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The flavonoids from Pentorum chinense *** ferroptosis to alleviate sorafenib-induced liver injury in BRL-3A cells

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Traditional Medicine Research 2024年第2期9卷 18-26页

作者： Di Yang Bo-Wen Zhang Shan Lei Jin-Tao Li mei-Hao peng Jia-Qing Liao Xue Tang Qi Zhao Qiu-Xia Lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China Chengdu Analytical Applications Center Shimadzu(China)Co.Ltd.Chengdu 610023China

Background:Drug-induced liver damage is a severe medical issue that affects people all over the *** has some side effects that cause liver injury.A dietary medicinal plant called Penthorum chinense Pursh.(PCP)has hepatoprotective *** are currently few reports on PCP’s protective impact and mechanism against sorafenib-induced liver ***:To create a liver injury model,sorafenib was administered to BRL-3A *** viability assays,immunofluorescence tests,Western blotting,real-time quantitative PCR,and high-content imaging systems were utilized to examine PCP’s effect and ***:In this study,PCP treatment mitigated the liver damage caused by sorafenib by enhancing cell survival,lowering lipid reactive oxygen species and malondialdehyde levels,and elevating glutathione *** addition,PCP can enhance the protein expression of cystine/glutamate transporter xCT and glutathione peroxidase 4,reduce iron content and alleviate mitochondrial *** mechanism studies revealed that PCP inhibited ferroptosis by promoting the production of nuclear factor E2-related factor 2 nuclear translocation and subsequently affecting target genes(HO-1 and NQO1).Conclusion:Together,PCP regulates the nuclear factor E2-related factor 2 pathway,which helps to lessen ferroptosis brought on by sorafenib.

关键词： sorafenib Pentorum chinense Pursh. ferroptosis oxidative stress Nrf2

基于稳定性SPH-SWE数值模型的真实感流体动画实时模拟

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物理学报 2021年第23期70卷 254-265页

作者：邵绪强梅鹏陈文新华北电力大学控制与计算机工程学院保定071003

流体动画模拟的真实感与实时性一直是流体模拟研究中的热点.针对在复杂地形场景中不稳定的流体表面运动现象,本文提出一种基于地形差异的自适应流体速度控制力,建立了稳定性光滑粒子流体动力学方法以求解浅水方程数值模型.首先,将模拟... 详细信息

流体动画模拟的真实感与实时性一直是流体模拟研究中的热点.针对在复杂地形场景中不稳定的流体表面运动现象,本文提出一种基于地形差异的自适应流体速度控制力,建立了稳定性光滑粒子流体动力学方法以求解浅水方程数值模型.首先,将模拟域从三维降至二维表面来降低计算量,通过粒子的密度大小表示其水深高度值;其次,采用变长光滑搜索半径,确保搜索邻域内的粒子数目稳定在固定范围内,提高模拟精度;最后引入一种基于地形差异的自适应流体速度控制力,根据粒子密度大小的实时变化来确定计算速度控制力的地形研究范围,通过插值计算粒子运动前后时间步所处地形位置的差异来修正粒子的速度和位置.本文使用屏幕空间流体渲染方法对流体表面进行绘制,避免了表面网格的提取与重建,流体的运动数值计算和渲染均被加载到GPU上并行化执行,实验结果表明在达到实时交互级别的同时,本文方法有效地改善了在复杂地形场景中流体表面的不稳定运动现象,同时流体模拟过程中密度与压强的分布均匀.

关键词：光滑粒子动力学浅水方程并行计算复杂地形

傅里叶变换光谱仪多次反射杂光对调制度的影响分析

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光谱学与光谱分析 2018年第9期38卷 2966-2970页

作者：陈芳高超徐彭梅北京空间机电研究所北京100086

为满足遥感探测领域对高光谱干涉探测仪的高信噪比和高光谱分辨率的要求,针对我国目前在研高光谱分辨率傅里叶变换光谱仪,详细分析了采用分束器及补偿器分光方案的迈克尔逊干涉仪中,增透面上多次反射杂光对光谱仪调制度的影响。分析表... 详细信息

为满足遥感探测领域对高光谱干涉探测仪的高信噪比和高光谱分辨率的要求,针对我国目前在研高光谱分辨率傅里叶变换光谱仪,详细分析了采用分束器及补偿器分光方案的迈克尔逊干涉仪中,增透面上多次反射杂光对光谱仪调制度的影响。分析表明增透面透过率越低,光谱仪调制度越低。理论分析发现,引入分束器和补偿器的楔角和倾斜角可以实现正常光斑与多次反射光斑分离,从而减弱甚至消除多次反射杂光的影响。通过理论计算给出了二次反射杂光与正常光路夹角与楔角和倾斜角的关系式,并依据光斑分离要求确定了楔角和倾斜角优化方法。由于干涉仪结构参数的相互关联特性,在优化楔角和倾斜角后,需要对入射角进行调整,使得反射光路与透射光路关于分束面对称,以消除其对光谱分辨率的影响;需要对补偿器厚度进行调整匹配,消除由于角度调整引入的正常光路光程差改变导致的调制度下降。按此步骤进行设计优化,在保持原有高精度设计指标的前提下,可消除干涉仪多次反射杂光的影响,该干涉仪优化设计步骤及结构参数调整方法适用于采用分束器补偿器分光方案的傅里叶变换光谱仪。

