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Novel Point Mutations in 3'-Untranslated Region of GATA4 Gene Are Associated with Sporadic Non-syndromic Atrial and Ventricular Septal Defects

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Current Medical Science 2022年第1期42卷 129-143页

作者： Mehri KHATAMI Sajedeh GHORBANI Mojgan Rezaii ADRIANI Sahar BAHALOO Mehri Azami NAEINI Mohammad mehdi HEIDARI mehdi HADADZADEH Department of Biology Faculty of ScienceYazd UniversityYazd ***Iran Department of Cardiac Surgery Afshar HospitalShahid Sadoughi University of Medical SciencesYazd ***Iran

Objective:Transcription factor GATA4 has significant roles in embryonic heart *** of GATA4 appear to be responsible for a wide variety of congenital heart defects(CHD).Despite the high prevalence of GATA4 mutations in CHD phenotypes,extensive studies have not been *** 3'-untranslated region(3'-UTR)of tho GATA4 gene comprises regulatory motifs and microRNA binding sites that are critical for the appropriate gene expression,nuclear transportation,and regulation of translation,and stability of *** study aimed to evaluate the association between mutations in the 3'-UTR of the GATA4 gene and CHD risk among Iranian patients.

关键词： congenital heart disease GATA4 S'-untranslated region mutation in-silico analysis

Fuzzy logic classification of mature tomatoes based on physical properties fusion

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Information Processing in Agriculture 2022年第4期9卷 547-555页

作者： Seyed mehdi Nassiri Amir Tahavoor Abdolabbas Jafari Department of Biosystems Engineering Shiraz UniversityShiraz 71441Iran Lincoln Agritech Ltd. Lincoln UniversityLincoln 7616New Zealand

Grading of fruits and vegetables is an initial step after *** is also an essential operation before *** the present study,different fuzzy algorithms for classifica-tion of mature tomato were applied and evaluated based on combinations of fruit color,size and *** membership functions of hardness were established by subject-ing samples to Instron compression test as well as the rates of *** sample was also used for image processing to determine the color and size of fruit using Matlab image processing *** and size fuzzy membership functions were established by pub-lished *** fuzzy If-Then rules were applied to classify the samples within five group outputs viz.“grade I”,“grade II”,“grade I-far market”,“processing”,and“storage”.Eighty-one fuzzy rules were reduced to 25 rules by combining the compatible *** fuzzy algorithms with different fuzzifiers(zmf,sigmf,gbellmf)and defuzzifiers(bisector,mom,and centroid)were applied,and the outputs were compared to the panelists’classi-fications in cross *** to the classification results,fuzzy algorithms grouped the fruits into correct classes with 90.9%,92.3%,88.7%,87.4%,92.4%and 93.3%accuracy for 6 models,*** best result was observed with zmf and sigmf,and gbellmf as fuzzifier and mom as defuzzifier with 93.3%***,the results revealed that the fusion of aforementioned tomato properties based on fuzzy membership functions could accurately classify the tomatoes in correct groups for different markets.

关键词： Fuzzy logic Grading Hardness Tomato Sorting

Combined Effects of Exposure to Noise and Vibration on Human Postural Equilibrium under Simulated Driving Conditions

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Sound & Vibration 2022年第1期56卷 37-49页

作者： Seyyed Mohammad Javad Golhosseini Mohsen Aliabadi Rostam Golmohammadi Maryam Farhadian mehdi Akbari Morteza Hamidi Nahrani mehdi Samavati Department of Occupational Health Engineering School of Public HealthHamadan University of Medical SciencesHamadanIran Center of Excellence for Occupational Health School of Public Health and Occupational Health&Safety Research CenterHamadan University of Medical SciencesHamadanIran Center of Excellence for Occupational Health School of Public Health and Research Center for Health SciencesHamadan University of Medical SciencesHamadanIran Department of Biostatistics School of Public Health and Research Center for Health SciencesHamadan University of Medical SciencesHamadanIran Department of Audiology School of RehabilitationIran University of Medical SciencesTehranIran Department of Audiology School of RehabilitationHamadan University of Medical SciencesHamadanIran Department of Medical Physics and Biomedical Engineering School of MedicineTehran University of Medical SciencesTehranIran

