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真皮脂肪调控毛发生长的研究进展

中国修复重建外科杂志 2024年第5期38卷 626-632页

作者：张悦汤炜田卫东于湄四川大学华西口腔医学院、口腔再生医学国家地方联合工程实验室成都610041 四川大学华西口腔医院口腔颌面创伤整形外科成都610041

目的总结毛发周期和真皮脂肪之间的动态同步变化以及真皮脂肪对毛发生长的影响,为临床治疗脱发提供新的研究思路。方法广泛查阅国内外相关文献,分析和总结真皮脂肪前体细胞、真皮成熟脂肪细胞以及成脂分化过程对毛发周期转变的影响。结... 详细信息

目的总结毛发周期和真皮脂肪之间的动态同步变化以及真皮脂肪对毛发生长的影响,为临床治疗脱发提供新的研究思路。方法广泛查阅国内外相关文献,分析和总结真皮脂肪前体细胞、真皮成熟脂肪细胞以及成脂分化过程对毛发周期转变的影响。结果真皮脂肪组织与毛囊解剖结构相邻,并且与毛发周期变化息息相关。真皮脂肪前体细胞的增殖分化促进毛发由静止期向生长期转变,但成熟脂肪细胞能够通过表达调节毛发周期的信号分子以加速毛发周期生长期-退行期转变。真皮脂肪的成脂分化与毛发周期转变共同受到多种信号通路的综合调节。结论真皮脂肪通过分泌多种信号分子来影响毛发周期转变以调节毛发生长,但目前研究结果尚不足以充分阐明真皮脂肪在调节毛发周期中的突出作用,具体调节机制有待进一步研究。

关键词：真皮脂肪前体细胞真皮成熟脂肪细胞毛发周期信号分子

Report on the 3rd Board Meeting of the International Human Phenome Consortium

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Phenomics 2023年第1期3卷 77-82页

作者： mei tian Han Liu Shunling Chen Zhong Yang Weishuo Tao Shiwen Peng Huiting Che Li Jin The Secretariat of International Human Phenome Consortium Human Phenome Institute Fudan UniversityShanghai 200438China International Human Phenome Institutes(Shanghai) Shanghai 200433China School of Life Sciences Fudan UniversityShanghai 200438China Shanghai Medical College Fudan UniversityShanghai 200032China

Introduction The phenome is a set of measurable traits,including the physical,chemical and biological traits of individuals and populations,that result from the complex interactions of genes,epigenetics,symbiotic microorganisms,diet and environmental exposures(Jin 2021).The aim of human phe-nomics is to precisely measure the human phenotypes and to comprehensively analyze the human phenome.In doing so,we can systemically deconstruct the relationship among perceived phenotypes,compile phenotypic network,expand multi-dimensional and cross-scale correlations between macro and micro phenotypes,and eventually clarify the correlations among these phenotypes.After the completion of the Human Genome Project,there is an urgent need for discovering the multi-level association among genes,envi-ronment and phenotypes to complement the other half of the required information for human health.Therefore,Fudan University has initiated the International Human Phenome Project in 2018,providing a new opportunity for biomedical research and leading the development of biomedicine.

关键词： Human eventually initiated

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke

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Frontiers of Medicine 2022年第3期16卷 429-441页

作者： Yao Chen Fahuan Song Mengjiao Tu Shuang Wu Xiao He Hao Liu Caiyun Xu Kai Zhang Yuankai Zhu Rui Zhou Chentao Jin Ping Wang Hong Zhang mei tian Department of Nuclear Medicine and Medical PET Center The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Institute of Nuclear Medicine and Molecular Imaging Zhejiang UniversityHangzhou 310009China Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou 310009China Shanxi Medical University Taiyuan 030001China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310027China Department of Radiology Zhejiang HospitalHangzhou 310030China Department of PET Center The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310006China

The local microenvironment is essential to stem cell-based therapy for ischemic stroke,and spatiotemporal changes of the microenvironment in the pathological process provide vital clues for understanding the therapeutic mechanisms.However,relevant studies on microenvironmental changes were mainly confined in the acute phase of stroke,and long-term changes remain unclear.This study aimed to investigate the microenvironmental changes in the subacute and chronic phases of ischemic stroke after stem cell transplantation.Herein,induced pluripotent stem cells(iPSCs)and neural stem cells(NSCs)were transplanted into the ischemic brain established by middle cerebral artery occlusion surgery.Positron emission tomography imaging and neurological tests were applied to evaluate the metabolic and neurofunctional alterations of rats transplanted with stem cells.Quantitative proteomics was employed to investigate the protein expression profiles in iPSCs-transplanted brain in the subacute and chronic phases of stroke.Compared with NSCs-transplanted rats,significantly increased glucose metabolism and neurofunctional scores were observed in iPSCs-transplanted rats.Subsequent proteomic data of iPSCs-transplanted rats identified a total of 39 differentially expressed proteins in the subacute and chronic phases,which are involved in various ischemic stroke-related biological processes,including neuronal survival,axonal remodeling,antioxidative stress,and mitochondrial function restoration.Taken together,our study indicated that iPSCs have a positive therapeutic effect in ischemic stroke and emphasized the wide-ranging microenvironmental changes in the subacute and chronic phases.

