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Boldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats:Role of oxidative stress,inflammation and caspase-3

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BIOCELL 2022年第9期46卷 2111-2122页

作者： NERGIZ HACER TURGUT HUSEYIN GUNGOR mehmet EKICI MUMIN ALPER ERDOGAN mehmet ONDER KARAYIGIT HAKI KARA Department of Pharmacology Faculty of PharmacyIzmir Katip Celebi UniversityIzmir35620Turkey Department of Pharmacology and Toxicology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey Department of Physiology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey Department of Physiology Faculty of MedicineIzmir Katip Celebi UniversityIzmir35620Turkey Department of Pathology Faculty of Veterinary MedicineCumhuriyet UniversitySivas58140Turkey

Side effects of cisplatin,especially dose-dependent nephrotoxicity,are major factors limiting its use in ***((S)-2,9-dihydroxy-1,10-dimethoxy-aporphine)is a natural alkaloid known for its strong antioxidant activity present in leaves/bark of boldo tree(Peumus boldus Molina),a native tree in ***,we aimed to investigate the nephroprotective effect of boldine and its underlying mechanisms on cisplatin-induced rat renal *** Wistar albino rats divided into 5 groups(Control,Cis,Bold.40,Cis+Bold.20,Cis+Bold.40 groups)were *** received boldine(20 or 40 mg/kg/day),or vehicle(saline)intraperitoneal for 14 days and a single dose cisplatin(7 mg/kg,ip)was applied on the 10th day to induce *** and kidney tissue were weighed to determine kidney *** urea nitrojen(BUN)and creatinine levels,the amount of thiobarbituric acid reactive substances(TBARS,an index of lipid peroxidation),superoxide dismutase(SOD),glutathione peroxidase(GPx)enzyme activities and tumor necrosis factor alpha(TNF-α)levels were measured and histopathologic examination was *** nitric oxide synthase(iNOS)and caspase-3 expressions were detected *** induced by cisplatin was apparent by elevated levels of BUN,creatinine,kidney index,TBARS and TNF-α,and decreased body weight,SOD and GPx enzyme *** with boldine protected the renal function at both boldine doses by fixing the renal damage markers,oxidative stress,caspase-3 and iNOS *** findings supported biochemical *** together these findings indicate that boldine has promising protective effect against cisplatin nephrotoxicity by improving oxidative stress,inflammation,histopathological alterations and by alleviating caspase 3 expression.

关键词： Boldine Caspase-3 Cisplatin nephrotoxicity Inflammation Oxidative stress

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Coexistence of duodenum derived aggressive fibromatosis and paraduodenal hydatid cyst: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2018年第8期10卷 90-94页

作者： Sami Akbulut mehmet Yilmaz Saadet Alan mehmet Kolu Nese Karadag Department of Surgery and Liver Transplant Institute Inonu University Faculty of Medicine Department of Surgery Inonu University Faculty of Medicine Department of Pathology Inonu University Faculty of Medicine Department of Radiology Inonu University Faculty of Medicine

Intra-abdominal aggressive fibromatosis is a locally aggressive tumor mostly originating from the mesentery or retroperitoneal space, infiltrating adjacent tissues, and very rarely metastasizing to distant organs. There are only two case reports in the English language literature where intra-abdominal aggressive fibromatosis originated from the intestinal wall. In this study, we aimed to report a case of aggressive fibromatosis originating from the muscularis propria layer of the duodenum and invading pancreas. Another interesting aspect of this case is that a primary paraduodenal hydatid cyst was incidentally detected in the surgical specimen. A 46-year-old female patient presented to our clinic with postprandial nausea and vomiting. A contrast-enhanced abdominal computerized tomography revealed a mass lesion with a size of 100 mm × 80 mm which originated from the distal pancreas and compressed the gastric pilor externally. Upon exploration the distal part of duodenum, proximaljejunum, and pancreatic mass were noted to form a conglomerated structure. Therefore, the fourth part of the duodenum, a 25 cm part of the proximal jejunum, distal pancreas, and the spleen were excised enbloc. The pathology report of the specimen indicated fibromatosis with a diameter of 55 mm that originated from the muscularis propria of the duodenum and extended into the pancreatic parenchyma. There was also an incidentally detected 10 mm paraduodenal hydatid cyst. No tumor recurrence was detected at a follow-up period of 24 mo. In conclusion, the most ideal treatment of desmoid-type fibromatosis is surgical resection of the mass lesion with clean surgical borders. Although rare, this tumor may originate from the intestinal wall. Histopathological verification is of great significance for a proper diagnosis.

