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Effects of sociodemographic characteristics and patients’health beliefs on tuberculosis treatment adherence in Ethiopia:a structural equation modelling approach

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Infectious Diseases of Poverty 2017年第1期6卷 1506-1515页

作者： Habteyes Hailu Tola mehrdad karimi Mir Saeed Yekaninejad Department of Epidemiology and Biostatics School of Public HealthTehran University of Medical SciencesInternational CampusTehranIran Tuberculosis/HIV Research Directorate Ethiopian Public Health InstituteP.O.Box 1242/5654 Addis AbabaEthiopia

Background:Patients’beliefs are a major factor affecting tuberculosis(TB)treatment ***,there has been little use of Health Belief Model(HBM)in determining the pathway effect of patients’sociodemographic characteristics and beliefs on TB treatment ***,this study was aimed at determining the effect of sociodemographic characteristics and patients’health beliefs on TB treatment adherence based on the HBM concept in ***:A cross-sectional study was conducted in Addis Ababa,Ethiopia among TB patients undertaking *** health centres were randomly selected and one hospital was purposely *** hundred and ninety-eight TB patients who had been on treatment for 1-2 month,were aged 18 years or above,and had the mental capability to provide consent were enrolled consecutively with non-probability sampling technique from the TB registration book until required sample size *** questionnaires were used to collect *** equation modelling was employed to assess the pathway relationship between sociodemographic characteristics,patients’beliefs,and treatment ***:Of the 698 enrolled participants,401(57.4%)were male and 490(70.2%)were aged 35 years and *** mean age of participants was 32(±11.7)and the age range was 18-90 *** barrier/benefit was shown to be a significant direct negative effect on TB treatment adherence(ß=−0.124,P=0.032).In addition,cue to action(ß=−0.68,P≤0.001)and psychological distress(ß=0.08,P<0.001)were shown significant indirect effects on TB treatment adherence through perceived barrier/***:Interventions intended to decrease perceived barriers and maximize perceived benefits should be implemented to enhance TB treatment *** addition,it is crucial that counselling is incorporated with the regular directly observed therapy ***(cue to actions)such as friends,family,healthcare workers,and the media could be used t

关键词： Tuberculosis Health belief Treatment adherence Structural equation modelling Ethiopia

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Antiviral Activity of Medicinal Plants against Human Coronavirus: a systematic scoping review of in vitro and in vivo experimentations

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Journal of Traditional Chinese Medicine 2022年第3期42卷 332-343页

作者： Parva Namiranian Omid Sadatpour Sadegh Azimzadeh Jamalkandi Mohammad Hossein Ayati mehrdad karimi Department of Traditional Medicine School of Persian MedicineTehran University of Medical SciencesTehranIran Department of Immunology School of MedicineTehran University of Medical SciencesTehranIran Chemical Injuries Research Center Systems Biology and Poisonings InstituteBaqiyatallah University of Medical SciencesTehranIran

OBJECTIVE:To investigate the in vitro and in vivo studies of natural compounds and medicinal plants with anti-coronavirus ***:A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Animal Research:Reporting of in vivo experiments guidelines to find data for medicinal plants and natural products effective against human coronaviruses in in vitro or in vivo *** published up to September 6,2020 were ***(in vitro or in vivo)reporting the effect of medicinal plants and natural products or their derivatives on human coronavirus were included RESULTS:Promising anti-coronavirus effects are seen with different herbal compounds like some diterpenoids,sesquiterpenoids,and three compounds in tea with 3 CLpro inhibiting effect of Severe Acute Respiratory Syndrome Coronavirus(SARS-Co V);Hirsutenone,Six cinnamic amides and bavachinin are PLpro inhibitors and Tanshinones are active on both 3 CLpro and *** flavonoid compounds of Citrus fruits act on Immunoregulation and target angiotensin-converting enzyme 2 which is used by SARS-COV for *** helicase is possibly inhibited by two compounds myricetin and ***:This review shows that complementary medicine have the potential for new drug discovery against *** research is needed before definitive conclusions can be made concerning the safety and efficacy of the use of these medicinal plants.

