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Recent trends on wound management:New therapeutic choices based on polymeric carriers

Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 661-684页

作者： mehmet evren okur Ioannis D.Karantas Zeynep Senyigit Neslihan Ustundag okur Panoraia I.Siafaka Department of Pharmacology Faculty of PharmacyUniversity of Health SciencesIstanbul TR-34668Turkey Hippokration General Hospital 2nd Clinic of Internal MedicineThessaloniki 54124Greece Department of Pharmaceutical Technology Faculty of PharmacyIzmir Katip Qelebi UniversityIzmirTurkey Department of Pharmaceutical Technology Faculty of PharmacyUniversity of Health SciencesIstanbul TR-34668Turkey Department of Chemistry Aristotle University of ThessalonikiThessaloniki 54124Greece

Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing *** can mainly be categorized as acute or *** is well referred that the acute wound displays normal wound physiology while healing,in most cases,is seemed to progress through the normal phases of wound *** the other hand,a chronic wound is physiologically *** main problem in wound management is that the majority of wounds are colonized with microbes,whereas this does not mean that all wounds will be *** this review,we address the problems that clinicians face to manage while treat acute and chronic ***,we demonstrate the pathophysiology,etiology,prognosis and microbiology of *** further introduce the state of art in pharmaceutical technology field as part of wound management aiming to assist health professionals to overcome the current implications on wound *** addition,authors review researches which included the use of gels and dermal films as wound healing *** can be said that natural and synthetic drugs or carriers provide promising solutions in order to meet the wound management ***,are the current strategies as desirable as medical society wish?

关键词： Wound Infection Dressings Scaffolds Biomaterials Wound healing

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Current update on nanoplatforms as therapeutic and diagnostic tools:A review for the materials used as nanotheranostics and imaging modalities

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 24-46页

作者： Panoraia I.Siafaka Neslihan Ustundag okur Ioannis D.Karantas mehmet evren okur evren Atlihan Gundogdu Department of Chemistry Aristotle University of ThessalonikiThessalonikiGreece Faculty of Pharmacy Department of Pharmaceutical TechnologyUniversity of Health SciencesIstanbulTurkey 2nd Clinic of Internal Medicine Hippokration General HospitalThessalonikiGreece Faculty of Pharmacy Department of PharmacologyUniversity of Health SciencesIstanbulTurkey Faculty of Pharmacy Department of RadiopharmacyEge UniversityIzmir 35100Turkey

In the last decade,the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases,especially cancer,is held great *** to date,several approaches have been employed in order to develop smart nanotheranostics,which combine bioactive targeting on specific tissues as well as diagnostic *** nanotheranostics can deliver therapeutic agents by concomitantly monitor the therapy response in ***,the possibility of over-or under-dosing is *** non-invasive imaging techniques have been used to quantitatively monitor the drug delivery *** of nanomaterials is widely used as powerful diagnostic approach on nuclear medicine *** fact,various radiolabeled nanomaterials have been designed and developed for imaging tumors and other lesions due to their efficient *** nanoparticles as gold,silver,silica based nanomaterials or organic nanoparticles as polymers,carbon based nanomaterials,liposomes have been reported asmultifunctional *** this review,the imaging modalities according to their use in various diseases are summarized,providing special details for *** further,the most current nanotheranostics categorized via the used nanomaterials are also summed *** conclude,this review can be beneficial for medical and pharmaceutical society as well as material scientists who work in the field of nanotheranostics since they can use this research as guide for producing newer and more efficient nanotheranostics.

关键词： Theranostics Nanomedicine Nanotechnology Nanoparticles Radiopharmaceuticals

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