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艾司氯胺酮复合右美托咪定对学龄前儿童扁桃体切除及低温等离子腺样体消融术麻醉苏醒的影响

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中国医学创新 2024年第3期21卷 18-22页

作者：欧阳年春胡德铭甘露平廖梅李建华宜春市人民医院麻醉科江西宜春336000

目的:探讨在学龄前儿童扁桃体切除及低温等离子腺样体消融术中采用艾司氯胺酮复合右美托咪定(DEX)对麻醉苏醒的影响。方法:选取2019年7月—2022年6月于宜春市人民医院行扁桃体切除及低温等离子腺样体消融术的患儿共计80例,按照随机数字... 详细信息

目的:探讨在学龄前儿童扁桃体切除及低温等离子腺样体消融术中采用艾司氯胺酮复合右美托咪定(DEX)对麻醉苏醒的影响。方法:选取2019年7月—2022年6月于宜春市人民医院行扁桃体切除及低温等离子腺样体消融术的患儿共计80例,按照随机数字表法分成ED组(n=40)和E组(n=40),麻醉诱导期前,E组给予艾司氯胺酮麻醉,ED组给予艾司氯胺酮复合DEX麻醉,比较两组躁动情况、疼痛程度、心率(HR)、麻醉恢复情况及不良反应。结果:ED组儿童警觉-镇静观察(OAA/S)评分较E组更高(P0.05),ED组T_(1)、T_(2)、T_(3)时期HR均较E组更低(P0.05)。结论:在学龄前儿童扁桃体切除及低温等离子腺样体消融术中采用艾司氯胺酮复合DEX麻醉,可改善躁动情况及疼痛程度,改善麻醉恢复情况,安全性较高,对HR的影响更小。

关键词：艾司氯胺酮右美托咪定学龄前儿童扁桃体切除低温等离子腺样体消融术麻醉苏醒

FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

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Current Medical Science 2024年第1期44卷 187-194页

作者： Xiao-mei HUANG E liao Jun-qun liao Ya-ling LIU Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA ***(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

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药剂学多维实验教学体系的构建

中国中医药现代远程教育 2024年第7期22卷 203-205页

作者：赵莹杨宇辉聂华张声源廖梅叶小玲嘉应学院医学院广东梅州514031

为更好地满足应用型人才培养需求、强化学生的职业素养、促进学生养成科学严谨的实验习惯,学院药剂学教学团队通过设计与建立《药品生产质量管理规范》(GMP)模拟实训车间,采用情境式教学法,使学生身临其境,缩小实验教学与生产实际的差... 详细信息

为更好地满足应用型人才培养需求、强化学生的职业素养、促进学生养成科学严谨的实验习惯,学院药剂学教学团队通过设计与建立《药品生产质量管理规范》(GMP)模拟实训车间,采用情境式教学法,使学生身临其境,缩小实验教学与生产实际的差距。同时,将标准操作规程(SOP)贯穿GMP实训车间现场教学过程,关注实验操作细节,并辅以问题式学习(PBL)-任务驱动(TDL)教学法,充分调动学生学习的积极性,有助于提高学生的实践技能,有利于为我国中医药事业的长足发展输入送更多的优质人才。

关键词：药剂学 GMP模拟实训车间问题式学习任务驱动教学法

Early hemodynamics after tibial transverse transport in patients with nonarterial stenosis and arterial stenosis diabetic foot

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World Journal of Diabetes 2023年第12期14卷 1784-1792页