关键词： Duodenal wall Hydatid cyst Aggressive fibromatosis Intra-abdominal fibromatosis Desmoid tumor Desmoid-type fibromatosis

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The resource-based Kuznets curve hypothesis:An empirical exploration

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Geoscience Frontiers 2024年第5期15卷 162-173页

作者： mehmet Akif Destek Tanaya Saha Gamze Destek Avik Sinha Department of Economics Gaziantep UniversityGaziantepTurkey Research Methods Application Center of UNEC Azerbaijan State University of Economics(UNEC)Baku AZ1001Azerbaijan General Management and Economics Goa Institute of ManagementIndia Adnan Kassar School of Business Lebanese American UniversityBeirut 1102-2801Lebanon Management Development Institute Gurgaon India

Countries face the risk of natural resource curse because of making their economic growth excessively dependent on natural *** excessive resource dependence causes such a risk,it is inevitable that resource-rich countries will need resource rent up to a certain level of economic *** the other hand,transferring the wealth achieved after this maturity level to productive investment areas also reduces the resource dependency levels of *** this context,countries that capture the possible inverted U-shaped relationship between economic growth and resource dependence can escape the *** on this,the aim of this research is to determine the validity of the Kuznets type relationship between resource dependence and economic growth for the first time in the *** nations that rely heavily on natural resources are used as a sample for *** countries with a share of total resource rent in national revenue greater than 25%are taken into consideration throughout the selection process for these *** novel panel data methodologies,the effects of capital accumulation,public spending,foreign direct investment,and economic growth on the dependence on natural resources is examined from 1993 to *** results reveal that capital accumulation reduces resource dependency while foreign investments and government size increases *** addition,the Resource-Based Kuznets curve concept is supported by empirical data demonstrating an inverted-U-shaped relationship between economic growth and resource dependence for these *** thresholds derived from the parameters show that Saudi Arabia and Kazakhstan are well beyond this *** Democratic Republic of the Congo and the Republic of the Congo,on the other hand,remain a long way from this ***,Iraq,Mongolia,Iran,and Azerbaijan have national incomes that are close at the threshold.

关键词： Resource-based Kuznets curve Economic growth Natural resources Foreign direct investment Government size

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Development of a measurement system for noise and vibration of combine harvester

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International Journal of Agricultural and Biological Engineering 2020年第6期13卷 104-108页

作者： Deniz Yilmaz mehmet Emin Gökduman Department of Agricultural Machinery&Technology Engineering Faculty of AgricultureIsparta University of Applied SciencesIspartaTurkey

Combine harvesters are important in that grain and legumes directly affect the production *** the other hand,it forms an important branch of the agricultural machinery *** are many unknown constraints on machines when harvesting with a combine harvester,including the noise and vibration that occur in the combine harvester *** study aims to analyze noise and vibration in conventional combine harvesters using *** accelerometers were installed on each side of the concave and two microphones were used to register the noise of the threshing *** result showed that effects of machine speeds(3.5 km/h,4.5 km/h and 5.5 km/h)and rotor speeds(950 r/min,850 r/min and 950 r/min)were significantly important for the mean range values of the left and right accelerometer in the X,Y and Z *** machine’s speed and rotor speed were not significantly important for the mean range values of the left and right microphones.

关键词： measurement combine harvester sensors noise vibration

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Synthesis and characterization of Dy-Eu-Tm co-doped cubic phase stabilized bismuth oxide based electrolytes in terms of intermediate temperature-solid oxide fuel cells(IT-SOFCs)

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Journal of Rare Earths 2023年第3期41卷 406-412,I0003页

作者： Ayhan Güldeste Mustafa Aldoori Murat Balci mehmet Ari Yasin Polat Department of Physics Erciyes University38039KayseriTurkey Ministry of Higher Education and Scientific Research Allraqia University10011BaghdadIraq Science and Technology Application and Research Center Nevşehir HacıBektaşVeli University50300NevşehirTurkey

In this study,a new Dy-Eu-Tm co-doped cubic phase stabilized bismuth oxide solid electrolyte system was synthesized by using solid-state reaction method in atmospheric *** conductivity measurements,X-ray diffraction(XRD)pro files of the annealed samples show that created mixtures have heterogeneous phase,but after conductivity measurements,the face-centered cubic(FCC)crystal structure is stabilized for all ***,the increase in total dopant rate causes an increase in full width half maxima(FWHM)of main peak(111)on the XRD pattern while average crystal size decreases with *** the other hand,the highest conductivity value was obtained for the sample having 15%total dopant rate with 0.62 S/cm at 750℃,whose dopants are evenly distributed in mole *** thermal analysis(DTA)results of the samples having 1:1:1 and 1:2:1 dopant content ratios show that endothermic peak occurs on their DTA curve,indicating crystal structure transformation such as phase transition or order-disorder ***,thermo-gravimetric analysis(TGA)depending on temperature was evaluated in terms of mass *** to TGA curves,mass loss for both heating and cooling process can be negligible due to the small fluctuations(2%)on their TGA curves.

