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Self-adaptive hydrogel for breast cancer therapy via accurate tumor elimination and on-demand adipose tissue regeneration

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Chinese Chemical Letters 2024年第1期35卷 371-378页

作者： Ran Tian Xinyu Qiu Wenyun Mu Bolei cai Zhongning liu Shiyu liu Xin Chen School of Chemical Engineering and Technology Department of Chemical EngineeringShaanxi Key Laboratory of Energy Chemical Process IntensificationXi'an Jiao Tong UniversityXi'an 710049China School of Stomatology State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral DiseasesDepartment of Preventive DentistryThe Fourth Military Medical UniversityXi'an 710032China School of Stomatology State Key Laboratory of Military StomatologyDepartment of Oral and Maxillofacial SurgeryThe Fourth Military Medical UniversityXi'an 710032China Department of Prosthodontics Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China School of Stomatology State Key Laboratory of Military StomatologyNational Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringThe Fourth Military Medical UniversityXi'an 710032China

The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer ***,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection *** hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed *** bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose ***,the sustained release of AP could be simultaneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.

关键词： Smart hydrogel with self-adaptable size Breast cancer therapy Dual responsive cargoes release Selective tumor elimination On-demand adipose tissue regeneration Effective bacteria inhibition

Migration mechanism of atrazine in the simulated lake icing process at different freezing temperatures based on density function theory

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Journal of Environmental Sciences 2024年第10期144卷 45-54页

作者： Yan Zhang Hao Lin Aixin Yu Xiaozhuang Wang Yucan liu Tongshuai liu Chen Zhao Rui mei School of Civil Engineering Yantai UniversityYantai 264005China

Atrazine causes concern due to its resistant to biodegradation and could be accumulated in aquatic organisms,causing pollution in *** study measured the concentration of atrazine in ice and the water under ice through a simulated icing experiment and calculated the distribution coefficient K to characterize its migration ability in the freezing ***,density functional theory(DFT)calculations were employed to expatiate the migration law of atrazine during icing *** to the results,it could release more energy into the environment when atrazine staying in water phase(-15.077 kcal/mol)than staying in ice phase(-14.388 kcal/mol),therefore it was beneficial for the migration of atrazine from ice to *** explains that during the freezing process,the concentration of atrazine in the ice was lower than that in the *** calculations indicated thatwhen the temperature decreases from268 to 248 K,the internal energy contribution of the compound of atrazine and ice molecule(water cluster)decreases at the same vibrational frequency,resulting in an increase in the free energy difference of the compound from-167.946 to-165.390 kcal/*** demonstrated the diminished migratory capacity of *** study revealed the environmental behavior of atrazine during lake freezing,which was beneficial for the management of atrazine and other pollutants during freezing and environmental protection.

关键词： Density functional theory(DFT) Icing process Atrazine Migration behavior Free energy

Ultra-robust informational metasurfaces based on spatial coherence structures engineering

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Light(Science & Applications) 2024年第7期13卷 1310-1319页

作者： Leixin liu Wenwei liu Fei Wang Xiaofeng Peng Duk-Yong Choi Hua Cheng Yangjian cai Shuqi Chen Shandong Provincial Engineering and Technical Center of Light Manipulations Collaborative Innovation Center of Light Manipulation and ApplicationsShandong Provincial Key Laboratory of Optics and Photonic DeviceSchool of Physics and ElectronicsShandong Normal UniversityJinan 250014China. The Key Laboratory of Weak Light Nonlinear Photonics Ministry of EducationSchool of PhysicsSchool of Materials Science and EngineeringSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300071China. School of Physical Science and Technology Soochow UniversitySuzhou 215006China. Laser Physics Centre Research School of PhysicsAustralian National UniversityCanberraACT 2601Australia. The Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi 030006China

Optical information transmission is vital in modern optics and photonics due to its concurrent and multi-dimensional nature,leading to tremendous applications such as optical microscopy,holography,and optical *** optical information transmission technologies suffer from bulky optical setup and information loss/crosstalk when meeting scatterers or obstacles in the light ***,we theoretically propose and experimentally realize the simultaneous manipulation of the coherence lengths and coherence structures of the light beams with the disordered *** ultra-robust optical information transmission and self-reconstruction can be realized by the generated partially coherent beam with modulated coherence structure even 93%of light is recklessly obstructed during light transmission,which brings new light to robust optical information transmission with a single *** method provides a generic principle for the generalized coherence manipulation on the photonic platform and displays a variety of functionalities advancing capabilities in optical information transmission such as meta-holography and imaging in disordered and perturbative media.

