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CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： tao SUN QINGhua SONG hua LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

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Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-mei Wang mei-Xia tao Kai-Ming Mo Xu Chen Shu-hua Zhong Elena S Shubina Guo-Hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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2-(2-Phenylethyl)chromones from Endophytic Fungal Strain Botryosphaeria rhodina A13 from Aquilaria sinensis

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Chinese Herbal Medicines 2017年第1期9卷 58-62页

作者： Yao Zhang Hong-xin Liu Wen-shan Li mei-hua tao Qing-ling Pan Zhang-hua Sun Wei Ye Hao-hua Li Wei-min Zhang State Key Laboratory of Applied Microbiology Southern China Guangdong Open Laboratory of Applied Microbiology Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Institute of Microbiology Guangzhou 510070 China

Objective To study the characteristic 2-（2-phenylethyl）chromone components of endophytic fungal strain of Aquilaria sinensis by solid culture. Methods The compounds were isolated by various chromatographic methods such as silica gel, reverse-phase silica gel, Sephadex-LH20 column chromatography as well as crystallization. Results Seven 2-（2-phenylethyl）chromone analogues were isolated from the solid culture of Botryosphaeria rhodina A13. Their structures were established by spectral data as well as physicochemical properties, and identified as 6-hydroxy-7-methoxy-2-（2-phenylethyl）chromone （1）, 6,7-dimethoxy-2-（2-phenylethyl） chromone （2）, （5S,6R,7S,8R）-2-（2-phenylethyl）-5,6,7,8-tetrahydrchromone （3）, 6- hydroxy-2-（2-phenylethyl）chromone （4）, 4＇-hydroxy-2-（2-phenylethyl）chromone （5）, 6-methoxy-2-phenethyl-4H-chromen-4-one （6）, and 6-methoxy-2-（4＇-methoxy-phenethyl）-4H-chromen-4-one （7）. Conclusion All of the compounds are isolated for the first time from the genus Botryosphaeria. This research opens up a new vista to produce the characteristic components of agarwood by endophytic fungi.

关键词： agarwood Aquilaria sinensis Botryosphaeria rhodina A13 2-(2-phenylethyl) chromones solid culture

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The Chemical Constituents of Endophytic Fungus Phomopsis sp.A240 Isolated from Taxus chinensis ***

The Chemical Constituents of Endophytic Fungus Phomopsis sp....

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第五届全国微生物资源学术暨国家微生物资源平台运行服务研讨会

作者： mei-hua tao Yu-Chan Chen Xiao-Yi Wei Jian-Wen Tan Wei-Min Zhang Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of Sciences

A new sesquiterpene,△9(10))-eremophilene-11,12,13-triol(1),a new oxazole, 4-(2-hydroxyethyl)-5-methyloxazoIe(2) and two known lactone 5’-hydroxy-alternariol(3),alternariol(4) were isolated from the extract of Phomopsis sp.A240,an endophytic fungus isolated from the bark of Taxus chinensis *** structures of isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature *** isolated compounds were evaluated for their cytotoxic and antioxidant activities.

关键词： Taxus chinensis var.mairei Phomopsis sp. endophytic fungus chemical constituent

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基于直觉模糊支配的混合多目标粒子群算法

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计算机科学 2017年第1期44卷 253-258页

作者：梅海涛华继学王毅文童空军工程大学防空反导学院西安710051

为提高求解多目标优化问题的精确性和解集分布的均匀性,提出了一种基于直觉模糊支配的混合粒子群算法。通过引入种群全局目标值标量参数、直觉模糊隶属度和排序方法,定义一种新的最优解支配关系;采用基于模拟退火的Meta-Lamarckian局部... 详细信息

为提高求解多目标优化问题的精确性和解集分布的均匀性,提出了一种基于直觉模糊支配的混合粒子群算法。通过引入种群全局目标值标量参数、直觉模糊隶属度和排序方法,定义一种新的最优解支配关系;采用基于模拟退火的Meta-Lamarckian局部学习策略,结合粒子群算法,以避免算法陷入局部最优和早熟;此外,定义种群同构因子来衡量种群多样性,以自适应调节惯性权重和加速因子;提出一种递减扰动策略对粒子飞行速度进行扰动;最后,与多种经典多目标优化算法进行仿真测试比较,结果表明该算法在求解精度、解集分布均匀性上具有明显优势。

关键词：直觉模糊支配混合粒子群优化模拟退火拉马克学习同构因子

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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu hua-tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Counterion-Mediated Hydrogen Bonding Making Strong Polyelectrolytes pH-Responsive:Current Understanding and Perspectives

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Chinese Journal of Polymer Science 2024年第9期42卷 1270-1277,I0005页

