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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1712-1718页

作者： Jian-Hui Chen mei-fen zhang Wen-Chao Du Yan-An zhang Emergency Department Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 364000Fujian ProvinceChina

BACKGROUND There are many risk factors for severe acute pancreatitis(SAP)complicated with acute gastrointestinal injury(AGI),but few reports on the interaction between these risk *** To analyze the risk factors for SAP complicated with AGI and their interactive *** We selected 168 SAP patients admitted to our hospital between December 2019 and June *** were divided into AGI group and non-AGI group according to whether AGI was *** data and laboratory test data were compared between the two *** risk factors for SAP with concomitant AGI were analyzed using multifactorial logistic regression,and an analysis of the interaction of the risk factors was *** The percentage of patients with multiple organ dysfunction syndrome,acute physiological and chronic health scoring system II(APACHE II)score,white blood cell count and creatinine(CRE)level was higher in the AGI group than in the non-AGI *** was a statistically significant difference between the two groups(P15 and CRE>100μmol/L were risk factors for SAP complicating *** interaction index of APACHE II score and CRE level was *** An APACHE II score>15 and CRE level>100μmol/L are independent risk factors for SAP complicated with AGI,and there is a positive interaction between them.

关键词： Severe acute pancreatitis Acute gastrointestinal injury Risk factors Interactions Acute physiological and chronic health scoring system II Creatinine

Methotrexate for chronic non-necrotizing anterior scleritis in Chinese patients

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1261-1265页

作者： Jun-Yan Xiao An-Yi Liang Fei Gao Chan Zhao mei-fen zhang Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Ophthalmology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangdong Eye InstituteGuangzhou 510080Guangdong ProvinceChina Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

AIM:To evaluate the effectiveness and corticosteroidsparing capabilities of methotrexate(MTX)in the treatment of chronic non-necrotizing anterior scleritis in Chinese ***:A retrospective chart review of all patients with active anterior scleritis between January 2015 and June 2019 was *** patients received 10 to 15 mg/wk MTX orally,and corticosteroids(10 to 40 mg/d prednisolone or equivalent methylprednisolone)with slow *** corticosteroid eye drops(1%prednisolone actate,0.1%dexmathosone or 0.1%fluoromethalone)were applied to control comorbid anterior uveitis at presentation or during follow *** main outcomes were inflammation control and corticosteroid-sparing success,and secondary outcomes were reduction of immunosuppression load and best-corrected visual acuity(BCVA).RESULTS:Thirty-two eyes(22 patients)were *** proportion of patients who achieved corticosteroidsparing success was 50.0%at 3mo and 77.3%at 12mo[8(36.4%)patients discontinued corticosteroid].The proportion of eyes that achieved inflammation control was 59.4%at 3mo and 78.1%at *** immunosuppression load was 5.14±0.87 at presentation and 2.76±2.34 at 12mo(P<0.01).BCVA maintained unchanged or improved in 29(90.6%)of all affected *** patient discontinued MTX treatment because of an abnormal liver function test,and no other serious adverse effects were ***:According to this pilot study,low dose MTX appear to be a well-tolerated and effective treatment for chronic non-necrotizing anterior scleritis patients in the Chinese population.

关键词： methotrexate non-necrotizing anterior scleritis pharmacotherapy corticosteroid-sparing Chinese population

Efficacy and safety of non-penetrating glaucoma surgery with phacoemulsification versus non-penetrating glaucoma surgery:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1970-1978页

作者： Jun-Yan Xiao An-Yi Liang Yue-Lin Wang Gang-Wei Cheng mei-fen zhang Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