There is little information about drivers’body balance responses to combined exposure of noise and *** fill the gap,this study aims to investigate the combined effects of exposure to noise and whole-body vibration(WBV)on the body balance under simulated driving *** this purpose,30 male participants were exposed to noise level at 85 dB(A)and two vibration levels(0.87 and 1.3 m/s^(2))in five *** design of the study was repeated-measures,and it attempted to assess the effects of 40 minutes of exposure to noise and/or ***,the participants’fatigue was measured with the Borg scale(CR 10).The findings revealed there was a significant change in body sway after WBV and combined noise and WBV exposure(p0.05).The effect sizes of exposure to noise,WBV(1.3 m/s^(2)),and combined noise and WBV(1.3 m/s^(2))on body balance were 0.035,0.425,and 0.635,***,single exposure to WBV caused more fatigue than single exposure to noise(p<0.05).Combined noise and WBV exposure descriptively caused more fatigue in comparison with the influence of WBV *** study concluded that the combined effects of exposure to noise and vibration are more than the sum of ***,some synergistic effects may be observed in human body *** is essential to increase drivers’awareness and revise current health care interventions about new possible effects of combined exposures.

关键词： Body balance noise whole-body vibration(WBV) fatigue combined exposure

The static and cidal effects of veterinary antibiotics on soil microorganisms in the presence of organic and mineral amendments

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Soil Ecology Letters 2023年第4期5卷 125-135页

作者： Ali Akbar Safari Sinegani mehdi Rashtbari Department of Soil Science College of AgricultureBu-Ali Sina UniversityHamadan ***Iran Department of Soil and Plant Microbiome Institute of PhytopathologyChristian-Albrechts-University of KielKielGermany

●Gentamicin initially decreased microbial activity comparative to penicillin higher.●Recovery was comparatively high in oxytetracycline treated soils.●Organic amendments improved the resilience indices.●Unexpectedly the qCO_(2) decreased in the antibiotic treated soils.●The static effects of the applied antibiotics were higher than their cidal *** study aimed to describe the static and cidal adverse effects of antibiotics on soil microbial activity resulting from manure ***,in the present study,the treatments included:without antibiotics;application of gentamicin,oxytetracycline,and penicillin each in different concentrations(50,100,and 200 mg kg−1 dry soil).They were applied in soils treated with and without organic and mineral conditioners(cow manure,biochar,and nano-zeolite).Soil microbial respiration and metabolic quotient were studied at three time periods(1−7,7−30,and 30−90 days)during a 90-day incubation of the treated *** applied to the soil samples significantly decreased soil basal respiration(BR)values compared to those of the control,and the most significant decrease was observed for *** had a short intensive impact,alleviated by manure and biochar,on soil *** a significant initial reduction in substrate-induced respiration(SIR),gentamicin application then caused a substantial increase in SIR *** metabolic quotient decreased in the antibiotic-treated *** study revealed that the static effects of the applied antibiotics in soil were greater than the cidal effects.

关键词： antibiotic resistance metabolic quotient microbial respiration soil resilience

Comparison of post-urethroplasty complication rates in pediatric cases with hypospadias using Vicryl or polydioxanone sutures

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Asian Journal of Urology 2022年第2期9卷 165-169页

作者： mehdi Shirazi Abdolreza Haghpanah Anahita Dehghani Sezaneh Haghpanah mehdi Ghahartars Mahdi Rahmanian Shiraz Nephro-urology Research Center Shiraz University of Medical SciencesShirazIran Hematology Research Center Shiraz University of Medical SciencesShirazIran Molecular Dermatology Research Center Shiraz University of Medical SciencesShirazIran Medical School MPH DepartmentShiraz University of Medical SciencesShirazIran

Objective:Hypospadias is a common congenital problem among male *** rapid absorbable sutures(polyglactin,Vicryl)and delayed absorbable sutures(polydioxanone,PDO)are used in hypospadias repair based on the surgeon's *** study was conducted to compare post-urethroplasty complication rates in pediatric patients with hypospadias using Vicryl or PDO ***:This is a retrospective study which was designed and performed on 583 children aged 1-7 years old who had undergone hypospadias repair from January 2012 to December *** data were obtained from the patients'medical ***:Overall,post-surgical complications were observed in 60(10.3%)patients comprising urethro-cutaneous fistula(n=39,6.7%),meatal stenosis(n=10,1.7%),urethral stricture(n=7,1.2%),and glans dehiscence(n=4,0.7%).The mean age of the children with complications was 3.0±1.3 *** to Kaplan-Meier estimate,the interval between surgery and development of complications was significantly shorter in the Vicryl group(p=0.037).Overall,complications were more prevalent in Vicryl suture than PDO suture(15.1%vs.5.3%,p<0.001).Regression model revealed that in comparison to the distal type,proximal hypospadias(odds ratio[OR]:103.9,95%confidence interval[CI]:32.2-334.9,p<0.001)and mid-shaft hypospadias(OR:82.9,95%CI:25.9-264.6,p<0.001)while using Vicryl suture instead of PDO suture(OR:62.4,95%CI:21.2-183.8,p<0.001)increased the odds of developing post-urethroplasty ***:We suggest PDO suture in the repair of hypospadias due to its lower complication rate,especially in cases of proximal and mid-shaft hypospadias which can get more complicated than the distal type.

