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Profilin-1 is involved in macroangiopathy induced by advanced glycation end products via vascular remodeling and inflammation

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World Journal of Diabetes 2021年第11期12卷 1875-1893页

作者： Zhi-Lin Xiao Li-Ping Ma Da-Feng Yang mei Yang Zhen-Yu Li mei-fang chen Department of Geriatric Cardiology National Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Cardiology Shandong Provincial Qianfoshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina Department of Cardiovascular Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND The accumulation of advanced glycation end products(AGEs)have been implicated in the development and progression of diabetic ***,the role of profilin-1 as a multifunctional actin-binding protein in AGEs-induced atherosclerosis(AS)is largely *** To explore the potential role of profilin-1 in the pathogenesis of AS induced by AGEs,particularly in relation to the Janus kinase 2(JAK2)and signal transducer and activator of transcription 3(STAT3)signaling *** Eighty-nine individuals undergoing coronary angiography were enrolled in the *** cytokine levels were detected using ELISA *** aortic vascular smooth muscle cells(RASMCs)were incubated with different compounds for different *** proliferation was determined by performing the MTT assay and EdU *** AGEs-induced vascular remodeling model was established in rats and histological and immunohistochemical analyses were *** mRNA and protein levels were detected using real-time PCR and Western blot analysis,*** vivo,shRNA transfection was performed to verify the role of profilin-1 in AGEs-induced proatherogenic mediator release and aortic *** analyses were performed using SPSS 22.0 *** Compared with the control group,plasma levels of profilin-1 and receptor for AGEs(RAGE)were significantly increased in patients with coronary artery disease,especially in those complicated with diabetes mellitus(P<0.01).The levels of profilin-1 were positively correlated with the levels of RAGE(P<0.01);additionally,the levels of both molecules were positively associated with the degree of coronary artery stenosis(P<0.01).In vivo,tail vein injections of AGEs induced the release of proatherogenic mediators,such as asymmetric dimethylarginine,intercellular adhesion molecule-1,and the N-terminus of procollagen III peptide,concomitant with apparent aortic morphological changes and significantly upregulated expression of t

关键词： Advanced glycation end products Profilin-1 Diabetic macroangiopathy Atherosclerosis Vascular remodeling Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

Preparation of Low Ratio Magnesium Ccement by Acid Leaching Treatment of Boron Mud

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 120-129页

作者： YANG mei ZHANG Mingzhe chen Hao School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China School of Physical Science and Technology Shenyang Normal UniversityShenyang 110168China

The effects of liquid-solid ratio and reaction time on the leaching rate of magnesium at room temperature were investigated,as well as the effects of the molar ratio of MgO/MgCl_(2),the amount of water added,and the amount of acid-impregnated slag dosed on the compressive strength and water resistance of *** results showed that the magnesium element in the boron mud could be maximally leached under the conditions of 1:1 concentration of hydrochloric acid at room temperature,liquid-solid ratio of 2.5 mL·g^(-1),and reaction time of 5 h,and the main products were amorphous SiO_(2) as well as a small amount of magnesium olivine which had not been completely *** LR-MOC prepared using the acid-soaked mixture could reach a softening coefficient of 0.85 for 28 d of water immersion when the molar ratio of MgO/MgCl_(2) was 2.2,the amount of water added was 0 g,and the acid-soaked slag dosing was 40 wt%,which also led to an appreciable late-strength,with an increase of 19.4%in compressive strength at 28 d compared to that at 7 *** previous studies,LR-MOC prepared in this way has a final strength phase that is not the more easily hydrolysed 3-phase but the lath-like *** this phenomenon,we analyzed the mechanism and found that,during the acid leaching process,a part of amorphous SiO_(2) dissolved in the acid leaching solution formed a silica sol,in which Mg^(2+)played a bridging role to make the silica sol more *** the addition and hydrolysis of MgO,the silica sol gel coagulation slows down,providing a capping layer to inhibit the hydrolysis of the 5-phase crystals and providing some strength after *** amorphous SiO_(2) in the other part of the acid-impregnated slag generated M-S-H gel with Mg^(2+)and OH-,which synergised with the dense structure composed of interlocking crystals to improve the water resistance of LR-MOC.

关键词： boron mud magnesium chloride-oxygen cement acid immersion water resistance silica sol

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Efficiencies of Generating Selectable Marker-Free Transgenic Rice with Different Transformation Methods

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Rice science 2009年第4期16卷 254-260页

作者： Yu Heng-xiu Lu mei-fang chen Xiu-hua GONG Zhi-yun LIU Qiao-quan Gu Ming-hong Key Laboratory of Plant Functional Genomics of Ministry of Education/Key Laboratory of Crop Genetics and Physiology of Jiangsu Province Yangzhou University Yangzhou 225009 China

To study the efficiency of generating selectable marker-free （SMF） transgenic rice, two transformation methods were employed for four rice varieties （Wuxiangjing 9, Longtefu, Xieqingzao and Zhenshan 97）. One method is by using a single twin T-DNA binary vector pYH592 in one Agrobacterium strain, which is composed of two separate T-DNA regions （one carrying an antisense Wx gene and the other carrying a HPTgene）. The other one, named as two-strain/two-vector system, is by using two separate binary vectors in two separate Agrobacterium cultures. The results indicated that the average co-transformation frequencies of the antisense Wx gene and the HPT gene were 10.1% and 45.0%, respectively, for the four rice varieties. And the SMF transgenic plants selected from the offsprings of co-transformants were 55.6% and 60.0% in the two-strain/two-vector and twin T-DNA vector binary systems, respectively.