关键词： Coronavirus medicine,Persian medicine,Chinese traditional plants,medicinal new drug discovery

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Lavender and dodder combined herbal syrup versus citalopram in major depressive disorder with anxious distress: A double-blind randomized trial

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Journal of Integrative Medicine 2020年第5期18卷 409-415页

作者： Toktam Sadat Firoozeei Majid Barekatain mehrdad karimi Arman Zargaran Shahin Akhondzadeh Hossein Rezaeizadeh Deportment of Persion Medicine School of Persian MedicineTehron University of Medical SciencesTehran ***Iran Department of Psychiatry 5chool of Medicine.lsfahan University of Medical Sctences.Isfahan ***Iran Depertment of Trditioniod Phormay School of Persion Medicine.Tehran Untiversity of Medical Sciences.Tehran *** Iran Pschitric Research Center Roozbeh HospitalTehran University of Medical Sctences.Tehran ***Iran

Background: Major depressive disorder(MDD) accompanied by anxious distress is a chronic and disabling disorder. Its conventional drug therapies often have low patient compliance due to drug-related side effects. In Persian medicine, lavender-dodder syrup is one formula often recommended for such ***: This study compares the effects of lavender-dodder syrup to the standard drug, citalopram, for treating MDD with anxious ***, setting, participants and intervention: This six-week, double-blind, randomized, clinical trial was carried out in a psychiatric outpatient clinic. During the six-week intervention period, patients in citalopram group received citalopram tablets 20 mg/d plus 5 mL placebo syrup every 12 h;patients in group B received placebo tablets once daily plus 5 mL of lavender-dodder herbal syrup every 12 *** outcome measures: Primary outcome measures, depression and anxiety, were evaluated using the Hamilton Depression/Anxiety Rating Scales, and were scored at the beginning of the study and at weeks three and six. Secondary outcome measures including response to treatment and remission rates were also compared between the two ***: Fifty-six participants with MDD and anxious distress were randomly assigned to two *** depression scores significantly decreased in citalopram and herbal groups at weeks three and six(time effect: P < 0.001), although the observed changes were not significantly different between the groups(intervention effect: P = 0.61). Mean anxiety scores were not significantly different between the two groups at week three(P = 0.75). However, at the end of week six, the observed decrease was significantly higher in the herbal syrup group than the citalopram group(intervention effect: P = 0.007).Conclusion: The herbal syrup is an effective and tolerable supplement for treating MDD with anxious *** registration number: IRCT2016102430459 N1 on Iranian Registry of Clinical Trials.

关键词： Persian medicine Traditional medicine Anxiety Depression Phytotherapy Lavender Dodder Citalopram

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Jadwar(Delphinium denudatum Wall.):a medicinal plant

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Traditional Medicine Research 2020年第6期5卷 487-497页

作者： Roghayeh Baghervand Navid mehrdad karimi Morteza Ghojazadeh Seyed Mostafa Araj-Khodaei Alireza Bagherzadeh karimi Sanam Dolati Mehri Bansans Seyed Mohammad Bagher Fazljou Department of Persian Medicine School of Traditional MedicineTabriz University of Medical SciencesTabriz ***Iran Department of Iranian Traditional Medicine School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran Research Center for Evidence Based Medicine Tabriz University of Medical SciencesTabriz ***Iran Physical Medicine&Rehabilitation Research Center Aging Research InstituteTabriz University of Medical SciencesTabriz ***Iran Department of Divinities and Islamic Sciences Faculty of TheologyTabriz UniversityTabriz ***Iran

Delphinium denudatum *** one of the important medicinal herbs of traditional Persian medicine and is known as *** plants are the most widely used drugs in traditional Persian medicine and has been used for various diseases since earlier *** medicinal uses of Delphinium denudatum *** back to over 1,000 years ***(845–925 C.E.)was the first Persian physician and scientist who reported the use of Delphinium denudatum *** a herbal *** the following centuries,the usages of Delphinium denudatum *** the treatment of various diseases has been mentioned in the books and references of traditional Persian medicine for cures to various diseases such as neurologic and psychiatric disease,gastrointestinal disease,fever,pain,and *** to modern studies,the dried roots of Delphinium denudatum *** antipyretic,antimicrobial,anticonvulsant,hepatoprotective,antioxidant,and pain-relieving *** from roots of Delphinium denudatum *** also identified as potential cures for central nervous system diseases as well as for the amelioration of morphine *** denudatum Wall.,with its properties involving the prevention of mitochondrial dysfunction,reduction of oxidative stress,and inflammation and immune dysregulation,can be utilized in curing inflammatory *** effective therapeutic influence of root extract of Delphinium denudatum *** several diseases needs to be confirmed through controlled clinical *** article reviews the different features of Delphinium denudatum *** focuses on the well-known therapeutic effects of this herbal drug on various human disorders and animal disease models.