关键词： Hypospadias Urinary fistula Polyglactin Polydioxanone

Numerical simulation of fatigue crack propagation in heterogeneous geomaterials under varied loads using displacement discontinuity method

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 702-716页

作者： Rezvan Alizadeh Mohammad Fatehi Marji Abolfazl Abdollahipour mehdi Pourghasemi Sagand Department of Mining and Metallurgical Engineering Faculty of EngineeringYazd UniversityYazdIran School of Mining Engineering College of EngineeringUniversity of TehranTehranIran

Heterogeneous brittle geomaterials are highly susceptible to cyclic *** contain inherent flaws and cracks that grow under fatigue loads and lead to *** study presents a numerical model for analyzing fatigue in these materials based on the two-dimensional(2D)boundary element method and linear elastic fracture *** process is formulated by coupling the displacement discontinuity method with the incorporation technique of dissimilar regions and the governing equations of *** heterogeneous media are assumed to consist of materials with different properties,and the interfaces are assumed to be completely *** addition,the domains include multiple cracks exposed to constant and variable amplitude cyclic *** stress intensity factor is a crucial parameter in fatigue analysis,which is determined using the displacement field around crack *** incremental crack growth scheme is applied to calculating the fatigue *** growth rate values are employed to estimate the length of crack extension when there are multiple *** interaction between cracks is considered,which also includes the coalescence ***,various structures under different cyclic loads are examined to evaluate the accuracy of this *** results demonstrate the efficiency of the proposed approach in modeling fatigue crack growth and life *** behavior of life curves for the heterogeneous domain was as *** curves illustrate the breakpoints caused by utilizing discrete incremental life *** these points,the trend of the curves changed with the material properties and fatigue characteristics of the new material around the crack tips.

关键词： Fatigue life Crack coalescence Interface Incorporation technique Variable amplitude loading

Changes in hydrologic components from a mid-sized plots induced by rill erosion due to cyanobacterization

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International Soil and Water Conservation Research 2022年第1期10卷 143-148页

作者： Atefeh Jafarpoor Seyed Hamidreza Sadeghi Behrouz Zarei Darki mehdi Homaee Department of Watershed Management Engineering Faculty of Natural ResourcesTarbiat Modares UniversityNoorIran Department of Watershed Management Engineering Faculty of Natural ResourcesTarbiat Modares University.Noor46417-76489Iran Department of Marine Biology Faculty of Marine ScienceTarbiat Modares UniversityNoorIran Agrohydrology Research Group College of AgricultureTarbiat Modares UniversityTehran 14115-336Iran Department of mining Engineering Faculty of EngineeringTarbiat Modares UniversityTehran 14115Iran

Runoff components are the most important factors in explaining the hydrological behaviour of a *** that the proper understanding of the runoff processes may effectively help managers and decision-makers adopt appropriate *** this regard,there are variety of approaches to handle runoff generation,but the application of environmentally friendly,biologic-based and cost-effective approaches such as soil microorganisms has been seldom *** study has therefore tried to investigate the role of inoculation of cyanobacteria on runoff components under rain simulation conditions at the mid-sized(i.e.,6×1m)plots installed at=30% slope *** treated plots were subjected to a simulated rainfall with an intensity of 50 mm h^(-1) and an initial duration of 30 min with three replica-tions.A simulated runoff of 2.18±0.32 Lmin^(-1) was also performed simultaneously on the onset of starting surface *** results showed significant differences(P<0.021)in hydrological behaviours in control and treated *** that no surface runoff was produced in treated plots up to the end of the initial duration of 30 min of simulated *** results revealed that cyanobacterization by secretion of exopolysaccharides not only postponed runoff generation but also effectively inhibited runoff com-ponents even if the rainfall incident extended for longer *** positive effect of cyanobacterization on increasing infiltration and potential storage of water beneath the soil was also verified in the present study,which suggests the profitable application of cyanobacteria for regulating hydrologic components.