关键词： Solid electrolyte Order-disorder transition Phase transition Ionic conductivity Activation energy Rare earths

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In-vivo corneal biomechanical analysis of unilateral keratoconus

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1141-1145页

作者： Orhan Ayar mehmet Cuneyt Ozmen Orkun Muftuoglu mehmet Orcun Akdemir Mustafa Koc Kemal Ozulken Department of Ophthalmology Bulent Ecevit University Department of Ophthalmology Gazi University Department of Ophthalmology Medipol University Ulucanlar Eye Research and Education Hospital Kudret Eye Hospital

AIMTo evaluate and compare corneal biomechanical findings measured by ocular response analyzer, topographic and pachymetric findings in patients with unilateral keratoconus patients and healthy *** is an observational, case-control study. Patients with keratoconus in one eye and forme fruste keratoconus in the fellow eye were compared with sex and age matched with controls healthy subjects. All subjects were evaluated with rotating scheimpflug imaging system. The receiver-operating-characteristic curves were analyzed to evaluate the sensitivity and specificity of the ***-seven patients with keratoconus in one eye and forme fruste keratoconus in the fellow eye were compared with 40 eyes of 40 normal subjects. Corneal hysteresis (CH) was 8.0±1.7 mm Hg in keratoconus group, 8.3±1.6 mm Hg in forme fruste keratoconus group, and 9.8±1.6 mm Hg in control groups (P=0.54 between keratoconus and forme fruste keratoconus groups, P<0.01 between control group and other groups). Corneal resistance factor (CRF) was 7.1±2.2 mm Hg in keratoconus group, 7.8±1.2 mm Hg in forme fruste keratoconus group and 9.9±1.5 mm Hg in control group (P<0.001 between control group and other groups). Using receiver-operating-characteristic analysis, the area under curve values of the parameters to distinguish forme fruste keratoconus from control subjects were: CH (0.768), CRF (0.866). Best cut-off points were 9.3 mm Hg and 8.8 mm Hg for CH and CRF *** response analyzer parameters (CH and CRF) are found to be significantly lower in forme fruste keratoconus patients compared to normal control subjects.

关键词： forme fruste keratoconus keratoconus ocular response analyzer

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Is every microorganism detected in the intensive care unit a nosocomial infection?Isn’t prevention more important than detection?

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World Journal of Clinical Cases 2022年第20期10卷 7184-7186页

作者： Fatma Yildirim Irem Karaman mehmet Yildirim Department of Pulmonary Disease and Critical Care Medicine Pulmonary Intensive Care UnitUniversity of Health SciencesDışkapıYıldırım Beyazıt Training and Research HospitalAnkara 06110Turkey School of Medicine Bahcesehir UniversityIstanbul 34740Turkey Department of Internal Medicine Internal Medicine Intensive Care UnitUniversity of Health SciencesDışkapıYıldırım Beyazıt Training and Research HospitalAnkara 06110Turkey

The present letter to the editor is related to the study entitled“Multidrug-resistant organisms in intensive care units and logistic analysis of risk factors.”Not every microorganism grown in samples taken from critically ill patients can be considered as an infectious *** and adequate information about nosocomial infections is essential in introducing effective prevention programs in ***,the development and implementation of care bundles for frequently used medical devices and invasive treatment devices(e.g.,intravenous catheters and invasive ventilation),adequate staffing not only for physicians,nurses,and other medical staff but also for housekeeping staff,and infection surveillance and motivational feedback are key points of infection prevention in the intensive care unit.

