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Photopromoted carbonylation of bromobenzene under ambient conditions

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Chinese Chemical Letters 2009年第5期20卷 531-534页

作者： Li Zhuo Mu Ying Ping Jia Jing mei Yin guang Yun zhou Ying Na Cui Da Bin Gao Liaoning Key Laboratory of Bio-organic Chemistry Dalian University Dalian 116622 China

The photopromoted carbonylation of bromobenzene with carbon monoxide catalyzed by inexpensive commercially available cobalt salts [Co（OAc）2, COCl2] was carried out under ambient conditions. The results revealed that methyl benzoate was produced in the presence of basic additives （CH3ONa, NaOAc or （n-C4H9）3N）. The catalytic activity of Co（OAc）2 was higher than that of COCl2. Furthermore, the activity of the carbonylation was greatly improved by addition of acetophenone, e.g. both the yield and selectivity of the ester were increased from 47% to 91% with Co（OAc）2 as catalyst and CH3ONa as additive, while the yield of byproduct benzene from hydrodehalogenation of bromobenzene decreased from 32% to 8%.

关键词： Photopromoted carbonylation Bromobenzene Cobalt salts Sodium methoxide Acetophenone

Safety and efficacy of thalidomide in patients with transfusiondependentβ-thalassemia:a randomized clinical trial

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3723-3729页

作者： Jiang-Ming Chen Wei-Jian Zhu Jie Liu Gui-Zhen Wang Xiao-Qin Chen Yun Tan Wei-Wei Xu Li-Wei Qu Jin-Yan Li Huan-Ju Yang Lan Huang Ning Cai Wei-Da Wang Ken Huang Jian-Quan Xu Guo-Hui Li Sheng He Tian-Ying Luo Yi Huang Song-Hua Liu Wen-Qiang Wu Qi-Yang Lu mei-guang zhou Shu-Ying Chen Rong-Lan Li mei-Ling Hu Ying Huang Jin-Hua Wei Jun-Min Li Sai-Juan Chen guang-Biao zhou Department of Hematology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina Department of Hematology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 541000 GuangdongChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Reproductive Medicine The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000 HebeiChina State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhou 510060 GuangdongChina State Key Laboratory of Medical Genomics Shanghai Institute of HematologyNational Research Center for Translational MedicineRuijin Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Department of Pediatrics Affiliated Hospital of Youjiang Medical University for NationalitiesBaise City 533000 GuangxiChina Department of Hematology Yulin Guinan HospitalYulin 537005 GuangxiChina Department of neurology Wuzhou Gongren HospitalWuzhou 543001 GuangxiChina guangxi Key Laboratory of Basic Research on Birth Defects Prevention and Treatment Guangxi Zhuang Autonomous Region Women and Children Health Care HospitalNanning 530000 GuangxiChina Department of Hematology Guigang People’s HospitalGuigang 537100 GuangxiChina Department of Hematology Hospital of Traditional Chinese Medicine of Wuzhou CityWuzhou 543002 GuangxiChina Department of Hematology Wuzhou Red Cross HospitalWuzhou 543002 GuangxiChina Department of Hematology Hechi People’s HospitalHechi City 547000 GuangxiChina

Thalidomide inducesγ-globin expression in erythroid progenitor cells,but its efficacy on patients with transfusion-dependentβ-thalassemia(TDT)remains *** this phase 2,multi-center,randomized,double-blind clinical trial,we aimed to determine the safety and efficacy of thalidomide in TDT patients.A hundred patients of 14 years or older were randomly assigned to receive placebo or thalidomide for 12 weeks,followed by an extension phase of at least 36 *** primary endpoint was the change of hemoglobin(Hb)level in the *** secondary endpoints included the red blood cell(RBC)units transfused and adverse *** the placebo-controlled period,Hb concentrations in patients treated with thalidomide achieved a median elevation of 14.0(range,2.5 to 37.5)g/L,whereas Hb in patients treated with placebo did not significantly *** the 12 weeks,the mean RBC transfusion volume for patients treated with thalidomide and placebo was 5.4±5.0 U and 10.3±6.4 U,respectively(P<0.001).Adverse events of drowsiness,dizziness,fatigue,pyrexia,sore throat,and rash were more common with thalidomide than *** the extension phase,treatment with thalidomide for 24 weeks resulted in a sustainable increase in Hb concentrations which reached 104.9±19.0 g/L,without blood *** increase in Hb concentration and reduction in RBC transfusions were associated with nonβ0/β0 and HBS1L-MYB(rs9399137 C/T,C/C;rs4895441 A/G,G/G)*** results demonstrated that thalidomide is effective in patients with TDT.

