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Torsion of the Spermatic Cord: Clinical and Therapeutic Aspects in the Region of Thies (Senegal)

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Advances in Reproductive Sciences 2019年第3期7卷 60-70页

作者： Yoro Diallo Johanitha Lionnelle Elonme Alissoutin Saint Charles Kouka Modou Diop N’diaye mehdi Daher Ramatoulaye Ly Cheikh Diop Seydou Diaw Cheickna Sylla Department of Urology Faculty of Health Sciences University of Thies Thies Senegal

Introduction: The purpose of this work is to evaluate the epidemiological, clinical and therapeutic aspects of spermatic cord in our context. Patients and Methods: This is a retrospective study over a period of 4 years from January 1, 2014 to June 30, 2018. Results: We collected 55 cases divided into 26 cases, 44.27% for the Thies Regional Hospital, 21% or 38.18% for the Mbour EPS and 8 cases representing 14.55% for the Saint Jean de Dieu Hospital. We found an average age of 20.03 years with extremes of 4 years and 56 years. In 28 patients or 50% of cases, we found no particular pathological history, while in 4 patients or 7.14%, we found a notion of recurrent ipsilateral testicular pain. We recorded 67.27% (n = 37) of the cases received for testicular pain;15 patients or 27.27% presented a large painful pouch. Two patients (3.64%) were received for inguinal swelling and 1 patient (1.82%) presented testicular atrophy. The average consultation time is 16.9 hours with extremes of 2 hours and 96 hours. The torsion was in 59.61% of cases (n = 32) located on the right versus 40.38% (n = 22) on the left. There was no bilateral form. The pick-up time was 3 hours with extremes of 1 h to 24 h. All patients benefited from an exploratory scrotomy. We found a total of 22 patients or 40% of cases with ischemic testis, 8 cases or 14.55% of patients with necrotic testis and 2 cases or 3.64% where the testis was normal. Orchidopexy was performed in 46 patients or 83.63% and orchiectomy in 9 patients. Conclusion: Care is urgent. There is a need for better awareness of the population and the medical staff for the early diagnosis.

关键词： Spermatic Cord Torsion Young Subject Exploratory Scrotomy Orchiectomy

Synthesis of New 2-Phenylamino-4<i>H</i>-chromene-3-carbonitrile Derivatives and Their Effects on Tumor Cell Lines and against Protein Kinases

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International Journal of Organic Chemistry 2020年第2期10卷 88-103页

作者： Ali Bouattour mehdi Fakhfakh Souhir Abid Ludovic Paquin Rémy Le Guével Thierry Charlier Sandrine Ruchaud Stéphane Bach Jean-Pierre Bazureau Houcine Ammar Laboratoire de Chimie Appliquée: Hétérocycles Corps Gras et Polymères Faculté des Sciences de Sfax Université de Sfax Sfax Tunisie Département de Chimie Collège des Sciences et des Arts Université de Jouf Al Qurayyat KSA Institut des Sciences Chimiques de Rennes (ISCR) UMR CNRS 6226 Université de Rennes 1 Campus de Beaulieu Rennes France S2 Wave Platform ScanMAT UMS 2001CNRS Université de Rennes 1 Campus de Beaulieu Rennes France Université de Rennes 1 ImPACcell Platform Campus Villejean Rennes France Sorbonne Universités UPMC Université Paris 06 CNRS USR3151 Protein Phosphorylation and Human Disease Unit KISSf Platform Station Biologique Place Georges Teissier Roscoff France

The synthesis of 2-phenylimino-4H-chromene-3-carbonitriles 6(a-d) in good overall yields using an efficient and practical methodology in 3 steps has been implemented in this present work. The first step was a heterocyclization between 2-hydroxybenzaldehyde 1 and propanedinitrile 2 which produced 2-iminocoumarin 3 which was submitted to nitrogen/nitrogen displacement in the presence of aromatic primary amine 4. In the third step, reduction of 5 led to the desired 2-phenylimino-4H-chromene-3-carbonitriles 6. Compounds 5(a-d) and 6(a-d) were evaluated for their potential in vitro cytotoxicity against six selected tumor cell lines (Huh7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and tested for their protein kinase inhibition on eight selected protein kinases. Among them, compounds 5c and 6b exhibited inhibition on HsCK1e (5c: 44% and 6b: 42% at 1 μM) and 5c for cytotoxicity on PC3 cell lines (63% at 25 μM).

