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Assessment of laryngologists'ratings on physician review websites

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 1-6页

作者： Meleeka Akbarpour Karen Tawk Madelyn Frank Alizah S.Gomez Navid Mostaghni mehdi Abouzari Department of Otolaryngology-Head and Neck Surgery University of CaliforniaIrvineUSA

Objective:To assess and characterize online ratings and comments on laryngologists and determine factors that correlate with higher ***:All the American Laryngological Association(ALA)members were queried across several online *** were normalized for comparison on a five-point Likert *** were categorized based on context and for positive/negative ***:Of the 331 ALA members,256(77%)were rated on at least one online *** all platforms,the average overall rating was 4.39±0.61(range:1.00-5.00).Specific positive ratings including“bedside manners,”“diagnostic accuracy,”“adequate time spent with patient,”“appropriate follow-up,”and“physician timeliness”had significant positive correlations to overall ratings,by Pearson's correlation(P<0.001).Long wait times had significant negative correlations to overall ratings(P<0.001).Conclusion:Online ratings and comments for laryngologists are significantly influenced by patient perceptions of bedside manner,physician competence,and time spent with the patient.

关键词： laryngologist online rating patient rating physician review website

走滑断层对裂缝分布的控制——来自离散元数值模拟的启示

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中国科学：地球科学 2024年第1期54卷 152-171页

作者：曾联波毛哲刘国平田鹤姚迎涛祖克威董少群 mehdi OSTADHASSAN 中国石油大学(北京)油气资源与探测国家重点实验室北京102249 中国石油大学(北京)地球科学学院北京102249 北京大学能源学院北京100871 中国石化中原油田分公司勘探开发研究院郑州457001 东北石油大学大庆163318

走滑断层控制的缝洞储层是塔里木盆地超深层碳酸盐岩油气勘探的主要对象,走滑断层相关裂缝分布规律对指导超深层油气勘探开发具有重要意义.本文利用离散元数值模拟方法,对6组不同排列和活动方式的走滑断层相关裂缝发育规律进行了研究,... 详细信息

走滑断层控制的缝洞储层是塔里木盆地超深层碳酸盐岩油气勘探的主要对象,走滑断层相关裂缝分布规律对指导超深层油气勘探开发具有重要意义.本文利用离散元数值模拟方法,对6组不同排列和活动方式的走滑断层相关裂缝发育规律进行了研究,并与塔里木盆地北部地表露头区走滑断层实测结果进行了对比验证.走滑断层的纯走滑段应力分布稳定,其最大主应力保持水平,且方位不变,形成的优势裂缝走向与断层面呈小角度斜交.当走滑断层的叠接段或转折段为拉分区时,其最大主应力方位由水平变为垂直,形成的优势裂缝走向与断面大角度斜交.当走滑断层的叠接段或转折段为挤压区时,其最大主应力保持水平,但应力方位随断距增加而发生明显偏转.因而在走滑断层活动早期,主要发育与走滑断层呈小角度斜交的优势裂缝;在走滑断层活动后期,主要发育与主断面平行或者反向小角度相交的裂缝.在走滑断层的不同构造部位,裂缝发育程度存在明显差异.在走滑断层端部、连接部位和主断层面处裂缝相对发育,且前两者裂缝分布范围明显大于后者.相对于走滑断层的位移量,走滑断层的主位移带对裂缝发育的影响更大.在主位移带形成之前,走滑断层相关裂缝发育带宽度和裂缝密度随位移量的增加而快速增大,而在主位移带形成之后其增速显著降低.由于主位移带在拉分区和纯走滑段形成的时间要远早于挤压区,挤压区在主位移带形成之前吸收的应变量更大,因而挤压区裂缝最发育,其次是拉分区和纯走滑段.本文研究结果有助于认识不同排列和活动方式走滑断层相关裂缝发育规律.

关键词：走滑断层天然裂缝断层转折断层叠接主位移带离散元方法

Amyloid-beta and tau protein beyond Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine T.O.Nguyen David I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.Salekdeh Stuart L.Graham mehdi Mirzaei ProGene Technologies Pty Ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA School of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vision Sciences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia The Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVICAustralia School of Natural Sciences Macquarie UniversityMacquarie ParkNSWAustralia

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating ***,these two proteins are produced and expressed within the normal human ***,under pathological conditions,abnormal expression,posttranslational modifications,conformational changes,and truncation can make these proteins prone to aggregation,triggering specific disease-related *** studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as retinal neurodegenerative diseases like Glaucoma and age-related macular ***,these proteins have been linked to cardiovascular disease,cancer,traumatic brain injury,and diabetes,which are all leading causes of morbidity and *** this comprehensive review,we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration Tau traumatic brain injury

囊型包虫病流行现状及犬抗成虫疫苗候选抗原研究进展

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中国兽医学报 2024年第2期44卷 403-412页

作者：吴小霞鄂玉婷丁静刘晓雷 mehdi Borhani 王学林刘明远吉林大学动物医学学院人兽共患病研究所人兽共患病研究教育部重点实验室吉林长春130062

棘球蚴病/包虫病(cystic echinococcosis,CE)是一种全球性的人畜共患动物源性疾病,严重威胁人类和家畜的生命。由细粒棘球蚴引起的CE在我国高发流行,免疫接种是预防该病流行的最理想途径,在过去的几十年中,许多研究已经描述了该病的保... 详细信息

棘球蚴病/包虫病(cystic echinococcosis,CE)是一种全球性的人畜共患动物源性疾病,严重威胁人类和家畜的生命。由细粒棘球蚴引起的CE在我国高发流行,免疫接种是预防该病流行的最理想途径,在过去的几十年中,许多研究已经描述了该病的保护性候选抗原及其在终末宿主和中间宿主免疫中的作用。目前EG95重组蛋白疫苗效果最好,对中间宿主羊的保护力可达到96%~100%。但终末宿主犬作为传播的核心传染源,对其仍缺乏有效的防控手段,尤其是缺乏有效的接种疫苗,因此疫苗在犬身上的潜在应用是未来研究的重点。能抑制犬体内虫体发育并减少虫体在犬肠道内产卵量的疫苗研发将有望控制包虫病在流行地区的传播,大大加快该病的控制和消除。本研究从细粒棘球绦虫的生命周期、分子流行病学、地理分布以及终末宿主犬疫苗候选抗原等方面进行系统综述,旨在对CE的传播、未来发展方向和防治提供理论参考,为加速我国在CE终末宿主疫苗的研发进程和尽早应用于防控实践奠定基础。

关键词：棘球蚴病/包虫病细粒棘球绦虫流行病学候选抗原疫苗犬

Universal silicon ring resonator for error-free transmission links

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Photonics Research 2024年第4期12卷 701-711页

作者： JUNBO ZHU WEIWEI ZHANG KE LI BHARAT PANT MARTIN EBERT XINGZHAO YAN mehdi BANAKAR DEHN T.TRAN CALLUM G.LITTLEJOHNS FUWAN GAN GRAHAM REED DAVID J.THOMSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d B optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

New 4-imino-4H-Chromeno[2,3-d]Pyrimidin-3(5H)-Amine: Synthesis, Cytotoxic Effects on Tumoral Cell Lines and in Silico ADMET Properties

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International Journal of Organic Chemistry 2024年第3期14卷 107-122页

作者： Marwa Dhiabi Sirine Karoui mehdi Fakhfakh Souhir Abid Emmanuelle Limanton Rémy Le Guével Thierry Charlier Ludovic Paquin Jean-Pierre Bazureau Houcine Ammar Laboratoire de Chimie Applique: Htrocycles Corps et Polymres Facult des Sciences de Sfax Universit de Sfax Sfax Tunisie Institut des Sciences Chimiques de Rennes Universit de Rennes Campus de Beaulieu Rennes Cedex France Department of Chemistry (Science and Arts): Al Qurayat Al-Jouf University Al Jawf Saudi Arabia S2Wave Platform ScanMAT UAR CNRS Universit de Rennes Campus de Beaulieu Rennes Cedex France ImPACcell Platform Biosit SFR UMS CNRS Inserm Campus de Villejean Rennes France Institut de Recherche en Sant Environnement et Travail IRSET Inserm UMR_S Rennes France

The synthesis of new 4-imino-4H-chromeno[2,3-d]pyrimidin-3(5H)-amine in four steps including one step under microwave dielectric heating is reported. The structural identity of the synthesized compounds was established according to their spectroscopic analysis, such as FT-IR, NMR and mass spectroscopy. These new compounds were tested for their antiproliferative activities on seven representative human tumoral cell lines (Huh7 D12, Caco2, MDA-MB231, MDA-MB468, HCT116, PC3 and MCF7) and also on fibroblasts. Among them, only the compounds 6c showed micromolar cytotoxic activity on tumor cell lines (1.8 50 50 > 25 μM). Finally, in silico ADMET studies ware performed to investigate the possibility of using of the identified compound 6c as potential anti-tumor compound.

关键词： 2-Amino-4H-Chromene 4H-Chromeno[2 3-d]Pyrimidin-3(5H)-Amine Microwave Irradiation Tumoral Cell Line in Silico ADMET

A Study on Flame Forming of Bowl Shaped Surface with Various Spiral Irradiating Schemes

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Acta Mechanica Solida Sinica 2016年第3期29卷 328-336页

作者： mehdi Safari Department of Mechanical Engineering Arak University of Technology

In this paper, various strategies of spiral irradiating scheme for the flame forming of a bowl shaped surface are investigated experimentally and numerically. Experimental work is performed using a flame torch integrated with a 2-axis CNC workstation. The ABAQUS implicit solver is used in the numerical simulation. Three different strategies of the spiral irradiating scheme are investigated for the flame forming of a bowl shaped surface. The first strategy is the Simple spi- ral irradiating scheme, the second is the Rotational spiral irradiating scheme, and the third is the Symmetrical-Rotational spiral irradiating scheme. The results show that using the Symmetrical- Rotational spiral irradiating scheme, a bowl shaped surface with the maximum deformation can be produced, followed by using the Rotational scheme, and the Simple spiral scheme. It is also concluded from the results that the spiral irradiating scheme with Symmetrical-Rotational, Rota- tional and Simple spiral schemes lead to the maximum symmetries in the produced bowl shaped surface, respectively. All the numerical results are in good agreement with the experimental ob- servations.

关键词： flame forming bowl shaped surface spiral irradiating strategy

BLUNT CRACK-TIP ELASTOPLASTIC ZONE OF MIXED MODE FRACTURE

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Acta Mechanica Solida Sinica 2014年第5期27卷 531-541页

作者： mehdi Khojastehpour Department of Biosystems Engineering Ferdowsi University of Mashhad

This article discusses the characterization of fracture process zone at the tip of a blunt crack in elastoplastic materials under mixed mode loading. The analysis includes the description of elastoplastic zone geometry around the blunt crack tip for predicting crack growth direction. The deformed zone appearing at the crack front is described by presenting a criterion based on the subloading surface concept falling within the framework of unconventional plasticity. The mixed mode crack propagates along the minimum value of the elastoplastic region. The present solutions are reduced to those previously reported in literature, when the elastic perfectly plastic material is considered.

关键词： crack fracture elastic plastic materials stress concentration

Human reliability analysis in maintenance team of power transmission system protection

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Protection and Control of Modern Power Systems 2020年第1期5卷 290-302页

作者： mehdi Tavakoli mehdi Nafar Department of Electrical Engineering Marvdasht BranchIslamic Azad UniversityMarvdashtIran

The requirement for reliable electrical energy supply increases continuously because of its vital role in our ***,events due to various factors in the power grid can cause energy supply to be *** of these factors is human error and thus human reliability analysis is a serious element in the *** first step is to identify the roots of human error,on which there has been limited research in this *** this paper,the potential and actual causes of human error in maintenance teams of power transmission system protection are identified and predicted within a framework of human factors analysis and classification system ***,human error factors are ranked to help improve human *** proposed method is implemented in the Fars Electricity Maintenance Company.

关键词： Power transmission system protection Maintenance teams Human reliability HFACS method