关键词： Critical care Prevention Intensive care unit Nosocomial infection Detection

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Neutronic study on the effect of first wall material thickness on tritium production and material damage in a fusion reactor

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Nuclear Science and Techniques 2022年第4期33卷 33-50页

作者： Hacımehmet S¸ahin Güven Tunc¸ Alper Karakoc¸ Melood Mohamad Omar Department of Energy Systems Engineering Technology FacultyKarabuk UniversityKarabukTurkey Department of Energy Systems Engineering Technology FacultyGazi UniversityAnkaraTurkey Department of Energy Systems Engineering Institute of Graduate ProgramsKarabuk UniversityKarabukTurkey

In this study,the effects of changing first wall materials and their thicknesses on a reactor were investigated to determine the displacement per atom(DPA)and gas production(helium and hydrogen)in the first wall,as well as the tritium breeding ratio(TBR)in the coolant and tritium breeding ***,the modeling of the magnetic fusion reactor was determined based on the blanket parameters of the International Thermonuclear Experimental Reactor(ITER).Stainless steel(SS 316 LNIG),Oxide Dispersion Strengthened Steel alloy(PM2000 ODS),and China low-activation martensitic steel(CLAM)were used as the first wall(FW)*** family molten salt materials(FLiBe,FLiNaBe,FLiPb)and lithium oxide(LiO_(2))were considered the coolant and tritium production material in the blanket,*** transport calculations were performed using the wellknown 3D code MCNP5 using the continuous-energy Monte Carlo *** built-in continuous energy nuclear and atomic data libraries along with the Evaluated Nuclear Data file(ENDF)system(ENDF/B-V and ENDF/B-VI)were ***,the activity cross-section data library CLAW-IV was used to evaluate both the DPA values and gas production of the first wall(FW)*** interface computer program written in the FORTRAN 90 language to evaluate the MCNP5 outputs was developed for the fusion reactor *** results indicated that the best TBR value was obtained for the use of the FLiPb coolant,whereas depending on the thickness,the first wall replacement period in terms of radiation damage to all materials was between 6 and 11 years.

关键词： ITER First wall material Material damage Tritium breeding ratio Fluorides family molten salt materials

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Influence of Microstructures on Thermal Shock and Sintering Behavior of YSZ-based Thermal Barrier Coatings

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表面技术 2019年第4期48卷 28-33页

作者： Kirsten Bobzin Lidong Zhao mehmet ?te Tim K?nigstein Surface Engineering Institute RWTH Aachen University

In this study, two thermal barrier coatings based on YSZ were produced by using a commercially available agglomerated and sintered powder and a special spray powder prepared by high energy ball milling. Both thermal barrier coatings exhibited similar overall porosities, but significantly different microstructures. Application of the special spray powder prepared by high energy ball milling led to a microstructure with numerous inclusions of semi-molten agglomerates, which introduced a plethora of clusters of fine pores into the coating and several more microstructural defects. This microstructure resulted in a significantly better thermal shock behavior compared to the conventional thermal barrier coating. The heat treatment of both thermal barrier coatings atθ=1150℃for t=100 h led to a sintering of both coatings. The results were reduced overall porosity and significantly increased fracture toughness. A correlation between the fracture toughness of both coatings after the heat treatment and the thermal shock life time could not be identified.

关键词： thermal barrier coating ZrO2-7%Y2O3 high energy ball milling thermal shock

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Investigation of trace metals distribution in water,sediments and wetland plants of Kizilirmak Delta,Turkey

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International Journal of Sediment Research 2017年第1期32卷 90-97页

作者： mehmet Soner Engin Ahmet Uyanik Seydahmet Cay Department of Food Engineering Faculty of EngineeringGiresun University Department of Chemistry Faculty of Science and ArtsOndokuz Mayis University Department of Environmental Engineering Faculty of EngineeringGiresun University

In this study,accumulation and distribution of Pb,Cu,Zn,Co,Ni,Mn and Fe in water,bottom sediments and four plant species(Myriophyllum verticillatum,Hydrocharis morsus-ranae,Nymphaea alba and Typha latifolia) were investigated in Cernek Lake of Kizilirmak *** Kizilirmak Delta is one of the largest natural wetlands of Turkey and it is protected by the Ramsar convention since *** physico-chemical parameters such as pH,conductivity and dissolved oxygen and also trace metal concentrations were monitored in *** the parameters obtained were found higher than that of the national standards for the protected lakes and *** accumulated amounts of various trace metals in bottom sediments and wetland plants were found in the following order of Fe>Mn>Zn>Ni>Co>Cu>Pb and Fe>Mn>Zn>Ni>Co *** historical trace metal intake of Myriophyllum verticillatum,Hydrocharis morsus-ranae,Typha latifolia and Nymphaea alba were obtained higher than that of the toxic metal levels and these plants may be accepted as accumulators for the detected trace metals and also bioindicators in the historically polluted natural areas.

关键词： Trace metals Wetland plants BCF Pollution Phytoremediation Kizilirmak Delta

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