关键词： Iminocoumarin 2H-benzopyran 2-Imino-2H-benzopyran 4H-chromene 2-Amino-4H-chromene Nitrogen/Nitrogen Displacement Protein Kinase Inhibition Cytotoxicity

Synthesis,characterization,in vitro antimicrobial and antioxidant activities of catecholthioethers

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Synthesis,characterization,in vitro antimicrobial and antiox...

Role of Coelioscopy in the Etiologic Diagnosis of Exudative Ascites of Unknown Origin of the Women

13th Asian Chemical Congress

作者： ADIBI HADI KHODAEI MOHAMMAD mehdi ALIZADEH ABDOLHAMID PAKRAVAN NARGES RASHIDI ATEFEH MAJNOONI MOHAMMAD BAGHER ABIRI RAMIN NEMATOLLAHI DAVOOD Faculty of Pharmacy Kermanshah University of Medical SciencesKermanshahIran Faculty of of Chemistry Razi University Faculty of Medicine Kermanshah University of Medical SciencesKermanshahIran Faculty of Chemistry Bu-Ali Sina University

＜正＞Generation of reactive oxygen species（ROS）and free radicals in vivo is involved in a wide range of human ***,including superoxide anion,hydrogen peroxide and hydroxyl radical,are by products of a variety of pathways of aerobic *** catecholthioethers have become an important structural motif in biological *** report here the synthesis of a series of

关键词： Catecholthioethers Antioxidant Antimicrobial

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Journal of Cancer Therapy 2015年第5期6卷 466-471页

作者： Mohamed Ben Mabrouk Aida Ben Slama Trabelsi Mohamed Ben Rejeb Hanène Jaziri mehdi Ksiaa Sassi Bouguizane Badreddine Sriha Ali Jmaa Ali Ben Ali Department of Digestive Surgery Sahloul Hospital Sousse Tunisia Department of Gastroenterology Sahloul Hospital Sousse Tunisia Department of Preventive Medicine Sahloul Hospital Sousse Tunisia Department of Gynecology Farhat Hached Hospital Sousse Tunisia Department of Pathology Farhat Hached Hospital Sousse Tunisia

Introduction: The aim of this study was to clarify the role of laparoscopy in the etiological diagnosis of exudative ascites of unknown origin in women. Materials and Methods: This?was?a prospective study from 2007 to 2012, including 83 women with exudative ascites of unknown origin and had a laparoscopy diagnostic purpose. Results: Carcinomatosis and peritoneal tuberculosis were the two most common causes found in 31% (26 cases) and 66% (55 cases) of cases respectively. The average age of the patients was 56 years. Weight loss and abdominal pain were the most frequent, observed symptoms in 71 cases (85.5%) and 53 cases (63.8%) respectively. The CT scan abnormalities noted?were a peritoneal thickening in 32 cases (38.5%), peritoneal nodules in 15 cases (18%), and agglutination of the digestive handles in 12 cases (14.4%). Laparoscopic Visual diagnosis was in favor of a peritoneal carcinomatosis in 32 cases (38.5%), peritoneal tuberculosis in 45 cases (54.2%), and non specific infection in 6 cases (7.3%). The histological diagnosis was a peritoneal carcinomatosis in 26 cases (31%), and peritoneal tuberculosis in 55 cases (66%). The positive predictive value of laparoscopic vision Diagnostics in Peritoneal tuberculosis was 100% and the negative predictive value was 73.7%. In peritoneal carcinomatosis, the positive predictive value was 81.3% and the negative predictive value was 100%. Conclusion: The etiologic diagnosis of exudative ascites in women is difficult despite the availability of several tests. Currently, laparoscopy with peritoneal biopsy remains the gold standard for etiologic diagnosis.

