖理论的应用范围,丰富了疫情背景下管理者权力与短视主义波动的相关研究,从所有权性质、冗余资源和管理者任期等维度审视管理者权力与短视主义波动关系的情境,为疫情背景下避免管理者出现短视主义波动和稳定管理者决策视野提供有益指导。

关键词：管理者权力管理者短视主义波动所有权性质冗余资源管理者任期

在线全文

学校读者我要写书评

暂无评论

北方农牧交错带耕地压力时空演变规律及预测

水土保持通报 2024年第4期44卷 394-404页

作者：曹浩然孟梅新疆农业大学公共管理学院(法学院) 新疆乌鲁木齐830002

[目的]研究中国北方农牧交错带耕地压力时空演变状况及空间分异状况,为北方农牧交错带未来粮食安全发展战略布局提供决策参考。[方法]基于修正的耕地压力指数模型分析北方农牧交错带2000—2023年耕地资源状况,并细分研究区域,分析耕地... 详细信息

[目的]研究中国北方农牧交错带耕地压力时空演变状况及空间分异状况,为北方农牧交错带未来粮食安全发展战略布局提供决策参考。[方法]基于修正的耕地压力指数模型分析北方农牧交错带2000—2023年耕地资源状况,并细分研究区域,分析耕地压力时空发展态势,利用预测模型测算耕地压力未来变化状况,最后提出相应对策建议。[结果](1)北方农牧交错带耕地压力总体上升,在时间序列上呈现“W”形变化;空间格局呈现“整体警戒,局部平稳”的态势,压力重心随时间总体向西南迁移;(2)区域耕地压力异质性呈逐渐分异趋势,受区域功能及产业结构发展的影响,时间格局上呈现异质性逐渐明显的趋势,空间格局分布上呈现出“长城沿线沙化地区长期稳定,黄土丘陵沟壑地区逐渐上升,京津冀水源涵养地区平缓下降”的特征;(3)未来7 a北方农牧交错带耕地压力呈现整体升高态势,对粮食安全及区域发展构成一定威胁,需引起有关部门的保护及重视。[结论]北方农牧交错带耕地压力总体呈上升趋势,且区域内差异逐渐明显,未来应提高全域耕地地力及环境整治能力,开展跨区域耕地保护补偿机制。

关键词：耕地压力指数粮食安全预测模型北方农牧交错带

Leaching behavior and microstructure of phosphorus in converter slag

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2024年第7期31卷 1646-1660页

作者： Chao-gang Zhou Jin-yue Li Qing-gong Chen Yin-ye Yang Wei Gong Li-qun Ai Shu-huan Wang Bei-yue Ma College of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210HebeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina College of Materials Science and Engineering Guizhou Minzu UniversityGuiyang 550025GuizhouChina School of Materials and Architectural Engineering Guizhou Normal UniversityGuiyang 550025GuizhouChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

Converter slag is a by-product of the steelmaking process and contains a large amount of Ca,Fe,P and other *** the phosphorus in the converter slag can be effectively extracted,the resulting phosphorus can be used as a phosphate *** in converter slag is mainly enriched in 2cao·SiO_(2)-3cao·P_(2)O_(5)(C_(2)S-C_(3)P)solid solution and is easily dissolved in ***,acid leaching method was used to dissolve the solid solution to extract phosphorus in converter slag,so as to realize the recycling of phosphorus resources in converter *** leaching behavior of three actual converter slags from different steel mills in acid leaching solutions composed of citric acid,sodium hydroxide,hydrochloric acid and deionized water was studied by X-ray diffraction,scanning electron microscopy combined with energy dispersive spectrometry,Fourier transform infrared spectroscopy and Raman spectroscopy to reveal the change in object image structure as well as SiO_(4) and PO_(4) tetrahedron before and after acid *** results show that only a small amount of phosphorus in converter slag with too low basicity is enriched in C_(2)S-C_(3)P solid solution,resulting in poor leaching *** the converter slag has a high basicity,the removal effect of phosphorus is 70.64%-81.88%.In addition,when the basicity of converter slag is roughly the same,the dephosphorization effect of slag with high FeO content is relatively *** acid leaching will cause depolymerization behavior of SiO_(4) and PO_(4) tetrahedron,so that the mole fraction of Q0(Si)(asymmetric stretching vibration of Si-O bond in SiO_(4) tetrahedron with bridge oxygen number of 0)and NBO/Si(non-bridging oxygen in silicate tetrahedra)will ***-containing solids can be obtained from the solution after acid leaching through static precipitation,and the solids have the potential to make phosphate fertilizers.

关键词： Dephosphorization converter slag Acid leaching Phosphorus Solid solution Slag structure

Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1665-1674页

作者： Jie Xiong Shu Cheng Xiao Gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-Fu Wang Hong-mei Yi Hao Zhang Wei-Guo cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nuclear Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Shanghai Rujin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiation Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology Navy Medical Center of PLAShanghaiChina Pole de Recherches Sino-Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghaiChina

Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive *** explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 *** complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),*** a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),*** most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of *** proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab *** conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage *** lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.

关键词： killer metabolism lymphoma

Covering corneal stromal lenticule for macular hole in pathological myopia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第9期17卷 1675-1680页

作者： Zi-Yan Tang Gang Qiao Xiao-Juan Zhang Li-Jun Xie Qiang-Xing Zou Chun-mei He Long Zhao Hua-Qing Yang Yu Quan Kui cao Hui Jiang Yu-Kun He Wanjiang Eye Hospital of Mianyang Mianyang 621000Sichuan ProvinceChina

AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological ***:This was a prospective non-randomized series case *** eyes of 14 patients whose axial length were more than 29 mm and suffered from MH and macular hole retinal detachment(MHRD)were included in this *** cases were treated with 25-gauge pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling,covering CSL and C_(3)F_(8) gas *** cases were followed for 6mo,and the best-corrected visual acuity(BCVA),healing status of MH,the reattached rate of retinal detachment(RD),and reoperation rate were ***:All cases were successfully performed the surgery and the postoperative follow-up was *** surgery,MHs were healed in all 14 eyes(100%,14/14)after assessed by optical coherence *** reattachment of retina was achieved in all 6 eyes(100%,6/6)with *** was improved in 12 eyes(85.71%,12/14),and had no significant change in 2 eyes(14.29%,2/14).The overall mean BCVA was improved from 1.80±0.77 to 0.82±0.46 logMAR(F=10.46,P<0.01).No serious complications occurred in all ***:The new surgery technique(covering CSL)has high reattached rate of RD and high healing rate of MH in pathological myopia in the preliminary *** it can effectively improve the visual function of *** new technique offers meaningful new ideas for treating refractory MH in pathological myopia.

关键词： corneal stromal lenticule macular hole pathological myopia