关键词： Delphinium denudatum Wall. Jadwar root Traditional Persian medicine Neurologic and psychiatric effects Anticonvulsant effects

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Thyroid storm precipitated by acute biliary pancreatitis

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Journal of Acute Disease 2017年第1期6卷 43-44页

作者： mehrdad karimi Adnan Tizmaghz Minimally Invasive Surgery Research Center Iran University of Medical SciencesTehranIran Rasool-e-Akram Hospital Iran University of Medical SciencesTehranIran

Thyroid storm is an acute, life-threatening exacerbation and sudden releasing large amounts of thyroid hormone in a short period of time. Nevertheless, critical aggravation of hyperthyroidism typically resulted from concurrent disorder. Synchronous management of thyroid storm along with its precipitant, such as infection is recommended. We described the case of an acute biliary pancreatitis complicated with a thyroid storm. The patient was successfully managed with a quick surgical intervention and further critical care for thyroid storm. Although it is widely believed that pancreatitis is seldom concurrent with thyrotoxicosis, thyroid storm can be precipitated by a variety of factors, including intra-abdominal infections such as acute pancreatitis or perforated peptic ulcer. In conclusion, acute pancreatitis in patients with thyrotoxicosis seems to be extremely rare, but such patients should be managed intensively against underlying thyroid disorders as well as pancreatitis.

关键词： Thyroid storm Biliary pancreatitis Intra-abdominal infections Thyroid hormone

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Petrology and Geochemistry of Ophiolitic Host Rocks of Copper Mineralization in Dowlat Abad-Tang e Hana Area (Neyriz-Iran)

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Open Journal of Geology 2016年第8期6卷 703-720页

作者： Pedram Attarzadeh Mohammad Yazdi mehrdad karimi Kamal Noori Khankahdani Department of Geology North Tehran Branch Islamic Azad University Tehran Iran Department of Geology Faculty of Earth Sciences Shahid Beheshti University Tehran Iran Department of Geology Shiraz Branch Islamic Azad University Shiraz Iran

Dowlat Abad-Tang e Hana area is a part of Neyriz ophiolite zone, parallel to the Zagros thrust, SW of Iran. It is also a part of obduction thrusting belt over the edge of the Arabian continent during the late Cretaceous. Petrographic investigation indicates the main host rocks are harzburgite, dunite, pyroxenite, basalt, gabbro and pelagic marine sediments. The main magma type of this ophiolite complex is sub-alkaline. The geochemical data of analysed samples show depletion of Na and K, and enrichment in Ca. Copper mineralization in Dowlat Abad-Tang e Hana is hosted mainly in peridotite rocks. The mineralizations are vein type and are associated as copper carbonate (malachite and less azurite). The average of Cu grade is 2.3 wt%. The geochemical and mineralogical data show that the primary source of copper is ortho-magmatic (from ultra-basic rocks and ferro magnesium minerals), which later influenced by hydrothermal processes.

关键词： Ophiolite Copper Mineralization Tang-e-Hana Neyriz SW of Iran

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Geochemistry of Chromitites in Eastern Part of Neyriz Ophiolite Complex (Southern Iran)

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Open Journal of Geology 2017年第3期7卷 213-233页

作者： Pedram Attarzadeh mehrdad karimi Mohammad Yazdi Kamal Nouri Khankahdani Department of Geology North Tehran Branch Islamic Azad University Tehran Iran Department of Geology Shiraz Branch Islamic Azad University Shiraz Iran Department of Geology Faculty of Earth Sciences Shahid Beheshti University Tehran Iran

The Neyriz ophiolite complex is a part of NW-SE thrust belt (Late Cretaceous) of Iran, which is over the Arabian plate margin. The complex is mainly composed of the upper mantle rocks. Our research was focused on the eastern part of Neyriz ophiolite complex so called as “Dowlat Abad-Tang e Hana”. Mantle sequence of this ophiolitic complex is comprising predominantly of harzburgite and minor lherzolite, dunitc sheaths and chromite pods. Harzburgite is the most abundant ultramafic rock and is associated with the less dunite masses. The chromites are known with Cr# 42 to 76 and Mg# 73 to 89. There is a negative correlation between Cr#-Mg# which is one of the features of podiform chromites. The geochemistry of these chromites is consistent with the overall composition of podiform chromites in terms of Cr#, Mg#, the amounts of Cr2O3 (13.35% - 54.47%), Al2O3 (0.43% - 8%), MgO (13.25% - 38.56%), TiO2 (0.003% - 0.206%) as well as the correlations between various oxides and all of them are high chromium types.

