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Mortality and Morbidity among COVID-19-Associated Mucormycosis Patients in Iran: A Prospective Cohort Study

Advances in Infectious Diseases 2023年第3期13卷 407-423页

作者： Somayeh Dolatabadi mehdi bakhshaee Masoumeh Hosseinpoor Ali Alizadeh Noghani Mohammadreza Afzalzadeh Imaneh Roshanzamir Bashir Rasoulian Zahra Eslami Mohammadie Alireza Ghodsi Nazanin Forghani Parisa Arjmand Zahra Valipour Nima Ameli Department of Biology Hakim Sabzevari University Sabzevar Iran Sinus and Surgical Endoscopic Research Center Mashhad University of Medical Sciences Mashhad Iran Student Research Committee Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Student Research Committee Faculty of Paramedical Sciences Mashhad University of Medical Sciences Mashhad Iran Department of Otolaryngology Mashhad University of Medical Sciences Mashhad Iran

Background: The key contribution of this paper is from investigating the mortality and morbidity rates and related factors associated with COVID-19-associated-mucormycosis among Iranian patients. The existing literature is scarce on this topic, particularly in the context of Iran. The present study investigates mortality and morbidity among 62 confirmed COVID-19-associated-mucormycosis Iranian patients in relation to their demographic characteristics, laboratory test results, predisposing factors, and COVID-related factors. Material and Methods: In this prospective cohort study, the patients were identified in the fifth wave of the disease, between 1st August and 15th October 2021, with data collected at baseline with a three-week follow-up. This was a multicenter investigation with patients admitted to two clinics in Iran. 62 participants were admitted, with the key criteria of them being COVID-19-associated-mucormycosis patients. 53 out of 60 patients underwent corticosteroid therapy and debridement surgery. Intravenous remdesivir (200 mg/ kg/day at day 1, 100 mg/kg/day in following days for up to 5 days) and corticosteroids were administered for 53 out 54 patients. Oxygen therapy was only needed for 30% (n = 19) of the patients. Results: A 40% mortality rate was observed within the three-week follow-up, with deaths concentrated among those with controlled diabetes mellitus (61%) and long-term diabetes mellitus patients (an average of eight versus four years). Higher mortality was also observed in patients with higher leucocytes and those with rhino-orbital-cerebral (59%), followed by nasal (55.6%) mucormycosis. Among survivors, 32% were reinfected, and 56% suffered from loss of vision. Conclusion: The study concludes that mucormycosis is associated with a higher mortality rate among COVID-19 patients with diabetes mellitus, particularly corticosteroid recipients. Thus, urgent attention to this coinfection is warranted in Iran.

关键词： Mucorales COVID-19 Mucormycosis Coinfection Dexamethasone Diabetes Mellitus

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Abundance,spatial distribution,and physical characteristics of microplastics in stormwater detention ponds

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Frontiers of Environmental Science & Engineering 2023年第10期17卷 75-87页

作者： Muhammad Masood Ashiq Farhad Jazaei Kati Bell Ahmed Shakir Ali Ali Alireza bakhshaee Peyman Babakhani Department of Civil Engineering University of MemphisMemphisTN 38152USA Brown and Caldwell NashvilleTN 37228USA Earth Surface Science Institute School of Earth and EnvironmentUniversity of LeedsLeedsLS29JTUK

Despite extensive research on microplastics (MP) in marine environments, little is known about MP abundance and transport in terrestrial systems. There is, therefore, still little understanding of the main mechanisms driving the substantial transport of MP across different environmental compartments. Storm events can transport MP beyond boundaries, such as from the land to groundwater or the ocean, as has already been discovered for organic carbon transport. Urban stormwater detention ponds are suitable environments to study the impact of stormwater on the environmental fate and transport of MP. Herein, we investigate the longitudinal and vertical distribution of MP within two detention ponds with different physical characteristics. Soil samples were collected at various locations and from multiple depths (surface and subsurface layers) for measuring MP concentrations using fluorescence microscopy. Our findings show that MP are retained more near the inlet of the ponds, and MP of larger sizes were found more abundantly near inlets than outlets. We also found that MP mass and sizes decrease from surface soil to subsurface soil. In the pond, where vegetation (grass root network) was more considerable, MP were found more evenly distributed along the depth. In terms of shape, the fragments were the most abundant MP shape.

关键词： Microplastic Environmental transport Soil pollution Stormwater Detention ponds

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Multilayer CVD graphene electrodes using a transfer-free process for the next generation of optically transparent and MRI-compatible neural interfaces

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Microsystems & Nanoengineering 2022年第5期8卷 183-196页

作者： Nasim bakhshaee Babaroud Merlin Palmar Andrada Iulia Velea Chiara Coletti Sebastian Weingärtner Frans Vos Wouter A.Serdijn Sten Vollebregt Vasiliki Giagka Department of Microelectronics Faculty of Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyMekelweg 4Delft 2628 CDThe Netherlands Technologies for Bioelectronics Group Department of System Integration and Interconnection TechnologiesFraunhofer Institute for Reliability and Micro-integration IZMGustav-Meyer-Allee 25Berlin 13355Germany Department of Imaging Physics Faculty of Applied ScienceDelft University of TechnologyLorentzweg 1Delft 2628 CJThe Netherlands Erasmus University Medical Center(Erasmus MC) dr.Molewaterplein 40Rotterdam 3015 GDThe Netherlands

Multimodal platforms combining electrical neural recording and stimulation,optogenetics,optical imaging,and magnetic resonance(MRI)imaging are emerging as a promising platform to enhance the depth of characterization in neuroscientific *** conductive,optically transparent,and MRI-compatible electrodes can optimally combine all *** as a suitable electrode candidate material can be grown via chemical vapor deposition(CVD)processes and sandwiched between transparent biocompatible ***,due to the high graphene growth temperature(≥900℃)and the presence of polymers,fabrication is commonly based on a manual transfer process of pre-grown graphene sheets,which causes reliability *** this paper,we present CVD-based multilayer graphene electrodes fabricated using a wafer-scale transfer-free process for use in optically transparent and MRI-compatible neural *** fabricated electrodes feature very low impedances which are comparable to those of noble metal electrodes of the same size and *** also exhibit the highest charge storage capacity(CSC)reported to date among all previously fabricated CVD graphene *** graphene electrodes did not reveal any photo-induced artifact during 10-Hz light pulse ***,we show here,for the first time,that CVD graphene electrodes do not cause any image artifact in a 3T MRI *** results demonstrate that multilayer graphene electrodes are excellent candidates for the next generation of neural interfaces and can substitute the standard conventional metal *** fabricated graphene electrodes enable multimodal neural recording,electrical and optogenetic stimulation,while allowing for optical imaging,as well as,artifact-free MRI studies.

关键词： transparent transfer process

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