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Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu yan-Ping Guo yan-mei Lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(P<0.05).Tumor marker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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Stochastic resonance in coupled weakly-damped bistable oscillators subjected to additive and multiplicative noises

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Acta Mechanica Sinica 2012年第2期28卷 505-510页

作者： yan-mei Kang mei Wang Yong Xie Department of Applied Mathematics School of Mathematics and StatisticsXi'an Jiaotong University710049 Xi'anChina State Key Laboratory of Mechanical Structure Strength and Vibration School of AerospaceXi'an Jiaotong University710049 Xi'anChina

With coupled weakly-damped periodically driven bistable oscillators subjected to additive and multiplicative noises under concern, the objective of this paper is to check to what extent the resonant point predicted by the Gaussian distribution assumption can approximate the simulated one. The investigation based on the dynamical mean-field approx- imation and the direct simulation demonstrates that the pre- dicted resonant point and the simulated one are basically co- incident for the case of pure additive noise, but for the case including multiplicative noise the situation becomes some- what complex. Specifically speaking, when stochastic res- onance （SR） is observed by changing the additive noise in- tensity, the predicted resonant point is lower than the sim- ulated one; nevertheless, when SR is observed by chang- ing the multiplicative noise intensity, the predicted resonant point is higher than the simulated one. Our observations im- ply that the Gaussian distribution assumption can not exactly describe the actual situation, but it is useful to some extent in predicting the low-frequency stochastic resonance of the coupled weakly-damped bistable oscillator.

关键词： Stochastic resonance Dynamical mean-field approximation Direct simulation

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Pairing effects on the fragment mass distribution of Th,U,Pu,and Cm isotopes

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Nuclear Science and Techniques 2023年第11期34卷 128-139页

作者： Xin Guan Jin‑Huan Zheng mei‑yan Zheng Department of Physics Liaoning Normal UniversityDalian 116029China

In this article,a comprehensive study of the fission process of Th,U,Pu,and Cm isotopes using a Yukawa-folded meanfield plus standard pairing model is *** study focused on analyzing the effects of the pairing interaction on the fragment mass distribution and its dependence on nuclear *** significant role of pairing interactions in the fragment mass distributions of^(230)Th,^(234)U,^(240)Pu,and^(246)Cm was *** analysis revealed that increasing the pairing interaction strength decreased the asymmetric fragment mass distribution and increased the symmetric ***,the odd-even mass differences at symmetric and asymmetric fission points were examined,highlighting their sensitivity to changes in the pairing interaction *** analysis of the Th,U,Pu,and Cm isotope fragment mass distributions demonstrated the effectiveness of the model in reproducing the experimental *** addition,the effects of the zero-point energy and half-width parameter on the fragment mass distribution for^(240)Pu were ***,this study provides valuable insights into the fission process by emphasizing the importance of pairing interactions and their relationship with nuclear elongation.

关键词： Nuclear fission Pairing interaction Fragment mass distribution Actinide nuclei

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Global-local combined features to detect pain intensity from facial expression images with attention mechanism

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Journal of Electronic Science and Technology 2024年第3期22卷 80-93页

作者： Jiang Wu Yi Shi Shun yan Hong-mei yan yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China MOE Key Laboratory for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China College of Engineering University of California at Santa BarbaraSanta Barbara93106USA

The estimation of pain intensity is critical for medical diagnosis and treatment of *** the development of image monitoring technology and artificial intelligence,automatic pain assessment based on facial expression and behavioral analysis shows a potential value in clinical *** paper reports a framework of convolutional neural network with global and local attention mechanism(GLA-CNN)for the effective detection of pain intensity at four-level thresholds using facial expression ***-CNN includes two modules,namely global attention network(GANet)and local attention network(LANet).LANet is responsible for extracting representative local patch features of faces,while GANet extracts whole facial features to compensate for the ignored correlative features between *** the end,the global correlational and local subtle features are fused for the final estimation of pain *** under the UNBC-McMaster Shoulder Pain database demonstrate that GLA-CNN outperforms other state-of-the-art ***,a visualization analysis is conducted to present the feature map of GLA-CNN,intuitively showing that it can extract not only local pain features but also global correlative facial *** study demonstrates that pain assessment based on facial expression is a non-invasive and feasible method,and can be employed as an auxiliary pain assessment tool in clinical practice.

关键词： Attention Convolutional neural network Facial expression Pain intensity

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L^p(R^n)-Boundedness of certain commutators

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Applied Mathematics(A Journal of Chinese Universities) 2010年第2期25卷 185-191页

作者： DI yan-mei JIANG Li-ya Department of Mathematics Zhejiang University of Technology Hangzhou 310023 China

In this paper, the LP（Rn）-boundedness of the commutators generalized by BMO（Rn） function and the singular integral operator T with rough kernel Ω∈ L log＋ L（Sn-1）is proved by using the Bony＇s formula for the... 详细信息

关键词： Commutators paraproduct Littlewood-Paley theory.

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The Ruin Probability of the Renewal Model with Constant Interest Force and Upper-tailed Independent Heavy-tailed Claims

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1815-1826页

作者： Xin mei SHEN Zheng yan LIN Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China

In this paper, we obtain the uniform estimate for discounted aggregate claims in the continuous-time renewal model of upper-tailed independent and heavy-tailed random variables. With constant interest force and constant premium rate, we establish a uniform simple asymptotic formula for ruin probability of the renewal model in the case where the initial surplus is large.

