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Hydrothermal calcification surface modification of biomedical tantalum

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Rare Metals 2021年第4期40卷 928-933页

作者： Di-Feng Luo Pan Ning Fan zhang Yan Zhou hong-mei zhang Tao Fu Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi'an 710049China Bioinspired Engineering and Biomechanics Center Xi’an Jiaotong UniversityXi’an 710049China

Tantalum(Ta) as a new type of medical metal is now utilized in several orthopedic applications due to its excellent fracture toughness and workability,high corrosion resistance,good biocompatibility and X-ray visibility,but it lacks ***,pure Ta was hydrothermally calcified in CaHPO4 solution at 120-200℃ here for bioactive surface *** electron microscopy(SEM),energy-dispersive X-ray spectroscopy(EDX),X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD) and Raman spectroscopy analyses show that thin tantalum oxide film with a few calcium phosphate precipitates is formed at the surface after the treatment at 200℃.The hydrothermally treated sample has good hydrophilicity and corrosion resistance evidenced by the water contact angle measurement and the potentiodynamic polarization test,respectively,and it can induce the formation of apatite layer after soaked in the simulated body fluid for 1 *** present method would be applicable for bioactive surface modification of tantalum implants with irregular shapes and even porous structure.

关键词： Tantalum Hydrothermal Calcification Corrosion Bioactivity

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Chinese Physics Letters 2018年第6期35卷 41-44页

作者： hong-mei zhang Cheng Cai Xiu-Jun Fu School of Physics and Optoelectronics South China University of Technology

Based on the matching rules for squares and rhombuses,we study the self-similar transformation and the vertex configurations of the Ammann-Beenker *** structural properties of the configurations and their relations during the self-similar transformation are *** results reveal the distribution correlations of the configurations,which provide an intuitive understanding of the octagonal quasi-periodic structure and also give implications for growing perfect quasi-periodic tiling according to the local rules.

关键词： Self-Similar Transformation and Vertex Configurations of the Octagonal Ammann-Beenker Tiling

Role of laser scan strategies in defect control,microstructural evolution and mechanical properties of steel matrix composites prepared by laser additive manufacturing

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International Journal of Minerals,Metallurgy and Materials 2021年第3期28卷 462-474页

作者： hong-yu Chen Dong-dong Gu Qing Ge Xin-yu Shi hong-mei zhang Rui Wang Han zhang Konrad Kosiba College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Jiangsu Provincial Engineering Laboratory for Laser Additive Manufacturing of High-Performance Metallic Components Nanjing University of Aeronautics and AstronauticsNanjing 210016China Leibniz IFW Dresden Institute for Complex MaterialsHelmholtzstr.2001069 DresdenGermany

Steel matrix composites(SMCs)reinforced with WC particles were fabricated via selective laser melting(SLM)by employing various laser scan strategies.A detailed relationship between the SLM strategies,defect formation,microstructural evolution,and mechanical properties of SMCs was *** laser scan strategies can be manipulated to deliberately alter the thermal history of SMC during SLM ***,the involved thermal cycling,which encompassed multiple layers,strongly affected the processing quality of *** scan sequence combined with interlayer offset and orthogonal stagger mode can effectively eliminate the metallurgical defects and retained austenite within the produced ***,due to large thermal stress,microcracks that were perpendicular to the building direction formed within the *** employing the checkerboard filling(CBF)hatching mode,the thermal stress arising during SLM can be significantly reduced,thus preventing the evolution of interlayer *** compressive properties of fabricated SMCs can be tailored at a high compressive strength(~3031.5 MPa)and fracture strain(~24.8%)by adopting the CBF hatching mode combined with the optimized scan sequence and stagger *** study demonstrates great feasibility in tuning the mechanical properties of SLM-fabricated SMCs without varying the set energy input,e.g.,laser power and scanning speed.

