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Correlative factors of poor prognosis and abnormal cellular immune function in patients with Alzheimer’s disease

World Journal of Clinical Cases 2024年第6期12卷 1063-1075页

作者： Hua Bai Hong-mei zeng Qi-Fang Zhang Yue-Zhi Hu Fei-Fei Deng Department of Neurology The Third Affiliated Hospital of Guizhou Medical University in ChinaDuyun 558099Guizhou ProvinceChina Department of Neurology Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Key Laboratory of Medical Molecular Biology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social *** quality of life and prognosis of AD patients have attracted much *** role of chronic immune inflammation in the pathogenesis of AD is becoming more and more *** To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in *** A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November *** cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other *** logistic regression analysis was used to determine independent prog-nostic *** modified Rankin scale(mRS)was used to determine whether the prognosis was *** correlation between drug treatment and prognostic mRS score was tested by the rank sum *** Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD *** logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of *** number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T

关键词： Alzheimer’s disease Cellular immunity Prognosis T lymphocytes Magnetic resonance spectroscopy

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Self-assembled high-entropy nitride multilayer coating

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Rare Metals 2024年第6期43卷 2876-2883页

作者： Xiang-Yu Zhang Yan Liu Vasiliy Pelenovich Xiao-mei zeng Jie Liu Qiang Wan Alexander Pogrebnjak Long-Jian Xue Zhi-Wen Chen Yan Lei Bing Yang School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China Hubei JiuFengShan Future Science and Technology Laboratory Wuhan 420000China Institute of Technological Sciences of Wuhan University Wuhan 430072China Hubei Key Laboratory of Electronic Manufacturing and Packaging Integration Wuhan UniversityWuhan 430072China College of Engineering Huazhong Agricultural UniversityWuhan 430070China Sumy State University Sumy 40007Ukraine Institute of Materials Science Slovak University of Technology in BratislavaJána Bottu2591724 TrnavaSlovak Republic Shenzhen Research Institute of Wuhan University Shenzhen 518057China

The development of advanced materials and construction of multilayer structure contribute to enhancing the performance of protective coatings,further improving the industrial productivity and conserving *** this paper,the self-assembled high-entropy nitride(HEN)AlCrNbSiTiN multilayer coating was designed by harnessing the plasma distribution characteristics and depos-ited by arc ion plating using single target.

关键词： coating energy multilayer

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基础研究人才成长特征及培养策略研究——基于2019—2022年湖北省自然科学奖获得者的分析

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科学管理研究 2024年第1期42卷 135-142页

作者：黄涛曾美武汉科技大学武汉科技大学法学与经济学院湖北武汉430065 武汉科技大学人文社会科学高等研究院湖北武汉430065

以湖北省2019—2022年自然科学奖获得者为研究对象,通过履历分析法,从自然特征、社会特征、成长周期三个维度分析湖北省基础研究人才成长特征。研究发现,湖北省基础研究人才性别占比失衡,获奖年龄跨度大,主要集中在36~45岁;拥有良好的... 详细信息

以湖北省2019—2022年自然科学奖获得者为研究对象,通过履历分析法,从自然特征、社会特征、成长周期三个维度分析湖北省基础研究人才成长特征。研究发现,湖北省基础研究人才性别占比失衡,获奖年龄跨度大,主要集中在36~45岁;拥有良好的高等教育背景及留学经历;高校和科研院所是培养基础研究人才的主阵地,企业参与率低;学科结构分布不均;平均成长周期大约为12.05年。针对以上成长特征,从优化性别结构、提高生活保障、加强国内国际联合培养、提高企业参与率、劣势学科人才引进、促进人才合理流动六方面提出培养基础研究人才相关建议。

关键词：基础研究基础研究人才成长特征湖北省自然科学奖

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Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-Li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min Liu Hai-Lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang Ling Cao Yan-Hui Jia Luo-Na Lin Jiong Li Chuang-Li Hao Xiao-Yan Dong Dao-Jiong Lin Hong-mei Xu De-Yu Zhao mei zeng Zhi-Min Chen Li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

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Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

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World Journal of Diabetes 2024年第6期15卷 1254-1262页

