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Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2575-2602页

作者： Tian Peng fang Sun Jia-Chun Yang mei-Hong Cai Man-Xiu Huai Jia-Xing Pan Fei-Yu Zhang Lei-Ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200092China

BACKGROUND Lactate,previously considered a metabolic byproduct,is pivotal in cancer progression and maintaining the immunosuppressive tumor *** investigations confirmed that lactate is a primary regulator,introducing recently described post-translational modifications of histone and non-histone proteins,termed lysine *** adenocarcinomas are characterized by increased glycolysis and lactate ***,our understanding of lactylation-related genes in pancreatic adenocarcinomas remains *** To construct a novel lactylation-related gene signature to predict the survival of patients with pancreatic *** RNA-seq and clinical data of pancreatic adenocarcinoma(PDAC)were obtained from the GTEx(Genotype-Tissue Expression)and TCGA(The Cancer Genome Atlas)databases via Xena Explorer,and GSE62452 datasets from *** on lactylation-related genes were obtained from publicly available *** expressed genes(DEGs)were acquired by using R package“DESeq2”in *** COX regression analysis,LASSO Cox and multivariate Cox regressions were produced to construct the lactylation-related prognostic *** analyses,including functional enrichment,ESTIMATE,and CIBERSORT,were performed to analyze immune status and treatment responses in patients with pancreatic *** and normal human cell lines were subjected to western blot analysis under lactic acid intervention;two PDAC cell lines with the most pronounced lactylation were ***,RT-PCR was employed to assess the expression of LRGs genes;SLC16A1,which showed the highest expression,was selected for further ***16A1-mediated lactylation was analyzed by immunofluorescence,lactate production analysis,colony formation,transwell,and wound healing assays to investigate its role in promoting the proliferation and migration of PDAC *** vivo validation was performed using an established tumor *** In this stud

关键词： Pancreatic adenocarcinoma Lactylation Prognosis Immunotherapy Tumor microenvironment

Research trends in exercise therapy for the treatment of pain in postmenopausal osteoporosis over the past decade:A bibliometric analysis

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World Journal of Orthopedics 2024年第10期15卷 950-964页

作者： Zhao-Qiu Dai Xiao-Yan Gong Rong Zhang mei-Qin Jin Wei Lu Wen Wen Jie Chen fang-Jie Lu Yi-Fan Yang Lei wang Xiao-Jin He Changshu Hospital Affiliated with Nanjing University of Chinese Medicine Changshu 215500Jiangsu ProvinceChina Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Nanjing University of Chinese Medicine Nanjing 210023Jiangsu ProvinceChina

BACKGROUND Postmenopausal osteoporosis(PMOP)is the most common form of primary osteoporosis among women,and the associated pain often drives patients to seek clinical *** studies have highlighted the unique clinical benefits of exercise therapy(ET)in alleviating PMOP-related ***,bibliometric analyses examining collaboration,development trends,and research frontiers in the field of ET for PMOP pain remain *** To explore the research trends in ET for pain treatment in PMOP patients over the past *** All scholarly works were meticulously sourced from the Science Citation Index-Expanded within the prominent Web of Science Core *** the capabilities of CiteSpace 6.2.R5,we conducted a thorough analysis of publications,authors,frequently cited scholars,contributing nations,institutions,journals of significant citation,comprehensive references,and pivotal ***,our examination explored keyword cooccurrences,detailed timelines,and periods of heightened citation *** comprehensive search,from 2014 through 2023,was completed within a single day,on October 11,*** In total,2914 articles were ultimately included in the *** was a rapid increase in annual publication output in 2015,followed by stable growth in subsequent ***,Michael L,is the most prolific author,whereas Ware JE has the most *** United States’global influence is significant,surpassing all other *** University of California System and Harvard University are the most influential academic institutions.J Bone Joint Surg Am is the most influential journal in this field.“Spinal cord injury”is the keyword that has garnered the most attention from *** developmental pattern in this field is characterized by interdisciplinary fusion,with different disciplines converging to drive *** The academic development of the field of ET for pain in PMOP has matured and stabili

关键词： Exercise therapy Pain Postmenopausal osteoporosis CiteSpace Bibliometric analysis Web of Science

The role and research progress of MDSC in immune aging-related diseases

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Biomedical Engineering Communications 2024年第2期3卷 4-9页

作者： Xi-Xing fang Han-Zhou Li Xue-mei Piao Yu-Ming wang Yu-Hong Bian Medical School Hubei Minzu UniversityEnshi 445099China College of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Nursing Department People's Hospital of Longjing CityLongjing 133499China

Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the pathological conditions of hypoxia,inflammation,infection,and *** individuals age,there is a significant increase in myeloid-derived suppressor cells(MDSCs),which subsequently enhance the immunosuppressive functions of Tregs(regulatory T cells)and Bregs(regulatory B cells).Therefore,MDSC may be related to immune system remodeling,thereby preventing excessive lesions caused by *** indicates that MDSC could serve as a potent inducer of immune *** senescence,characterized by immune dysfunction with aging,is closely linked to the onset of diseases like infections,pulmonary fibrosis,and *** achieve the purpose of anti-aging by intervening in immune aging and slow down the occurrence and development of related ***,understanding the biological characteristics of MDSC and its role in immune aging is crucial for immunotherapy targeting *** article reviews the different roles of MDSC in immune aging and its relationship with pulmonary fibrosis,tumor and other related diseases to provide theoretical basis for more comprehensive targeted MDSC immunotherapy.