关键词： Ophiolite Podiform Chromite Neyriz Iran

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Prevention and treatment of constipation in children from the perspective of Iranian traditional medicine

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Journal of Integrative Medicine 2016年第6期14卷 429-435页

作者： Monireh Sadat Motaharifard Zahra Jafari Maryam Sadat Paknejad Laleh Oveidzadeh mehrdad karimi School of Traditional Medicine Tehran University of Medical Sciences Department of Traditional Medicine Faculty of Iranian Traditional MedicineShahid Sadoughi University of Medical Sciences

Constipation is one of the most common complaints of children and a common cause of referrals to pediatricians. Numerous reasons for this disease have been mentioned in the Iranian traditional medicine （ITM）. It is believed that this disorder is mostly due to the lack of consideration of the six essential principles （Setteh-ye-Zarurieah）, which are necessary to maintain health and prevent disease. In this descriptive study we collected and classified the concepts related to the topic by reviewing reliable ITM text books. Scientific databases were also searched for the most commonly used herbs in the treatment of constipation. The results showed that, from the perspective of ITM, the first step in treating constipation in children is making lifestyle changes. This includes giving appropriate training in the six essential principles, and making modification in existing habits where necessary. In the next steps, using some herbal remedies for topical or oral administration is recommended. On the other hand, a few clinical trials have been done concerning the effects of herbal medicines on pediatric constipation. Therefore, ITM＇s preventive and curative strategies can provide an efficient and cost-effective way to address constipation in children. This study can serve as a preface to performing clinical studies in this field.

关键词： children constipation Iranian traditional medicine six essential principles

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Reversible heart failure in a patient with hypocalcemic cardiomyopathy

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Journal of Geriatric Cardiology 2021年第12期18卷 1063-1067页

作者： mehrdad Jafari Fesharaki Nooshin Ahmadi Kimia karimi Taheri Department of Cardiology Shahid Beheshti University of Medical SciencesTehranIran School of Medicine Shahid Beheshti University of Medical SciencesTehranIran Research Institute for Endocrine Sciences Shahid Beheshti University of Medical SciencesTehranIran

The parathyroid gland is essential to maintaining the serum calcium level within the normal range by secreting the parathyroid hormone(PTH).Significant incidences of increased blood pressure,arrhythmia,left ventricular(LV)hypertrophy,and congestive heart failure(CHF)can occur in patients with parathyroid *** can cause dilated cardiomyopathy,whether this is *** caused by thyroidectomy and primary hypoparathyroidism are the greatest causes of hypocalcemic heart failure(HF).

关键词： cardiomyopathy parathyroid ventricular

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Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures

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Journal of Cancer Therapy 2013年第8期4卷 1335-1340页

作者： N. Behtash M. karimi Zarchi A. A. Shamshirsaz A. A. Shamshirsaz Ashrafosadt Miratashi-Yazd N. mehrdad Gynecological Oncology Fellowship Shahid Sadoughi University of Medical Science Yazd Iran

Background: Primary choriocarcinoma of the cervix is a very rare entity. Case: A 35-year-old patient had been admitted to our hospital with vaginal bleeding for 7 months. A cervical mass measured 4 × 4 cm was palpated on the anterior surface of the cervix. Biopsy of the lesion demonstrated extensive necrosis and was in favor of squamous cell carcinoma. Patient was accepted as FIGO stage Ib1-2 and underwent type II hysterectomy with bilateral salpingoopherectomy and bilateral pelvic lymph node dissection was carried out. Post operative pathologic evaluation of the surgical specimen evinced that the case was primary cervical choriocarcinoma. Conclusion: Primary choriocarcinoma of the cervix should be considered in patients in their reproductive years with cervical lesion and negative cervical cytology. Beta-hCG assay and transvaginal color Doppler sonography are useful for early diagnosis.

关键词： Choriocarcinoma Cervix Primary

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