关键词： ischemic stroke microenvironment induced pluripotent stem cells(iPSCs) positron emission tomography(PET) quantitative proteomics

集成视觉显著性和群决策的航空零件孔特征检测

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光学精密工程 2024年第1期32卷 125-136页

作者：田佳淳王亮梅标朱伟东浙江大学工程师学院浙江杭州310015 中航西安飞机工业集团股份有限公司陕西西安710089 中国科学院福建物质结构研究所泉州装备制造研究中心福建泉州362100 浙江大学机械工程学院浙江杭州310058

为了实现复杂环境下航空零件孔特征的高效高精度检测,提出了一种集成视觉显著性和群决策的检测方法。在经典FT显著性检测算法中引入图像增强步骤,并为每个像素赋予以最大显著区域中心为参考的权重,使用改进后的方法对图像进行孔区域分... 详细信息

为了实现复杂环境下航空零件孔特征的高效高精度检测,提出了一种集成视觉显著性和群决策的检测方法。在经典FT显著性检测算法中引入图像增强步骤,并为每个像素赋予以最大显著区域中心为参考的权重,使用改进后的方法对图像进行孔区域分割。设计具有多尺度多结构元素的新型数学形态学边缘检测算法,结合轮廓细化算法对孔区域进行轮廓提取。最后,利用Meanshift算法寻找轮廓点的圆心位置,建立新的基于群决策的圆半径计算模型,获得孔特征的关键几何参数。结果表明:改进的视觉显著性特征检测算法能够生成更加突显孔特征的全分辨率显著图;新型数学形态学边缘检测算法能获得简化且可靠的轮廓点;该方法在不均匀光照、各类孔缺陷和孔内壁干扰等条件下均显示出较好的稳定性;即使在噪声密度高达30%时仍能成功完成孔检测,且圆心坐标和半径的误差均小于0.012 mm;平均检测时间仅为0.236 s。该方法能够在复杂环境下对航空零件孔特征进行准确、稳定的检测。

关键词：航空零件孔特征检测显著性检测数学形态学群决策

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Bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu Zou Ran Liu mei Huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min Huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang Qi Guo Yan Huang tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-Hang Luo Chang-Jun Li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key Laboratory of Joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture healing.Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair.Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence.Mechanistically,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular senescence.Depletion of Plxnb2 in SSPCs impaired fracture healing.Administration of GCA-neutralizing antibody enhanced fracture healing in aged mice.Thus,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

未来气候情景下甘南草地土壤有机碳密度的时空预测与分析

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环境科学 2024年第6期45卷 3308-3317页

作者：李钊张美玲张锐祺田景王晨甘肃农业大学理学院数量生物学研究中心兰州730070

研究草地土壤有机碳密度的时间和空间分布特征,并探究有机碳密度与影响因素之间的关系,对甘南自治州草地生态系统管理和维护具有重要意义,有助于实现“双碳”目标,促进碳汇和减缓气候变化.以甘肃省甘南藏族自治州为研究对象,基于SSP126... 详细信息

研究草地土壤有机碳密度的时间和空间分布特征,并探究有机碳密度与影响因素之间的关系,对甘南自治州草地生态系统管理和维护具有重要意义,有助于实现“双碳”目标,促进碳汇和减缓气候变化.以甘肃省甘南藏族自治州为研究对象,基于SSP126和SSP585这两种CMIP6未来气候情景数据,运用CENTURY模型模拟预测2023~2100年甘南草地土壤有机碳密度的时空变化,结果表明:①2023~2100年,总有机碳密度、缓性有机碳密度、惰性有机碳密度均呈现下降趋势,活性有机碳密度先波动下降再波动上升.同时,SSP585情景下的总有机碳、活性、缓性和惰性有机碳密度均高于SSP126情景;②MannKendall突变分析表明土壤总有机碳密度之差(Δsomtc)的突变发生在2030年;土壤活性碳密度之差(Δsom1c)的突变发生在2027年;③研究期内,在SSP126情景下,甘南州草地土壤有机碳密度平均值为7505.69 g·m^(-2),在SSP585情景下则为7551.87g·m^(-2).甘南州草地土壤有机碳密度整体呈现西部高东部低,变异系数整体比较稳定的特点;④偏相关分析结果表明未来气候情景下,降水与土壤有机碳密度呈正相关,温度与土壤有机碳密度呈显著负相关;⑤Theil-Sen Median趋势分析和MannKendall检验结果表明,在两个气候情景下,甘南州的土壤有机碳密度整体呈现下降趋势,其中碌曲县的下降趋势相对最快,迭部县最缓慢.