关键词：迈克尔逊干涉仪杂散光分束器补偿器调制度

变透平效率有机朗肯循环工质筛选及多目标优化

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化工学报 2018年第6期69卷 2603-2611页

作者：韩中合梅中恺李鹏华北电力大学电站设备状态监测与控制教育部重点实验室河北保定071003

针对523.15 K的中高温余热烟气热源,选取戊烷、己烷、庚烷、环己烷、MM(六甲基二硅氧烷)、苯和甲苯为候选工质,引入一维向心透平效率预测模型取代固定透平效率,以?效率和系统净功为目标函数,基于NSGA-Ⅱ算法对ORC系统进行多目标求解,采... 详细信息

针对523.15 K的中高温余热烟气热源,选取戊烷、己烷、庚烷、环己烷、MM(六甲基二硅氧烷)、苯和甲苯为候选工质,引入一维向心透平效率预测模型取代固定透平效率,以?效率和系统净功为目标函数,基于NSGA-Ⅱ算法对ORC系统进行多目标求解,采用理想点辅助法对各工质Pareto前沿进行决策寻优。得出以下结论:工质的透平效率与透平等熵膨胀比(VFR)存在较强的相关性,透平效率曲线与VFR曲线的变化趋势相反;在给定热源条件下,苯是最优工质,甲苯和环己烷是次优工质;当蒸发温度超过400 K时,?效率下降趋势加快,当蒸发温度超过410 K时,系统净功上升趋势放缓;定透平效率寻优会对最佳参数与最优工质筛选结果造成一定影响,与实际存在偏差;变透平效率寻优可以减少误差,更接近工程实际。

关键词：有机朗肯循环多目标优化一维向心透平效率预测模型热力学经济透平等熵膨胀比

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新型镦边U肋与面板连接焊缝切口应力分析

桥梁建设 2017年第1期47卷 65-70页

作者：梅大鹏廖贵星西南交通大学土木工程学院四川成都610031 中铁大桥勘测设计院集团有限公司湖北武汉430056

正交异性钢桥面板焊接部位疲劳问题突出,为研究采用新型镦边U肋替代传统U肋,其与正交异性钢桥面板焊缝处的应力改善情况,以典型正交异性钢桥面板为研究对象,按照实际尺寸参数采用ANSYS有限元软件建立足尺节段模型进行分析。确定关注区... 详细信息

正交异性钢桥面板焊接部位疲劳问题突出,为研究采用新型镦边U肋替代传统U肋,其与正交异性钢桥面板焊缝处的应力改善情况,以典型正交异性钢桥面板为研究对象,按照实际尺寸参数采用ANSYS有限元软件建立足尺节段模型进行分析。确定关注区域及最不利荷载加载位置,在此基础上,建立焊缝局部精细模型,采用切口应力法分析镦边U肋与面板焊缝和传统U肋与面板焊缝在焊趾及焊根部位的应力。结果表明:采用镦边U肋与传统U肋在U肋与面板焊缝处应力分布基本相似;相对于传统U肋焊缝,镦边U肋焊缝在面板焊趾、焊根和U肋焊趾处应力最大降幅分别为24.3%、43.8%、60.5%,镦边U肋可以较好地改善U肋与面板焊缝处的应力集中效应,有利于提高结构的抗疲劳性能。

关键词：正交异性钢桥面板镦边U肋焊缝切口应力疲劳性能有限元法

Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients

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World Journal of Gastroenterology 2019年第17期25卷 2099-2109页

作者： Xue Yang Zhi-Jie Xu Xi Chen Shuang-Shuang Zeng Long Qian Jie Wei mei peng Xiang Wang Wan-Li Liu Hong-Ying Ma Zhi-Cheng Gong Yuan-Liang Yan Department of Pharmacy Institute for Rational and Safe Medication PracticesNational Clinical Research Center for Geriatric DisordersXiangya HospitalCentral South University Department of Pathology Xiangya HospitalCentral South University

BACKGROUND The methylated septin 9(mSEPT9) assay was the first blood-based test approved by the United States Food and Drug Administration as a colorectal screening ***, the diagnostic and prognostic role of preoperative mSEPT9 for colorectal cancer(CRC) in Chinese patients is still *** To improve the understanding of diagnostic and prognostic factors, serum m SEPT9 was detected in Chinese CRC *** A retrospective analysis of 354 cases, of which 300 had CRC and 54 were normal,was performed in China. Patients' characteristics, treatments, and laboratory data, including age, the date of surgery, Union for International Cancer Control(UICC) stages, distant metastasis(M), and so on, were collected. Methylation levels of SEPT9 were quantified by quantitative, methylation-specific polymerase chain reaction before surgery. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 CRC cases from The Cancer Genome Atlas(TCGA) database were evaluated using bioinformatics analyses. Potential prognostic factors for overall survival(OS) and progression-free survival(PFS)were evaluated by Kaplan-meier univariate *** Chinese CRC patients, positive mSEPT9 was strongly associated with advanced UICC stages, deeper invasion by the primary tumor, and more distant metastasis. Methylation levels of SEPT9 were stage-dependent and showed a stepwise increase in UICC stages(I–IV), primary tumor categories(T1–T4),regional node categories(N0–N2), and distant metastasis categories(M0–M1).The patients with positive mSEPT9 showed a tendency toward lower PFS. After analyzing TCGA clinical data, the high mSEPT9 group was found to be obviously correlated only with more distant metastasis. The patients with high mSEPT9 levels showed a tendency toward lower OS. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up *** MSEPT9 analysis may add valuable information to current tumor staging. Serum m