作者： Yue huang Guang-tao mei Zan hua Guang-Ming Liu Hefei National Research Center for Physical Sciences at the Microscale Department of Chemical PhysicsKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei230026China The Key Laboratory of Functional Molecular Solids Ministry of Educationand Department of Materials ChemistrySchool of Chemistry and Materials ScienceAnhui Normal UniversityWuhu214002China

The counterion-mediated hydrogen bonding(CMHB)is related to the hydrogen bonding between bound counterions and polyelectrolyte chains in polyelectrolyte systems,where the counterions can both electrostatically bind to the charged groups of polyelectrolyte chains and act as hydrogen bond donors or acceptors to form hydrogen bonds with the hydrogen bond sites associated with polyelectrolyte chains simultaneously.A large number of literatures illustrate that strong polyelectrolytes(SPs)are insensitive to pH,which severely limmits the applications of SPs as smart ***,our studies have demonstrated that the CMHB makes SPs *** perspective discusses the mechanism of pH responsiveness of SPs and the pH-tunable properties of SPs,based on the pH-controlled CMHB *** future research directions on the pH responsiveness of SPs are also discussed *** is anticipated that the study of the pH responsiveness of SPs not only will provide a new understanding of the fundamental properties of SPs,but also will greatly expand the applications of SPs in the field of smart materials.

关键词： Counterion binding Hydrogen bond Polyelectrolyte brush Polyelectrolyte complexation

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A novel trilinear decomposition algorithm:Three-dimension non-negative matrix factorization

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Chinese Chemical Letters 2007年第4期18卷 495-498页

作者： Hong tao Gao Dong mei Dai Tong hua Li College of Chemistry and Molecular Engineering Qingdao University of Science ＆ Technology Qingdao 266042 China Department of Chemistry Jining Teachers College Jining 273100 China Department of Chemistry Tongji University Shanghai 200092 China

Non-negative matrix factorization （NMF） is a technique for dimensionality reduction by placing non-negativity constraints on the matrix. Based on the PARAFAC model, NMF was extended for three-dimension data decomposition. The three-dimension nonnegative matrix factorization （NMF3） algorithm, which was concise and easy to implement, was given in this paper. The NMF3 algorithm implementation was based on elements but not on vectors. It could decompose a data array directly without unfolding, which was not similar to that the traditional algorithms do, It has been applied to the simulated data array decomposition and obtained reasonable results. It showed that NMF3 could be introduced for curve resolution in chemometrics.

关键词： Three-dimension non-negative matrix factorization NMF3 Algorithm Data decomposition Chemometrics

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Performance evaluation of ultra-long lithium heat pipe using an improved lumped parameter model

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Nuclear Science and Techniques 2021年第12期32卷 89-102页

作者： Chong-Ju Hu Da-Li Yu mei-Sheng He hua-Ping mei Jie Yu tao-Sheng Li Institute of Nuclear Energy Safety Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Suzhou University Suzhou 234000China

Lithium heat pipes have broad applications in heat pipe cooling reactors and hypersonic vehicles owing to their ultra-high working *** particular,when the length of the lithium heat pipe is ultra-long,the flow and heat transfer characteristics are more *** this study,an improved lumped parameter model that considers the Marangoni effect,bending effect,and different vapor flow patterns and Mach numbers was ***after,the proposed model was verified using the University of New Mexico’s Heat Pipe and HTPIPE ***,the verified model was applied to simulate the steady-state operation of an ultra-long lithium heat pipe in a Heat PipeSegmented Thermoelectric Module Converters space *** on the results:(1)Vapor thermal resistance was dominant at low heating power and decreased with increasing heating *** vapor flow inside the heat pipe developed from the laminar to the turbulent phase,whereas the liquid phase in the heat pipe was always laminar.(2)The vapor pressure drop caused by bending was approximately 22–23%of the total,and the bending effect on the liquid pressure drop could be ignored.(3)The Marangoni effect reduced the capillary limit by hindering the liquid reflux,especially at low vapor *** considering the Marangoni effect,the capillary limit of the lithium heat pipe was overestimated by 9%when the vapor temperature was 1400 K.(4)The total thermal resistance of the heat pipe significantly increased with increasing adiabatic length when the vapor temperature was ***,the wick dryness increased with increasing adiabatic length at any vapor *** findings improve on current knowledge for the optimal design and safety analysis of a heat pipe reactor,which adopts ultra-long lithium heat pipes.

关键词： Lithium heat pipe Bending effect Marangoni effect Capillary limit Heat Pipe-Segmented Thermoelectric Module Converters(HP-STMC)

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang hua-Wei Zhang Xiao-mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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