作者： zeng-mei Sun Yuan-Ze Du Su-Yuan Wang Shu-Yao Sun Yan Ye Xue-Ping Sun Ming-Xia Li Hua He Wun-Chun Long Cheng-Hui Zhang Xuan-Yu Yao Wu-Yi Fan Ling Wang Yun-Hong Wu Department of Endocrinology and Metabolism Hospital of the People's Government of the Tibet Autonomous Region in ChengduChengdu 614000Sichuan ProvinceChina Department of Nursing Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina Department of Endocrinology Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood *** to its increased usage in clinics,the number of studies investigating its accuracy has ***,its accuracy has not been investigated in highland populations in *** To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to *** Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 *** the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three ***,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 *** accuracy of the FGM system was evaluated according to the CGM ***,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression *** Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and *** to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when

关键词： Type 2 diabetes Flash glucose monitoring Accuracy Continuous glucose monitor High altitude

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离子色谱法测定水中磷酸根的测量不确定度评定

实验室检测

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实验室检测 2024年第6期2卷 110-114页

作者：曾梅娟清远市清环检测技术有限公司

目的在化学分析中，过去通常把重点放在检测结果的精密度和准确度上。但是，目前很多检测活动都要求建立结果的可信度。特别是通过度量结果的可信度来证明结果的适宜性，这一般包括期望某个结果与其他结果相吻合的程度，这也是我们探... 详细信息

目的在化学分析中，过去通常把重点放在检测结果的精密度和准确度上。但是，目前很多检测活动都要求建立结果的可信度。特别是通过度量结果的可信度来证明结果的适宜性，这一般包括期望某个结果与其他结果相吻合的程度，这也是我们探究不确定度的意义。方法本文据CNAS-GL06化学分析中不确定度的评估指南，对某工业废水中磷酸根含量进行了检测，对实验过程中影响测量不确定度的分量进行了研究与分析。结果通过计算可知，当磷酸根结果为3.00 mg/L时，其可信度区间为2.86-3.14 mg/L(k=2)。结论影响其测量不确定度的主要因素是校准曲线拟合引入的不确定度。为了使检测结果更加科学准确，在日常工作中，要注意离子色谱仪的维护及保养，尽量降低仪器背景噪声，提高仪器灵敏度和准确度。

关键词：不确定度离子色谱法磷酸根

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卡度尼利单抗不良反应临床特点分析

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中国新药杂志 2024年第6期33卷 619-624页

作者：李金兰潘勇曾媚姿陈珊珊湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院药学部长沙410013

目的:分析卡度尼利单抗所致不良反应(adverse drug reaction,ADR)的发生情况及临床特点,为临床合理用药提供参考。方法:对2021年1月—2022年12月我院应用卡度尼利单抗发生ADR的18例住院患者病例资料进行回顾性分析。结果:18例发生卡度... 详细信息

目的:分析卡度尼利单抗所致不良反应(adverse drug reaction,ADR)的发生情况及临床特点,为临床合理用药提供参考。方法:对2021年1月—2022年12月我院应用卡度尼利单抗发生ADR的18例住院患者病例资料进行回顾性分析。结果:18例发生卡度尼利单抗相关ADR中,男性12例(66.67%),女性6例(33.33%),中位发病年龄为64岁,原发疾病以肺癌为主(14例,77.78%)。临床主要表现为皮疹瘙痒、免疫相关甲状腺功能异常、免疫相关垂体炎、免疫相关心肌炎等。免疫相关肝炎和甲状腺功能减退ADR的中位发生时间分别为11和12周,免疫相关肺炎中位发生时间为给药19.7周,脑炎中位发生时间为43.3周,心肌炎和垂体炎的中位发生时间为30周左右,皮肤毒性的中位时间为6.1周。所有的ADR经对症支持治疗后症状治愈或好转,无不良事件相关死亡病例。结论:在临床合理使用卡度尼利单抗时,应提高临床工作者卡度尼利单抗ADR的监测,保障患者安全有效用药。

关键词：卡度尼利单抗不良反应程序性细胞死亡蛋白1 细胞毒性T淋巴细胞相关抗原4 临床特点

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2017-2019年上海市某儿科医院疫苗咨询门诊特殊健康状态儿童疫苗接种现状

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中国疫苗和免疫 2024年第1期30卷 77-82页

作者：李晶晶王楚宁王中林周蓓华曾玫复旦大学附属儿科医院上海201102

目的评价特殊健康状态儿童疫苗接种现状。方法在上海市某儿科医院疫苗咨询门诊收集2017-2019年就诊的特殊健康状态儿童既往接种信息,开展疫苗接种评估和推荐,随访再接种情况和预防接种不良事件(Adverse event following immunization,AE... 详细信息