作者： mei-mei liao Sen Chen Jia-Rui Cao Meng-Wei Wang Zhi-Hui Jin Jia Ye Yi-Jun Ren Rui-Qiang Guo Department of Ultrasound Imaging Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Orthopedics Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND The diagnosis of peripheral arteriopathy in the diabetic foot is complicated by diabetes and its advanced *** has been found that diabetic foot can be categorized into arterial stenosis and non-arterial stenosis,both of which have significant differences in hemodynamic *** To evaluate the early hemodynamic changes in diabetic foot patients with nonarterial stenosis and arterial stenosis treated by tibial transverse transport(TTT)using high-frequency color Doppler ultrasonography(HFCDU)and a laser Doppler *** Twenty-five patients with Wagner grades 3-5 diabetic foot ulcers were treated with TTT,and the wound healing time and rate were *** were grouped according to the results of preoperative lower-extremity *** with≥50%stenosis in any of the femoral,popliteal,posterior tibial,anterior tibial,and peroneal arteries of the affected limb were classified as the arterial stenosis group(n=16);otherwise,they were classified as the nonarterial stenosis group(n=9).Before and one month after surgery,HFCDU was used to evaluate the degree of lower limb artery lesions and hemodynamic changes in *** degree of femoral-popliteal atherosclerotic stenosis,the degree of vascular stenosis and occlusion of the lower-knee outflow tract,and the degree of medial arterial calcification were scored;the three scores were added together to obtain the total score of lower extremity ***3,a laser Doppler flowmeter system,was used to detect alterations in plantar microcirculation before and 1 mo after *** healing and hemodynamic indices were compared between the two *** The wound healing time of the diabetic foot was significantly shorter in the nonarterial stenosis group than in the arterial stenosis group(47.8±13 vs 85.8±26,P<0.05),and the wound healing rate of both groups was 100%.The preoperative total lower extremity arteriopathy scores were lower in the nonar

关键词： High-frequency color Doppler ultrasonography Diabetic foot Tibial transverse transport Nonarterial stenosis Arterial stenosis

基于Box-Behnken响应面设计优选乌蕨总黄酮的超声提取工艺

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赣南医学院学报 2024年第5期44卷 488-494页

作者：王若乔袁丰华罗娟娟廖梅香温慧玲赣南医科大学药学院江西赣州341000 赣南医科大学生物技术教研室江西赣州341000 赣南医科大学基础医学院分子病理学中心江西赣州341000

目的:利用Box-Behnken响应面设计法优选乌蕨总黄酮的超声提取工艺。方法:以乙醇浓度、液料比、超声提取温度作为考察因素,乌蕨总黄酮的提取量作为评价指标,采用Box-Behnken响应面设计法,优化乌蕨总黄酮提取工艺。结果:超声提取乌蕨总黄... 详细信息

目的:利用Box-Behnken响应面设计法优选乌蕨总黄酮的超声提取工艺。方法:以乙醇浓度、液料比、超声提取温度作为考察因素,乌蕨总黄酮的提取量作为评价指标,采用Box-Behnken响应面设计法,优化乌蕨总黄酮提取工艺。结果:超声提取乌蕨总黄酮的最佳工艺条件:乙醇浓度34%,液料比30∶1(mL·g^(-1)),超声提取温度72℃,超声时间40 min,在此条件下响应面预测值为46.132 mg·g^(-1),实测值为46.052 mg·g^(-1),RSD=1.61%。结论:基于Box-Behnken响应面设计方法实用可靠,效果较好,可以应用于乌蕨总黄酮的提取中,为乌蕨总黄酮的提取提供了一定的理论参考价值。

关键词：乌蕨总黄酮超声波响应面优化提取工艺

VMMAO-YOLO:an ultra-lightweight and scale-aware detector for real-time defect detection of avionics thermistor wire solder joints

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Frontiers of Mechanical Engineering 2024年第3期19卷 77-92页

作者： Xiaoqi YANG Xingyue LIU Qian WU Guojun WEN Shuang mei Guanglan liao Tielin SHI School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

The quality of the exposed avionics solder joints has a significant impact on the stable operation of the inorbit ***,the previously reported inspection methods for multi-scale solder joint defects generally suffer low accuracy and slow detection ***,a novel real-time detector VMMAO-YOLO is demonstrated based on variable multi-scale concurrency and multi-depth aggregation network(VMMANet)backbone and“one-stop”global information gather-distribute(OS-GD)*** with infrared thermography technology,it can achieve fast and high-precision detection of both internal and external solder joint ***,VMMANet is designed for efficient multi-scale feature extraction,which mainly comprises variable multi-scale feature concurrency(VMC)and multi-depth feature aggregation-alignment(MAA)*** can extract multi-scale features via multiple fix-sized and deformable convolutions,while MAA can aggregate and align multi-depth features on the same order for feature *** allows the low-level features with more spatial details to be transmitted in depth-wise,enabling the deeper network to selectively utilize the preceding inference *** VMMANet replaces inefficient highdensity deep convolution by increasing the width of intermediate feature levels,leading to a salient decline in *** OS-GD is developed for efficacious feature extraction,aggregation and distribution,further enhancing the global information gather and deployment capability of the *** a self-made solder joint image data set,the VMMAOYOLO achieves a mean average precision mAP@0.5 of 91.6%,surpassing all the mainstream YOLO-series ***,the VMMAO-YOLO has a body size of merely 19.3 MB and a detection speed up to 119 frame per second,far superior to the prevalent YOLO-series detectors.

