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Effects of rutin on oxidative stress in mice with kainic acid-induced seizure

Journal of Integrative Medicine 2013年第5期11卷 337-342页

作者： Marjan Nassiri-asl Taghi Naserpour Farivar Esmail Abbasi Hamid Reza Sadeghnia mehdi Sheikhi Mina Lotfizadeh Parisa Bazahang Cellular and Molecular Research Centre Department of Pharmacology Qazvin University of Medical Sciences Cellular and Molecular Research Centre Qazvin University of Medical Sciences Department of Pharmacology Qazvin University of Medical Sciences Department of Pharmacology School of Medicine Mashhad University of Medical Sciences School of Medicine Tehran University of Medical Sciences School of Medicine Qazvin University of Medical Sciences

Flavonoids are present in foods such as fruits and vegetables. Several studies have demonstrated a relationship between the consumption of flavonoid-rich foods and prevention of human disease, including neurodegenerative disorders. We assessed the effect of rutin （quercetin-3-O-rutinoside） on oxidative stress in kainic acid （KA）-induced seizure. METHODS： Thirty-six BALB/c mice were randomly divided into three groups. In the control group, saline （intra-peritoneal, i.p.） was administered for 7 d, and on the last day, KA （10 mg/kg, i.p.） was injected 30 min after administration of saline. In rutin groups, mice were pretreated with rutin （100 and 200 mg/kg, i.p.） for 7 d, and on the last day, KA （10 mg/kg, i.p.） was injected 30 min after administration of rutin. Subsequently, behavioural changes were observed in mice. Lipid peroxidation and oxidative stress were measured respectively in the early and late phases after KA-induced seizures. RESULTS： Seizure scores in the rutin groups were significantly lower than those in the control group （P 〈 0.01）. Furthermore, rutin dose-dependently inhibited the number of wet-dog shakes （WDS）（P 〈 0.05）. Malondialdehyde level in the hippocampus of the rutin groups was significantly lower than that in the hippocampus of the control group on days 1 and 21 after KA administration. In the rutin groups, the thiol levels observed on day 1 after KA administration were higher than that in the control group （P 〈 0.01）. CONCLUSION： These results indicate that rutin has potential anticonvulsant and antioxidative activities against oxidative stress in KA-induced seizure in mice.

关键词： plant extracts rutin kainic acid oxidative stress epilepsy seizure mice

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Effects of Nitrogen and Phosphate Biofertilizers on Morphological and Agronomic Characteristics of Sesame (<i>Sesamum indicum</i>L.)

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Open Journal of Ecology 2017年第2期7卷 101-111页

作者： Ali Nasrollahzadeh asl Department of Agronomy College of Agriculture Khoy Science and Research Branch Islamic Azad University Khoy Iran

In order to investigate the effects of Barvar-2 phosphate biofertilizer and nitroxin biofertilizers on agronomical characteristics of sesame, an experiment was carried out as factorial based on randomized complete block design with three replications and two factors in Khoy city, northwest of Iran, in 2014 growing seasons. The factors were as follows: phosphorus fertilizer in three levels (control, barvar-2 phosphate bio-fertilizer with 100 kg triple superphosphate per hectare and 200 kg triple superphosphate per hectare) and nitrogen fertilizer in four levels (control, nitroxin bio-fertilizer with urea at rate of 100 kg·ha−1, nitroxin biofertilizer with urea at rate of 150 kg·ha−1 and urea at rate of 200 kg·ha−1). The results showed that a significant effect of nitrogen and phosphate biofertilizer, on plant height, branches per plant, pods per plant, seed in pod, oil percent, seed yield and harvest index. Maximum seed yield of 1274.37 and 1232.5 kg·ha−1 was obtained from treatments of 200 kg·ha−1 triple superphosphate and barvar-2 phosphate biofertilizer besides 100 kg·ha−1 triple superphosphate. For nitrogen biofertilizer, maximum seed yield of 1264.83 and 1246.12 kg·ha−1 was obtained from treatments of 200 kg·ha−1?urea and nitroxin biofertilizer besides urea 150 kg·ha−1?respectively. According to the results of this experiment, consumption of chemical fertilizer of triple super phosphate was reduced equal to 50% using Barvar-2 phosphate biofertilizer and consumption of chemical fertilizer of urea was reduced equal to 25% using nitroxin biofertilizer.

关键词： Seed Yield Components Fertilizer Sesame Harvest Index

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Proposed Models for Subcritical Water Extraction of Essential Oils

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Chinese Journal of Chemical Engineering 2009年第3期17卷 359-365页

作者： M.Khajenoori A.Haghighi asl F.Hormozi Chemical Engineering Department Faculty of EngineeringSemnan University

Mechanisms that control the extraction rate of essential oil from Zataria multiflora Boiss. (Z. multiflora) with subcritical water (SW) were studied. The extraction curves at different solvent flow rates were used to deter-mine whether the extractions were limited primarily by the near equilibrium partitioning of the analyte between the matrix and solvent (i.e. partitioning thermodynamics) or by the rates of analyte desorption from the matrix (i.e. ki-netics). Four simple models have been applied to describe the extraction profiles obtained with SW: (1) a model based solely on the thermodynamic distribution coefficient KD, which assumes that analyte desorption from the ma-trix is rapid compared to elution; (2) one-site kinetic model, which assumes that the extraction rate is limited by the analyte desorption rate from the matrix, and is not limited by the thermodynamic (KD) partitioning that occurs dur-ing elution; (3) two-site kinetic model and (4) external mass transfer resistance model. For SW extraction, the thermodynamic elution of analytes from the matrix was the prevailing mechanism as evidenced by the fact that ex-traction rates increased proportionally with the SW flow rate. This was also confirmed by the fact that simple re-moval calculations based on determined KD (for major essential oil compounds) gave good fits to experimental data for flow rates from 1 to 4 ml·min-1. The results suggested that the overall extraction mechanism was influenced by solute partitioning equilibrium with external mass transfer through liquid film.

关键词： essential oils Zataria multiflora Boiss. subcrltlcal water extraction mechanisn

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Detection of small bowel tumor in wireless capsule endoscopy images using an adaptive neuro-fuzzy inference system

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The Journal of Biomedical Research 2017年第5期31卷 419-427页

作者： Mahdi Alizadeh Omid Haji Maghsoudi Kaveh Sharzehi Hamid Reza Hemati Alireza Kamali asl Alireza Talebpour Department of Bioengineering Temple University Philadelphia PAl9121 USA Department of Medicine Section of Gastroenterology School of Medicine Temple University Philadelphia PA 19140. USA Department of Radiation Medicine Engineering ShahidBeheshti University Tehran *** Iran. Department of Electrical and Computer Engineering ShahidBeheshti University Tehran *** Iran.

Automatic diagnosis tool helps physicians to evaluate capsule endoscopic examinations faster and more *** purpose of this study was to evaluate the validity and reliability of an automatic post-processing method for identifying and classifying wireless capsule endoscopic images, and investigate statistical measures to differentiate normal and abnormal images. The proposed technique consists of two main stages, namely, feature extraction and classification. Primarily, 32 features incorporating four statistical measures(contrast, correlation, homogeneity and energy) calculated from co-occurrence metrics were computed. Then, mutual information was used to select features with maximal dependence on the target class and with minimal redundancy between features. Finally, a trained classifier, adaptive neuro-fuzzy interface system was implemented to classify endoscopic images into tumor, healthy and unhealthy classes. Classification accuracy of 94.2% was obtained using the proposed pipeline. Such techniques are valuable for accurate detection characterization and interpretation of endoscopic images.

关键词： adaptive neuro-fuzzy inference system co-occurrence matrix wireless capsule endoscopy texture feature

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Modification of the Surface Properties of Core-Shell Semiconductors and Their Effects on the Photodecolorization Activity and Adsorption

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Modern Research in Catalysis 2017年第1期6卷 65-72页

作者： Shahab K. asl Faculty of Mechanical Engineering Department of Ceramic Engineering University of Tabriz Tabriz Iran

Semiconductor-based photocatalysts have been extensively studied for oxidative photodestruction of organic pollutants in wastewaters, releasing non-toxic substances such as Azo dyes. Various synthesized catalyst specimens were characterized to determine the correlation between preparation conditions (catalyst type, dopant, microstructure, preparation routs, optical and physico-chemical properties) on the photocatalytic activity. Some researchers focused on the process parameters to optimize them to reach higher photoactivity. The specific surface areas, crystalline size, charge and pretreatment of the surface have significant effects on the physical and photocatalytic properties of the semiconductors. The surface sites of catalyst (TiO2) were modified by doping ZnS nanoparticles in the form of Core-Shell structure and the photocatalytic activities were determined by using color degradation and hydrogen production tests. The dye adsorption isotherms of photocatalyst were determined using UV-Vis spectroscopy. The specific surface properties were determined from BET, Zeta meter and Particle size analyzer tests. Photocatalytic decolorization of AR and water splitting test were applied to understand the relation between the surface properties and the photocatalytic activity. The result indicated that core-shell prepared samples had different surface suitable sites to cooperate in photocatalytic reaction.

