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An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 386-403,I0014-I0016页

作者： Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng Department of Nephrology Jiangnan University Medical CenterWuxiChina Affiliated Wuxi Clinical College of Nantong University WuxiChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineAzienda Ospedaliera Universitaria Integrata VeronaVeronaItaly Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southamptonand Southampton General HospitalUniversity of SouthamptonSouthamptonUK Department of Renal Medicine University College LondonLondonUK Department of Medicine and Therapeutics Chinese University of Hong KongHong KongChina Center for Fatty Liver Department of GastroenterologyXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Internal Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Division of Nephrology Department of MedicineWürzburg University ClinicWürzburgGermany Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghaiChina Section of Gastroenterology Boston Medical CenterBoston University School of MedicineBostonMAUSA Division of Nephrology Department of Medicine(M.K.)Koc University School of MedicineIstanbulTurkey Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCAUSA Section of Nephrology and Institute of Clinical and Translational Research Baylor College of Medicineand Michael E.DeBakey VA Medical CenterHoustonTXUSA Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRizeTurkey Department of Cardiology Shunde HospitalSouthern Medical UniversityFoshanChina Division of Hepat

Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly *** 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without ***,to date,there is no appropriate guidance on CKD in individuals with ***,there has been little attention paid to the link between MAFLD and CKD in the Nephrology *** and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and ***:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases.

关键词： Metabolic dysfunction-associated fatty liver disease(MAFLD) non-alcoholic fatty liver disease(NAFLD) chronic kidney disease(CKD) consensus

喀什地区原发性高血压患者血压变异性与无症状性脑梗死的关系

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岭南心血管病杂志 2015年第3期21卷 361-364页

作者：买买提依明外斯丁金海燕陈波米娜瓦尔新疆喀什地区第二人民医院神经内科新疆喀什844000

目的探讨喀什地区原发性高血压(高血压)患者24 h的血压变异性是否与无症状性脑梗死[又称静止性脑梗死(silent cerebral infarct,SCI)]的发病具有相关性。方法 272例高血压合并SCI患者为观察组,142例单纯高血压患者为对照组,对两组进行2... 详细信息

目的探讨喀什地区原发性高血压(高血压)患者24 h的血压变异性是否与无症状性脑梗死[又称静止性脑梗死(silent cerebral infarct,SCI)]的发病具有相关性。方法 272例高血压合并SCI患者为观察组,142例单纯高血压患者为对照组,对两组进行24 h动态血压监测,计算夜间血压下降率,并比较两组在年龄、血脂、血糖、肾功能、头颅计算机断层扫描或核磁共振成像结果。结果两组年龄和血清胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、血糖、尿素、肌酐浓度比较,差异无统计学意义(P>0.05)。而在夜间血压下降率方面,对照组夜间血压下降率明显高于观察组,差异有统计学意义(P<0.05)。与对照组相比,观察组的血压变异性昼夜模式的差异有统计学意义(P<0.05)。结论非杓型高血压与SCI的发生可能有一定关系。异常的血压昼夜节律可能是评估脑血管损害的参数,是SCI的一个危险相关因素。

关键词：高血压无症状性脑梗死血压变异性

赤霉素处理对火焰无核葡萄不同发育时期花穗拉长的影响

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农产品加工 2015年第4期 52-53页

作者：胡西旦.买买提艾尔肯.卡马力吾尔古丽.艾麦提新疆农科院吐鲁番农业科学研究所新疆吐鲁番838000 新疆自治区农产品质量安全监督检验中心新疆乌鲁木齐830000

以2年生的火焰无核葡萄品种为试材,分别于2013年和2014年,在葡萄发育期Ⅰ,Ⅱ,Ⅲ3个阶段,使用质量浓度60 mg/L的赤霉素处理,研究赤霉素(GA3)处理对不同发育期火焰无核葡萄花穗长度的影响。结果表明,处理Ⅰ的果穗拉长效果最为显著,其果实... 详细信息

以2年生的火焰无核葡萄品种为试材,分别于2013年和2014年,在葡萄发育期Ⅰ,Ⅱ,Ⅲ3个阶段,使用质量浓度60 mg/L的赤霉素处理,研究赤霉素(GA3)处理对不同发育期火焰无核葡萄花穗长度的影响。结果表明,处理Ⅰ的果穗拉长效果最为显著,其果实小穗节间长度,于2014年为对照的79.4%。

关键词：火焰无核葡萄赤霉素果穗

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拉合尔钝缘蜱的鉴定及其感染绵羊的调查

中国兽医杂志 2017年第5期53卷 6-8页

作者：艾力西热.买买提巴音查汗吴辉吾斯曼.达古提努尔.库尔玛那里刘志强新疆农业大学动物医学院新疆乌鲁木齐830052 新疆畜牧科学院兽医研究所新疆乌鲁木齐830011 鄯善县达朗坎乡畜牧兽医站新疆鄯善838207

为了确诊拉合尔钝缘蜱种属及其感染绵羊的情况,在新疆鄯善县各乡镇(包括四镇、五乡)采集的软蜱(n=67277),借助扫描电镜进行了超微鉴定,结合病原学方法调查了感染当地绵羊的状况。结果经形态超微鉴定该软蜱为拉合尔钝缘蜱;在调查的各乡... 详细信息

为了确诊拉合尔钝缘蜱种属及其感染绵羊的情况,在新疆鄯善县各乡镇(包括四镇、五乡)采集的软蜱(n=67277),借助扫描电镜进行了超微鉴定,结合病原学方法调查了感染当地绵羊的状况。结果经形态超微鉴定该软蜱为拉合尔钝缘蜱;在调查的各乡镇绵羊(n=2 408)中感染拉合尔钝缘蜱的有1 734只,感染率为72.07%,其蜱指数为25~64个(平均蜱指数约28个)。该文首次对鄯善县绵羊感染的软蜱类进行超微鉴定,可为当地养殖羊业的健康发展及有关软蜱传播疾病的综合防治提供实验参数。

关键词：绵羊拉合尔钝缘蜱扫描电镜感染调查

A candidate identification questionnaire for postmenopausal osteoporosis patients switched from daily or weekly bisphosphonate to once-monthly ibandronate: An open, prospective, multicenter study—BONCURE study

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Health 2013年第7期5卷 30-40页

作者： Yesim Gokce Kutsal Nurten Eskiyurt Jale Irdesel Vesile Sepici Hatice Ugurlu Yesim Kirazli Fusun Ardic Mirko Korsic Tonko Vlak Mane Grlickov Snezana Markovic Temelkova Miroslav Lazarov Nada Pilipovic Vera Popovic Aleksandar Dimic Branka Kovacev Dorina Ruci Argjend Tafaj Elma Kucukalic-Selimovic Dijana Avdic Hajrija Seleskovic Snjezana Pejicic Bulent Butun Gulseren Akyuz Lale Cerrahoglu Omer Faruk Sendur Peyman Yalcin Sema Oncel Merih Saridogan Tunay Sarpel mehmet Tosun Kazim Senel Savas Gursoy Ferhan Canturk Huseyin Demir Blazenka Miskic Dalibor Krpan Franjo Skreb Simeon Grazio Zeljka Crncevic-Orlic Fatih Ozdener Hakan Oncel Clinic for Orthopaedic Surgery Clinical Centre Vodnjansk Skopje Macedonia Clinic of Endocrinology Diabetes and Metabolic Disorders Skopje Macedonia Clinic of Rheumatology Clinical Centre Skopje Macedonia Clinical Center of Vojvodina Novi Sad Serbia Clinical Center Banja Luka Bosnia and Herzegovina Clinical Hospital Centre Split Croatia Department of PMR Cerrahpasa School of Medicine Istanbul University Istanbul Turkey Department of PMR Clinical Hospital Center Rijeka Rijeka Croatia Department of PMR Dr. Josip Bencevic General Hospital Slavonski Brod Croatia Department of PMR Istanbul School of Medicine Istanbul University Istanbul Turkey Department of PMR Polyclinic for Internal Medicine Zagreb Croatia Department of PMR School of Medicine Adnan Menderes University Aydin Turkey Department of PMR School of Medicine Akdeniz University Ankara Turkey Department of PMR School of Medicine Ankara University Ankara Turkey Department of PMR School of Medicine Ataturk University Erzurum Turkey Department of PMR School of Medicine Celal Bayar University Manisa Turkey Department of PMR School of Medicine Cukurova University Adana Turkey Department of PMR School of Medicine Dokuz Eylul University Izmir Turkey Department of PMR School of Medicine Ege University Izmir Turkey Department of PMR School of Medicine Erciyes University Kayseri Turkey Department of PMR School of Medicine Gazi University Ankara Turkey Department of PMR School of Medicine Gaziantep University Gaziantep Turkey Department of PMR School of Medicine Hacettepe University Ankara Turkey Department of PMR School of Medicine Karadeniz Technical University Trabzon Turkey Department of PMR School of Medicine Marmara University Istanbul Turkey Department of PMR School of Medicine Ondokuz Mayis University Samsun Turkey Department of PMR School of Medicine Pamukkale University Denizli Turkey Department of PMR School of Medicine Selcuk University Konya Turkey Department

A candidate identification questionnaire (CIQ) was tested to determine its predictive value for patient-reported satisfaction in patients switched from once-weekly or once-daily treatment with a bisphosphonate to once-monthly dosing. This was a prospective, open-label, multicenter international study in patients with postmenopausal osteoporosis who had been receiving once-daily or once-weekly alendronate or risendronate for at least 3 months. Patients completed a CIQ, then commenced 150 mg monthly ibandronate for 6 months. Patients completed the Osteoporosis Patient Satisfaction Questionnaire (OPSAT-QTM) at baseline for 6 months. Scores were converted to composite satisfaction scores (CSS, scale 0-100). Totally 677 patients completed a CIQ, 645 were enrolled in the treatment phase and comprised the intent-to-treat (ITT) population, and 630 completed the study. In the ITT population, 68.1% patients answered “yes” to one or more CIQ questions. OPSAT-Q scores increased for the convenience, quality of life and overall satisfaction domains (p scores for the side effects domains were significant (p < 0.001) in the CIQ “yes” group, but not for the degree of bother (decrease in mean of 0.1 points, p = 0.50) or duration (no change, p = 0.84) of non-gastrointestinal side effects. Of 638 patients who completed the preference questionnaire, 93.0% of patients preferred the once-monthly dosing schedule and 563 patients (90.7%) found it more convenient. The most common adverse events were dyspepsia (1.9%), nausea (1.1%), and upper abdominal pain (0.9%). Patients are likely to prefer treatment with monthly ibandronate to a weekly or monthly bisphosphonate irrespective of their stated preference before switching treatment.

关键词： Bisphosphonate Compliance Ibandronate Postmenopausal Osteoporosis

新疆准噶尔盆地绵羊消化道线虫季节动态变化研究

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草食家畜 2013年第4期 49-51页

作者：努尔.库尔玛那里王光雷刘志强艾力西热.买买提新疆畜牧科学院兽医研究所新疆乌鲁木齐830000

在完全自然放牧条件下,准噶尔盆地绵羊消化道线虫优势虫种(马歇尔线虫、细颈线虫、夏伯特线虫、仰口线虫和毛首线虫)的季节动态变化:马歇尔线虫的感染强度从9月份开始上升,次年3月份最高;细颈线虫的感染强度从11月份开始上升,次年5月份... 详细信息

在完全自然放牧条件下,准噶尔盆地绵羊消化道线虫优势虫种(马歇尔线虫、细颈线虫、夏伯特线虫、仰口线虫和毛首线虫)的季节动态变化:马歇尔线虫的感染强度从9月份开始上升,次年3月份最高;细颈线虫的感染强度从11月份开始上升,次年5月份最高;夏伯特线虫的感染强度从11月份开始上升,次年4月份最高;仰口线虫的感染强度在11月至次年5月较高,毛首线虫感染强度在11月至次年3月份高,其9月份达到最高峰,所说的线虫其他月份维持在较低的数量水平上。

关键词：绵羊准噶尔盆地消化道线虫季节动态

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创新工作行为与跨政府建立关系网络

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国际行政科学评论（中文版） 2023年第1期 160-182页

作者：穆罕默德·阿基夫·德米西奥卢塔哈·哈梅杜丁科林·诺克斯王秋蕾(译) 熊缨(审校) 新加坡国立大学李光耀公共政策学院哈萨克斯坦纳扎尔巴耶夫大学公共政策研究生院中国人事科学研究院不详