AIM:To compare the clinical efficacy and safety of non-penetrating glaucoma surgery(NPGS)plus phacoemulsification(Phaco-NPGS)and ***:We systematically searched various databases and reviewed studies that had evaluated the effects of Phaco-NPGS or NPGS-alone for patients with *** outcomes included postoperative intraocular pressure(IOP)and the number of postoperative antiglaucoma *** outcomes were the prevalence of complications,incidence of needling or goniopuncture,and surgical success ***:In total,380 and 424 eyes in NPGS-alone and Phaco-NPGS groups respectively were *** postoperative IOP and number of medications were significantly lowered in the Phaco-NPGS group than that in the NPDS-alone group[weighted mean difference(WMD)=-1.12,95%confidence interval(CI):-2.11 to-0.12,P=0.03;WMD=-0.31,95%CI:-0.53 to-0.09,P=0.006].Moreover,Phaco-NPGS had a significantly lower prevalence of complications and postoperative procedures compared to NPGS-alone,while no significant difference existed for surgical ***:Phaco-NPGS superior to NPGS-alone in the reduction of IOP and ***-NPGS can be recommended for glaucoma patients with coexisting cataracts owing to its superior efficacy,fewer complications,and postoperative procedures.

关键词： cataract glaucoma non-penetrating glaucoma surgery phacoemulsification Meta-analysis

Subconjunctival injections of triamcinolone acetonide to treat uveitic macular edema

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1087-1091页

作者： Yi Qu Xin-Shu Liu An-Yi Liang Jun-Yan Xiao Chan Zhao Fei Gao mei-fen zhang Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College100730BeijingChina Department of Ophthalmology the Fourth People’s Hospital of ShenyangShenyang 110031Liaoning ProvinceChina Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

AIM:To evaluate the efficacy and safety of subconjunctival triamcinolone acetonide(TA)injections for treating uveitic macular edema(UME).METHODS:This retrospective case series study included patients with UME who received subconjunctival TA injections with a minimum follow-up period of 6 *** main outcome measure was central macular thickness(CMT).The secondary outcome measures included best-corrected visual acuity(BCVA),recurrence rate and intraocular pressure(IOP).RESULTS:In total,65 patients(80 eyes),mainly including idiopathic uveitis in 33 patients(50.77%)and VogtKoyanagi-Harada(VKH)syndrome in 19 patients(29.23%),were enrolled in this *** mean CMT decreased from 457.6±173.0μm at baseline to 325.9±176.8,302.7±148.2,332.2±177.3 and 270.6±121.6μm at 1-,2-,3-and 6-months postinjection,respectively(all P<0.001).BCVA increased from log MAR 0.5±0.3 at baseline to log MAR 0.4±0.3,0.4±0.3,0.4±0.4 and 0.4±0.3 at the 1-,2-,3-and 6-months postinjection visits,respectively(all P<0.001).Twenty-one(21/80,26.25%)eyes underwent relapse of UME within 6 mo.A total of 20/80(25%)eyes exhibited elevated IOPs,of which 13 eyes were controlled with topical IOP-lowering agents and 7 eyes underwent surgical removal of subconjunctival TA ***:Subconjunctival TA injections appear to be safe and effective for UME.

关键词： triamcinolone acetonide subconjunctival injection uveitis macular edema intraocular pressure

Spectral Domain Optical Coherence Tomography of Vogt-Koyanagi-Harada Disease: Novel Findings and New Insights into the Pathogenesis

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Chinese Medical Sciences Journal 2012年第1期27卷 29-34页

作者： Chan Zhao mei-fen zhang Fang-tian Dong Xu-qian Wang Xin Wen Rong-ping Dai Wei-hong Yu Zhi-qiao zhang Zhi-kun Yang Fei Gao Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To provide novel spectral domain optical coherence tomography (SD OCT) findings of Vogt-Koyanagi-Harada (VKH) disease as well as new insights into the pathogenesis of this disease. Methods Detailed SD OCT and fluorescein angiography (FA) findings of 18 consecutive VKH patients (11 women and 7 men) from December 2007 to April 2009 who were in acute uveitic stage at presentation were reviewed. All the patients had been followed up for at least 6 months with reevaluation(s) of SD OCT performed in 10 patients. Results Intraretinal cysts were found to be located in various layers of the outer retina. In addition to the photoreceptor layer, they could also be found between the outer plexiform layer and the outer nuclear layer, or spanning the external limiting membrane. On FA, intraretinal cysts could be hypofluorescent, normofluorescent, or hyperfluorescent. Some intraretinal cysts had a characteristic FA pattern, in which a small round hypofluorescent area was surrounded by a ring of hyperfluorescence (donut-shaped dye pooling). Subretinal fibrinoid deposit appeared in acute uveitic stage in two severe VKH patients and seemed to develop from subretinal exudates and evolved into typical subretinal fibrosis. Gradual transfiguration/migration and progressive proliferation/pigmentation of the subretinal fibrinoid deposit/subretinal fibrosis was observed in one patient. Conclusions Intraretinal cysts could form in various layers of the outer retina and may result from extension of choroidal inflammation. Subretinal fibrosis may develop from subretinal exudates in VKH patients and may cause substantial visual impairment.

