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Nanotechnology-based delivery systems to overcome drug resistance in cancer

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Medical Review

Medical Review 2024年第1期4卷 5-30页

作者： Harsh Patel Jiaxin Li Letao Bo riddhi mehta Charles R.Ashby Shanzhi Wang Wei Cai Zhe-Sheng Chen College of Pharmacy and Health Sciences St.John’s UniversityNew YorkNYUSA School of Pharmaceutical Sciences Hunan University of MedicineHuaihuaHunan ProvinceChina St.John’s College of Liberal Arts and Sciences St.John’s UniversityNew YorkNYUSA School of Pharmaceutical Sciences Hunan University of MedicineNo.492 Jinxi South RoadHuaihua41800Hunan ProvinceChina College of Pharmacy and Health Sciences St.John’s UniversityNo.8000 Utopia ParkwayQueensNew YorkNY 11439USA

Cancer nanomedicine is defined as the application of nanotechnology and nanomaterials for the formulation of cancer therapeutics that can overcome the impediments and restrictions of traditional *** resistance(MDR)in cancer cells can be defined as a decrease or abrogation in the efficacy of anticancer drugs that have different molecular structures and mechanisms of action and is one of the primary causes of therapeutic *** have been successes in the development of cancer nanomedicine to overcome MDR;however,relatively few of these formulations have been approved by the United States Food and Drug Administration for the treatment of *** is primarily due to the paucity of knowledge about nanotechnology and the fundamental biology of cancer ***,we discuss the advances,types of nanomedicines,and the challenges regarding the translation of in vitro to in vivo results and their relevance to effective therapies.

关键词： nanotechnology multidrug resistance drug delivery systems nanoformulations enhanced permeability and retention effect

An innovative approach to partial discharge measurement and analysis in DC insulation systems during voltage transient and in steady state

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High Voltage 2021年第4期6卷 565-575页

作者： Gian Carlo Montanari riddhi Ghosh Center for Advanced Power Systems Florida State UniversityTallahasseeFloridaUSA

Measuring partial discharges in DC insulation systems is an issue due to the lack of a reference relating the voltage waveform to the physics of discharge ***,DC is not always steady state,due to voltage and load transients that generate electric field profile variations inside an insulation system,which can affect partial discharge inception likelihood and *** discharge measurement technology must be able to separate discharge pulses from noise and identify the type of sources generating partial discharge,which is related to condition assessment and ***,measurement and analysis should be automatic and unsupervised,in order to get rid,partially or totally,of expert *** study addresses a new approach to partial discharge measurements in DC insulation systems,presenting algorithms for separation,recognition and identification,which are effective both in DC steady state and during voltage(and load)*** algorithms are automatic and do not require expert *** cases of algorithm application on test objects consisting of multilayer polymeric specimens with an internal cavity and defective cable models are presented and *** effectiveness is proved,at least at a laboratory level,with effective noise separation and identification of discharge typology.

关键词： insulation state separation

Ageing and reliability of electrical insulation: the risk of hybrid AC/DC grids

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High Voltage 2020年第5期5卷 620-627页

作者： Gian Carlo Montanari Peter Morshuis Paolo Seri riddhi Ghosh CAPS Florida State UniversityTallahasseeUSA School of Electrical Engineering Xi'an Jiaotong UniversityXi'anPeople's Republic of China University of Bologna BolognaItaly

With an impetuous growth of DC links and future grids that will be often hybrid,providing AC and DC supply to nearby or the same customer,an important element is often neglected,that is,electrical *** are no doubts that overhead lines will step back compared to insulated cables,for known reasons of environmental impact,right of way and reliability,especially in an urban or harsh *** the other hand,while AC insulation systems have been investigated and used for decades,there is no analogue experience for DC polymeric insulation,nor for insulation systems subjected to power electronics *** study aims at enhancing the attention on this topic,focusing on insulation ageing mechanisms and models of relevance for hybrid AC/DC assets and *** and life models for AC,DC and power electronics supply are discussed and compared to experimental data,focusing on partial discharge and space *** is shown how these two phenomena affect lifetime for different AC,DC and transient operating *** main drivers for insulation design and material selection are discussed,showing that insulation reliability can be achieved only if operating stresses,ageing mechanisms and life models are known and accounted for properly by insulation designers.