关键词： laser additive manufacturing selective laser melting scan strategy defect control mechanical property

Effects of microrolling parameters on the microstructure and deformation behavior of pure copper

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International Journal of Minerals,Metallurgy and Materials 2018年第1期25卷 45-52页

作者： Yi Jing hong-mei zhang Hao Wu Lian-jie Li hong-bin Jia Zheng-yi Jiang School of Material and Metallurgy University of Science and Technology Liaoning School of Mechanical Materials and Mechatronic EngineeringUniversity of Wollongong An-steel Group Da-Xing Plant

Microrolling experiments and uniaxial tensile tests of pure copper under different annealing conditions were carried out in this paper. The effects of grain size and reduction on non-uniform deformation, edge cracking, and microstructure were studied. The experimen- tal results showed that the side deformation became more non-uniform, resulting in substantial edge bulge, and the uneven spread increased with increasing grain size and reduction level. When the reduction level reached 80% and the grain size was 65 μm, slight edge cracks occurred. When the grain size was 200 μm, the edge cracks became wider and deeper. No edge cracks occurred when the grain size was 200 μm and the reduction level was less than 60%; edge cracks occurred when the reduction level was increased to 80%. As the reduction level increased, the grains were gradually elongated and appeared as a sheet-like structure along the rolling direction; a fine lamellar structure was obtained when the grain size was 20 lam and the reduction level was less than 60%.

关键词： micro-rolling grain size effect reduction deformation behavior microstructure pure copper

hTFtarget:A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 120-128页

作者： Qiong zhang Wei Liu hong-mei zhang Gui-Yan Xie Ya-Ru Miao Mengxuan Xia An-Yuan Guo Department of Bioinformatics and Systems Biology Key Laboratory of Molecular Biophysics of the Ministry of EducationHubei Bioinformatics and Molecular Imaging Key LaboratoryCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Clinical Center of Human Genomic Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Transcription factors(TFs)as key regulators play crucial roles in biological *** identification of TF-target regulatory relationships is a key step for revealing functions of TFs and their regulations on gene *** accumulated data of chromatin immunoprecipitation sequencing(ChIP-seq)provide great opportunities to discover the TF-target regulations across different *** this study,we constructed a database named hTFtarget,which integrated huge human TF target resources(7190 ChIP-seq samples of 659 TFs and high-confidence binding sites of 699 TFs)and epigenetic modification information to predict accurate TF-target *** offers the following functions for users to explore TF-target regulations:(1)browse or search general targets of a query TF across datasets;(2)browse TF-target regulations for a query TF in a specific dataset or tissue;(3)search potential TFs for a given target gene or noncoding RNA;(4)investigate co-association between TFs in cell lines;(5)explore potential coregulations for given target genes or TFs;(6)predict candidate TF binding sites on given DNA sequences;(7)visualize ChIP-seq peaks for different TFs and conditions in a genome *** provides a comprehensive,reliable and user-friendly resource for exploring human TF-target regulations,which will be very useful for a wide range of users in the TF and gene expression regulatiol *** is available at bttp://***/hTFtarget.

关键词： Transcription factor ChIP-seq Transcriptional regulation Human Database

Predicting the prognosis of primary orbital lymphoma by clinical characteristics and imaging features

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International Journal of Ophthalmology(English edition) 2023年第5期16卷 705-711页

作者： Jian-Bo Zhu Bin Li hong-mei zhang Ning-Li Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual ScienceBeijing 100730China Department of Diagnostic Radiology Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China

AIM: To analyze the 5-year disease-free survival(DFS) of primary orbital lymphoma(POL) by clinical characteristics and imaging ***: A total of 72 patients, 43 males and 29 females, with histologically confirmed POL, were retrospectively recruited between January 2012 and May 2017. The information on clinical characteristics, imaging features, and 5-year DFS was obtained. Univariate and multivariate forward logistic regression analyses were used to identify the variables significantly associated with 5-year DFS. Kaplan-meier was applied for survival analysis. RESULTS: Univariate analysis revealed that uni-or bilateral orbital involvement, single or multiple lesions, treatment methods, and contrast enhancement pattern on images were significant for 5-year DFS(P=0.022, 0.042, <0.001, and 0.028, respectively), while in multivariate logistic regression analysis, only uni-or bilateral orbital involvement, treatment methods and contrast enhancement pattern on images were significant(r=0.453, 0.897, and 0.556, P=0.038, <0.001 and 0.022, respectively). The survival curves for DFS were obtained. CONCLUSION: The majority of POL are B-cell lymphomas. Unilateral orbital involvement, homogeneous contrast enhancement on images, and the appropriate treatment schemes result to be significant factors for a good prognosis for POL.

