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Efficacy and safety of Tianqi pingchan Granule,a compound Chinese herbal medicine,for levodopa-induced dyskinesia in Parkinson’s disease:A randomized double-blind placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 545-551页

作者： yu Zhang xiao-bo Zhu Yang Zhao Gui-yun Cui Wen-tao Li Can-xing yuan Jian-ping Huang Ying Wan Na Wu Lu Song Jia-hao Zhao Yan Liang Chuan-ying xu mei-juan Liu Chen Gao xin-xin Chen Zhen-guo Liu Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Neurology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Parkinson’s Disease Center the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Neurology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200071China Department of Neurology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Neurology Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

Background Patients with Parkinson’s disease(PD)undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(LID).Amantadine is the main drug recommended for the treatment of LID by current guidelines,but it is far from meeting clinical *** pingchan Granule(TPG),a compound Chinese herbal medicine,has been developed to relieve symptom of *** This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for ***,setting,participants and interventions This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in Jiangsu,Zhejiang and Shanghai,*** hundred PD patients with≥0.5 h of LID were randomly assigned to either the TPG plus amantadine group(TPG group)or the placebo plus amantadine group(placebo group),and treated for a period of 12 *** ensure unbiased results,all study participants,investigators and sponsors were unaware of group ***,the data analysts remained blinded until the analysis was *** outcome measures The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0–104).The key secondary end point was improvement of motor and non-motor *** analyses included all enrolled *** One hundred patients were enrolled and randomized into the two treatment *** changes in UDysRS at week 12 were–11.02 for the TPG group and–4.19 for the placebo group(treatment difference–6.83[–10.53 to–3.12];P=0.0004).Adverse events were reported for 2 of 50 patients(4.0%)in each of the *** This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated,demonstrating the efficacy and safety of TPG for the treatment of LID in PD.

关键词： Parkinson’s disease Tianqi pingchan Granule Levodopa-induced dyskinesia

Arsenic and fluoride co-enrichment of groundwater in the loess areas and associated human health risks:A case study of Dali County in the Guanzhong Basin

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China Geology 2024年第3期7卷 445-459页

作者： Rui-ping Liu Fei Liu Hua-qing Chen yu-ting Yang Hua Zhu You-ning xu Jian-gang Jiao Refaey M El-Wardany xi'an Center China Geological SurveyMinistry of Natural ResourcesXi'an 710054China Observation and Research Station of Environmental Geology of Typical Mines in Shaanxi Province MNRXi'an 710054China Key Laboratory for Geo-hazards in Loess Area MNRXi'an 710054China Dalian Ocean and Fishery Comprehensive Administration Supervision Lochus Dalian 116000China pingliang City Development and Reform Commission Pingliang 744000China School of Earth Science and Resources Chang’an UniversityXi'an 710054China Faculty of Science Al-Azhar UniversityAssiut 71524Egypt

This study aims to reveal the occurrence and origin of typical groundwater with high arsenic and fluoride concentrations in the loess area of the Guanzhong Basin—a Neogene faulted *** findings are as follows:(1)Groundwater samples with high arsenic and fluoride concentrations collected from the loess area and the terraces of the Weihe River accounted for 26%and 30%,respectively,of the total samples,with primary hydrochemical type identified as HCO_(3)-*** karst and sand areas exhibit relatively high groundwater quality,serving as preferred sources for water *** is recommended that local governments fully harness groundwater in these areas;(2)groundwater with high arsenic and fluoride concentrations in the loess area and the alluvial plain of rivers in Dali County is primarily distributed within the Guanzhong Basin,which represents the drainage zone of groundwater;(3)arsenic and fluoride in groundwater originate principally from natural and anthropogenic sources;(4)the human health risk assessments reveal that long-term intake of groundwater with high arsenic and fluoride concentrations pose cancer or non-cancer risks,which are more serious to kids compared to *** study provides a theoretical basis for the prevention and treatment of groundwater with high arsenic and fluoride concentrations in loess areas.