长期以来,公共组织一直面临着变得更具创新性和协作性的压力。与此同时,在学术和实践方面,也伴随着从传统官僚结构向建立更多关系网络的公共行政转变的趋势。我们以澳大利亚公共服务部门为例,以其对增加关系网络建设的重视程度,来检验... 详细信息

长期以来,公共组织一直面临着变得更具创新性和协作性的压力。与此同时,在学术和实践方面,也伴随着从传统官僚结构向建立更多关系网络的公共行政转变的趋势。我们以澳大利亚公共服务部门为例,以其对增加关系网络建设的重视程度,来检验增加关系网络联系行为是否与更具创新性的工作行为相关。在开发理论模型时,我们假设建立关系网络活动与创新工作行为正相关,但建立关系网络的行为太少或太多与创新工作行为负相关。分析发现,建立关系网络的实践确实与更高水平的创新工作行为相关,但它们在公共管理者接触的不同利益相关者类型之间有所差异。此外,我们只找到了这两种结构之间曲线关系的有限证据。本文最后给出了对研究和实践的启示。

关键词：协作创新工作行为建立关系网络公共组织公共部门创新

伊犁河谷地域虻的鉴定及其携带伊氏锥虫的检测

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动物医学进展 2021年第9期42卷 141-144页

作者：祖力亚·克力木江努尔·库尔玛那里阿不来艾力西热·买买提王振宝叶尔保勒刘志强刘一凡巴音查汗·盖力克新疆农业大学动物医学学院新疆乌鲁木齐830052 新疆畜牧科学院兽医研究所新疆畜牧科学院动物临床医学研究中心新疆乌鲁木齐830013 伊宁海关新疆伊宁835000 察布查锡伯自治县纳达齐牛录乡政府畜牧兽医站新疆伊犁835000

为了解伊犁河谷区域虻的分布及其携带伊氏锥虫的情况,通过对虻的形态学鉴定及其特异性基因(CO1)和携带病原18S rRNA基因扩增、测序、同源性比对,鉴定和检测了采自伊犁河谷区域的虻及其携带病原情况。结果显示,所采集的虻为原虻属秋季原... 详细信息

为了解伊犁河谷区域虻的分布及其携带伊氏锥虫的情况,通过对虻的形态学鉴定及其特异性基因(CO1)和携带病原18S rRNA基因扩增、测序、同源性比对,鉴定和检测了采自伊犁河谷区域的虻及其携带病原情况。结果显示,所采集的虻为原虻属秋季原虻种,PCR扩增虻CO1基因和马伊氏锥虫18S rRNA基因序列分别为653 bp和205 bp。结果发现,秋季原虻的CO1基因与已发表的丹麦株(MT584147.1)同源性为98%,与形态学鉴定结果一致。在156只秋季原虻中携带伊氏锥虫的有9只,阳性率为5.7%(9/156),其阳性条带基因序列与GenBank中已发表的伊氏锥虫基因同源性为99%。试验结果表明,结合形态学分类和分子生物学方法对虻样品进行鉴定操作简单、准确度高。

关键词：秋季原虻形态学聚合酶链反应伊氏锥虫

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新疆石河子地区绵羊吸虫病调查

草食家畜 2015年第4期 52-54页

作者：徐雪萍王光雷张云峰王正荣张艳艳刘志强努尔艾力西热.买买提新疆农垦科学院畜牧兽医研究所新疆石河子832000 新疆畜牧科学院兽医研究所新疆乌鲁木齐830000

在新疆石河子地区对绵羊吸虫感染状况进行了连续12个月的调查,结果显示,被检的所有绵羊均有吸虫感染,感染率达100%;被调查的绵羊感染6种吸虫,分别是寄生于肝脏的矛形双腔吸虫、中华双腔吸虫、东方双腔吸虫和肝片吸虫,寄生在胰脏的胰阔... 详细信息

在新疆石河子地区对绵羊吸虫感染状况进行了连续12个月的调查,结果显示,被检的所有绵羊均有吸虫感染,感染率达100%;被调查的绵羊感染6种吸虫,分别是寄生于肝脏的矛形双腔吸虫、中华双腔吸虫、东方双腔吸虫和肝片吸虫,寄生在胰脏的胰阔盘吸虫和寄生在小肠的斯氏吸虫。必须引起足够的重视,选取有效药物进行驱治,保障羊群健康和养羊生产的经济效益。

关键词：绵羊吸虫调查