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Effectiveness of Hand Care Therapy and Garden Walks That Are Conscious of the Stimulation of the Five Senses for Recovery of Cognitive and Mental and Physical Dysfunction Caused by COVID-19

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Open Journal of Therapy and Rehabilitation 2021年第1期9卷 10-27页

作者： Seigo Koura Akiko Ikeda Risa Semba megumi Ito Kazuho Nagao Kentaro Higashi Yusuke Kumura Hiroki Yokota Shinya Matsutani Yasuhiko Fujioka Faculty of Rehabilitation Nishikyusyu University Kanzaki Japan Sophia Phyto-Therapy College Tokyo Japan Social Welfare Corporation Kanjikai Miyakonojyo Japan Department of Rehabilitation Center St. Mary’s Hospital Kurume Japan Fujioka Hospital Saga Japan

The Japan Dementia Prevention Society conducted a questionnaire survey of dementia specialists conducted in August 2020. Regarding the worsening of symptoms in people with dementia, 8% answered that they “accept more” and 32% answered that they “recognize a minority”. In the previous research report (Open Journal of Therapy and Rehabilitation Vol.8 No.3), we examined whether hand care therapy (HCT) as one of the passive horticultural therapy was effective in preventing dementia/MCI. Start of the test in August 2018 (I: BL) to February 2020 (VII: 18M) was, the use of HCT was to be effective in preventing dementia and MCI illness and slowing progression. Due to the COVID19 pandemic, VIII (24M) was evaluated in August 2020, and IX (27M) also measured ANS during activity. At that time, they divided into the Group E who had refrained from welfare facilities for the elderly due to the influence of COVID19 and the Group F who HCT continued. In the evaluation of VIII (24M), it was found that the cognitive function of the Group E was significantly reduced compared to VII, and Group F did not show a significant decrease. ADL decreased and depressive symptoms increase by continuing a life with less going out due to the influence of COVID 19 regardless of the use of the facility. It became clear that both Group E and Group F show good changes in ANS balance in the IX. Therefore, by utilizing horticultural therapy that the power of nature and plants in addition to utilizing welfare facilities for the elderly, cognitive impairment in COVID 19. It was expected to lead to prevention and prevention of negative psychology and behavior such

关键词： