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High sensitivity dual polarization four channels surface plasmon resonance refractive index sensor with wide detection range and high linearity based on photonic crystal fiber

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Optoelectronics Letters 2025年

作者： CUI nan PAN Honggang ZHANG Ailing ZHAO Zihong CHEN Zhipan ZHANG Bo Tianjin Key Laboratory of Film Electronic and Communication Devices， Engineering Research Center of Optoelectronic Devices and Communication Technology， Ministry of Education， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

In this paper， we propose and numerically characterize the optical characteristics of a high sensitivity dual polarization four channels surface plasmon resonance refractive index sensor with wide detection range and high linearity based on photonic crystal fiber （PCF）. Four light transmission channels are constructed by using big air holes. The small rectangular air hole in the center of the fiber core is used to add asymmetry. We use gold plasma material to achieve better sensing performance. A thin film of TiO2is placed on the PCF surface， which assists gold in the adhesion on PCF. The maximum wavelength sensitivity of the sensor can reach 20000 nm/RIU in both x and y polarization modes. While the maximum wavelength resolution of the sensor is 5×10-6RIU. The average wavelength sensitivity reached 15900nm/RIU and 15800nm/RIU in x and y polarization mode. The sensor features R2=0.9969 / R2=0.9966 high linear performance in x and y polarization mode and the maximum FOM values 509.13 RIU-1/ 489.63 RIU-1in x and y polarization mode. Besides the sensor’s detection range is 1.26-1.36， which is a wide refractive index detection range. The sensor has a wide range of applications in biomedical and other fields.

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Changes in posterior corneal elevation after small incision lenticule extraction for different myopic diopters

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 491-498页

作者： Xiao-Tong Sun Yang Zhang Xiao-Kun mei nan-nan Zheng ling-Zhi Niu Xiao-Li Qu Ai-Ping Song Jian Zhuo Department of Ophthalmology the First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan HospitalJinan 250014Shandong ProvinceChina

●AIM:To study the changes and effect factors of posterior corneal surface after small incision lenticule extraction(SMILE)with different myopic diopters.●METHODS:Ninety eyes of 90 patients who underwent SMILE were included in this retrospective *** were allocated into three groups based on the preoperative spherical equivalent(SE):low myopia(SE≥-3.00 D),moderate myopia(-3.00 D>SE>-6.00 D)and high myopia(SE≤-6.00 D).Posterior corneal surfaces were measured by a Scheimpflug camera preoperatively and different postoperative times(1wk,1,3,6mo,and 1y).Posterior mean elevation(PME)at 25 predetermined points of 3 concentric circles(2-,4-,and 6-mm diameter)above the best fit sphere was analyzed.●RESULTS:All surgeries were completed uneventfully and no ectasia was found through the *** difference of myopia group was significant at the 2-mm ring at 1 and 3mo postoperatively(1mo:P=0.017;3mo:P=0.018).The effect of time onΔPME was statistically significant(2-mm ring:P=0.001;4-mm ring:P<0.001;6-mm ring:P<0.001).The effect of different corneal locations onΔPME was significant except 1wk postoperatively(1mo:P=0.000;3mo:P=0.000;6mo:P=0.001;1y:P=0.001).Posterior corneal stability was linearly correlated with SE,central corneal thickness,ablation depth,residual bed thickness,percent ablation depth and percent stromal bed thickness.●CONCLUSION:The posterior corneal surface changes dynamically after *** protrusion is observed on the posterior corneal surface in patients with different degrees of myopia within one year after *** has good stability,accuracy,safety and predictability.

关键词： myopia posterior corneal elevation corneal ectasia small incision lenticule extraction

Bounded multi-soliton solutions and their asymptotic analysis for the reversal-time nonlocal nonlinear Schrodinger equation

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Communications in Theoretical Physics 2021年第10期73卷 1-13页

作者： Wei-Jing Tang Zhang-nan Hu Liming ling Department of Mathematics South China University of TechnologyGuangzhou510641China

In this paper, we construct the Darboux transformation(DT) for the reverse-time integrable nonlocal nonlinear Schrodinger equation by loop group method. Then we utilize the DT to derive soliton solutions with zero seed. We investigate the dynamical properties for those solutions and present a sufficient condition for the non-singularity of multi-soliton ***, the asymptotic analysis of bounded multi-solutions has also been established by the determinant formula.

关键词： nonlocal nonlinear Schrodinger equation multi-soliton solution singularity asymptotic analysis

脓毒症合并急性肾损伤采用连续性血液净化治疗的效果及预后影响因素

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罕少疾病杂志 2025年第1期32卷 99-101页

作者：孟贺玲王亚男驻马店市中心医院血液净化室河南驻马店463000

目的探讨脓毒症合并急性肾损伤患者采用连续性血液净化治疗的效果及预后影响因素。方法本研究中共纳入250例脓毒症合并急性肾损伤患者,选取时间为2019年5月至2022年5月,所有患者均来源于驻马店市中心医院,进行回顾性分析。所有患者均... 详细信息

目的探讨脓毒症合并急性肾损伤患者采用连续性血液净化治疗的效果及预后影响因素。方法本研究中共纳入250例脓毒症合并急性肾损伤患者,选取时间为2019年5月至2022年5月,所有患者均来源于驻马店市中心医院,进行回顾性分析。所有患者均接受连续性血液净化治疗,对患者28 d转归情况进行记录,分为死亡组(133例)和存活组(117例)。统计死亡组和存活组患者各项基线资料并进行对比,然后进行多因素回归分析模型,筛选患者预后不良的高危因素。结果死亡组患者APACHEⅡ、SOFA评分及有创机械通气占比均相较于存活组升高(t=5.824、5.311,χ~2=49.209,均P0.05);脓毒症合并急性肾损伤患者采用连续性血液净化治疗预后不良的高危因素有年龄、冠心病、AKI分期Ⅲ期、感染性休克、心功能Ⅳ级、高钾血脂症、APACHEⅡ评分、SOFA评分(OR=1.391、7.838、7.360、8.306、8.793、3.473、2.832、3.543,均P<0.05)。结论脓毒症合并急性肾损伤患者采用连续性血液净化治疗预后不良的高危因素有年龄、冠心病、AKI分期Ⅲ期、感染性休克、心功能Ⅳ级、高钾血脂症等,临床应据此采取相关措施,以改善患者预后。

关键词：脓毒症急性肾损伤连续性血液净化治疗效果预后影响因素

Paricalcitol in hemodialysis patients with secondary hyperparathyroidism and its potential benefits

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World Journal of Clinical Cases 2021年第33期9卷 10172-10179页

作者： Xiu Chen Feng Zhao Wei-Juan Pan Jia-mei Di Wei-nan Xie ling Yuan Zhi Liu Department of Nephrology The First Affiliated Hospital of Anhui University of Science and Technology(The First People’s Hospital of Huainan)Huainan 232007Anhui ProvinceChina

BACKGROUND Secondary hyperparathyroidism(SHPT)is a common complication in patients with end-stage renal disease and it is also common in hemodialysis *** can increase bone fragility and calcification of blood vessels and soft tissues,which greatly increases the risk of *** To discuss the outcome,safety and other potential benefits of paricalcitol injection in hemodialysis patients with *** We recruited 40 patients who received hemodialysis at our hospital for chronic renal failure with SHPT between March and December *** received paricalcitol injection for 24 wk(starting dose,0.06–0.08μg/kg),three times per *** were followed up at the baseline(week 0),week 4,week 12 and week *** primary outcome indicator was the percentage of patients with a>30%decrease in intact parathyroid hormone(iPTH)levels at week 24 compared with the *** secondary outcome indicators included percentage decrease in iPTH levels at week 24,standard-reaching rate of iPTH(percentage of patients with iPTH down to 130–585 pg/mL),changes in serum levels of calcium(Ca),phosphate(P),Ca×P product,alkaline phosphatase(ALP),creatinine(Cre),hemoglobin(Hb),and C-reactive protein(CRP),and incidence of adverse events(AEs).RESULTS After 24 wk of treatment,iPTH levels decreased significantly(598.88±381.29 pg/mL vs 888.84±376.88 pg/mL,P0.05).After 24 wk of treatment,serum P levels decreased compared with the baseline(1.91±0.40 mmol/L vs 2.16±0.66 mmol/L)(t=2.830,P<0.05).Ca×P product decreased significantly compared with the baseline(56.38±13.22 mg2/dL

关键词： Paricalcitol Hemodialysis Secondary hyperparathyroidism Drug efficacy Drug safety

For robust big data analyses:a collection of 150 important pro-metastatic genes

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Chinese Journal of Cancer 2017年第3期36卷 112-120页

作者： Yan mei Jun-Ping Yang Chao-nan Qian State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Metastasis is the greatest contributor to cancer?related *** the era of precision medicine,it is essential to predict and to prevent the spread of cancer cells to significantly improve patient *** to the application of a variety of high?throughput technologies,accumulating big data enables researchers and clinicians to identify aggressive tumors as well as patients with a high risk of cancer ***,there have been few large?scale gene collection studies to enable metastasis?related *** the last several years,emerging efforts have identi?fied pro?metastatic genes in a variety of cancers,providing us the ability to generate a pro?metastatic gene cluster for big data *** carefully selected 285 genes with in vivo evidence of promoting metastasis reported in the *** genes have been investigated in different tumor *** used two datasets downloaded from The Cancer Genome Atlas database,specifically,datasets of clear cell renal cell carcinoma and hepatocellular carcinoma,for validation tests,and excluded any genes for which elevated expression level correlated with longer overall survival in any of the ***,150 pro?metastatic genes remained in our *** believe this collection of pro?metastatic genes will be helpful for big data analyses,and eventually will accelerate anti?metastasis research and clinical intervention.

关键词： Pro-metastatic gene Big data analysis Renal cancer Liver cancer

Designer cell-self-implemented labeling of microvesicles in situ with the intracellular-synthesized quantum dots

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Science China Chemistry 2020年第4期63卷 448-453页

作者： ling-Hong Xiong Jia-Wei Tu Ya-nan Zhang ling-ling Yang Ran Cui Zhi-ling Zhang Dai-Wen Pang College of Chemistry and Molecular Sciences State Key Laboratory of VirologyInstitute for Advanced Studiesand Wuhan Institute of BiotechnologyWuhan UniversityWuhan 430072China State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratoryof Biosensing and Molecular RecognitionResearch Center for Analytical Sciencesand College of ChemistryNankai UniversityTianjin 300071China

Cell-derived microvesicles(MVs) are secreted from almost all kinds of mammalian cells into the extracellular space, and play crucial roles in intercellular communication and transporting biomolecules between cells. However, there is a great challenge for visualizing and monitoring of MVs’ bio-behaviors due to the limitations of existing labeling methods. Herein, we report the first paradigm of designer cell-self-implemented labeling of MVs secreted from living mammalian MCF-7 cells in situ using the intracellular-synthesized fluorescent quantum dots(QDs) during the formation of MVs. By elaborately coupling intracellular biochemical reactions and metabolism pathways, the MCF-7 cells can be illuminated brightly by intracellular-biosynthesized fluorescent CdSe QDs. Simultaneously, intracellular-synthesized QDs can be in situ encapsulated by the secreted MVs budding from the plasma membrane of the fluorescing cells to label the MVs with an efficiency of up to 89.9%. The whole labeling process skillfully combines designer precise cell-tuned intricate synthesis of CdSe QDs with mild in-situ labeling via cell-selfimplementation just after feeding the cell with suitable chemicals, which is structure-or function-nondestructive and much more straightforward and milder than those by chemical conjugation or indirect encapsulation with conventional fluorogenic labels.

关键词： in situ labeling live cell synthesis cell-derived microvesicles quantum dot cell-self-implementation

Preliminary assessment of two non-destructive instrumental techniques for quality evaluation of Lobelia chinensis Lour.

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Journal of Pharmaceutical Analysis 2016年第3期6卷 203-206页

作者： Hong-Peng Chen Wen-jia Pan nan Tang Yuan Zhang mei-ling Yu xing-da wu School of Information Engineering Guangdong Medical University Xincheng Road Dongguan 52380& China School of Pharmacy Guangdong Medical University Xincheng Road Dongguan 523808 China Department of Pharmacology Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 China Department of Pharmacy the First Affiliated Hospital of Bengbu Medical College Benghu 233004 China

Two non-destructive instrumental methods, infrared spectroscopy （IR） and X-ray diffraction （XRD）, were studied for qualiW evaluation of Lobelia chinensis Lour. （L chinensis）. We obtained the IR spectra and XRD patterns of L chinensis collected from different sources. The similarity of samples was analyzed by cal- culating the cosine coefficient. The cosine values were in the range of 0.83-0.90, indicating that the main components ofL chinensis samples are similar. Sample L1 and L6 showed a slightly lower similarity than that of L2, L3, L4, L5 detected by the two methods, which revealed that IR and XRD methods exhibited analogous detection ability for quality evaluation of L. chinensis. The two methods could be highly re- commended as simple and rapid detection means for quality evaluation of L. chinensis.

关键词： Lobelia chinensis Lour Infrared spectroscopy X-ray diffraction Quality evaluation

13-Methyltetradecanoic acid mitigates cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2016年第9期11卷 1431-1437页

作者： Juan Yu Li-nan Yang Yan-yun Wu Bao-hua Li Sheng-mei Weng Chun-lan Hu Yong-ling Han Department of Physiology and Pathophysiology School of Basic Medical SciencesFujian Medical University Department of Pharmacology School of PharmacyFujian Medical University

13-Methyltetradecanoic acid can stabilize cell membrane and have anti-inflammatory, antioxidant and anti-apoptotic effects. Previous studies mainly focused on peripheral nerve injury, but seldom on the central nervous system. We investigated whether these properties of 13-methyltetradecanoic acid have a neuroprotective effect on focal cerebral ischemia/reperfusion injury, and detected the expression of basic fibroblast growth factor and vascular endothelial growth factor. This study established rat models of middle cerebral artery occlusion/ reperfusion injury by ischemia for 2 hours and reperfusion for 24 hours. At the beginning of reperfusion, 13-methyltetradecanoic acid 10, 40 or 80 mg/kg was injected into the tail vein. Results found that various doses of 13-methyltetradecanoic acid effectively reduced infarct volume, mitigate cerebral edema, and increased the mRNA and protein expression of basic fibroblast growth factor and vascular endothe- lial growth factor at 24 hours of reperfusion. The effect was most significant in the 13-methyltetradecanoic acid 40 and 80 mg/kg groups. The findings suggest that 13-methyltetradecanoic acid can relieve focal ischemia/reperfusion injury immediately after reperfusion, stimu- late the upregulation of basic fibroblast growth factor and vascular endothelial growth factor to exert neuroprotective effects.

关键词： nerve regeneration brain injury 13-methyltetradecanoic acid cerebral ischemia/reperfusion injury basic fibroblast growth factor vascular endothelial growth factor cerebral infarction cerebral edema neural regeneration