关键词： Arsenic Fluoride Groundwater Cancer risk Kid and adult Human health risk assessment Hydrogeological survey engineering Environmental geological survey engineering Loess areas

Haploinsufficiency of A20 (HA20): updates on the genetics, phenotype, pathogenesis and treatment

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World Journal of Pediatrics 2020年第6期16卷 575-584页

作者： mei-ping yu.xi-sheng xu Qing Zhou Natalie Deuitch mei-ping Lu Department of Rheumatology Immunology and Allergy.Children's Hospital Zhejiang University School of MedicineHangzhou 310052China MOE Key Laboratory of Biosystems Homeostasis&Protection Life Sciences Institute.Zhejiang UniversityHangzhouChina Genetics Department Stanford UniversityCaliforniaUSA

Background A20,a protein encoded by the tumor necrosis factor alpha-induced protein 3 gene(TNFAIP3),plays a vital role in the negative regulation of inflammation and ***-of-function mutation in TNFAIP3 leads to a new described autoinflammatory disease-haploinsufficiency of A20(HA20).Since HA20 was first described in 2016,a number of new cases have been described in this literature,however,the disease and its pathogenesis are poorly *** review seeks to improve clinical recognition of this disorder,and promote both earlier diagnosis and initiation of targeted therapies to improve patients’*** We reviewed 26 papers about A20 and HA20,and we summarized genetic variants and clinical manifestations of a total of 61 reported patients from 26 families identified to have a genetic diagnosis of germline pathogenic variants in TNFAIP3/***,we discussed the pathogenesis and treatment of *** A total of 24 pathogenic variants of A20 had been *** was significant clinical heterogeneity,even among those with the same variants in *** to receiving a molecular diagnosis of HA20,patients had been diagnosed with Behcet's disease,rheumatoid arthritis,rheumatic fever,juvenile idiopathic arthritis,systemic lupus erythematosus,and even adult-onset Stills'*** patients with HA20 that presented with inflammatory signatures in NF-kB signaling were mostly responsive to *** HA20 is a monogenic autoinflammatory disease with highly variable clinical *** extensive heterogeneity makes it difficult to set a clinical diagnostic criteria,and genetic sequencing is necessary for a definitive diagnosis of HA20.

关键词： Autoinflammatory disease HA20 NF-κB signaling TNFAIP3 Treatment

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中药红花的化学成分及色素提取工艺研究进展

中国中药杂志 2024年第7期49卷 1725-1740页

作者：张喜妹肖江鸿王玉唐于平乐世俊陕西中医药大学、陕西省中医药管理局中药配伍重点实验室陕西西安712046 河北中医药大学、河北省中药资源利用与质量评价国际联合研究中心河北石家庄050200

红花具有活血通经、散瘀止痛的功效,是临床常用的活血化瘀类中药之一。迄今,红花中已分离并报道的化合物有210多种,包括醌式查尔酮类(红花黄色素和红色素)、黄酮类、亚精胺类、生物碱类、聚炔类、有机酸类等。红花黄色素作为红花主要的... 详细信息

红花具有活血通经、散瘀止痛的功效,是临床常用的活血化瘀类中药之一。迄今,红花中已分离并报道的化合物有210多种,包括醌式查尔酮类(红花黄色素和红色素)、黄酮类、亚精胺类、生物碱类、聚炔类、有机酸类等。红花黄色素作为红花主要的水溶性活性成分,常用水提法进行提取分离,而红色素常用碱提酸沉法进行提取。近年,天然深共熔溶剂作为一种绿色溶剂在红花的色素提取分离中呈现出较好的应用前景。该文针对红花的化学成分进行系统地归纳,并对红花中色素类成分的提取工艺进行分析,以期为进一步合理利用红花资源提供参考。

关键词：红花红花黄色素红花苷化学成分提取工艺

Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang sheng-Quan Yan Ming He Qing-Zhang Zhao Wen-Hui Zhang Chao-xin Kan Jian-Ming Zhou Kang-Ning Li xiao-Fei Wang Jian-Cheng Liu Zhao-Hua Peng Zhuo Liang Ai-Ling Li Jian Zheng Qi-Wen Fan yun-Ju Li You-Bao Wang Zhi-Hong Li Yang-ping Shen Ding Nan Wei Nan yu-Qiang Zhang Jia-Ying-Hao Li Jun-Wen Tian Jiang-Lin Hou Chang-xin Guo Zhi-Cheng Zhang Ming-Hao Zhu yu-Wen Chen yu-Chen Jiang Tao Tian Jin-Long Ma Yi-Hui Liu Jing-yu Dong Run-Long Liu mei-yue-Nan Ma Yong-Shou Chen Wei-ping Liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB

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Biomedical and Environmental Sciences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi yu JIANG Ting Ting DENG Wen CHANG Min WU Shu Ling CAO Wei Hua LU Yao SHEN Ge LIU Ru yu GAO yuan Jiao xu Meng Jiao HU Lei ping ZHANG Lu xiE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<*** Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： CHB Dendritic Cells Intermittent Interferon Therapy Plateau Phase

Acquired methemoglobinemia in a third trimester puerpera and her premature infant with sodium nitrite poisoning:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5151-5158页

作者： Dong-sheng Fei Yang Gao xue-Jiao Bao yu-Jia Tang Yi-Lu Lin Jia-xi xu Jia-Ning Zhang Bo-Wen Liu Kai Kang Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical UniversityHarbin 150027Heilongjiang ProvinceChina

BACKGROUND The common cause of sodium nitrite poisoning has shifted from previous accidental intoxication by exposure or ingestion of contaminated water and food to recent alarming intentional intoxication as an employed method of suicide/*** subsequent formation of methemoglobin(MetHb)restricts oxygen transport and utilization in the body,resulting in functional hypoxia at the tissue *** clinical practice,a mismatch of cyanotic appearance and oxygen partial pressure usually contributes to the identification of *** recognition of characteristic mismatch and accurate diagnosis of sodium nitrite poisoning are prerequisites for the implementation of standardized systemic *** SUMMARY A pregnant woman was admitted to the Department of Critical Care Medicine at the First Affiliated Hospital of Harbin Medical University due to consciousness disorders and drowsiness 2 h before ***,she developed vomiting and cyanotic *** woman underwent orotracheal intubation,invasive mechanical ventilation(IMV),and correction of internal environment disturbance in the *** premature infant was born with a higher-than-normal MetHb level of 3.3%,and received detoxification with methylene blue and vitamin C,supplemental vitamin K1,an infusion of fresh frozen plasma,as well as respiratory support via orotracheal intubation and *** day 3 after admission,the puerpera regained consciousness,evacuated the IMV,and resumed enteral *** was then transferred to the maternity ward 24 h *** day 7 after admission,the woman recovered and was discharged without any *** MetHb can cross through the placental *** of MetHb both reflects severity of the sodium nitrite poisoning and serves as feedback on therapeutic effectiveness.

关键词： Sodium nitrite poisoning Methemoglobinemia Methemoglobin Third trimester puerpera Premature infant Placental barrier Methylene blue Case report

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang Li-Tao Yang Qian yue Ke-Jun Kang yuan-Jing Li Hai-Peng An C.Greeshma Jian-ping Chang yun-Huan Chen Jian-ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang xin-ping Geng Hui Gong Qiu-Ju Guo xu-yuan Guo Li He sheng-Ming He Jin-Wei Hu Han-xiong Huang Tu-Chen Huang Hai-Tao Jia xi Jiang S.Karmakar Hao-Bin Li Jian-Min Li Jin Li Qian-yun Li Ren-Ming-Jie Li xue-Qian Li yu-Lan Li Yi-Fan Liang Bin Liao Fong-Kay Lin Shin-Ted Lin Jia-xuan Liu Shu-Kui Liu Yan-Dong Liu yu Liu yuan-yuan Liu Zhong-Zhi Liu Hao Ma yu-Cai Mao Qi-yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren xi-Chao Ruan Ze She Manoj Kumar Singh Tian-xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang Li Wang Qing Wang yu-Feng Wang yun-xiang Wang Henry-Tsz-King Wong Shi-Yong Wu yu-Cheng Wu Hao-Yang xing Rui xu Yin xu Tao xue yu-Lu Yan Nan Yi Chun-xu yu Hai-Jun yu Jian-Feng yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

NνDEx-100 conceptual design report

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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-Liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-yuan Huang Ze-yu Huang Lei Lang yu-Lan Li Zhi-Jie Li Tian-yu Liang Jun Liu Chen-Gui Lu Fa-Tai Mai yuan mei Hao Qiu xiang-Ming Sun xiao-xing Tang Hu-Lin Wang Qian-Ming Wang Le xiao Mu-yun xiao Jian-yu.xin Nu xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang yu Dong-Liang Zhang Jun-Wei Zhang Cheng-xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory