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CRISPR,CAR-T,and NK:Current applications and future perspectives

Genes & Diseases 2024年第4期11卷 246-257页

作者： Mohadeseh Khoshandam Hossein soltaninejad Amir Ali Hamidieh Saman Hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom branch***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14965/161Iran Department of stem cells technology and Tissue Regeneration Faculty of Interdisciplinary Science and TechnologiesTarbiat Modares UniversityTehran 15614Iran Pediatric Cell Therapy and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran University of Medical SciencesTehran ***Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 15614Iran

Chimeric antigen receptor T(CAR-T)cell therapy represents a breakthrough in personalized cancer *** this regard,synthetic receptors comprised of antigen recognition domains,signaling,and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy *** the success of this approach in refractory B-cell malignancies,the optimal potency of CAR T-cell therapy for many other cancers,particularly solid tumors,has not been *** killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity *** on these studies,many investigations are focused on the accurate designing of CAR T-cells with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system or other novel gene editing tools that can induce hereditary changes with or without the presence of a double-stranded break into the *** methodologies can be specifically focused on negative controllers of T-cells,induce modifications to a particular gene,and produce reproducible,safe,and powerful allogeneic CAR T-cells for on-demand cancer *** improvement of the CRISPR/Cas9 innovation offers an adaptable and proficient gene-editing capability in activating different pathways to help natural killer cells interact with novel CARs to particularly target tumor *** achievements and future challenges of combining next-generation CRISPR-Cas9 gene editing tools to optimize CAR T-cell and natural killer cell treatment for future clinical trials toward the foundation of modern cancer treatments have been assessed inthis review.

关键词： Cancer CAR T-cell CRISPR Gene editing Immunotherapy NK cell

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Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

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Genes & Diseases 2024年第1期11卷 268-282页

作者： Mohadeseh Khoshandam Hossein soltaninejad Marziyeh Mousazadeh Amir Ali Hamidieh Saman Hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom BranchQom ***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14155-6463Iran Faculty of Interdisciplinary Science and Technology Tarbiat Modares UniversityTehran 14117-13116Iran Pediatric Cell and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran UniversityofMedical SciencesTehran14155-6559Iran Department of Nanobiotechnology Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran

CRISPR/Cas9 is an effective gene editing tool with broad applications for the pre-vention or treatment of numerous *** depends on CRiSPR(clustered regularly inter-spaced short palindromic repeats)as a bacterial immune system and plays as a gene editing *** to the higher specificity and efficiency of CRISPR/Cas9 compared to other editing ap-proaches,it has been broadly investigated to treat numerous hereditary and acquired ill-nesses,including cancers,hemolytic diseases,immunodeficiency disorders,cardiovascular diseases,visual maladies,neurodegenerative conditions,and a few X-linked ***/Cas9 system has been used to treat cancers through a variety of approaches,with sta-ble gene editing ***,the applications and clinical trials of CRisPR/Cas9 in various illnesses are *** to its high precision and efficiency,CRISPR/Cas9 strategies may treat gene-related illnesses by deleting,inserting,modifying,or blocking the expression of specific *** most challenging barrier to the in vivo use of CRISPR/Cas9 like off-target effects will be *** use of transfection vehicles for CRISPR/Cas9,including viral vectors(such as an Adeno-associated virus(AAV),and the development of non-viral vectors is also considered.

关键词： Clinical trials CRISPR/Cas9 Gene therapy Non-viral vectors Viral vectors

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An Introduction to Architecture of Nasir Al-Mulk Mosque

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World Journal of Engineering and Technology 2019年第4期7卷 652-675页

作者： Azin Ehteshami mehdi soltaninejad Architecture and Planning Department of Art University of Isfahan Isfahan Iran

In analazying the form in architectural monuments or in a more comprehensive way, study of the monuments itself is one of the most fundamental and most important aspects of architecture that has several benefits and effects. One of the benefits of recognizing the shape of different building architecture is the categorization of architecture into different historical periods that can help us better understand the process of historical architectural developments in the past. Among the architectural monuments of Iran, Nasir al-Mulk Mosque in Shiraz which is a Qajar Mosque is one of the most important Mosques in Shiraz which is less focused in the previous studies. This article, which is mainly based on empirical research and field studies, was conducted for studying the architecture of the mosque and analyzing and explaining the most important architectural features of this monument. The main questions of this article are the following: 1) What are the most basic architectural features of Nasir al-Mulk Mosque and how different parts are organized and built next to each other? 2) What choices and opting out of the architectural design of the building have been carried out? To find the best answers to these questions, first we analyzed the structure and overall fitness of the Mosque and its characteristics had been enumerated. Then, we introduced and analyze the main sectors that make up the corpus such as the mosque entrance, courtyard, naves and porches, in which the form and structure of each of these sectors as well as their consort with each other in shaping the overall architecture of the mosque, are analyzed and discussed. The summary of the findings in the form of empirical statements is presented at the end of the article.

