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Inappropriate use of digoxin in patients presenting with digoxin toxicity

Journal of Geriatric Cardiology 2015年第2期12卷 143-146页

作者： Mustafa Adem Tatlisu Kazim Serhan Ozcan Baris Gungor Ahmet Zengin mehmet baran karatas Zekeriya Nurkalem Department of Cardiology Sivas Numune State Hospital Rahmi Crunay Street Sivas 58000 Turkey Department of Cardiology Kocaeli Derince Education and Research Hospital ibni Sina Street Kocaeli 41900 Turkey Department of Cardiology Dr.Siyami Ersek Cardiovascular Surgery Education and Research Hospital Tlbbiye street lstanbul 34668 Turkey Department of Cardiology Istanbul Medipol University Kosuyolu Istanbul 34718 Turkey

Background Digoxin remains widely used today despite its narrow therapeutic index and toxicity. The objective of this study was to investigate the percentage of inappropriate use of digoxin and long-term outcomes of elderly patients hospitalized for digoxin toxicity. Methods The study included 99 consecutive patients hospitalized for digoxin toxicity. The other study criteria for the inappropriate use of digoxin was regarded if participants having depressed left ventricular systolic function （ejection fraction 〈 45%） who were not on optimal medical therapy including beta-blocker and angiotensin-converting-enzyme inhibitor therapy or if participants having permanent AF who were not on optimal beta-blocker therapy. Results Appropriate digoxin usage was confirmed in 33 of patients in spite of its narrow therapeutic index. A total of 16 of 99 patients died, with a mean follow-up time of 22.1 ± 10.3 months. Conclusions Contrary to popular belief, the rate of inappropriate digoxin usage remains high. On account of its narrow therapeutic index and toxicity, digoxin should be used more carefully according to the current evidence and guidelines.

关键词： Digoxin Ejection fraction Indications Toxicity

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Evaluation of cardiovascular risk in patients with Parkinson disease under levodopa treatment

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Journal of Geriatric Cardiology 2016年第1期13卷 75-80页

作者： Zeki Yuksel Gunaydln Fahriye Feriha Ozer Ahmet Karagoz Osman Bektas mehmet baran karatas Ash Vural Adil Bayramoglu Abdullah Celik mehmet Yaman Department of Cardiology 0rdu University Medical School 0rdu Turkey Department of Neurology 0rdu University Medical School 0rdu Turkey Department of Cardiology Giresun University Medical School Giresun Turkey Department of Cardiology Siyami Ersek Research and Training HospitalIstanbul Turkey

BackgroundLevodopa 是在有 Parkinson 疾病(PD ) 的病人的中间的治疗的不可缺少的选择。因为 L-dopa 治疗被显示增加浆液 homocysteine 层次，为心血管的混乱的一个著名风险因素，有在 L-dopa 治疗下面的 PD 的病人将在为未来的增加的... 详细信息

BackgroundLevodopa 是在有 Parkinson 疾病(PD ) 的病人的中间的治疗的不可缺少的选择。因为 L-dopa 治疗被显示增加浆液 homocysteine 层次，为心血管的混乱的一个著名风险因素，有在 L-dopa 治疗下面的 PD 的病人将在为未来的增加的风险心血管的事件。这研究的目的是在 levodopa *** 学习下面与 PD 在病人评估心血管的风险人口在 L-dopa 治疗下面与自发的 PD 由 65 个病人组成了。控制组包括了 32 年龄，性匹配没有认知衰落的个人。Echocardiographic 大小，浆液 homocysteine 层次和主动脉的有弹性的参数与 PD 和 *** 在病人之间被作比较 L-dopa 治疗的一个期望的特征， Parkinson 组有显著地更高的 homocystein 层次(15.1 ±；3.9 µ； mol/L 对 11.5 ±；3.2 µ； mol/L， P = 0.02 ) 。当时，大动脉的膨胀性在有 PD 的病人是显著地更低的与控制相比(4.8 ±；1.5 dyn/cm 2 对 6.2 ±；1.9 dyn/cm 2, P = 0.016 ) 。另外，有 PD 的病人有更高大动脉的紧张和大动脉的僵硬索引(13.4%±；6.4% 对 7.4%±；3.6% ， P <；0.001 和 7.3 ±；1.5 对 4.9 ±；1.9， P <；0.001 分别地) 。而且，浆液 homocysteine 层次被发现断然与大动脉的僵硬索引被相关，在浆液 homocysteine 的大动脉的膨胀性和层次之间有否定关联(r = 0.674， P <；0.001；r =−； 0.602， P <；0.001，分别地) 有在 L-dopa 治疗下面的 PD 的 .ConclusionsThe 病人增加了大动脉的僵硬并且与健康个人相比损害了心脏舒张的功能。提高的浆液 homocysteine 层次可以是可能的 pathophysiological 机制。

关键词： Aortic distensibility Aortic stiffness Cardiovascular risk Homocysteine Parkinson disease

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Ti3C2Tx MXene-functionalized Hydroxyapatite/Halloysite nanotube filled poly-(lactic acid)coatings on magnesium:In vitro and antibacterial applications

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Journal of Magnesium and Alloys 2024年第9期12卷 3758-3771页

作者： mehmet Topuz Yuksel Akinay Erkan karatas Tayfun Cetin Department of Mechanical Engineering Van Yuzuncu Yil UniversityVan 65080Turkey Department of Mining Engineering Van Yuzuncu Yil UniversityVan65080Turkey Department of Molecular Biology and Genetics Erzurum Technical UniversityErzurum 25100Turkey Yuksekova Vocational High School Hakkari UniversityHakkari 30110Turkey