关键词： ZnS TiO2 Nanocomposite Core-Shell Surface Properties Photocatalysis

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Emerging Trends in Social Networking Systems and Generation Gap with Neutrosophic Crisp Soft Mapping

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Computer Modeling in Engineering & Sciences 2023年第8期136卷 1759-1783页

作者： Muhammad Riaz Masooma Raza Hashmi Faruk Karaaslan aslıhan Sezgin Mohammed M.Ali Al Shamiri Mohammed M.Khalaf Department of Mathematics University of the PunjabLahorePakistan Department of Mathematics CankırıKaratekin UniversityCankırıTurkey Department of Mathematics and Science Education Amasya UniversityAmasyaTurkey Department of Mathematics Faculty of Science and ArtsKing Khalid UniversityMuhayl AssirSaudi Arabia Department of Mathematics and Computer Faculty of ScienceIbb UniversityIbbYemen Higher Institute of Engineering and Technology King Marriott AlexandriaEgypt Faculty of Engineering Arab Academy for Science&Technology and Maritime Transport(AASTMT)Aswan BranchEgypt

This paper aims to introduce the novel concept of neutrosophic crisp soft set(NCSS),including various types of neutrosophic crisp soft sets(NCSSs)and their fundamental *** define NCS-mapping and its inverse NCS-mapping between two *** develop a robust mathematical modeling with the help of NCS-mapping to analyze the emerging trends in social networking systems(SNSs)for our various *** investigate the advantages,disadvantages,and natural aspects of SNSs for five *** the changing of the generations,it is analyzed that emerging trends and the benefits of SNSs are increasing day by *** suggested modeling with NCS-mapping is applicable in solving various decision-making problems.

关键词： Neutrosophic crisp soft set operations of NCSSs NCS-mapping inverse NCS-mapping social networking systems decision-making

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Evaluation of miR-21 and miR-150 expression in immune thrombocytopenic purpura pathogenesis： a case-control study

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Frontiers in Biology 2017年第5期12卷 361-369页

作者： Elahe Khodadi Ali Amin Asnafi Javad Mohammadi-asl Seyed Ahmad Hosseini Amal Saki Malehi Najmaldin Saki Thalassemia & Hemoglobinopathy Research center research institute of health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

BACKGROUND： Immune thrombocytopenic purpnra （ITP） is a common autoimmune disorder diagnosed with thrombocytopenia and bleeding symptoms due to production of autoantibodies （Abs） against platelets. Nowadays, microRNAs are known as novel biomarkers for diagnosis of diseases. The aim of this study was to investigate the expression levels of miR-21 and miR-150 in ITP patients and determine the role of these miRNAs in ITP pathogenesis. MATERIALS and METHODS： Thirty newly diagnosed patients with acute ITP and 30 healthy subjects（ age and sex matched） as controls were enrolled in this study. The expression level ofmiR-21 and miR- 150 was investigated using Real-time-PCR. Comparison of demographic characteristics of the cases was done using independent t-test and chi-square test. Comparison of the expression level of miR-21 and miR-150 with the related parameters was done using independent t-test or Mann-Whitney and Kruskal-Wallis test, Spearman rho correlation coefficient was used to investigate the relationship between the expression of miR-21 and miR-150 with demographic characteristics. RESULTS： The expression of miR-21, 150 in the patients was not different compared with the control group in general. A significant relationship between the expression of miR-21 with hemoglobin, hematocrit and red blood cell hemoglobin concentration was observed. DISCUSSION： Expression of miR-21 and miR-150 is not associated with pathogenesis of acute ITP and can involve the synergistic role of other miRNAs. Investigation of miR-21 and miR-150 expression along with other miRNAs and cytokines can be helpful in diagnosis and pathogenesis of ITP.

关键词： immune thrombocytopenic purpura miR-21 miR- 15 0

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Incidence of T3151 mutation in BCR/ABL-positive CML and ALL patients

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Frontiers in Biology 2016年第5期11卷 404-411页

作者： Fatemeh Norozi Javad Mohammadi-asl Tina Vosoughi Mohammad Ali Jalali Far Areal Saki Malehi Najmaldin Saki Health Research Institute Thalassemia and Hemoglobinopathy Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

OBJECTIVES： Targeted therapy of Philadelphia-positive ALL and CML patients using imatinib （IM） has caused significant changes in treatment course and has increased the survival of patients. A small group of patients show resistance to IM. Acquired mutations in tyrosine kinase domain of BCR-ABL protein are a mechanism for development of resistance. T315I is one of the most common acquired mutations in this domain, which occurs in ATP binding site and inhibits the formation of hydrogen bond with IM. The aim of this study was to evaluate the prevalence of this mutation in BCR/ABL-positive CML and ALL patients. METHODS： To conduct this study, 60 BCR-ABL-positive patients （including 50 CML and 10 ALL patients） who were subject to treatment with IM were selected. After taking the samples, presence of T315I mutation was assessed using ARMS- PCR on cDNA and its polymorphism was evaluated by sequencing. RESULTS： The results showed that among 60 patients, only three patients had T315I mutation, which was detected using ARMS technique. The three patients bearing mutation were afflicted with CML and no significant association was found between blood parameters with duration of treatment in presence of mutation. CONCLUSIONS： The mutation was found in three CML patients, which indicated lower likelihood and diagnostic value of this mutation in ALL patients. Given the negative direct sequencing results in T3151 patients, it can be concluded that ARMS- PCR is a more sensitive technique when the number of cancer cells is low in patients during treatment.

关键词： BCR-ABL T315I mutation imatinib CML ALL

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Experimental measurement and correlation of solubility of β-carotene in pure and ethanol-modified subcritical water

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Chinese Journal of Chemical Engineering 2020年第10期28卷 2620-2625页

作者： Hadi Share Mohammadi Ali Haghighi As Maryam Khajenoori Faculty of Chemical Petroleum and Gas EngineeringSemnan UniversitySemnan 35131-19111Iran

For the first time,the solubility ofβ-carotene in pure and ethanol-modified subcritical water(SW)using the static method was *** experimental runs were performed at a temperature ranging from 298.15 to 403.15 K and 0–10%(w/w)of ethanol as a modifier at a constant pressure of 5 *** were analyzed by UV–vis *** solubility ofβ-carotene was found to range from 1.084×10^-8 to 227.1×10^-8 mol fractions in the subcritical water in above mentioned *** obtainedβ-carotene solubility data were correlated using the linear model and modified Apelblat *** obtained results showed the modified Apelblat model was better for estimating the solubility ofβ-carotene in *** values of the rootmean-square deviation(RMSD)between experimental and correlated data were calculated and used as the index of validity and accuracy for the ***,thermodynamic properties of the solution such as the Gibbs free energy of solution,enthalpy,and entropy of solution were estimated.

关键词： Subcritical water β-Carotene Solubility Semi-empirical model

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Microfacies Patterns and Depositional Environments of the Sarvak Formation in the Abadan Plain, Southwest of Zagros, Iran

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Open Journal of Geology 2016年第3期6卷 201-209页

作者： Shahab Soleimani asl Mohsen Aleali Department of Geology Science and Research Branch Islamic Azad University Tehran Iran

The Sarvak Formation is the second major oil-bearing reservoir in the south and south west of Iran. The Middle Cretaceous Sarvak formation in the Zagros Mountains (Zagros Basin) is mainly composed of carbonate sequences. Based on facies studied, thirteen microfacies were recognized in the studied area, which were categorized in the three facies groups: including inner ramp, mid ramp and outer ramp. Evidences such as the gradual changes in the facies (basin slope), the absence of extensive uninterrupted barrier reef, the lack of calciturbidite and gravity sediments as well as the high proportion of grain-supported indicated that the Sarvak Formation was deposited in the ramp like depositional system, particularly on an inner ramp setting. Inner ramp facies group is the principal setting and subdivided to tidal flat, restricted and unrestricted lagoon as well as shoal sub-environments.

关键词： Microfacies Depositional Environments Sarvak Formation Zagros Iran

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