关键词： MDSC immunosenescence tumor progression pulmonary fibrosis immunosenescence therapy

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葡萄膜炎并发性白内障31例的手术治疗

国际眼科杂志 2005年第3期5卷 555-557页

作者：黄瑞华王梅芳汪金方郁文国中国上海市第一人民医院宝山分院眼科 200940

目的:探讨葡萄膜炎并发性白内障虹膜后粘连小瞳孔状态下手术技巧、时机及疗效。方法:对葡萄膜炎并发性白内障小瞳孔患者31例35眼,在葡萄膜炎控制稳定,炎症消退3mo后,借助粘弹剂分离虹膜后粘连或施行虹膜环形切除,再行白内障超声乳化或... 详细信息

目的:探讨葡萄膜炎并发性白内障虹膜后粘连小瞳孔状态下手术技巧、时机及疗效。方法:对葡萄膜炎并发性白内障小瞳孔患者31例35眼,在葡萄膜炎控制稳定,炎症消退3mo后,借助粘弹剂分离虹膜后粘连或施行虹膜环形切除,再行白内障超声乳化或囊外摘出及人工晶状体植入。结果:术后32眼(91%)视力较术前提高,其中≥0.5者13眼,0.3～0.5者12眼,0.1～03者7眼。瞳孔圆形或椭圆形。术后眼压均控制在正常范围。结论:葡萄膜炎并发性白内障虹膜后粘连,可使瞳孔扩大成圆形或椭圆型,有利于实施白内障超声乳化或囊外摘除,且瞳孔括约肌不受损伤,避免术后眩光,可获得良好视力,术中术后并发症减少。

关键词：葡萄膜炎并发症白内障瞳孔

The evolution and significance of medicine and food homology

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Acupuncture and Herbal Medicine 2024年第1期4卷 19-35页

作者： Huan Zhong Zhi-Qing Tang Yi-fang Li mei wang Wan-Yang Sun Rong-Rong He Guangdong Engineering Research Center of Traditional Chinese Medicine&Disease Susceptibility/International Cooperative Laboratory of TCM Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE)/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhouChina Naturalis Biodiversity Center Darwinweg RA Leidenthe Netherlands SU BioMedicine BD Leidenthe Netherlands School of Pharmacy Shenyang Pharmaceutical UniversityShenyangChina State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization Yunnan University of Chinese MedicineKunmingChina

Historical insights into medicine and food homology(MFH)Evolution of the MFH theory MFH,a basic concept in traditional Chinese medicine(TCM),suggests that many materials function as both food and medicine,providing nourishment and simultaneously treating *** concept has evolved significantly throughout TCM history^([1]).Integral to this evolution was the discovery of certain materials with dual purposes during early searches for *** materials not only offer sustenance and nutrition but are also capable of treating simple illnesses^([2]).

关键词： evolution insight medicine

乡村振兴背景下古镇居民房屋流转意愿及其影响因素研究——以峨眉山市罗目古镇为例

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Journal of Resources and Ecology 2024年第2期15卷 404-411页

作者：方美乐山职业技术学院四川乐山624000

将古镇居民房屋流转用于发展民宿,是发挥古镇在乡村振兴中引领作用的有效途径。本文基于峨眉山市罗目古镇居民问卷调查的数据,运用Logistic回归模型研究居民房屋流转意愿及其影响因素。结果显示:户主年龄、户主受教育程度、家庭外出务... 详细信息

将古镇居民房屋流转用于发展民宿,是发挥古镇在乡村振兴中引领作用的有效途径。本文基于峨眉山市罗目古镇居民问卷调查的数据,运用Logistic回归模型研究居民房屋流转意愿及其影响因素。结果显示:户主年龄、户主受教育程度、家庭外出务工人数、人均房屋面积对居民房屋流转意愿影响显著(家庭人均年可支配收入对流转意愿影响不显著);古镇居民对房屋流转价格、流转租金能否按期到账、民宿经营者的诚信与实力、有没有政府担保等问题关注度很高。根据研究结果,提出以下建议:(1)加大对年轻和学历较高家庭成员的宣传引导力度,以对户主产生正向影响;(2)加大古镇家庭劳动力的职业技能培训,促进更多家庭劳动力外出务工;(3)对古镇居民进行异地转移安置,另建安居乐园;(4)加大招商引资力度,吸引诚信度高、实力强的企业来整体流转运营,以确保能承受更高的流转价格;同时需要多措并举,减少居民房屋流转的风险担忧。

关键词：乡村振兴房屋流转意愿罗目古镇

复发性流产患者血清尿酸与胰岛素抵抗的关联分析

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实用妇产科杂志 2024年第9期40卷 739-744页