目的评价特殊健康状态儿童疫苗接种现状。方法在上海市某儿科医院疫苗咨询门诊收集2017-2019年就诊的特殊健康状态儿童既往接种信息,开展疫苗接种评估和推荐,随访再接种情况和预防接种不良事件(Adverse event following immunization,AEFI),分析疫苗接种现状、接种推荐依从性和AEFI发生率。结果共纳入9559例0-17岁特殊健康状态儿童,其中0-5岁儿童占92.9%;6种最常见疾病(神经系统疾病、早产、先天性心脏病、血液病、既往AEFI史和肛周脓肿)儿童占73.4%。在有明确接种记录的儿童中按免疫程序完成疫苗接种者占5.9%(454/7637)。在疫苗接种评估儿童中推荐按免疫程序常规接种者占85.1%(8132/9559)。在随访儿童中遵照推荐进行疫苗接种者占87.3%(804/921),AEFI发生率为1.7%(14/804),无严重AEFI发生。结论特殊健康状态儿童在门诊咨询之前疫苗接种率低,疫苗接种推荐的依从性良好,特殊健康状态儿童在原发病稳定时可安全接种疫苗。

关键词：特殊健康状态儿童疫苗接种依从性预防接种不良事件

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基于自监督学习的葡萄实例去重叠遮挡算法

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计算机工程 2024年第8期50卷 216-228页

作者：曾湄王逸涵雷志伟刘雪垠李柏林西南交通大学机械工程学院四川成都610031 四川省机械设计研究院研发中心四川成都610063

传统随机遮挡算法在合成葡萄遮挡图像时会导致合成数据失真,易使葡萄遮挡预测失效。因此,提出一种适用于葡萄遮挡预测的遮挡数据合成方法,并进一步提出基于自监督学习的葡萄实例去遮挡预测算法。在数据合成阶段,该算法采用接近式遮挡策... 详细信息

传统随机遮挡算法在合成葡萄遮挡图像时会导致合成数据失真,易使葡萄遮挡预测失效。因此,提出一种适用于葡萄遮挡预测的遮挡数据合成方法,并进一步提出基于自监督学习的葡萄实例去遮挡预测算法。在数据合成阶段,该算法采用接近式遮挡策略取代随机遮挡方式用于将完整葡萄实例合成为不同的被遮挡实例,并在合成过程前通过一系列预处理机制来控制互为遮挡的葡萄实例尺寸,从而保证合成的遮挡葡萄符合真实情形,不存在失真问题;随后,将遮挡预测过程拆分为掩码重构与语义填充2个部分,并挑选对应的合成数据分别用于训练基于通用Unet的掩码重构网络和语义填充网络。为了克服因实例分割截取尺寸限制而无法预测完整实例的问题,该算法在数据合成阶段充分考虑被遮挡实例与遮挡者实例,并提出对应的重构和填充函数;在遮挡预测阶段,基于开源架构训练的Pointrend实例分割网络以及所提出的掩码重构网络和语义填充网络被依次用来完成对被遮挡葡萄的预测。在遮挡估计数据集上进行实验,结果表明,该算法预测的遮挡葡萄掩码与真实标注间的交并比(IoU)值达到81.16%,高于其他对比方法,表明所提合成算法与重构框架能够用于葡萄遮挡预测任务。

关键词：葡萄遮挡遮挡预测重构网络遮挡合成实例分割

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基于Python的伦理审查资料管理功能的设计与实现

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科学与信息化 2024年第4期 145-148页

作者：曾美玲沈耐涛浙江大学医学院附属第四医院药剂科浙江义乌 322000

目的:通过Python进行伦理审查全流程中的资料管理.方法:使用Python语言,运用poblib、email、docx、pandas、numpy等第三方功能库对资料进行收集、处理、归档和统计.结果:相比人工,使用Python大大减少了工作时间,平均减少了84%.结论:Pyt... 详细信息

目的:通过Python进行伦理审查全流程中的资料管理.方法:使用Python语言,运用poblib、email、docx、pandas、numpy等第三方功能库对资料进行收集、处理、归档和统计.结果:相比人工,使用Python大大减少了工作时间,平均减少了84%.结论:Python在伦理审查资料管理中发挥了较好的作用.

关键词： Python 伦理审查资料管理

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