关键词： insulation electrical properly

Practical realization of dual S arm antenna for beam steering applications

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1901-1904页

作者： mehta Amit Institute of Advanced Telecommunications University of WalesSwansea SA2 8PP United Kingdom

A dual S shaped micro strip antenna with a realistic feed is proposed for generation of tilted beam radiation pattern pertaining for beam steering applications. To achieve this, four feeding points are located at a distance of 5.6 mm from the antenna centre. These feeding points when excited one by one generate four tilted beams in four different space quadrants, thus yielding a beam steerable antenna, Importantly, since the proposed antenna is symmetrical in the structure, all the four tilted beams have the same radiation pattern characteristics. A further enhancement of the antenna bandwidth is also achieved using 100-μn capacitive coupling between the feed and the antenna strip.

关键词： Beam steerable antenna S antenna. Switched beams

Testing cable system reliability after commissioning and during operation life:in medio stat virtus?

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High Voltage 2021年第1期6卷 34-41页

作者： Gian Carlo Montanari Paolo Seri riddhi Ghosh Stefano Franchi Bononi Marco Albertini Center for Advanced Power Systems Florida State University2000 Levy Avenue FLUSA DEI University of BolognaViale del RisorgimentoBolognaItaly Prysmian S.p.A. Via ChieseMilanItaly

Quality control,commissioning and diagnostic tests on insulation systems of electrical apparatus are necessary to reduce the failure risk under operation,eliminate infant mortality failures and reduce the impact of ageing on insulation system *** study tries to establish a path which,based on the statistical-phenomenological modelling of the hazard rate,or bathtub curve,drives in the choice of test overvoltage and *** choice of the test voltage and its waveform should be made carefully to improve reliability(reduce failure hazard)in any section of the bathtub *** may require,however,different choices depending on the section which corresponds to the planned *** example,large overvoltages could be acceptable to remove the infant mortality to ensure the highest reliability of newly commissioned apparatus,but they can incept highly energetic,and,thus,fast degradation mechanisms on apparatus operating on the field for a period of time,that can worsen,rather than improving,the insulation system *** to partial discharge measurement during any overvoltage test seems to be the optimal solution to find the most appropriate overvoltage for any type of testing need,leveraging the Latin concept that‘in medio stat virtus’.

关键词： apparatus insulation operation

Multispectral harvesting rare-earth oxysulphide based highly efficient transparent luminescent solar concentrator

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Journal of Rare Earths 2022年第1期40卷 41-48页

作者： Vanjula Kataria Dalip Singh mehta Green Photonics Laboratory Department of PhysicsIndian Institute of Technology(IIT)DelhiHauz KhasDelhi110016India

Transparent luminescent solar concentrator(LSC)is extensively regarded as the most promising sunlight tapping device for its application in buildings integrated with photovoltaics(BIPV)or as solar window *** LSCs doped with organic dyes suffered from high reabsorption losses with no transparency;whereas,recently reported heavy metal-doped quantum dots avoided such losses but possessed the risk of high toxicity and low ambient ***,luminophores with massive spectral shifts and co rdial relationships with the enviro nment are very much *** this paper,we report the fabrication of PMMA based transparent LSC embedded with nanocrystals of environmental friendiness and multispectral harvesting gadolinium oxysulphide(Gd_(2)O_(2) S:Er,Yb)*** Gd_(2)O_(2) S:Er,Yb nanofluorophore absorbs various excitation wavelengths ranging from UV to NIR and emits in the visible region offering huge Stoke’s and anti-Stoke’s shift *** non-existent reabsorption losses and overlapping maxima of Gd_(2)O_(2) S:Er,Yb nanofluorophore generated photon flux with solar cells’responsivity enhance the efficiency characteristics of the LSC *** analysis of LSC as a function of varying nanofluorophore dispersion ratio and changing edge width optimizes the fabrication process and exhibits high power conversion efficiency of-6,93%and optical efficiency of-8.57%.The LSC slab demonstrates high photostability under irradiation for prolonged hours without any dip in the emission *** Gd_(2)O_(2) S:Er,Yb nanofluorophore diffused LSC waveguide offering spectral tunability,cost-reduction,efficiency enhancement,and high concentration factor whilst being sustainable for long term use makes it a fascinating transparent solar window.