关键词： lymphoma orbital primary prognosis

Effect of large load on the wear and corrosion behavior of high-strength EH47 hull steel in 3.5wt%NaCl solution with sand

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International Journal of Minerals,Metallurgy and Materials 2020年第11期27卷 1525-1535页

作者： hong-mei zhang Yan Li Ling Yan Fang-fang Ai Yang-yang Zhu Zheng-yi Jiang School of Material and Metallurgy University of Science and Technology LiaoningAnshan 114051China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan Iron and Steel Research Institute of AnGang GroupAnshan 114009China School of Mechanical Materials and Mechatronic EngineeringUniversity of WollongongWollongong NSW 2522Australia

To simulate the wear and corrosion behavior of high-strength EH47 hull steel in a complicated marine environment in which seawater,sea ice,and sea sand coexist,accelerated wear and corrosion tests were performed in a laboratory setting using a *** effect of large loads on the behavior of abrasion and corrosion in a 3.5wt%NaCl solution with ice and sand to simulate a marine environment were *** experimental results showed that the coefficient of friction(COF)decreases with increasing working load;meanwhile,the loading force and sand on the disk strongly influence the *** mechanisms of friction and the coupling effect of abrasion and corrosion in the 3.5wt%NaCl solution with sand were the wear and corrosion mechanisms;furthermore,the wear mechanism exerted the predominant effect.

关键词： friction marine environment wear mechanism tribological tests

Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication

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World Journal of Gastroenterology 2024年第11期30卷 1609-1620页

作者： Jun-Tao Li hong-mei zhang Wei Wang Dong-Qing Wei College of Mathematics and Information Science Henan Normal UniversityXinxiang 453007Henan ProvinceChina College of Computer and Information Engineering Henan Normal UniversityXinxiang 453007Henan ProvinceChina State Key Laboratory of Microbial Metabolism and School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

BACKGROUND Liver cancer is one of the deadliest malignant tumors *** has provided hope to patients with advanced liver cancer,but only a small fraction of patients benefit from this treatment due to individual *** immune-related gene signatures in liver cancer patients not only aids physicians in cancer diagnosis but also offers personalized treatment strategies,thereby improving patient survival *** several methods have been developed to predict the prognosis and immunotherapeutic efficacy in patients with liver cancer,the impact of cell-cell interactions in the tumor microenvir-onment has not been adequately *** To identify immune-related gene signals for predicting liver cancer prognosis and immunotherapy *** Cell grouping and cell-cell communication analysis were performed on single-cell RNA-sequencing data to identify highly active cell groups in immune-related *** active immune cells were identified by intersecting the highly active cell groups with B cells and T *** significantly differentially expressed genes between highly active immune cells and other cells were subsequently selected as features,and a least absolute shrinkage and selection operator(LASSO)regression model was constructed to screen for diagnostic-related *** genes that were selected more than 5 times in 10 LASSO regression experiments were included in a multivariable Cox regression ***,3 genes(stathmin 1,cofilin 1,and C-C chemokine ligand 5)significantly associated with survival were identified and used to construct an immune-related gene *** The immune-related gene signature composed of stathmin 1,cofilin 1,and C-C chemokine ligand 5 was identified through cell-cell *** effectiveness of the identified gene signature was validated based on experi-mental results of predictive immunotherapy response,tumor mutation burden analysis,immune cell infiltrat

关键词： Liver cancer Cell-cell communication Gene signature Prognosis Immunotherapy Single-cell RNA sequencing

Removal of cadmium using MnO_2 loaded D301 resin

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Journal of Environmental Sciences 2007年第6期19卷 652-656页

作者： ZHU Zhi-liang MA hong-mei zhang Rong-hua GE Yuan-xin ZHAO Jian-fu Key Laboratory of Yangtze Aquatic Environment of Ministry of Education State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 China

MnO2 loaded weak basic anion exchange resin D301 （Anion exchange resin, macroreticular weak basic styrene） as adsorbent has been prepared and applied to the removal of cadmium. The adsorption characteristics have been investigated with respect to effect of pH, equilibrium isotherms, removal kinetic data, and interference of the coexisting ions. The results indicated that the Cd^2＋ could be efficiently removed using MnO2 loaded D301 resin in the pH range of 3-8 from aqueous solutions with the co-existence of high concentration of alkali and alkaline-earth metals ions. The saturate adsorption capacity of the Cd^2＋ was 77.88 mg/g. The adsorption process followed the pseudo first-order kinetics. The equilibrium data obtained in this study accorded excellently with the Langmuir adsorption isotherm.

关键词： cadmium kinetics adsorption loaded resin removal