关键词： Asymptotic estimate consistent variation renewal process upper-tail independent

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Polyoxometalate-based ionic liquids-promoted CO_2 conversion

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Science China Chemistry 2016年第5期59卷 507-516页

作者： mei-yan Wang Ran Ma Liang-Nian He State Key Laboratory and Institute of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering Nankai University

Polyoxometalates(POMs) are a class of molecular metal oxides, showing numerous applications in various chemical processes due to their unique acid/base and redox features. By adjusting the tunable molecular structures of the anions and counter cations, plenty of POM-based ionic liquids(POM-based ILs) have been fabricated to be used in various fields, such as catalysis, structural chemistry and material science. As a class of excellent catalysts, POM-based ILs have shown advantages in the emerging field of CO_2 utilization such as CO_2 capture, cycloaddition of CO_2 to epoxides, and reduction of CO_2, owing to the efficient activation of CO_2 by POM anions. This review summarizes recent advances in the catalysis of POM-based ILs, and particularly highlights the areas that are related to CO_2 conversion.

关键词： ionic liquid catalysis CO2 conversion polyoxometalate

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New progress in active immunotherapy targeting to amyloid beta

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Science China Chemistry 2015年第3期58卷 383-389页

作者： Gao Li Yong-Xiang Chen yan-mei Li Key Lab of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education Department of Chemistry Tsinghua University Beijing Institute for Brain Disorders

Alzheimer's disease(AD) is one of the most common types of dementia whose hallmarks include neurofibrillary tangles and senile plaques. The latter are mainly composed of amyloid-β proteins(Aβ), and it's suggested that Aβ may be the causative factor in AD pathogenesis. Immunotherapy targeting Aβ for preventing aggregation of Aβ and mildly clearing amyloid plaques has been a hot topic since 1999. Although the first clinical trial of Aβ vaccine, AN-1792, failed in phase II, its results suggested some key points in the design of Aβ vaccines. Avoiding the possible toxic Aβ specific T cell response and inducing a Th2 type cellular immune response may be beneficial for Aβ immunotherapy. Many associations and research groups are working on Aβ vaccine and some progress has been made in recent years. In this review, we have provided a detailed summary of past Aβ vaccines, which have been sorted by the immunogen, and we also discuss some recent progress and future perspectives.

关键词： Alzheimer's disease amyloid beta active immunotherapy peptide vaccine DNA vaccine

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First principles study of behavior of helium at Fe(110)-graphene interface

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Chinese Physics B 2021年第4期30卷 432-437页

作者： yan-mei Jing Shao-Song Huang Key Laboratory of Material Modification by Laser Ion and Electron Beams(Dalian University of Technology)Ministry of EducationDalian 116024China

Recently,metal-graphene nanocomposite system has aroused much interest due to its radiation tolerance ***,the related atomic mechanism for the metal-graphene interface is still ***,stainless steels with Fe as main matrix are widely used in nuclear ***,in this study,the atomic behaviors of point defects and helium(He) atoms at the Fe(110)-graphene interface are investigated systematically by first principles *** results indicate that graphene interacts strongly with the Fe(110) *** comparison with those of the original graphene and bulk Fe,the formation energy values of C vacancies and Fe point defects decrease significantly for Fe(110)-***,as He atoms have a high migration barrier and large binding energy at the interface,they are trapped at the interface once they enter into *** theoretical results suggest that the Fe(110)-graphene interface acts as a strong sink that traps defects,suggesting the potential usage of steel-graphene with multiply interface structures for tolerating the radiation damage.

关键词： Fe(110)-graphene helium interface first principles calculations

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Steric paper based ratio-type electrochemical biosensor with hollow-channel for sensitive detection of Zn2+

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Science Bulletin 2017年第16期62卷 1114-1121页

作者： Li Li yan Zhang Lina Zhang Shenguang Ge mei yan Jinghua Yu School of Chemistry and Chemical Engineering University of JinanJinan 250022China Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials University of JinanJinan 250022China

The construction of flexible platform possessing the functions of immobilizing, separating, rinsing, and high-throughput analysis plays a significant role in biological and clinical research. Herein, hollow- channel technique was integrated with lab-on-paper for the simultaneous determination of two different concentrations of Zn2＋ based on the origami principle, in which microfiuidic channels were first patterned on a cellulose paper using commercial solid-state wax printer. Hollow-channels were created by laser cutting method as the role of both injecting ending and reaction tank. After screen printing three elec- trodes system, the resulting planar paper sheets were then folded into steric structures and functional- ized by in-situ synthesized reduced graphene oxide. As a proof-of-concept, such lab-on-paper device was employed in the ratiometric electrochemical monitoring of zinc ion from the environment and HepG2 cells extract, by combining with co-catalysis of porous metal-organic frameworks and hemin/ G-quadruplex toward H202 in the linear range of 0.1-7,000 nmol/L. The results indicated that integrating hollow-channel with steric lab-on-paper offered a new methodological approach for the development of metal ions monitoring research. It is believed that it could be useful for various point-of-care related research fields, such as, on-site environmental monitoring, food safety, and disease diagnosis.

关键词： Flexible platform Lab-on-paper device Ratiometric electrochemical monitoring Zinc ion

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