关键词： transfusion patients thalidomide

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三峡地区柏木林种子雨和种子库的研究

福建林业科技 2007年第4期34卷 13-19页

作者：陈芳清梅光舟王传华三峡大学化学与生命科学学院湖北宜昌443002

柏木种子雨在8月底开始降落，10月达到顶峰，翌年5月结束，历经9个月左右。整个过程呈单峰曲线，10～11月的种子雨量占全年的67．5％。种子雨时间变化格局差异极显著，而水平空间分布格局没有显著差异。种子雨中柏木种子的年均密度为598... 详细信息

柏木种子雨在8月底开始降落，10月达到顶峰，翌年5月结束，历经9个月左右。整个过程呈单峰曲线，10～11月的种子雨量占全年的67．5％。种子雨时间变化格局差异极显著，而水平空间分布格局没有显著差异。种子雨中柏木种子的年均密度为5982．2粒·m^-2。63．4％的柏木种子直径大于2．5mm，构成了柏木种子雨的主体。由于这一级别柏木种子的萌发能力较强，因此三峡地区柏木林的更新能力强。柏木林中非柏木种子的种子雨每年主要发生在1月和5月，形成2个高峰，年均种子雨密度为1842．8粒·m^-2。土壤种子库中柏木种子的平均密度为608．8粒·m^-2。柏木种子在土壤种子库中垂直分布格局差异极显著。0～2cm土壤层所分布的柏木种子占种子库中柏木种子的80．49％。其它土壤层次所含有的种子比例很低，且萌发能力较低，因此，柏木林的更新主要依赖于表层土壤种子库的种子。柏木种子在种子库中的水平分布格局虽然随坡位的不同而有所变化，但是差异不显著，表明整个柏木林的更新能力在水平格局上无显著差异。

关键词：柏木林种子雨密度种子库群落更新三峡地区

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三峡地区柏木种子萌发和幼苗更新的研究

热带亚热带植物学报 2008年第1期16卷 69-74页

作者：陈芳清梅光舟曾旭许文年柯学莎三峡大学生态与环境科学研究中心湖北宜昌443002 长江水利委员会勘察规划设计研究院武汉430010

对三峡地区柏木(Cupressus funebris)林柏木种子的萌发、幼苗存活、幼苗生长进行了研究。结果表明,(1)柏木种子的萌动期约为10d,播种35-45d后进入萌发高峰期,柏木种子的平均萌发率为47.7%。土壤基质对种子萌发的影响是极显著的,光照对... 详细信息

对三峡地区柏木(Cupressus funebris)林柏木种子的萌发、幼苗存活、幼苗生长进行了研究。结果表明,(1)柏木种子的萌动期约为10d,播种35-45d后进入萌发高峰期,柏木种子的平均萌发率为47.7%。土壤基质对种子萌发的影响是极显著的,光照对萌发则没有显著的影响。(2)幼苗平均死亡率为52.6%。土壤类型和光照强度对幼苗的存活都有显著影响,在林下土和80%光照条件下幼苗的存活率最高。(3)柏木幼苗生长初期茎的生长动态呈"S"型,而叶片数量的增长动态近于直线型。幼苗生长初期生物量形成主要受光照条件的影响,土壤类型的影响不显著。土壤和光照条件对柏木林柏木幼苗的更新都有显著影响,但是土壤条件主要影响种子萌发和幼苗的存活,而光照条件则主要对幼苗的生长和存活产生影响。

关键词：种子萌发幼苗更新幼苗存活土壤类型光照

Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

Preparation, characterization and photocatalytic activity of N-doped TiO_2 nanocrystals

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International Journal of Minerals,Metallurgy and Materials 2009年第6期16卷 701-706页

作者： Hong-tao Gao Jing zhou Dong-mei Dai guang-jun Liu College of Chemistry and Molecular Engineering Qingdao University of Science ＆ Technology Qingdao 266042 China Department of Chemistry Jining University Jining 273155 China

N-doped TiO2 nanocrystals were prepared using titanium alkoxide as precipitant with different proportional materials. The products were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and UV-vis diffuse reflectance spectra. It is confirmed experimentally that the photocatalytic activity of N-doped TiO2 is much higher than that of Degussa P25, when used for the degradation of crystal violet. The degradation kinetics follows an apparent first-order reaction, which is consistent with a generally observed Langmuir-Hinshelwood mechanism. The doping of TiO2 with nitrogen significantly increases the absorption in the region of visible light. The energy of the band gap of N-doped TiO2 is 2.92 eV. The better performance of N-doped TiO2 can be explained by the fact that it is also excited with longer-wavelength light.

关键词： pbotocatalyst degradation nitrogen doping TiO2 nanocrystals visible light crystal violet

Evaluation of a rabbit rectal VX2 carcinoma model using computed tomography and magnetic resonance imaging

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World Journal of Gastroenterology 2009年第17期15卷 2139-2144页

作者： Xin-mei Liang guang-Yu Tang Ying-Sheng Cheng Bi zhou Department of Radiology the Sixth People's Hospital of Shanghai Jiaotong University Institute of Medical Imaging of Shanghai Jiaotong University No. 600 Yishan Road Shanghai 200233 China Department of Radiology the Tenth People's Hospital of Shanghai Tongji University No. 301 Yanchang Middle Road Shanghai 200072 China