关键词： defect detection of solder joints VMMAO-YOLO ultra-lightweight and high-performance multiscale feature extraction VMC and MAA modules OS-GD

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加强反刍思维在不同精神障碍中作用的理解

中华精神科杂志 2024年第8期57卷 465-472页

作者：张倩倩曾伶思马墨涵秦雪梅欧雯雯吕冠仪王汨廖梅张丽鞠玉朦刘帮杉柳进张燕中南大学湘雅二医院精神病学科国家精神心理疾病临床研究中心国家精神疾病医学中心长沙410011 中南大学湘雅医院临床心理中心长沙410008

反刍思维是一种在多种精神障碍中常见的病理性的习惯性思维模式,与抑郁、焦虑、创伤后应激和强迫障碍等精神障碍的症状严重程度、治疗结局和社会功能结局密切相关。近年来反刍思维成为了精神障碍临床诊疗关注的热点,但反刍思维的研究仍... 详细信息

反刍思维是一种在多种精神障碍中常见的病理性的习惯性思维模式,与抑郁、焦虑、创伤后应激和强迫障碍等精神障碍的症状严重程度、治疗结局和社会功能结局密切相关。近年来反刍思维成为了精神障碍临床诊疗关注的热点,但反刍思维的研究仍面临挑战,主要包括概念模糊、缺乏一致的评估工具、病理机制不明确以及缺乏有效的干预方法等。为增强对不同精神障碍反刍思维的理解,本文通过回顾国内外相关文献,概述介绍反刍思维的概念、评估、病理机制和干预手段,以期为反刍思维的临床诊疗提供借鉴和参考。

关键词：精神障碍反刍思维临床表征量化工具评估机制干预

Homochirality in Ferroelectrochemistry

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Chinese Journal of Chemistry 2024年第10期42卷 1133-1144页

作者： Hang Peng Jun-Chao Qi Yu-Si Liu Jia-mei Zhang Wei-Qiang liao Ren-Gen Xiong Ordered Matter Science Research Center Nanchang UniversityNanchangJiangxi 330031China

What is the most favorite and original chemistry developed in your research group?We originally proposed the design principle for molecular ferroelectrics:ferroelectrochemistry,including quasi-spherical theory,the introduction of homochirality,and H/F *** changed the blind search for molecular ferroelectrics into targeted chemical design,which will develop into a new discipline.

关键词： Molecular ferroelectrics Homochirality Ferroelectricity Chemical design Point groups

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复杂适应系统视角下的隐喻语篇分析框架建构

湖北大学学报（哲学社会科学版） 2022年第6期49卷 103-113,170页

作者：廖美珍黄冈师范学院外国语学院湖北黄冈438000

作为复杂适应系统(CAS),隐喻语篇系统由“微观系统”和“宏观系统”组成。微观系统的作用机制在于本体和喻体的投射互动,这种投射互动具有隐性和显性两种语篇表现。作为一种动态的适应过程,微观系统的隐显互动对语篇发展和格局产生影响... 详细信息

作为复杂适应系统(CAS),隐喻语篇系统由“微观系统”和“宏观系统”组成。微观系统的作用机制在于本体和喻体的投射互动,这种投射互动具有隐性和显性两种语篇表现。作为一种动态的适应过程,微观系统的隐显互动对语篇发展和格局产生影响并导致涌现特征出现。宏观系统的语篇作用机制在于作为微观系统的隐喻间互动。作为一种适应过程,这种互动影响语篇发展和格局并产生涌现特征。微观系统和宏观系统各自内部的互动以及两者之间的交错互动是隐喻语篇建构和组织的机制和动力。隐喻互动过程是语篇建构和组织过程,本质上是追求目的的适应过程。隐喻语篇分析框架旨在揭示隐喻作为复杂适应系统在语篇建构和组织中的动态性、互动性、适应性、涌现性、整体性以及层次性等典型特征。

关键词：语篇隐喻复杂适应系统分析框架微观隐喻系统宏观隐喻系统