作者：王梅王维静王芳兰州大学第二医院生殖医学中心甘肃兰州700030 甘肃省妇幼保健院妇产科重症监护中心甘肃兰州730050

目的:探讨复发性流产(RSA)患者血清尿酸(UA)水平与胰岛素抵抗(IR)的关联。方法:采用横断面设计,选择2019年9月1日至2022年2月28日于兰州大学第二医院门诊就诊的771例RSA患者为研究对象。根据UA水平分为高尿酸血症(HUA)组和非HUA组,比较... 详细信息

目的:探讨复发性流产(RSA)患者血清尿酸(UA)水平与胰岛素抵抗(IR)的关联。方法:采用横断面设计,选择2019年9月1日至2022年2月28日于兰州大学第二医院门诊就诊的771例RSA患者为研究对象。根据UA水平分为高尿酸血症(HUA)组和非HUA组,比较两组的临床特征;采用单因素和多因素Logistic回归分析RSA患者发生IR的影响因素及血清UA水平和IR之间的关联,并对相关指标进行分层分析和交互作用检验。结果:①HUA组与非HUA组在居住地占比和BMI、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDLC)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)及相关血糖指标的差异均有统计学意义(P1,P0.05)。结论:RSA患者中随着UA水平的升高发生IR的风险增加,HUA导致IR的发生,尤其在特定人群中(年龄≥30岁、BMI≥24 kg/m^(2)、居住在农村、流产次数≥4次、TG、ALT升高和LDL-C、HDL-C降低)更为显著。

关键词：复发性流产高尿酸血症胰岛素抵抗

Roles of the tumor microenvironment in the resistance to programmed cell death protein 1 inhibitors in patients with gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3820-3831页

作者： Ren-Jie Xia Xiao-Yu Du Li-Wen Shen Jian-Guo Ma Shu-mei Xu Rui-fang Fan Jian-Wei Qin Long Yan Department of General Surgery The 940^(th)Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Medicine Northwest Minzu UniversityLanzhou 730050Gansu ProvinceChina Department of Medical Support Center The 940^(th)Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina

Despite the continuous developments and advancements in the treatment of gastric cancer(GC),which is one of the most prevalent types of cancer in China,the overall survival is still poor for most patients with advanced *** recent years,with the progress in tumor immunology research,attention has shifted toward immunotherapy as a therapeutic approach for *** cell death protein 1(PD-1)inhibitors,as novel immunosuppressive medications,have been widely utilized in the treatment of ***,many patients are still resistant to PD-1 inhibitors and experience recurrence in the advanced stages of PD-1 *** reduce the occurrence of drug resistance and recurrence in GC patients receiving PD-1 immunotherapy,to maximize the clinical activity of immunosuppressive drugs,and to elicit a lasting immune response,it is essential to research the tumor microenvironment mechanisms leading to PD-1 inhibitor resistance in GC *** article reviews the progress in studying the factors influencing the resistance to PD-1 inhibitors in the GC tumor microenvironment,aiming to provide insights and a basis for reducing resistance to PD-1 inhibitors for GC patients in the future.

关键词： Gastric cancer Tumor microenvironment Programmed cell death protein 1 Immunotherapy Drug resistance

Effect analysis of applying high-quality service model to surgical nursing

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World Journal of Clinical Cases 2024年第19期12卷 3744-3751页

作者： Li Chen Qiu-mei Tu Zhao-Di Guo Xiao-Wei Zhu Wei wang Hui-fang Xie Yuan Ye Hand Surgery The First People’s Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina

BACKGROUND Surgical care of the hand plays a crucial role in the medical field,as problems with the hand can profoundly affect a patient's quality of life and *** order to meet the needs of patients,improve patient satisfaction and improve treatment outcomes,high-quality service models have been introduced in the field of *** To explore the effect analysis of applying high-quality service model to surgical *** We conducted a retrospective study of patients who underwent hand surgery at our hospital between 2019 and 2022,using a quality service model that included improved patient education,pain management,care team collaboration,and effective *** group of patients received traditional care as a control *** compared postoperative recovery,satisfaction,complication rate,and length of hospital stay between the two *** statistics were used to compare the difference between the two groups by independent sample t test,Chi-square test and other methods to evaluate the effect of intervention *** Postoperative recovery time decreased from 17.8±2.3 d to 14.5±2.1 d,pain score decreased from 4.7±1.9 to 3.2±1.4,and hand function score increased from 78.4±7.1 to 88.5±*** terms of patient satisfaction,the quality service model group scored 87.3±5.6 points,which was significantly higher than that of the traditional care group(74.6±6.3 points).At the same time,patients'understanding of medical information also improved from 6.9±1.4 to 8.6±*** terms of postoperative complications,the application of the quality service model reduced the incidence of postoperative complications from 26%to 10%,the incidence of infection from 12%to 5%,and the incidence of bleeding from 10%to 3%.The reduction in these data indicates that the quality service model plays a positive role in reducing the risk of *** addition,the average hospital stay of patients in the quality service model group was shortened fr

关键词： Hand surgery nursing Quality service model Clinical outcomes Patient satisfaction Collaboration Pain management