关键词： rice Agrobacterium tumeficien selectable marker-free co-transformation

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The comparison of potential angiotensin I converting enzyme inhibitory peptide derived from Tilapia skin with Captopril: Bioinformation characterization and molecular docking study

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The comparison of potential angiotensin I converting enzyme ...

Inexact proximal gradient algorithm with random reshuffling for nonsmooth optimization

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： Jia-Li chen Yuan-Yuan Zhang mei-fang chen fang Gong Peng Liang Zhong-Ji Qian College of Food Science and Technology Guangdong Ocean University College of Chemistry and Environment Guangdong Ocean University

In our study,the peptide from Tilapia skin Leu-Ser-Gly-Tyr-Gly-Pro(LSGYGP) presents ACE-inhibitory activity and its IC50 is 61.48 μM by HHL *** was found that the LSGYGP exhibiting a mixed inhibition pattern in Lineweaver-Burk plots,and molecular docking study suggested its effect mainly attributed to the hydrogen bond interactions and Pi-Alkyl while captopril inhibited ACE in a competitive manner upon hydrogen bond interactions and Zn(II) *** Pro generate three interactions(hydrogen bonds,hydrophilic and van der Waals interaction) in LSGYGP all amino acids,indicating that Pro contributed greatly to the formation of stable complexes,four residues of ACE active site(Glu281 from S2 pocket,Asn66,Glu143 and Tyr523 from S1 pocket) greatly contributed to the stabilization of the interaction of ACE with *** results suggest that the LSGYGP may be a potential natural ACE inhibitor that posses different interaction sites and inhibitory pattern with captopril,it can be used as a drug in vascular diseases,especially hypertension.

关键词： ACE Captopril Bioinformation Molecular docking

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Science China(Information Sciences) 2025年第1期68卷 219-237页

作者： Xia JIANG Yanyan fang Xianlin ZENG Jian SUN Jie chen National Key Lab of Autonomous Intelligent Unmanned Systems School of AutomationBeijing Institute of Technology Beijing Institute of Technology Chongqing Innovation Center School of Electronic and Information Engineering Tongji University

Proximal gradient algorithms are popularly implemented to achieve convex optimization with nonsmooth regularization. Obtaining the exact solution of the proximal operator for nonsmooth regularization is challenging because errors exist in the computation of the gradient; consequently, the design and application of inexact proximal gradient algorithms have attracted considerable attention from researchers. This paper proposes computationally efficient basic and inexact proximal gradient descent algorithms with random reshuffling. The proposed stochastic algorithms take randomly reshuffled data to perform successive gradient descents and implement only one proximal operator after all data pass through. We prove the convergence results of the proposed proximal gradient algorithms under the sampling-without-replacement reshuffling *** computational errors exist in gradients and proximal operations, the proposed inexact proximal gradient algorithms can converge to an optimal solution neighborhood. Finally, we apply the proposed algorithms to compressed sensing and compare their efficiency with some popular algorithms.

关键词： proximal operator random reshuffling inexact computation compressed sensing nonsmooth optimization

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： mei Zhang Wenhao Li Yangfei chen Yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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MixerKT:A Knowledge Tracing Model Based on Pure MLP Architecture

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Computers, Materials & Continua 2025年第1期82卷 485-498页

作者： Jun Wang Mingjie Wang Zijie Li Ken chen Jiatian mei Shu Zhang Key Laboratory of Education Informatization for Nationalities Ministry of EducationYunnan Normal UniversityKunming650000China Yunnan Key Laboratory of Smart Education Yunnan Normal UniversityKunming650000China

In the field of intelligent education,the integration of artificial intelligence,especially deep learning technologies,has garnered significant *** tracing(KT)plays a pivotal role in this field by predicting students’future performance through the analysis of historical interaction data,thereby assisting educators in evaluating knowledgemastery and tailoring instructional *** knowledge tracingmethods,largely based on Recurrent Neural Networks(RNNs)and Transformer models,primarily focus on capturing long-term interaction patterns in sequential ***,these models may neglect crucial short-term dynamics and other relevant *** paper introduces a novel approach to knowledge tracing by leveraging a pure Multilayer Perceptron(MLP)*** proposeMixerKT,a knowledge tracing model based on theHyperMixer framework,which uniquely integrates global and localMixer feature *** architecture enables more effective extraction of both long-terminteraction trends and recent learning behaviors,addressing limitations in currentmodels thatmay overlook these key *** evaluations on twowidely-used datasets,ASSIS Tments2009 and Algebra2005,demonstrate that MixerKT consistently outperforms several state-of-the-art models,including DKT,SAKT,and Separated Self-Attentive Neural Knowledge Tracing(SAINT).Specifically,MixerKT achieves higher prediction accuracy,highlighting its effectiveness in capturing the nuances of learners’knowledge *** results indicate that our model provides a more comprehensive representation of student learning patterns,enhancing the ability to predict future performance with greater precision.

关键词： Knowledge tracing multilayer perceptron channel mixer sequence mixer

Functional Proteomics of Chlamydomonas reinhardtii identification and characterization of proteins involved in photo-hydrogen evolution

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Functional Proteomics of Chlamydomonas reinhardtii identific...

Antioxidant Peptide Purified from Enzymatic Hydrolysates of Isochrysis Zhanjiangensis and its Protective Effect against Ethanol Induced Oxidative Stress of HepG2 Cells

第二届全国植物蛋白质组学学术研讨会

作者： mei chen fang Huang~* Photosynthesis Research Center,Institute of Botany Chinese Academy of Sciences,Beijing 100093

H production by microalgae via photosynthesis is an ideal way of obtaining hydrogen *** most challenging problem in establishing hydrogen as a fuel for the future,however,is the renewable generation of large quantitie...

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Antioxidant Peptide Purified from Enzymatic Hydrolysates of ...