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Achillea biebersteinii extracts suppress angiogenesis and enhance sensitivity to 5-fluorouracil of human colon cancer cells via the PTEN/AKT/mTOR pathway in vitro

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 505-515页

作者： mehmet Kadir Erdoğan Can Ali Ağca Hakan Aşkın Department of Biology Faculty of Arts and SciencesBingol University12000BingolTurkey Department of Molecular Biology and Genetics Faculty of Arts and SciencesBingol University12000BingolTurkey Department of Molecular Biology and Genetics Faculty of SciencesAtaturk University25000ErzurumTurkey

Objective:To investigate the antiproliferative,anti-angiogenic,and apoptotic effects of extracts of Achillea biebersteinii(ABE)and combined treatments of ABE with 5-fluorouracil(5-FU)on HT-29 ***:The effects of ABE,5-FU,and combined treatments on the viability of HT-29 cells were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** analysis was used to determine synergism between ABE and *** apoptotic and anti-angiogenic effects were determined by cell death detection and human vascular endothelial growth factor ELISA method,*** and translational expressions of p53,Bax,Bcl-2,p38 MAPK,Akt,PTEN,and m TOR were also evaluated by real-time PCR and Western blotting ***:ABE decreased the viability of HT-29 cells in a dosedependent *** treatment of hexane,chloroform,and methanol extracts of Achillea biebersteinii with 5-FU at IC50 doses decreased the cell viability to 26.0%,19.1%,and 14.9%,respectively(P<0.001).Furthermore,ABE treatment alone and combination with 5-FU,induced apoptosis,significantly downregulated m TOR,Akt,Bcl-2 expression,upregulated p53,Bax,PTEN,p38 MAPK expression,and exhibited anti-angiogenetic ***:Our findings indicate that ABE shows synergism with 5-FU and inhibits the proliferation of HT-29 cells by inducing apoptosis and suppressing angiogenesis,which may provide biological evidence for further use of ABE in the treatment of colorectal cancer.

关键词： angiogenesis doses colon

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Do we control gastric residuals unnecessarily in premature newborns?AGRA study:avoidance of gastric residual aspiration

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World Journal of Pediatric Surgery 2020年第1期3卷 1-5页

作者： Selahattin Akar mehmet Turgut Department of Neonatalogy Adiyaman Universitesi Tip FakultesiAdiyamanTurkey Department of Pediatrics Adiyaman Universitesi Tip FakultesiAdiyamanTurkey

BACKGROUND ground Aspiration and evaluation of gastric residuals are commonly performed interventions before each feeding in intensive care units,especially in very low birthweight ***,there is no sufficient evidence about the necessity of routine gastric residual *** this study,we aimed to investigate the time to full enteral intake and the incidence of necrotizing enterocolitis(NEC)in preterm infants in the period with gastric residual aspiration performed before each feeding,and those in the period without gastric residual *** Preterm infants with a gestational week≤33 were included in the *** group with gastric residual control before each feeding consisted of 169 infants,and the group without routine gastric residual aspiration included 122 *** The mean gestational week was 30.37±2.58 and 29.31±3.37 in the group with gastric residual control and in the group without routine residual control,respectively(p<0.05).Birth weight,male gender,and mode of delivery were similar between both *** time to full enteral intake was shorter in the group without routine residual control(p<0.05).Total durations of parenteral nutrition,≥grade 2 NEC,weight at discharge and duration of hospitalization were similar between the *** of invasive mechanical ventilator support was shorter in the group without routine residual *** Avoidance of routine gastric residual aspiration in preterm infants shortens the time to full enteral intake without increasing the incidence of NEC.

关键词： routine intake shorter

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Use of Atomic Absorption Spectrometry in Assessment of Biomonitor Plants for Lead,Cadmium and Copper Pollution

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光谱学与光谱分析 2012年第1期32卷 229-234页

作者： Gokce Kaya mehmet Yaman Tunceli University Engineering Faculty Department of Food Sciences Tunceli-Turkey Firat University Sciences Faculty Department of Chemistry Elazig-Turkey

Eleven plant species were collected from the vicinity of lead-battery plant in the city of Gaziantep,***,cadmium and copper concentrations in the soil and leaves of plants were determined by atomic absorption ***,Cd and Cu concentrations in the soil samples taken from battery area were found to be in the ranges of 304～602,0.4～0.44 and 31～37 mg·kg-1,*** increased lead concentration up to 2 750 mg·kg-1 was found in the leaves of Eleagnus angustifolia *** lead concentrations in the other plant leaves taken from 50 m around battery factory followed the order Ailanthus altissima>Morus sp.>Juglans regia L.>Ficus carica L.>Cydonia oblonga Miller>Prunus x domestica *** plants,Populus nigra L.,Eleagnus angustifolia *** Salix *** found useful for Cd,and the plant,Eleagnus angustifolia *** Pb,to be considered as potential ***,leaves of trees and plants taken from the distance of 50 m from battery plant have relatively higher Pb ***,people who and animals which live in this area and benefit from these soil and plants have vital risks.

关键词： Atomic absorption Lead Cadmium Coper Biomonitor plants Pollution

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Effect of hydroxyapatite:zirconia volume fraction ratio on mechanical and corrosive properties of Ti-matrix composite scaffolds

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Transactions of Nonferrous Metals Society of China 2022年第3期32卷 882-894页

作者： mehmet TOPUZ Burak DIKICI mehmet GAVGALI Yasemin YILMAZER Department of Mechanical Engineering Van YüzüncüYıl UniversityVan 65080Turkey Department of Metallurgical and Materials Engineering Atatürk UniversityErzurum 25240Turkey Department of Mechanical Engineering Necmettin Erbakan UniversityKonya 42090Turkey Department of Molecular Biology and Genetics İstanbul Sabahattin Zaim Universityİstanbul 34303Turkey

Ti-based scaffolds reinforced with zirconia and hydroxyapatite were produced successfully by a hybrid method with an eco-friendliness and low cost to obtain low elastic modulus(E) with sufficient physical, electrochemical and biological properties. The effect of simultaneous modification of the volume fraction of hydroxyapatite(HA) and zirconia(ZrO_(2)) on scaffolds was investigated in terms of mechanical, corrosive, and antibacterial properties. Scanning electron microscopy with attached electron dispersive spectroscopy and X-ray diffraction were used for the characterization of scaffolds. Compression and electrochemical tests were performed to determine mechanical properties with detailed fracture mechanism and in-vitro corrosion susceptibility to simulated body fluid at 37 ℃,respectively. Antibacterial tests were carried out by comparing the inhibition areas of *** and *** bacteria. It was observed that the mechanical strength of the scaffolds decreased with increasing HA:ZrO_(2)volume fraction *** lowest E was achieved(6.61 GPa) in 6:4 HA:ZrO_(2)composite scaffolds. Corrosion current density(J_(corr)) values were calculated to be 21, 337, and 504 μ A/cm^(2) for unreinforced Ti, 3:2 and 6:4 HA:ZrO_(2)reinforced scaffolds,respectively. The inhibition capacity of the 6:4 reinforced composite scaffold was found to be more effective against *** bacteria than other scaffolds.

关键词： titanium biocomposite hydroxyapatite zirconia scaffold mechanical properties in-vitro corrosion

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Estimating uniaxial compressive strength of rocks using genetic expression programming

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第4期5卷 325-329页

作者： Ahmet Ozbek mehmet Unsal Aydin Dikec Department of Geological Engineering Kahramanmaras Sutcu Imam University Department of Civil Engineering Kahramanmaras Sutcu Imam University

The aim of this paper is to estimate the uniaxial compressive strength（UCS） of rocks with different characteristics by using genetic expression programming（GEP）.For this purpose,five different types of rocks including basalt and ignimbrite（black,yellow,gray,brown） were *** of unit weight,water absorption by weight,effective porosity and UCS of rocks were determined *** using these experimental data,five different GEP models were developed for estimating the values of UCS for different rock *** agreement between experimental data and predicted results is obtained.

关键词： Uniaxial compressive strength(UCS) Genetic expression programming(GEP) Rock masses

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Comment on “The diurnal variation pattern of choroidal thickness in macular region of young healthy female individuals using spectral domain optical coherence tomography”

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1789-1790页

作者： Salih Uzun Emre Pehlivan mehmet Gulmez Department of Ophthalmology Etimesgut Military HospitalAnkara 06200 Turkey Department of Ophthalmology Eskisehir Military Hospital Eskisehir 26010 Turkey Department of Ophthalmology Dunya Goz Hastanesi Konya 42000 Turkey

Dear Editor,We have read and reviewed the article entitled＂The diurnal variation pattern of choroidal thickness in macular region of young healthy female individuals using spectral domain optical coherence tomography... 详细信息

关键词： CT The diurnal variation pattern of choroidal thickness in macular region of young healthy female individuals using spectral domain optical coherence tomography cycle

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SOME CLASSES OF DIFFERENCE SEQUENCES OF FUZZY NUMBERS DEFINED BY A SEQUENCE OF MODULI

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Acta Mathematica Scientia 2011年第1期31卷 229-236页

作者： Ayhan Esi mehmet Aikgz Department of Mathematics Science and Art Faculty Adiyaman University Department of Mathematics Faculty of Science and Literature University of Gaziantep

In this article, we introduce and examine some properties of new difference sequence spaces of fuzzy numbers defined using a sequence of modulus functions.

关键词： Fuzzy numbers paranorm difference sequences modulus function

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Transmural dispersion of repolarization：a complementary index for cardiac inhomogeneity

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Journal of Geriatric Cardiology 2016年第1期13卷 99-100页

作者： mehmet Dogan Omer Yiginer Gokhan Degirmencioglu Haluk Un Ankara Mevki Military Hospital Department of Cardiology Ankara Turkey Gulhane Military Medical Academy Haydarpasa Training Hospital Department of Cardiology Istanbul Turkey

We read the article written by Nuis, et al. The authors investigated the effects of transcatheter aortic valve implantation （TAVI） on corrected QT dispersion （cQTD） in severe aortic stenosis patients. They concluded that, 40% of patients had defective cQTD recovery at six months after the procedure and this was associated with increased late mortality risk. We would like to contribute to the study from a different methodological perspective.

关键词： QT dispersion Repolarization Transcatheter aortic valve implantation

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Does it make sense evaluating cardiac resynchronization therapy in the elderly regardless of the type of the device？

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Journal of Geriatric Cardiology 2016年第4期13卷 371-372页

作者： mehmet Tezcan Omer Uz Gokhan Degirmencioglu Mustafa Aparci Department of Cardiology Gumussuyu Military Hospital Beyoglu lstanbul Turkey Department of Cardiology GMMA Haydarpasa Training Hospital Uskudar lstanbul Turkey

We read the research article entitled Is cardiac resyn- chronisation therapy feasible, safe and beneficial in the very elderly？ with great interest. The authors emphasized that despite the average age of heart failure was 77 years in the general population of UK,patients receiving cardiac re- synchronisation therapy [with pacemaker alone （CRT-P） or with additional defibrillator capabilities （CRT-D）] were on younger ages at 72 and 67 years respectively. In the lights of this data, we agree with the authors that CRT seems to be undemtilized in the elderly patients with heart failure.

关键词： Cardiac resynchronization therapy Defibrillator Pacemaker

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The role of HBD-2,HBD-3,and calprotectin in the relationship between chronic periodontitis and atherosclerosis

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BIOCELL 2020年第3期44卷 337-344页

作者： mehmet TASPINAR ALIHAN BOZOGLAN ABDULLAH SECKIN ERTUGRUL LEVENT ELMAS Faculty of Medicine Aksaray UniversityAksarayTurkey Faculty of Medicine Yuzuncu Yil UniversityVanTurkey Department of Periodontology Faculty of DentistryFırat UniversityElazığTurkey Department of Periodontology Faculty of DentistryYuzuncu Yil UniversityVanTurkey Department of Periodontology Faculty of Dentistryİzmir KatipÇelebi UniversityİzmirTurkey Faculty of Medicine Pamukkale UniversityDenizliTurkey

This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins(HBD)HBD-2,HBD-3,and *** is the most frequently observed cardiovascular *** and periodontal infections are known to provide a considerable basis for atheroma plaque *** study group consists of a total number of 40 subjects,with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic *** periodontal and blood parameters and HBD-2,HBD-3,and calprotectin biomarkers in the gingival crevicular fluid were *** both groups,following clinical periodontal treatment,a statistically significant decrease in white blood cells(WBC),low-density lipoproteins(LDL),fibrinogen,creatinine,and platelets(PLT),a statistically significant increase in high-density lipoproteins(HDL)in blood samples,statistically meaningful decrease in HBD-2,HBD-3,and calprotectin in the gingival crevicular fluid were *** values and HBD-2,HBD-3,calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group.A positive correlation was observed between decreases in HBD-2,HBD-3,calprotectin,and clinical periodontal *** in systemic inflammation was observed after clinical periodontal *** is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.

关键词： Atherosclerosis Periodontal Diseases HBD-2 HBD-3 Calprotectin

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