关键词： Ascites Exudative Laparoscopy Peritoneal Tuberculosis Peritoneal Carcinomatosis

美国北达科他州巴肯烃源岩的热成熟度测井预测

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海洋地质 2019年第3期35卷 12-24页

作者： Arash Abarghani mehdi Ostadhassan Bailey Bubach 康冬菊(翻译) 顾元(校对) 不详广州海洋地质调查局水合物工程技术中心

利用页岩的岩石物理和岩石力学特征结合地球化学特征构建预测模型的研究已广泛开展。本研究将利用一系列测井资料预测巴肯泥岩的热成熟度。首先,利用横波和纵波速度以及密度获取动态模量(Ed),然后利用己有的Ed和Ei的实验关系获取Ei(基... 详细信息

利用页岩的岩石物理和岩石力学特征结合地球化学特征构建预测模型的研究已广泛开展。本研究将利用一系列测井资料预测巴肯泥岩的热成熟度。首先,利用横波和纵波速度以及密度获取动态模量(Ed),然后利用己有的Ed和Ei的实验关系获取Ei(基于纳米压痕的杨氏模量)。之后,利用测井曲线得到的泥岩E和实测TOC建立经验公式,解释单井TOC曲线。三口井实测TOC和计算值的差值在合理误差范围内。在缺乏镜质组成分时,采用固体沥青的反射率(BRo%)作为反映成熟度的指标,并建立了12口井GR/NPHI/RHOZ和BR0%的关系。根据不同测井曲线与BR0%的相关性,重新定义了“■”反映成熟度,结果发现■与BR0%在整个泥岩段均有较好的相关性。最终,可以利用BR0%与实测Tmax计算巴肯泥岩的Tmax曲线。使用重构的GR/NPHI/RHOZ曲线,可以构建BR0%和Tmax的三维地质模型,进而开展含油气系统的评价。

关键词：巴肯烃源岩沥青反射率热成熟度测井

Mitral Valve Commissurotomy: Which One between the Three Techniques Gives a Better Long-Team Outcome?

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World Journal of Cardiovascular Diseases 2017年第2期7卷 37-45页

作者： Mahdi Aithoussa Noureddine Atmani Ayoub Abetti mehdi Bamous Abdessamad Abdou Younes Moutakiallah Anis Seghrouchni Fouad Nya Siham Bellouize Mohamed Drissi Ilyas Asfalou Abdelatif Boulahya Department of Cardiac Surgery Mohamed V Military Hospital Mohammed V University Rabat Morocco Department of Cardiology Mohamed V Military Hospital Mohammed V University Rabat Morocco

Objective: we sought to compare long-term results of three techniques: CMC, OMC and PMC in patients with rheumatic mitral stenosis. Patients and Method: Between January 1994 and December 2015, 183 patients underwent mitral valve surgery for rheumatic mitral restenosis. All patients were investigated by echocardiography-Doppler performed by a senior cardiologist. The patients were divided into 3 groups: patients who have previously closed mitral commissurotomy (CMC n = 101), patients with previously open mitral commissurotomy (OMC n = 28) and those treated by Balloon mitral valvuloplasty (PMC = 54). Results: The three groups were comparable in term of major demographic data. Mitral restenosis occurred precociously in groups treated by PMC (7 ± 4 years), followed by group with OMC 11.4 ± 4 years and CMC group but it occurred later CMC 16.8 ± 7.8 years (p Conclusion: CMC produces better long-term outcome than OMC and PMC. However, it would be premature to conclude to its superiority.

关键词： Rheumatic Mitral Stenosis Closed Mitral Commissurtomy Open Mitral Commissurotomy Balloon Mitral Valvuloplasty

Common Prothrombotic Gene Mutations in Cerebral Venous Sinus Thrombosis in North-West of Iran

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Neuroscience & Medicine 2017年第4期8卷 68-76页

作者： Elyar Sadeghi-Hokmabadi Ebrahim Sakhinia mehdi Farhoudi Somayyeh Hasaneh Morteza Ghojazadeh Mohammad Amin Farzi Sasan Andalib Masoumeh Nemati Omid Abbaszadeh Reza Rikhtegar Reshad Mirnour Neurosciences Research Center Department of Neurology Imam-Reza Hospital School of Medicine Tabriz University of Medical Sciences Tabriz Iran Connective Tissue Research Center Department of Medical Genetics Faculty of Medicine and Tabriz Genetic Analysis Centre (TGAC) Tabriz University of Medical Sciences Tabriz Iran Liver and Gastrointestinal Disease Research Center Tabriz University of Medical Sciences Tabriz Iran Department of Neurosurgery Poursina Hospital School of Medicine Guilan University of Medical Sciences Rasht Iran