关键词： optics coherent holography

Three dimensional velocity model and its tectonic implications at China Seismic Experimental Site,eastern margin of the Tibetan Plateau

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Science China Earth Sciences 2024年第7期67卷 2268-2290页

作者： Jianping WU Yan cai Wei WANG Weilai WANG Changzai WANG Lihua FANG Yaning liu Jing liu Institute of Geophysics China Earthquake AdministrationBeijing 100081China Beijing Baijiatuan Earth Science National Observation and Research Station Beijing 1095China Beijing Earthquake Agency Beijing 100080China

The China Seismic Experimental Site(CSES)is located at the intersection of the Tibetan Plateau,South China Block,and Indian Plate and has complex geological settings and intense crustal deformation,making it one of the most seismically active areas in Chinese mainland.A high-resolution,three-dimensional(3D)crust-mantle velocity structure is crucial for understanding seismotectonic environments,lithospheric deformation mechanisms,and deep dynamic *** first constructed a high-vertical-resolution 3D initial velocity model using the joint inversion of receiver functions and surface waves and then obtained a 3D P-and S-wave velocity model(CSES-VM1.0)with the highest lateral resolution of 0.25°for the CSES using double-difference *** to the limitations of the Sn observation data,the resolution of the S-wave velocity model in the lower crust and upper mantle was reduced,making it closer to the initial model provided by joint inversion.A comparison with explosive-source seismic data showed that the synthetic P-wave first-arrival travel times of the new model were closer to the observations than those of the previous velocity *** velocity cross-sections across the source areas of the 2022 Lushan MS6.1 and Ludian MS6.8 earthquakes reveal that the former earthquake occurred near a weak contact zone between the Tibetan Plateau and Sichuan Basin,and the rupture of the latter earthquake occurred in a granitic area,with the northern end blocked by rigid high-velocity bodies.A clear high-velocity anomaly zone is distributed along the western margin of the Yangtze Block,revealing the spatial distribution of Neoproterozoic intermediate-basic *** high-velocity zone significantly controls the morphology of fault zones and influences the rupture processes of major *** northeast-southwest and north-south trending high-velocity anomalies were found near Panzhihua,potentially related to Neoproterozoic and Middle-Late Permian intermediate

关键词： Eastern Tibetan Plateau China Seismic Experimental Site Yangtze Block Velocity model Double-difference tomography

LLTH‑YOLOv5:A Real‑Time Traffic Sign Detection Algorithm for Low‑Light Scenes

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Automotive Innovation 2024年第1期7卷 121-137页

作者： Xiaoqiang Sun Kuankuan liu Long Chen Yingfeng cai Hai Wang Automotive Engineering Research Institute Jiangsu UniversityZhenjiang 212013China School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang 212013China

Traffic sign detection is a crucial task for autonomous driving ***,the performance of deep learning-based algorithms for traffic sign detection is highly affected by the illumination conditions of *** existing algo-rithms demonstrate high accuracy in well-lit environments,they suffer from low accuracy in low-light *** paper proposes an end-to-end framework,LLTH-YOLOv5,specifically tailored for traffic sign detection in low-light scenarios,which enhances the input images to improve the detection *** proposed framework comproses two stages:the low-light enhancement stage and the object detection *** the low-light enhancement stage,a lightweight low-light enhancement network is designed,which uses multiple non-reference loss functions for parameter learning,and enhances the image by pixel-level adjustment of the input image with high-order *** the object detection stage,BIFPN is introduced to replace the PANet of YOLOv5,while designing a transformer-based detection head to improve the accuracy of small target ***,GhostDarkNet53 is utilized based on Ghost module to replace the backbone network of YOLOv5,thereby improving the real-time performance of the *** experimental results show that the proposed method significantly improves the accuracy of traffic sign detection in low-light scenarios,while satisfying the real-time requirements of autonomous driving.

关键词： Deep learning Traffic sign detection Low-light enhancement YOLOv5 Object detection

Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liu Xiao-rong LI Shuo-fu mei Wen-ya liu Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(P<0.05).Isorhamnetin downregulated the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1βin RA-FLS(P<0.05).The overexpression of either MMP2 or MMP9 reversed isorhamnetin-inhibited RA-FLS migration and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(P<0.05).Furthermore,isorhamnetin bound to SRC and reduced the phosphorylation of SRC,ERK,and CREB(P<0.05).SRC overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

GmNF-YC4 delays soybean flowering and maturation by directly repressing GmFT2a and GmFT5a expression

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Journal of Integrative Plant Biology 2024年第7期66卷 1370-1384页