关键词： Iranian Architecture Qajar Mosque Shiraz Mosque Nasir Al-Mulk Mosque

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Micro-organic dust combustion considering particles thermal resistance

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Journal of Central South University 2015年第7期22卷 2833-2840页

作者： Mohammadamin soltaninejad Farzad Faraji Dizaji Hossein Beidaghy Dizaji mehdi Bidabadi School of Mechanical Engineering Department of Energy Conversion Combustion Research LaboratoryIran University of Science and Technology School of Engineering The University of Vermont Young Researchers and Elite Club Tabriz Branch Islamic Azad University

Organic dust flames deal with a field of science in which many complicated phenomena like pyrolysis or devolatization of solid particles and combustion of volatile particles take place. One-dimensional flame propagation in cloud of fuel mixture is analyzed in which flame structure is divided into three zones. The first zone is preheat zone in which rate of the chemical reaction is small and transfer phenomena play significant role in temperature and mass distributions. In this model, it is assumed that particles pyrolyze first to yield a gaseous fuel mixture. The second zone is reaction zone where convection and vaporization rates of the particles are small. The third zone is convection zone where diffusive terms are negligible in comparison of other terms. Non-zero Biot number is used in order to study effect of particles thermal resistance on flame characteristics. Also, effect of particle size on combustion of micro organic dust is investigated. According to obtained results, it is understood that both flame temperature and burning velocity decrease with rise in the Biot number and particle size.

关键词：粉尘燃烧颗粒燃烧热阻化学反应速率气体燃料火焰温度火焰处理固体颗粒

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Trend of blood lactate level in acute aluminum phosphide poisoning

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World Journal of Emergency Medicine 2017年第2期8卷 116-120页

作者： Peyman Erfantalab Kambiz soltaninejad Shahin Shadnia Nasim Zamani Hossein Hassanian-Moghaddam Arezou Mahdavinejad Behrooz Hashemi Damaneh Toxicological Research Center Excellent Center of Clinical ToxicologyDepartment of Clinical ToxicologyLoghman Hakim HospitalSchool of MedicineShahid Beheshti University of Medical SciencesTehranIran Department of Forensic Toxicology Legal Medicine Research CenterLegal Medicine OrganizationTehranIran

BACKGROUND: Aluminum phosphide(Al P) poisoning is common in the developing countries. There is no specifi c antidote for the treatment of acute Al P poisoning. Early diagnosis of poisoning and outcome predictors may facilitate treatment decisions. The objective of this study was to determine the trend of blood lactate level in acute Al P poisoning to evaluate its role as a prognostic ***: This was a prospective study on acute Al P intoxicated patients during one year. Demographic data, clinical and laboratory data on admission, and outcome were recorded in a selfmade questionnaire. Blood lactate levels were analyzed every two hours for 24 ***: Thirty-nine(27 male, 12 female) patients were included in the study. The mortality rate was 38.5%. The mean blood pressure, pulse rate, blood p H and serum bicarbonate level were significantly different between the survivors and non-survivors groups. Blood lactate level was signifi cantly higher in the non-survivors group during 8 to 16 hours post ***: Blood lactate level could be used as an index of severity of acute Al P poisoning.

关键词： Aluminum phosphide Poisoning Blood lactate Prognostic factor

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Analyzing Drivers’ Mental Patterns Using Q-Methodology

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Journal of Transportation Technologies 2020年第2期10卷 169-181页

作者： Abbas Sheykhfard Farshid Reza Haghighi Mostafa soltaninejad Ali Karji Department of Civil Engineering Babol Noshirvani University of Technology Babol Iran Jacobs Engineering Group Omaha NE USA Department of Architectural Engineering Pennsylvania State University University Park PA USA

The human factor is the most important cause of road accidents. Investigating the drivers’ mental patterns can lead to a better understanding of the factors that affect drivers to make a mistake and thus increase the likelihood of an accident. In this study, mental patterns of drivers as a human characteristic are determined through a questionnaire survey. To do this, 166 participants (18 - 65 years) were asked to express their opinion on the possible effect of 25 factors on the occurrence of accidents. These factors were selected through the investigation of the accident database during the last three years in different areas of the case study. To analyze the data extracted from the survey, Q-methodology was used. The results of the factor analysis showed that there are 5 mental patterns among the participants. Based on the driver’s opinion, human factors and road conditions were the most and least influential accident-generating items, respectively. The most significant reason for accidents determined by drivers was human errors including 1) unauthorized overtaking, 2) unauthorized speed, 3) driver distractions (such as cell phone), and 4) driver physical disability (such as visual impairment). Moreover, the failure of the vehicle was mostly reported as another influential contributor to accidents. It is worth mentioning that the results of this study can be used to minimize accidents resulted from drivers’ behavioral errors by suggesting strategies for enhancing their performance through new manuals which is a step towards a safer road.

关键词： Human Factor Driver Mental Pattern Q-Methodology Factor Analysis Questionnaire

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