AIM： To establish a rabbit rectal VX2 carcinoma model for the study of rectal ***： A suspension of VX2 cells was injected into the rectum wall under the guidance of X-ray fluoroscopy. Computed tomography （CT） and magnetic resonance imaging （MRI） were used to observe tumorgrowth and metastasis at different phases. Pathological changes and spontaneous survival time of the rabbits were ***： Two weeks after VX2 cell implantation, the tumor diameter ranged 4.1-5.8 mm and the success implantation rate was 81.8%. CT scanning showed low-density loci of the tumor in the rectum wail, while enhanced CT scanning demonstrated a symmetrical intensification in tumor loci. MRI scanning showed alow signal of the tumor on T1-weighted imaging anda high signal of the tumor on T2-weighted *** types of signals were intensified with enhanced MRI. Metastases to the liver and lung could beobserved 6 wk after VX2 cell implantation, and a largearea of necrosis appeared in the primary tumor. The spontaneous survival time of rabbits with cachexia and multiple organ failure was about 7 wk after VX2 cell ***： The rabbit rectal VX2 carcinoma model we established has a high stability, and can be used in the study of rectal carcinoma.

关键词： Rectal carcinoma, Animal model Rabbit, VX2 Computed tomography Magnetic resonance imaging

组织工程颞下颌关节生物髁突裸鼠皮下再生研究

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中国实用口腔科杂志 2017年第3期10卷 135-141页

作者：王飞宇何冬梅周广东杨秀娟上海交通大学医学院附属第九人民医院·口腔医学院口腔外科上海市口腔医学重点实验室上海200011

目的探讨不同复合材料构建的生物髁突在裸鼠皮下再生的可行性。方法分别采用软骨细胞膜片+骨相支架(PCL/HA)复合骨髓间充质干细胞(BMSCs)(细胞膜片组),以及软骨相支架(PGA/PLA)复合耳软骨细胞+骨相支架细胞复合BMSCs(双相支架组)体外构... 详细信息

目的探讨不同复合材料构建的生物髁突在裸鼠皮下再生的可行性。方法分别采用软骨细胞膜片+骨相支架(PCL/HA)复合骨髓间充质干细胞(BMSCs)(细胞膜片组),以及软骨相支架(PGA/PLA)复合耳软骨细胞+骨相支架细胞复合BMSCs(双相支架组)体外构建具有三维组织形态的生物髁突,经体外分别培养不同时间后将软骨相复合物和骨相复合物缝合在一起后植入裸鼠皮下,12周后处死并取材。分别进行组织学和免疫组化染色,对再生的软骨组织、骨组织以及骨软骨交界面进行评价。结果在裸鼠体内,细胞膜片组和双相支架组的软骨相修复体形成了类似成熟的软骨组织,可见大量的软骨细胞、典型的软骨陷窝和丰富的软骨基质,形成的软骨完整、连续、均质、无血管。双相支架组软骨层中仍有少量未降解的复合材料纤维。2组的软骨相修复体和骨相修复体都能够通过组织连接紧密结合在一起;骨相支架空隙内都有软骨组织以及少量的骨组织和脂肪组织形成。细胞膜片组的软骨修复组织学评分高于双相支架组,但差异无统计学意义(P>0.05)。软骨膜片组的每单位软骨细胞数量多于双相支架组,但差异亦无统计学意义(P>0.05)。骨相组织成骨2组类似,离软骨相修复体近的BMSCs向软骨分化,离软骨相修复体远的BMSCs向骨组织和脂肪组织分化。结论软骨细胞膜片复合骨相细胞支架,以及软骨-骨细胞复合双相支架均能够在裸鼠皮下成功构建生物髁突;软骨细胞膜片复合骨相支架再生的生物髁突在具备完善免疫力的哺乳动物体内更具有应用前景。

关键词：颞下颌关节再生生物髁突裸鼠

5-羟甲基糠醛在CuPd(111)上的加氢反应机理研究

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原子与分子物理学报 2025年第4期42卷 53-57页

作者：张兴云周广丽石云山东临沂大学化学化工学院临沂276000

采用密度泛函理论,利用包含零点能校正的PBE-D3方法研究了5-羟甲基糠醛在双金属催化剂CuPd(111)上表面的加氢还原反应,考虑了两种反应路径,第一种反应路径是侧链上的醛基氧首先发生加氢反应生成F-CHOH中间体,然后F-CHOH中间体继续加氢生... 详细信息

采用密度泛函理论,利用包含零点能校正的PBE-D3方法研究了5-羟甲基糠醛在双金属催化剂CuPd(111)上表面的加氢还原反应,考虑了两种反应路径,第一种反应路径是侧链上的醛基氧首先发生加氢反应生成F-CHOH中间体,然后F-CHOH中间体继续加氢生成2,5-二羟甲基呋喃;第二种反应路径是侧链上的醛基碳先加氢原还原生成F-CH_(2)O中间体,生成的F-CH_(2)O进一步加氢还原生成2,5-二羟甲基呋喃.计算了两种竞争反应路径的活化能垒和反应热,结果表明,5-羟甲基糠醛在CuPd(111)面加氢还原生成2,5-二羟甲基呋喃的最佳反应路径为:F-CHO→F-CHOH→F-CH_(2)OH.

关键词： 5-羟甲基糠醛活化能垒反应热