关键词：土壤有机碳密度(SOCD) CENTURY模型气候情景时空分布趋势分析

高熵型MnCuNiFeZn阻尼合金的高温阻尼行为与相变特征

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材料工程 2024年第1期52卷 193-199页

作者：梅玲牛红康丁双东田青超上海大学省部共建高品质特殊钢冶金与制备国家重点实验室上海200444 南通东凯精密科技有限公司江苏南通226534

制备了新型MnCuNiFeZn高熵阻尼合金,利用X射线衍射仪、扫描电镜、透射电镜、动态热机械分析仪(DMA)与热膨胀仪等研究其微观组织、阻尼特性以及相变特征。研究表明,在固溶以及不同时效工艺下,MnCuNiFeZn合金均为单一母相,合金晶粒大小均... 详细信息

制备了新型MnCuNiFeZn高熵阻尼合金,利用X射线衍射仪、扫描电镜、透射电镜、动态热机械分析仪(DMA)与热膨胀仪等研究其微观组织、阻尼特性以及相变特征。研究表明,在固溶以及不同时效工艺下,MnCuNiFeZn合金均为单一母相,合金晶粒大小均匀,呈现出高位错密度特征。随着时效时间的延长,合金常温下发生磁性转变,但常温段的内耗值很低;在673 K以上的高温域,MnCuNiFeZn合金因相变使得内耗值急剧提高。

关键词： Mn基高熵合金内耗相变高温阻尼性能

Value of Coronary Sinus During Computed Tomography Pulmonary Angiography for Predicting Pulmonary Hypertension in Patients with Acute Pulmonary Embolism

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Cardiology Discovery 2023年第2期3卷 78-84页

作者： Chuang Zhang Qian Xin Hongling Xu Xiangyu Wang Zhiqiang Yan Shengtao Sun Xiangmin Shi mei tian Department of Cardiology The Sixth Medical Center of People’s Liberation Army General HospitalBeijing 100048China Department of Cardiology The Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China Department of Radiology The Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China Department of Radiology The Sixth Medical Center of People’s Liberation Army General HospitalBeijing 100048China.

Objective:Computed tomography pulmonary angiography(CTPA)parameters are valuable for predicting pulmonary hypertension(PH)in patients with pulmonary embolism(PE).However,few studies have used the coronary sinus ostium area(CSOA),derived from CTPA,to detect PH.This study aimed to compare the prognostic values of the CSOA,coronary sinus ostium diameter(CSOD),and right ventricular(RV)/left ventricular(LV)ratio for PH.Methods:This study retrospectively analyzed 78 patients(mean age,(51.94±12.33)years;53.8%male)with acute PE confirmed by CTPA at the Sixth and Eighth Medical Centers of the People’s Liberation Army General Hospital between June 2018 and June 2020.Patients were categorized into 2 groups using a pulmonary artery systolic pressure(PASP)cut-off of 30 mmHg.CTPA parameters were compared between these groups.Results:Patients with PASP>30 mmHg(n=22)had a larger CSOA,CSOD,RV diameter,RV/LV ratio,and inferior vena cava diameter compared with patients with PASP≤30 mmHg(n=56).The CSOA had an area under the receiver-operating characteristic curve(AUC,0.84;95%confidence interval(CI),0.74–0.94;P30 mmHg.

关键词： Angiography Computed tomography Coronary sinus Diagnosis Pulmonary embolism Pulmonary hypertension Right ventricle

Brain dopaminergic system changes in drug addiction:a review of positron emission tomography findings

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Neuroscience Bulletin 2014年第5期30卷 765-776页

作者： Haifeng Hou Chunyan Wang Shaowei Jia Shu Hu mei tian Department of Nuclear Medicine the Second Affiliated Hospital of Zhejiang University School of Medicine Zhejiang University Medical PET Center Institute of Nuclear Medicine and Molecular Imaging Zhejiang University Key Laboratory of Medical Molecular Imaging of Zhejiang Province Beijing 307 Hospital Department of Nuclear Medicine Peking University Shenzhen Hospital

Dopamine （DA） is considered crucial for the rewarding effects of drugs of abuse, but its role in addiction remains unclear. Positron emission tomography （PET） is the first technology used for in vivo measurement of components of the dopaminergic system in the human brain. In this article, we review the major findings from PET imaging studies on the involvement of DA in drug addiction, including presynaptic DA synthesis, vesicular monoamine transporter 2, the DA transporter, and postsynaptic DA receptors. These results have corroborated the role of DA in addiction and increased the understanding of its underlying mechanisms.

关键词： dopamine dopaminergic system drug addiction positron emission tomography