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Acaricidal Activity of Extracts of Juglans regia L. on Tetranychus urticae Koch （Acari： Tetranychidae）

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Journal of Food science and Engineering 2017年第4期7卷 202-208页

作者： Pervin Erdogan Betul sever Yilmaz Plant Protection Central Research Institute Gayret Mah. Fatih sultan mehmet Bulvart Yenimahalle-Ankara 66 06172 Turkey Ankara University Faculty of Pharmacy Tandogan-Ankara 06100 Turkey

Two-spotted spider mite （Tetranychus urticae Koch）（Acari： Tetranychidae） is a very serious pest worldwide, causing considerable damage to vegetables, flowers and fruit crops. The application of plant extracts to control insects can be an effective alternative. In this study, the efficacy of an extract from Juglans regia L. （Juglandecaea） was tested as an alternative to conventional acaricides. Using two different methods, bioassays were used to determine the effects of varying concentrations J. regia （1%, 3%, 6%, 12%） of the extracts. Experiments were carried out using 3 cm diameter leaf disks of Phaseolus vulgaris L. In addition, the effects of the extract on mite reproduction and oviposition were investigated. As a result, in the leaf dipping method, the 12% concentration of the extract caused the highest mortality of nymph （90%） and adult （83.00%） stages. For the spraying method, the mortality of adults at the same concentration was 100%. In bioassays at lower concentrations, the adult mites laid lower numbers of eggs in comparison to the untreated mites. The highest effect occurred at concentration of 12% and the lowest effect was at 1%. The extract was no observed ovicidal effect.

关键词： Two-spotted spider mite duglans regia L. extract acaricidal effect.

阿柏西普治疗雷珠单抗效果不佳的CNV伴难治性色素上皮脱离的疗效（英文）

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国际眼科杂志 2017年第10期17卷 1812-1816页

作者： sever Ozkan Horozoglu Fatih Namik Kemal大学医学院眼科土耳其泰基尔达59000

目的:评估雷珠单抗反应欠佳患者治疗早期转为阿柏西普治疗疗效。方法:该研究包括38例湿性年龄相关性黄斑变性(W-AMD)患者。18例反应欠佳患者改用玻璃体内阿柏西普(IVA)每月3次疗法,其余20例反应欠佳患者持续进行玻璃体内雷珠单抗(IVR)治... 详细信息

目的:评估雷珠单抗反应欠佳患者治疗早期转为阿柏西普治疗疗效。方法:该研究包括38例湿性年龄相关性黄斑变性(W-AMD)患者。18例反应欠佳患者改用玻璃体内阿柏西普(IVA)每月3次疗法,其余20例反应欠佳患者持续进行玻璃体内雷珠单抗(IVR)治疗,每月增加3次使用。所有改变均行荧光素血管造影术(FA)和光学相干断层扫描成像术(OCT)评估。结果:患者术前平均视力(VA)和黄斑中心厚度(CMT)分别为0.84±0.47 logM AR和360±84μm。经过6次IVR或3次IVR联合3次IVA治疗1mo后,两组患者视力分别为1.1±0.14(P=0.11)logM AR和0.48±0.37(P=0.019)logM AR,黄斑中心厚度分别为300±79μm(P=0.002)和271±51μm(P=0.002)。结论:对于雷珠单抗治疗反应欠佳患者,减少重复性治疗早期转为使用阿柏西普疗法对于视力康复是更好的选择。

关键词：阿柏西普反应欠佳难治性脉络膜新生血管早期

贝伐单抗单用与联合曲安奈德治疗糖尿病性黄斑水肿的疗效比较（英文）

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国际眼科杂志 2019年第1期19卷 1-8页

作者： sever Ozkan Horozoglu Fatih Celik Erkan Topcu Birol Namik Kemal大学医学院眼科土耳其泰基尔达159000 萨卡里亚教学与研究医院眼科土耳其萨卡里亚54100 Namik Kemal大学医学院生物统计学系土耳其泰基尔达59000

目的:比较单用贝伐单抗与贝伐单抗联合曲安奈德治疗糖尿病黄斑水肿疗效。方法:回顾性比较随机研究。对21例42眼黄斑水肿的糖尿病患者进行了评估。单眼内注射1. 25 mg贝伐单抗(IVB组),在同组的眼玻璃体内注射1. 25 mg贝伐单抗和1 mg曲安... 详细信息

目的:比较单用贝伐单抗与贝伐单抗联合曲安奈德治疗糖尿病黄斑水肿疗效。方法:回顾性比较随机研究。对21例42眼黄斑水肿的糖尿病患者进行了评估。单眼内注射1. 25 mg贝伐单抗(IVB组),在同组的眼玻璃体内注射1. 25 mg贝伐单抗和1 mg曲安奈德(IVTA-IVB组)。使用光学相干断层扫描(OCT)、ETDRs视力和眼压测量黄斑中心厚度(CMT)。结果:平均随访时间为4. 7±1. 5mo。在IVB组和IVTAIVB组中,注射前平均CMT分别为494. 7±114. 4μm,546. 8±165. 6μm;第一个月分别为430. 4±133. 2μm,363. 7±105. 3μm;第三个月分别为484. 8±167. 4μm,407. 3±108. 7μm;六个月后分别为550. 4±191. 5μm,516. 8±158μm。第一个月和第三个月存在显著差异(P s视力数分别为57. 1±13. 5,48. 9±13. 9;第一个月分别为2. 2±14,58. 8±12. 1;第三个月分别为59±13. 7,59. 3±13. 6;第六个月分别为55. 6±14. 9,55. 5±8. 7。第三个月和第六个月存在显著差异(P<0. 05)。IOP无差异。第一次注射后IVTA-IVB组在第三个月时视力最佳并持续6个月,而IVB组在第一个月时视力最佳但仅持续了3个月。结论:6个月后发现,IVTA-IVB组较IVB组疗效显著,且无激素依赖性并发症。

关键词：糖尿病视网膜病变曲安奈德贝伐单抗

Ethanol Extraction of Hyoscyamus niger and Hypericum calycinum Evaluated for Acaricidal Activity against Tetranychus urticae Koch （Acari： Tetranychidae）

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Journal of Food science and Engineering 2018年第1期8卷 46-54页

作者： Pervin Erdogan Errol Hassan Betul sever Yilmaz Gulcin saltan Plant Protection Central Research Institute Gayret Mah. Fatih Sultan Mehmet Bul. 66 06172 Yenimahalle Ankara 06172Turkey school of Agriculture and Food sciences 4343 Queensland 4343 Australia Ankara University Faculty of Pharmacy Emniyet Mah. 06100 Tandogan Ankara 06100 Turkey

Hyoscyamus niger L. （solanaceae） and Hypericum calycinum L. （Hypericaceae） were collected from two provinces Bursa and Ankara in Turkey during flowering stages. Extracts obtained from H. niger and H. calycinum were tested against two-spotted mite as an acaricidal pesticide. Bioassay experiments were carried out under laboratory conditions using two different methods namely, leaf disc dipping and direct leaf spraying. Two-spotted mite was reared in insectary using Phaseolus vulgaris L. （Fabaceae）. In the leaf dipping method, H. niger extract resulted in an effective adjusted mortality for larvae of 87.13% and for adults of 81.66%. For H. calycinum the adjusted mortality for larvae and adults was 77.77% and 85.97% respectively at the highest concentration. In larval stage, LCs0 values were 5.47 w/v and 3.32 w/v dipping and spraying method respectively. In addition, adult stage, it was determined that LCs0 values were 1.17 w/v and 3.56 w/v in both methods. For leaf spraying method. H. niger resulted in an adjusted showed an effect against larvae and adults mortality rate was 95% and 91% respectively. However, H. calycinum mortality percentage was 80% and 87% at 12% concentration, with LC50 values of 9.62 w/v and 2.13 w/v in dipping method. In this research apart from mortality effects on egg, reproduction was also investigated. Each concentration showed that treated females laid less eggs compared to the untreated females.

关键词： Two-spotted spider mite henbane st-John's Wort extract acaricidal effect.

Comparing solutions to the Nonlinear Dissipative Wave Equation

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Journal of Applied Mathematics and Physics 2022年第4期10卷 1281-1296页

作者： Zaki Mrzog Alaofi Talaat sayed El-Danaf silvestru sever Dragomir Department of Mathematics College of Science and Arts King Khalid University Muhayil Asir KSA Mathematics College of Engineering & Science Victoria University Melbourne Australia Department of Mathematics Faculty of Sciences and Arts Taibah University Medina KSA

In previous decades, many of the practical problems arising in scientific fields such as physics, engineering, and mathematics have been related to nonlinear fractional partial differential equations. One of these nonlinear partial differential equations, the dissipative wave equation, has been found to have a plethora of useful applications in different fields. A special class of solutions has been studied for the dissipative wave equation including exact solutions and approximate solutions. The aim of this article is to compare the non-polynomial spline method and the cubic B-spline method with the solution of a nonlinear dissipative wave equation. We will conduct a comparison of the stability of the two methods using the Von Neumann stability analysis. In addition, a numerical example will be presented to illustrate the accuracy of these methods.

关键词： Dissipative Wave Equation Cubic B-spline Non-Polynomial spline Truncation Error Von Neumann stability

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灾后挤压伤的处理

中华创伤骨科杂志 2008年第6期10卷 561-565页

作者： mehmet sukru sever Raymond Vanholder Norbert Lameire 荆小伟(译) 王簕(译) Departments of Internal Medicine and Nephrology Istanbul School of Medicine Istanbul Turkey Departments of Internal Medicine and Nephrology University Hospital Ghent Belgium 南方医科大学南方医院创伤骨科 510515

灾害很少能被预防，能被预防的更少。在发生自然灾害（如地震、飓风、龙卷风、山体滑坡）和人为灾害（如战争、矿难、恐怖袭击）时，重要器官的死亡可以导致立即死亡。迟发性死亡主要归因于横纹肌溶解，并因此产生挤压综合征，这是在地... 详细信息

灾害很少能被预防，能被预防的更少。在发生自然灾害（如地震、飓风、龙卷风、山体滑坡）和人为灾害（如战争、矿难、恐怖袭击）时，重要器官的死亡可以导致立即死亡。迟发性死亡主要归因于横纹肌溶解，并因此产生挤压综合征，这是在地震后除了创伤之外最常见的死亡原因。挤压相关性急性肾功能衰竭是挤压伤少数几个威胁生命的并发症之一，它是可以逆转的。

关键词：挤压伤迟发性死亡急性肾功能衰竭灾后自然灾害横纹肌溶解挤压综合征恐怖袭击

Computational Analysis for solving the Linear space-Fractional Telegraph Equation

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Open Journal of Modelling and simulation 2022年第3期10卷 267-282页

作者： Zaki Mrzog Alaofi Talaat sayed El-Danaf Adel Hadhoud silvestru sever Dragomir Department of Mathematics College of Science and Arts King Khalid University Muhayil Asir Saudi Arabia Mathematics College of Engineering & Science Victoria University Melbourne Australia Department of Mathematics Faculty of Sciences and Arts Taibah University Medina Saudi Arabia Department of Mathematics and Computer science Faculty of Science Menoufia University Shebeen El-Kom Egypt

Over the last few years, there has been a significant increase in attention paid to fractional differential equations, given their wide array of applications in the fields of physics and engineering. The recent development of using fractional telegraph equations as models in some fields (e.g., the thermal diffusion in fractal media) has heightened the importance of examining the method of solutions for such equations (both approximate and analytic). The present work is designed to serve as a valuable contribution to work in this field. The key objective of this work is to propose a general framework that can be used to guide quadratic spline functions in order to create a numerical method for obtaining an approximation solution using the linear space-fractional telegraph equation. Additionally, the Von Neumann method was employed to measure the stability of the analytical scheme, which showed that the proposed method is conditionally stable. What’s more, the proposal contains a numerical example that illustrates how the proposed method can be implemented practically, whilst the error estimates and numerical stability results are discussed in depth. The findings indicate that the proposed model is highly effective, convenient and accurate for solving the relevant problems and is suitable for use with approximate solutions acquired through the two-dimensional differential transform method that has been developed for linear partial differential equations with space- and time-fractional derivatives.

关键词： Fractional Differential Equations Quadratic spline Functions Linear space-Fractional Telegraph Equation Von Neumann stability

Quartic Non-Polynomial spline for solving the Third-Order Dispersive Partial Differential Equation

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American Journal of Computational Mathematics 2021年第3期11卷 189-206页

作者： Zaki Mrzog Alaofi Talaat sayed Ali Faisal Abd Alaal silvestru sever Dragomir Department of Mathematics College of Science and Arts King Khalid University Muhayil Asir Saudia Arabia Mathematics College of Engineering & Science Victoria University Melbourne Australia Department of Mathematics Faculty of Sciences and Arts Taibah University Medina Saudi Arabia Department of Mathematics Faculty of Science Damanhour University Damanhour Egypt

In the present paper, we introduce a non-polynomial quadratic spline method for solving third-order boundary value problems. Third-order singularly perturbed boundary value problems occur frequently in many areas of a... 详细信息

In the present paper, we introduce a non-polynomial quadratic spline method for solving third-orderspan>span> boundary value problems. span>span>Third-orderspan>span> singularly perturbed boundary value problems occur frequently in many areas of applied sciences such as solid mechanics, quantum mechanics, chemical reactor theory, Newtonian fluid mechanics, optimal control, convectionspan>span>span>-span>span>diffusionspan>span> processes, hydrodynamics, aerodynamics, etc. These problems have various important applications in fluid dynamics. The procedure involves a reduction of a span>span>third-orderspan>span> partial differential equation to a firstspan>span>-span>span>span>span>span style="font-family:;" "="">span style="font-family:Verdana;">order ordinary diff

关键词： Non-Polynomial spline Third-Order Dispersive Partial Differential Equation stability Convergent

Risk of lymph node metastases in patients with T1b oesophageal adenocarcinoma: A retrospective single centre experience

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World Journal of Gastroenterology 2018年第41期24卷 4698-4707页

作者： David Graham Nejc sever Cormac Magee William Waddingham Matthew Banks Rami sweis Hannah Al-Yousuf Miriam Mitchison Durayd Alzoubaidi Manuel Rodriguez-Justo Laurence Lovat Marco Novelli Marnix Jansen Rehan Haidry GI services University College London Hospital Division of surgery and science University College London Gastroenterology Department University Medical Center Ljubljana Department of Metabolism and Experimental Therapeutics University College London

AIM To assess clinical outcomes for submucosal (T1b) oesophageal adenocarcinoma (OAC) patients managed with either surgery or endoscopic eradication *** Patients found to have T1b OAC following endoscopic resection between January 2008 to February 2016 at University College London Hospital were retrospectively analysed. Patients were split into low-risk and high-risk groups according to established histopathological criteria and were then further categorised according to whether they underwent surgical resection or conservative management. study outcomes include the presence of lymphnode metastases, disease-specific mortality and overall survival. REsULTs A total of 60 patients were included; 22 patients were surgically managed (1 low-risk and 21 high-risk patients) whilst 38 patients were treated conservatively (12 low-risk and 26 high-risk). Overall, lymph node metastases (LNM) were detected in 10 patients (17%); six of these patients had undergone conservative management and LNM were detected at a median of 4 mo after endoscopic mucosal resection (EMR). All LNM occurred in patients with highrisk lesions and this represented 21% of the total high-risk lesions. Importantly, there was no statistically significant difference in tumor-related deaths between those treated surgically or conservatively (P = 0.636) and disease-specific survival time was also comparable between the two treatment strategies (P = 0.376).CONCLUsION T1b tumours without histopathological high-risk markers of LNM can be treated endoscopically with good outcomes. In selected patients, endoscopic therapy may be appropriate for high-risk lesions.

关键词： Oesophageal adenocarcinoma submucosal invasion T1b Lymph node metastasis Risk prediction Endoscopy