关键词： Luminescent solar concentrator Gadolinium oxysulphide Stoke's shift Anti-Stoke's shift Efficiency enhancement Photostability

Analytical method for cell displacement defect quantum-dot cellular automata primitive

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Journal of Electronic Science and Technology 2023年第1期21卷 26-34页

作者： Vaishali Dhare Usha mehta Institute of Technology Nirma UniversityAhmedabad382481India

Quantum-dot cellular automata(QCA)is an emerging computational paradigm which can overcome scaling limitations of the existing complementary metal oxide semiconductor(CMOS)*** existence of defects cannot be ignored,considering the fabrication of QCA devices at the molecular level where it could alter the ***,defects in QCA devices need to be *** far,the simulation-based displacement defect analysis has been presented in the literature,which results in an increased demand in the corresponding mathematical *** this paper,the displacement defect analysis of the QCA main primitive,majority voter(MV),is presented and carried out both in simulation and mathematics,where the kink energy based mathematical model is *** results demonstrate that this model is valid for the displacement defect in QCA MV.

关键词： Displacement defect Kink energy Majority voter(MV) Quantum-dot cellular automata (QCA)

3D printed microfluidic devices:a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

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Bio-Design and Manufacturing 2021年第2期4卷 311-343页

作者： Viraj mehta Subha N.Rath Regenerative Medicine and Stem Cells Laboratory Department of Biomedical EngineeringIndian Institute of Technology HyderabadKandiTelangana 502285India

In the last fewyears,3D printing has emerged as a promising alternative for the fabrication ofmicrofluidic devices,overcoming some of the limitations associated with conventional ***(SLA),extrusion-based technology,and inkjet 3D printing are three of the widely used 3D printing technologies owing to their accessibility and *** devices can be 3D printed by employing a manufacturing approach from four fundamental manufacturing approaches classified as(1)direct printing approach,(2)mold-based approach,(3)modular approach,and(4)hybrid *** evaluate the feasibility of 3D printing technologies for fabricating microfluidic devices,a review focused on 3D printing fundamental manufacturing approaches has been *** a broad spectrum of additive manufacturing materials,3D printed microfluidic devices have been implemented in various fields,including biological,chemical,and material ***,some crucial challenges are associated with the same,including low resolution,low optical transparency,cytotoxicity,high surface roughness,autofluorescence,non-compatibility with conventional sterilization methods,and low gas *** recent research progress in materials related to additive manufacturing has aided in overcoming some of these ***,we outline possible implications of 3D printed microfluidics on the various fields of healthcare such as in vitro disease modeling and organ modeling,novel drug development,personalized treatment for cancer,and cancer drug screening by discussing the current state and future outlook of 3D printed‘organs-on-chips,’and 3D printed‘tumor-on-chips.’We conclude the review by highlighting future research directions in this field.

关键词： 3D printing Additive manufacturing Microfluidics Lab-on-a-chip Organ-on-a-chip Tumor-on-a-chip

Effect of NO_3^--N Enrichment on Seawater Stress Tolerance of Jerusalem Artichoke (Helianthus tuberosus)

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Pedosphere 2008年第1期18卷 113-123页

作者： S.K.mehta College of Resources and Environmental Sciences Nanjing Agricultural University

A hydroponic experiment with six treatments, i.e., 0% seawater （control）, 10% seawater, 25% seawater, 0% seawater ＋ N （7.5 mmol L-1 NaNO3）, 10% seawater ＋ N （7.5 mmol L-1 NaO3）, and 25% seawater ＋ N （7.5 mmol L-1 NaNO3）, was carried out to study the effect of nitrogen addition on the growth and physiological and biochemical characteristics of Jerusalem artichoke （Helianthus tuberosus） seedlings under seawater stress. The 10% seawater stress treatment had the least effect on plant growth while at 25% seawater growth was significantly inhibited. The malondialdehyde content and electrolyte leakage in leaves under 10% seawater were similar to those of the control, but significantly higher under the 25% seawater stress. The activities of superoxide dismutase, peroxidase and catalase in the leaves increased concomitantly with increasing seawater concentration and time. Proline and soluble-sugars in the leaves and Na^＋, K^＋, and Cl- contents in shoots and roots increased significantly with the concentration of seawater increasing. Nitrogen addition resulted in increasing fresh and dry weights of shoots and roots compared with seawater treatment without N. Nitrogen supplementation also significantly enhanced the activities of antioxidant enzymes in leaves. Addition of N to seawater enhanced the contents of proline and soluble-sugars in the leaves and K^＋ and total-N in the aerial parts and roots of H. tuberosus, but it resulted in declined concentrations of Na^＋ and Cl- in the aerial parts and roots. Nitrogen addition ameliorated the toxicity of seawater by improving the antioxidative enzymes, accumulating of proiine and soluble-sugars, and altering the distribution of inorganic ions in H. tuberosus.

关键词： Helianthus tuberosus ions distributions malondialdehyde nitrate seawater stress