关键词： Vogt-Koyanagi-Harada disease spectral domain optical coherence tomography fluorescein angiography subretinal fibrosis intraretinal cysts

A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet's disease in a Chinese Han population

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1315-1320页

作者： Xin-Shu Liu Zi-Yan Wu Si Chen Chan Zhao Fei Gao Ming-Hang Pei Shan-Shan Jia Yong-Zhe Li Pei-Zeng Yang mei-fen zhang Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Clinical Laboratory Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Clinical Laboratory Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology and Chongqing Eye InstituteChongqing 400016China

AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han ***:A total of eight SNPs in the candidate gene region(rs11792633,rs7025417,rs10975519 and rs1048274 in IL33;rs2310220,rs12712142,rs13424006 and rs3821204 in IL1RL1)were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array i PLEX ***:A statistically significant association was observed between IL1RL1 rs12712142 and BD *** frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls(OR=0.8,95%CI:0.69-0.94,Pc=0.039);the genotype distribution(Pc=0.043)and additive and dominant genetic model analyses(OR=0.8,95%CI:0.69-0.94,Pc=0.040 and OR=0.72,95%CI:0.58-0.88,Pc=0.011)also indicated a strong association between rs12712142 and BD ***:This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population,indicating a protective role of IL1RL1 in the pathogenesis of BD.

关键词： Behcet’s disease single nucleotide polymorphism Chinese Han population IL33 IL1RL1

Preparation of Low Ratio Magnesium Ccement by Acid Leaching Treatment of Boron Mud

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 120-129页

作者： YANG mei zhang Mingzhe CHEN Hao School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China School of Physical Science and Technology Shenyang Normal UniversityShenyang 110168China

The effects of liquid-solid ratio and reaction time on the leaching rate of magnesium at room temperature were investigated,as well as the effects of the molar ratio of MgO/MgCl_(2),the amount of water added,and the amount of acid-impregnated slag dosed on the compressive strength and water resistance of *** results showed that the magnesium element in the boron mud could be maximally leached under the conditions of 1:1 concentration of hydrochloric acid at room temperature,liquid-solid ratio of 2.5 mL·g^(-1),and reaction time of 5 h,and the main products were amorphous SiO_(2) as well as a small amount of magnesium olivine which had not been completely *** LR-MOC prepared using the acid-soaked mixture could reach a softening coefficient of 0.85 for 28 d of water immersion when the molar ratio of MgO/MgCl_(2) was 2.2,the amount of water added was 0 g,and the acid-soaked slag dosing was 40 wt%,which also led to an appreciable late-strength,with an increase of 19.4%in compressive strength at 28 d compared to that at 7 *** previous studies,LR-MOC prepared in this way has a final strength phase that is not the more easily hydrolysed 3-phase but the lath-like *** this phenomenon,we analyzed the mechanism and found that,during the acid leaching process,a part of amorphous SiO_(2) dissolved in the acid leaching solution formed a silica sol,in which Mg^(2+)played a bridging role to make the silica sol more *** the addition and hydrolysis of MgO,the silica sol gel coagulation slows down,providing a capping layer to inhibit the hydrolysis of the 5-phase crystals and providing some strength after *** amorphous SiO_(2) in the other part of the acid-impregnated slag generated M-S-H gel with Mg^(2+)and OH-,which synergised with the dense structure composed of interlocking crystals to improve the water resistance of LR-MOC.