关键词： Methylated septin 9 Methylated Colorectal cancer Diagnosis Prognosis

初盛唐文艺审美趋向——以刘希夷诗歌的接受为例

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华南师范大学学报（社会科学版） 2008年第5期 58-63页

作者：彭梅芳华南师范大学文学院广东广州510631

初唐诗人刘希夷的诗歌在初、盛唐经历了由受冷落到被推崇的接受过程。初唐诗坛以及盛唐社会对刘诗的评价相差较大,这一现象恰体现了初盛唐文艺审美趣味演变的规律,即由典雅靡丽、贵族化向雅俗共赏、大众化演进。而刘希夷的诗歌也正是因... 详细信息

初唐诗人刘希夷的诗歌在初、盛唐经历了由受冷落到被推崇的接受过程。初唐诗坛以及盛唐社会对刘诗的评价相差较大,这一现象恰体现了初盛唐文艺审美趣味演变的规律,即由典雅靡丽、贵族化向雅俗共赏、大众化演进。而刘希夷的诗歌也正是因为顺应了此发展趋势而得以在盛唐诗坛获得相应的地位。

关键词：文艺审美文学接受刘希夷

Physics design of the HEPS LINAC

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Radiation Detection Technology and Methods 2020年第4期4卷 497-506页

作者： Cai Meng Xiang He Yi Jiao Xiaojun Nie Yue mei peng Shengchang Wang Ouzheng Xiao Jingru Zhang Shipeng Zhang Jingyi Li Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina

Purpose The High Energy Photon Source(HEPS)is a synchrotron radiation source with an ultrahigh brightness and under construction in *** accelerator system is comprised of a 6-GeV storage ring,a full energy booster,a 500-meV Linac and three transport *** deepening investigations on the physics designs of the storage ring and the booster,the physics scheme of the Linac has evolved through multiple *** The final version of the Linac,including the electron gun,bunching system and main accelerator,has been *** Linac is an s-band normal conducting electron linear accelerator with a very high bunch charge and a large bunch charge *** Based on simulations,the Linac could provide electron bunches with charge greater than 8.5-nC,meeting the energy spread and emittance *** This paper first reviews the evolution and main considerations for different design versions and then describes the physics design and dynamic simulation results of the final scheme in detail.

关键词： 5 HEPS Linac Bunch charge Emittance

Effects of montelukast sodium combined with pidotimod on acute phase protein and immune function in children with acute bronchitis

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Journal of Hainan Medical University 2017年第16期23卷 74-77页

作者： Jing Wang Chong-De Liu mei-Fang peng Cai-Ping Ran Department of Paediatrics The Third People's Hospital of XiningXining810005China Neonatal Department Qinghai Women's and Children's HospitalXining810000China Pediatrics Yanjiao Beijing Yan Da HospitalBejing101601China Pediatrics Qinghai Maternal and Child Health Care HospitalXining810000China

Objective: To observe the effects of montelukast sodium combined with pidotimod on acute phase protein (APP) and indexes of immunologic function in pediatric acute bronchitis treatment. Methods: A total of 180 cases children with acute bronchitis acted as research objects were randomly divided into control group (n=65) and observation group (n=63). On the basis of conventional therapy, control group was treated by plus pidotimod. On this base, observation group was treated with montelukast sodium. The changes of acute phase proteins (CRP, HP, a1-AAG and CER) and immune function (CD3+, CD4+, CD8+ and CD4+/CD8+) levels before and after treatment were observed after 2 months. Results: Before treatment, CRP, HP, a1-AAG, CER, CD3+, CD4+, CD8+ and CD4+/CD8+ levels of two groups had no statistically significant difference;CRP, HP, a1-AAG, CER, and CD8+ levels of control and observation groups decreased significantly after treatment, the decreases of observation group were more obvious than that of control group, and the levels after treatment were significantly lower than that of control groups. The levels of CD3+, CD4+ and CD4+/CD8+ in two groups after treatment were significantly higher than those before treatment. For observation group, the levels of CD3+, CD4+ and CD4+/CD8+ increased more significantly after treatment, which were significantly higher than that of the control group. Conclusion: Using Montelukast sodium combined with pidotimod can effectively reduce the children's acute phase protein levels, improve immune function, which has clinical value for the treatment of children with acute bronchitis.

关键词： Pediatric acute bronchitis Pidotimod Montelukast sodium Acute phase protein Immune function