作者： Yupeng cai Li Chen Xiaoqian liu Weiwei Yao Wensheng Hou State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Ministry of Agriculture Key Laboratory of Soybean Biology(Beijing) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Flowering time and growth period are key agronomic traits which directly affect soybean(Glycine max(L.)Merr.)adaptation to diverse latitudes and farming *** FLOWERING LOCUS T(FT)homologs GmFT2a and GmFT5a integrate multiple flowering regulation pathways and significantly advance flowering and maturity in *** the genes responsible for regulating GmFT2a and GmFT5a will improve our understanding of the molecular mechanisms governing growth period in *** this study,we identified the Nuclear Factor Y-C(NFY-C)protein GmNF-YC4 as a novel flowering suppressor in soybean under long-day(LD)***-YC4 delays flowering and maturation by directly repressing the expression of GmFT2a and *** addition,we found that a strong selective sweep event occurred in the chromosomal region harboring the GmNF-YC4 gene during soybean *** GmNF-YC4Hap3 allele was mainly found in wild soybean(Glycine soja Siebold&Zucc.)and has been eliminated from *** landraces and improved cultivars,which predominantly contain the GmNF-YC4Hap1 ***,the Gmnf-yc4 mutants displayed notably accelerated flowering and maturation under LD *** alleles may prove to be valuable genetic resources for enhancing soybean adaptability to higher latitudes.

关键词： CRISPR/Cas9 early flowering and maturity GmNF-YC4 regional adaptability soybean

Graphitic carbon nitride nanosheets mitigate cadmium toxicity in Glycine max *** promoting cadmium retention in root and improving photosynthetic performance

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Journal of Environmental Sciences 2024年第5期139卷 543-555页

作者： Kai Xu Yunyu Guo Chenghua Xing Ronglong Fu Bin Zou Rongchuan liu Luyi cai Jianfang Yan Xi-Lin Wu Miaozhen cai College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China College of Agriculture Jinhua PolytechnicJinhua 321007China

Cadmium(Cd)pollution poses a serious threat to plant growth and *** have shown great application potential for alleviation of Cd toxicity to *** this study,we applied graphitic carbon nitride nanosheets(g-C_(3)N_(4)NSs)for alleviation of Cd-toxicity to soybean(Glycine max L.).The g-C_(3)N_(4)NSs supplementation significantly improved plant growth and reduced oxidative damage in the Cd-toxicated soybean seedlings through hydroponic ***,the g-C_(3)N_(4)NSs dynamically regulated the root cell wall(RCW)components by increasing pectin content and modifying its demethylation via enhancing pectin methylesterase(PME)activity,therefore greatly enhanced stronger RCW-Cd retention(up to 82.8%)and reduced Cd migration to the ***,the g-C_(3)N_(4)NSs reversed the Cd-induced chlorosis,increased photosynthetic efficiency because of enhancement in F_v/F_mration,Y(Ⅱ)and sugars *** results provide new insights into the alleviation of Cd toxicity to plants by g-C_(3)N_(4)NSs,and shed light on the application of low-cost and environmental-friendly carbon-based NMs for alleviating heavy metal toxicity to plants.

关键词： Cadmium Carbon nitride nanosheets Cell wall Pectin Pectin methylesterase Soybean

Climate warming is significantly influenced by rising summer maximum temperatures: insights from tree-ring evidence of the Western Tianshan Mountains, China

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Journal of Forestry Research 2024年第5期35卷 47-59页

作者： Meng Ren Yu liu Qiufang cai Qiang Li Huiming Song Changfeng Sun The State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061People’s Republic of China Xi’an Institute for Innovative Earth Environment Research Xi’an 710061People’s Republic of China Institute of Desert Meteorology China Meteorological AdministrationÜrümqi 830002People’s Republic of China Center for Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061People’s Republic of China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China Qingdao National Laboratory for Marine Science and Technology Qingdao 266237People’s Republic of China

As one of the regions most affected by global cli-mate warming,the Tianshan mountains has experienced sev-eral ecological crises,including retreating glaciers and water *** warming in these mountains is considered mainly to be caused by increases in minimum temperatures and winter temperatures,while the influence of maximum temperatures is *** this study,a 300-year tree-ring chronology developed from the Western Tianshan Moun-tains was used to reconstruct the summer(June-August)maximum temperature(T_(max6-8))variations from 1718 to *** reconstruction explained 53.1% of the variance in the observed T_(max6-8).Over the past 300 years,the T_(max6-8)reconstruction showed clear interannual and decadal *** was a significant warming trend(0.18°C/decade)after the 1950s,which was close to the increasing rates of the minimum and mean *** increase in maximum temperature was also present over the whole Tianshan mountains and its impact on climate warming has *** T_(max6-8) variations in the Western Tianshan mountains were influenced by frequent volcanic eruptions combined with the influence of solar activity and the sum-mer North Atlantic *** study reveals that cli-mate warming is significantly influenced by the increase in maximum temperatures and clarifies possible driving mech-anisms of temperature variations in the Western Tianshan mountains which should aid climate predictions.

关键词： Tree rings Western Tianshan mountains Temperature change Climate warming