关键词： boron mud magnesium chloride-oxygen cement acid immersion water resistance silica sol

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： mei zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

MixerKT:A Knowledge Tracing Model Based on Pure MLP Architecture

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Computers, Materials & Continua 2025年第1期82卷 485-498页

作者： Jun Wang Mingjie Wang Zijie Li Ken Chen Jiatian mei Shu zhang Key Laboratory of Education Informatization for Nationalities Ministry of EducationYunnan Normal UniversityKunming650000China Yunnan Key Laboratory of Smart Education Yunnan Normal UniversityKunming650000China

In the field of intelligent education,the integration of artificial intelligence,especially deep learning technologies,has garnered significant *** tracing(KT)plays a pivotal role in this field by predicting students’future performance through the analysis of historical interaction data,thereby assisting educators in evaluating knowledgemastery and tailoring instructional *** knowledge tracingmethods,largely based on Recurrent Neural Networks(RNNs)and Transformer models,primarily focus on capturing long-term interaction patterns in sequential ***,these models may neglect crucial short-term dynamics and other relevant *** paper introduces a novel approach to knowledge tracing by leveraging a pure Multilayer Perceptron(MLP)*** proposeMixerKT,a knowledge tracing model based on theHyperMixer framework,which uniquely integrates global and localMixer feature *** architecture enables more effective extraction of both long-terminteraction trends and recent learning behaviors,addressing limitations in currentmodels thatmay overlook these key *** evaluations on twowidely-used datasets,ASSIS Tments2009 and Algebra2005,demonstrate that MixerKT consistently outperforms several state-of-the-art models,including DKT,SAKT,and Separated Self-Attentive Neural Knowledge Tracing(SAINT).Specifically,MixerKT achieves higher prediction accuracy,highlighting its effectiveness in capturing the nuances of learners’knowledge *** results indicate that our model provides a more comprehensive representation of student learning patterns,enhancing the ability to predict future performance with greater precision.

关键词： Knowledge tracing multilayer perceptron channel mixer sequence mixer

保留盆腔神经宫颈癌根治术对患者性生活质量的影响

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中国肿瘤临床与康复 2017年第4期24卷 456-459页

作者：张美芬张洁山东省临朐县人民医院妇产科潍坊262600 山东省益都中心医院妇科潍坊262500

目的探讨保留盆腔神经宫颈癌根治术对患者性生活质量的影响。方法选取2013年7月至2015年7月间山东省临朐县人民医院收治的90例子宫颈癌患者,采用随机数字表法分为观察组与对照组,每组45例。观察组患者给予保留盆腔神经宫颈癌根治术,对... 详细信息

目的探讨保留盆腔神经宫颈癌根治术对患者性生活质量的影响。方法选取2013年7月至2015年7月间山东省临朐县人民医院收治的90例子宫颈癌患者,采用随机数字表法分为观察组与对照组,每组45例。观察组患者给予保留盆腔神经宫颈癌根治术,对照组患者给予传统宫颈癌根治术,对比两组患者围术期指标、术后并发症发生率和术后6个月的性生活质量。结果对照组患者肛门排气时间、肛门排便时间和保留输尿管的天数分别为(120.34±24.23)h、(90.67±12.90)h和(15.67±2.09)d,观察组患者分别为(78.90±10.56)h、(62.77±11.33)h和(11.21±1.87)d,两组比较,差异均有统计学意义(均P<0.05)。对照组患者性欲望、性唤起、阴道润滑度、性高潮、性生活满意度和性交疼痛评分分别为(2.67±0.34)分、(2.54±0.67)分、(2.83±0.66)分、(2.77±0.53)分、(2.90±0.78)分和(2.92±0.67)分,观察组患者分别为(3.25±0.35)分、(3.30±0.56)分、(3.43±0.71)分、(3.56±0.65)分、(3.73±0.83)分和(3.90±0.62)分,两组比较,差异均有统计学意义(均P<0.05)。结论保留盆腔神经宫颈癌根治术比传统宫颈癌根治术治疗早期宫颈癌的临床疗效更加显著,围术期指标较好,可改善患者术后性生活质量。

关键词：宫颈癌根治术宫颈肿瘤性生活质量