Objective: Cerebral venous sinus thrombosis (CVST) is a life-threatening cerebrovascular disease which has high prevalence and mortality rate in Iran. Thrombophilia caused by gene mutation is a common cause of CVST. The present study aimed at assessing the prevalence of thrombophilic gene mutations in Iranian CVST patients and then comparing it with normal population. Materials and methods: In a case-control study, polymerase chain reaction-restriction fragment length polymorphism (PCR_RFLP) and amplification-refractory mutation system (ARMS-PCR) were carried out to detect common thrombophilic mutations in 70 CVST patients. Next, it was compared with 82 sex- and age-matched healthy controls. Results: Factor-V-Leiden, Factor-V-Leiden HR2, Factor prothrombin II, MTHFR (667C/T) and MTHFR (1298A/C) prevalence were significantly high in cases of CVST as compared to the controls (P values: 0.012, 0.019, 0.007 and 0.036, respectively). However, there was no significant difference between the two groups in plasminogen activator inhibitor (PAI), angiotensin-converting enzyme (ACE), beta-fibrinogen (FGB), Factor VIII, Factor XIII, and tissue plasminogen activator (tPA) mutations. Conclusion: The findings of the present study suggest that Factor V-Leiden, Factor-V-Leiden HR2, prothrombin II (G20210A), and MTHFR (667C/T & 1298A/C) mutations are more frequent in CVST. Detection of these mutations may help clinicians to decide on the duration of treatment and referral to genetic counseling for valuable prevention.

关键词： Gene Mutation Cerebral Venous Sinus Thrombosis Thrombophilia

Evaluating mechanism and severity of injuries among trauma patients admitted to Sina Hospital,the National Trauma Registry of Iran

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Chinese Journal of Traumatology 2021年第3期24卷 153-158页

作者： Mina Saeednejad Mohammadreza Zafarghandi Narjes Khalili Vali Baigi Moein Khormali Zahra Ghodsi Mahdi Sharif-Alhoseini Reilly Gerard M.O’ Khatereh Naghdi Melika khaleghi-Nekou Seyed mohammad Piri Vafa Rahimi-Movaghar Somayeh Bahrami Marjan Laal Mahdi Mohammadzadeh Esmaeil Fakharian Habibollah Pirnejad Hamid Pahlavanhosseini Payman Salamati Homayoun Sadeghi-Bazargani Sina Trauma and Surgery Research Center Tehran University of Medical SciencesTehranIran Preventive Medicine and Public Health Research Center Department of Community and Family MedicineSchool of MedicineIran University of Medical SciencesTehranIran National Health and Medical Research Council(NHMRC) AustraliaNational Trauma Research InstituteThe Alfred Hospital and Monash UniversityMelbourneAustralia Trauma Research Center Kashan University of Medical SciencesKashanIran Patient Safety Research Center Urmia University of Medical SciencesUrmiaIran Trauma Research Center Shahid Sadoughi University of Medical SciencesYazdIRIran Road Traffic Injury Research Center Tabriz University of Medical SciencesTabrizIran

Purpose:Injuries are one of the leading causes of death and lead to a high social and financial *** patterns can vary significantly among different age groups and body *** study aimed to evaluate the relationship between mechanism of injury,patient comorbidities and severity of ***:The study included trauma patients from July 2016 to June 2018,who were admitted to Sina Hospital,Tehran,*** inclusion criteria were all injured patients who had at least one of the following:hospital length of stay more than 24 h,death in hospital,and transfer from the intensive care unit of another *** collection was performed using the National Trauma Registry of Iran minimum ***:The most common injury mechanism was road traffic injuries(49.0%),followed by falls(25.5%).The mean age of those who fell was significantly higher in comparison with other mechanisms(p<0.001).Severe extremity injuries occurred more often in the fall group than in the vehicle collision group(69.0%vs.43.5%,p<0.001).Moreover,cases of severe multiple trauma were higher amongst vehicle collisions than injuries caused by falls(27.8%vs.12.9%,p=0.003).Conclusion:Comparing falls with motor vehicle collisions,patients who fell were older and sustained more extremity *** injured by motor vehicle collision were more likely to have sustained multiple trauma than those presenting with *** of the relationship between mechanisms and consequences of injuries may lead to more effective interventions.

关键词： Wounds and injuries Multiple trauma Abbreviated injury scale Injury severity score Registries

基于一类新型分子骨架构建具有AIE性能的荧光传感材料

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基于一类新型分子骨架构建具有AIE性能的荧光传感材料