关键词： Soil bio-crust Soil infiltration Water balance Water management

Axial length and anterior chamber indices in elderly population: Tehran Geriatric Eye Study

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1876-1882页

作者： Hassan Hashemi Samira Heydarian Alireza Hashemi mehdi Khabazkhoob Noor Research Center for Ophthalmic Epidemiology Noor Eye HospitalTehran ***Iran Department of Rehabilitation Science School of Allied Medical SciencesMazandaran University of Medical SciencesSari ***Iran Noor Ophthalmology Research Center Noor Eye HospitalTehran ***Iran Department of Basic Sciences School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To determine the normative distribution of axial length(AL),anterior chamber depth(ACD),anterior chamber volume(ACV),anterior chamber angle(ACA),and some of their associated factors in subjects aged 60 and ***:In this cross-sectional study,160 clusters were sampled using multi-stage cluster sampling in Tehran,*** a preliminary interview,the participants underwent optometric examinations including visual acuity and refraction measurement followed by slit lamp ***,ocular imaging was done using the Pentacam AXL to measure AL,ACD,ACV,and ***:A total of 4519 eyes of 2436 participants were evaluated,of whom 58.0%(n=1412)were *** mean age of the subjects was 67.32±6.05y(range:60-95y).The mean AL,ACD,ACV,and ACA was 23.22 mm(23.18-23.27 mm),2.61 mm(2.59-2.62 mm),126.56 mm3(125.08-128.04 mm3),and 30.61°(30.3°-30.92°),*** the multivariable model,after adjusting for the effect of both eyes,the longest and shortest AL was seen in myopic and hyperopic subjects,***,ACD,ACV and ACA were significantly larger in men compared to women(P<0.001).Except ACA,other evaluated parameters showed an inverse correlation with age(P<0.001),however,this correlation was insignificant for AL(P=0.623).CONCLUSION:Normative value of AL,and other biometric parameters are specific for each ethnicity,age and sex *** alteration in these parameters and their effect on refraction should be considered in this age group,especially in case of cataract surgery.

关键词： biometry elderly axial length anterior chamber depth

Agreements’profile of Scheimpflug-based optical biometer with gold standard partial coherence interferometry

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2095-2104页

作者： Sara Sardari Akbar Fotouhi Ebrahim Jafarzadehpur mehdi Khabazkhoob Research and Technology Deputy Tehran University of Medical SciencesTehran ***Iran Noor Ophthalmology Research Center Noor Eye HospitalTehran ***Iran Department of Epidemiology and Biostatistics School of Public HealthTehran University of Medical SciencesTehran ***Iran Noor Research Center for Ophthalmic Epidemiology Noor Eye HospitalTehran ***Iran Department of Basic Sciences School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To determine the agreement of ocular biometric indices including axial length,keratometric readings,anterior chamber depth,and horizontal corneal diameter between the Pentacam AXL and IOL Master ***:The study was a large cross-sectional population-based study(Tehran Geriatric Eye Study)conducted from Jan 2019 to Jan 2020.A total of 160 clusters were randomly selected proportional to size(each cluster contained 20 individuals)from 22 strata of Tehran *** people aged 60y and above were invited to participate in the *** all participants,preliminary ocular examinations were performed including the measurement of uncorrected and best-corrected visual acuity,objective and subjective refraction,anterior and posterior segment *** participants underwent an ocular biometry using the Pentacam AXL and IOL Master ***:The 95%limits of agreement(LoA)between the two devices were-0.13 to 0.19,-0.15 to 0.17,and-0.13 to 0.19 in normal,pseudophakic,and cataractous eyes,*** increasing the axial length,the difference between the two devices significantly increased in all three groups of normal,pseudophakic,and cataractous eyes(P<0.001).The 95% LoAs between the two devices regarding the mean keratometry shows that the best LoAs were seen in cataractous(-0.33 to 0.81)and followed by normal eyes(-0.36 to 0.86)and the pseudophakic eyes(-0.48 to 0.90)had the widest *** 95% LoAs for horizontal corneal diameter measurements were-0.08 to 0.86,-0.03 to 0.83,and-0.07 to 0.87 in normal,pseudophakic,and cataractous eyes,*** 95% LoAs of anterior chamber depth measurements between the two devices was-0.39 to 0.19 and-0.37 to 0.13 in normal eyes and cataractous,***:The Pentacam AXL has excellent agreement with the gold standard,IOL Master 500 in measuring axial *** eyes with cataracts,the difference between the two devices is more *** the increasing of axial length,the difference between the

关键词： ocular biometry optical biometer Pentacam AXL