Magnesium(Mg)stands out in temporary biomaterial applications due to its biocompatibility,biodegradability,and low Young’s ***,controlling its corrosion through next-generation polymer-based functional coatings is crucial due to the rapid degradation behavior of *** this study,the function of 2D lamellar Ti_(3)C_(2)T_(x)(MXene)in Hydroxyapatite(HA)and Halloysite nanotube(HNT)hybrid coatings in biodegradable poly-(lactic acid)(PLA)was *** morphological and structural characterizations of the coatings on Mg were revealed through HRTEM,XPS,SEM-EDX,XRD,FTIR,and contact angle analyses/*** in vitro corrosion tests(OCP,PDS,and EIS-Nyquist)were conducted for evaluate corrosion resistance under simulated body fluid(SBF)*** bioactivity of the coatings in SBF have been revealed in accordance with the ISO 23,317 ***,antibacterial disk diffusion tests were conducted to investigate the functional effect of MXene in *** has been determined that the presence of MXene in the coating increased not only surface wettability(131°,85°,77°,and 74°for uncoated,pH,PHH,and PHH/MXene coatings,respectively)but also increased corrosion resistance(1857.850,42.357,1.593,and 0.085×10^(-6),A/cm^(2) for uncoated,pH,PHH,and PHH/MXene coatings,respectively).It has been proven that the in vitro bioactivity of PLA-HA coatings is further enhanced by adding HNT and MXene,along with SEM morphologies after ***,2D lamellar MXene-filled coating exhibits antibacterial behavior against both *** and *** bacteria.

关键词： Magnesium Pla coating Ti3c2tx mxene In-vitro bioactivity Disk diffusion

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Free and liposome form of gallic acid improves calvarial bone wound healing in Wistar rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 156-163页

作者： Ahmet Altan Hatice Balci Yuce Ozkan karatas mehmet Murat Taskan Fikret Gevrek Sefa Colak Nihat Akbulut Department of Oral and Maxillofacial Surgery Faculty of DentistryGaziosmanpasa UniversityTokatTurkey Department of Periodontology Faculty of DentistryGaziosmanpasa UniversityTokatTurkey Department of Histology and Embryology Faculty of MedicineGaziosmanpasa UniversityTokatTurkey

Objective:To evaluate the effect of free and liposome form of gallic acid on bone regeneration in critical defects in Wistar ***:Thirty-two female Wistar rats were divided into four study groups:group 1,negative control;group 2,positive control;group 3,gallic acid powder;group 4,gallic acid liposome.A critical-sized defect was created in all *** 2 to 4 had xenograft,autograft and membrane placement while negative control rats did not receive any *** defect area was sutured and rats were kept alive for 30 *** the end of the study,a bone specimen including the defect area was removed from *** specimens were evaluated under the stereomicroscope,then underwent histological *** cell counts,osteoblast,osteoclast counts,receptor activator of nuclear factorκ-B(RANKL),osteoprotegerin(OPG),runt-related transcription factor 2(Runx2),bone morphogenetic protein-2(BMP-2),and alkaline phosphatase were ***:The biggest unhealed defect area was observed in the negative control group and the smallest was observed in the gallic acid liposome *** were no differences between the positive control group *** gallic acid powder group and the gallic acid powder group *** gallic acid liposome *** severity of inflammation was the highest in the negative control group and the lowest in the gallic acid liposome group with significant differences between the *** groups had similar osteoblast counts while osteoclast counts were the highest in the positive control *** acid groups had a lower number of osteoclasts compared with the positive control ***2 and alkaline phosphatase levels were similar in the groups while OPG and BMP-2 levels exhibited a significant increase compared with the negative control group and the positive control *** was similar in the negative control group,the positive control group,and the gallic acid powder groups but decreased in the gallic acid liposome

关键词： Anti-inflammatory Antioxidants Bone regeneration Gallic acid

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Survival of Chemically Modified Titanium Surfaced Implants in Irradiated Jaws of Oral Cancer Patients

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Open Journal of Stomatology 2015年第7期5卷 202-209页

作者： mehmet Yaltirik Bilge Gokcen Rohlig Meltem Ozdemir karatas Melike Ordulu Sübay Rustu Cem Tanyel Meltem Koray Department of Oral and Maxillofacial Surgery Faculty of DentistryIstanbul UniversityIstanbulTurkey Department of Prosthodontics Faculty of DentistryIstanbul UniversityIstanbulTurkey

Objective: To investigate the clinical performance of implants with chemically modified surfaces in irradiated bone in a period of five-years. Patients & Methods: 15 (6 females, 9 males, 50.2 years with a range of 38 - 60 years) patients who had been operated for oral tumors and had undergone radiotherapy were enrolled and 40 SLActive surface implants were placed (24 in the maxilla, 16 in the mandible). Implants were allowed to integrate for a period of 90 days and the stability of the implants was measured with Resonance Frequency Analyzer/Osstell? Mentor (Integration Diagnostics, Savedalen, Sweden) at implant placement, 30 days later and at the end of the 90th day. Patients follow up periods after the implant placement varied from 20 months to 60 months (mean: 45 months). Results: Two implants were lost in maxilla in healing period as a result of osseointegration failure. The survival rate was 95%. During the observation period, totally 4 implants were lost. The overall success rate was 90%. 3 of the lost implants were in maxilla and one was in mandible. The initial ISQ values of the implants differed from 20 - 71;the second values were between 24 - 71 and the last values were between 30 - 89. The implants which were lost could not show a value greater than 35. Conclusion: There was no any complication on the SLActive surface implant placed bones due to irradiation. Within the limitations of this study, it may be concluded that osseointegrated implants can be placed in irradiated bones, unless a careful patient selection and treatment planning is performed.

关键词： Irradiation Resonance Frequency Analysis SLActive Success Criteria

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