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Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU Man-qi YAN ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

一些具有3-羟基-5-烯结构甾体骨架衍生物的合成及其VEGF抑制活性

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复旦学报（医学版） 2008年第6期35卷 897-901,907页

作者：张璐戈梅朱丽夏鹏陈瑛复旦大学药学院药物化学教研室上海200032 上海来益生物药物研究开发中心有限责任公司上海201203

目的设计合成一系列具有3-羟基-5-烯骨架的五环甾体骨架衍生物,并测试其抑制乳腺癌细胞新血管生成的活性的抑制作用。方法以孕烯醇酮醋酸酯为原料经3条不同合成路线对甾体D环16、17及20位进行一系列结构修饰。结果一共合成了12个化合物... 详细信息

目的设计合成一系列具有3-羟基-5-烯骨架的五环甾体骨架衍生物,并测试其抑制乳腺癌细胞新血管生成的活性的抑制作用。方法以孕烯醇酮醋酸酯为原料经3条不同合成路线对甾体D环16、17及20位进行一系列结构修饰。结果一共合成了12个化合物,其中新化合物有6个,结构均经核磁共振氢谱、碳谱及质谱确证。结论生物活性检测显示上述结构修饰的化合物对乳腺癌细胞血管内皮生长因子(vascularendothelial growth factor,VEGF)的活性均具有显著的抑制作用,EC50均在1 mmol/L或低于1 mmol/L的水平,其中化合物2a和4b的治疗指数TI值高于阳性对照品2-甲氧基雌二醇(2-Methoxyl Estradiol,2-ME)。

关键词：新血管生成血管内皮生长因子抑制剂甾体

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响应面法优化超高压菠萝汁保活和减敏工艺

食品与生物技术学报 2017年第1期36卷 15-21页

作者：梁娟潘见葛梅徐金凤合肥工业大学农产品生物化工教育部工程研究中心安徽合肥230009

为了同时实现菠萝汁的保活和减敏,分别考察了压力、加压温度、pH和NaCl添加量4因素对菠萝汁纤溶活性和致敏性的影响。并在此基础上,采用Box-Behnken试验设计和响应面法优化该工艺。结果表明这4个因素对纤溶活性和致敏性的影响的不同,通... 详细信息

为了同时实现菠萝汁的保活和减敏,分别考察了压力、加压温度、pH和NaCl添加量4因素对菠萝汁纤溶活性和致敏性的影响。并在此基础上,采用Box-Behnken试验设计和响应面法优化该工艺。结果表明这4个因素对纤溶活性和致敏性的影响的不同,通过工艺优化可以实现菠萝汁的保活和减敏,其最优工艺条件参数为压力425 MPa,加压温度50℃,p H 3.22,盐添加量为质量分数0.55%。在该条件下,菠萝汁的纤溶活性保留88.34%,致敏性降至33.71%。说明该方法能够较好的实现菠萝汁的保活和减敏。

关键词：超高压菠萝汁纤溶活性致敏性响应面法

Immune Based Intrusion Detector generating Algorithm

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Immune Based Intrusion Detector Generating Algorithm

The 1st Chinese Conference on Trusted Computing and Information Security

作者： DONG Xiao-mei. YU ge, XIANG Guang School of Information Science and Engineering, Northeastern University, Shenyang 110004, Liaoning, China

＜正＞ Immune-based intrusion detection approaches are studied. The methods of constructing self set and generating mature detectors are researched and improved. A binary encoding based self set construction method is applied. First, the traditional mature detector generating algorithm is improved to generate mature detectors and detect intrusions ***, a novel mature detector generating algorithm is proposed based on the negative selection mechanism. Accordingto the algorithm, less mature detectors are needed to detect the abnormal activities in the network. Therefore, the speed of generating mature detectors and intrusion detection is improved. By comparing with those based on existing algorithms,the intrusion detection system based on the algorithm has higher speed and accuracy.

关键词： immune intrusion detection negative selectionsself set mature detector

来源： cnki会议评论

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完带汤辨治子宫内膜癌术后患者的临床分析

中国实验方剂学杂志 2019年第14期25卷 130-135页

作者：琪美格李莉祁嶙宋静青海大学附属医院

目的:观察完带汤辨证治疗子宫内膜癌(EC)术后患者的症状、生活质量和免疫功能的影响,并从EC微环境的调控方面探讨了其作用机制。方法:将109例EC术后患者,采用随机按数字表法分为对照组54例和观察组55例。对照组术后根据不同分期给予放... 详细信息

目的:观察完带汤辨证治疗子宫内膜癌(EC)术后患者的症状、生活质量和免疫功能的影响,并从EC微环境的调控方面探讨了其作用机制。方法:将109例EC术后患者,采用随机按数字表法分为对照组54例和观察组55例。对照组术后根据不同分期给予放射治疗或(和)化疗;观察组在对照组治疗的基础上,采用完带汤辨证治疗,1剂/d。两组疗程均为连续治疗3个月。进行治疗前后症状、体征评分,进行癌症治疗前后功能评价量表(FACT-G)评分;检测治疗前后T淋巴细胞亚群(CD3+,CD4+,CD8+,CD4+/CD8+)和自然杀伤细胞(NK)水平;检测治疗前后血管内皮生长因子(VEGF),转化生长因子-β(TGF-β),胰岛素样生长因子(IGF-1),白细胞介素-17(IL-17)和IL-10水平。结果:治疗后观察组患者各症状、体征评分和总积分均低于对照组(P <0. 01);观察组FACT-G量表各维度评分和总分均高于对照组(P <0. 01);治疗后观察组NK,CD3+,CD4+和CD4+/CD8+均高于对照组(P <0. 01),CD8+低于对照组(P <0. 01);治疗后观察组患者血清VEGF,TGF-β,IGF-1,IL-17和IL-10水平均低于对照组(P <0. 01)。结论:完带汤辨证治疗EC术后患者,可进一步改善患者的临床症状,提高患者生活质量和机体免疫功能,可改变子宫内膜癌肿瘤微环境,对患者多种细胞因子具有调节作用。

关键词：子宫内膜癌完带汤生活质量免疫功能肿瘤微环境

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie ge Mingjia Chen Ruixin Yao mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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油脂废水生化处理工艺研究

上海化工 2006年第12期31卷 1-5页

作者：葛梅上海船舶运输科学研究所上海200135

分析了油脂加工废水的产生过程及其生物降解特性,采用较为典型的厌氧反应器UASB和好氧反应器SBR进行连续流中试。中试结果表明油脂废水采用UASB反应处理,容积负荷在9．6～13．7 kg COD/m^3·d时,COD去除率可达88%以上。使用SBR工艺处理... 详细信息

分析了油脂加工废水的产生过程及其生物降解特性,采用较为典型的厌氧反应器UASB和好氧反应器SBR进行连续流中试。中试结果表明油脂废水采用UASB反应处理,容积负荷在9．6～13．7 kg COD/m^3·d时,COD去除率可达88%以上。使用SBR工艺处理油脂废水在处理周期为24小时的情况下,COD去除率可达93%以上。并对两种生化方法工程应用时投资、占地面积、运行费用及操作维修难易程度进行了比较,以供工程设计人员和用户参考。

关键词：油脂废水生物降解 UASB SBR COD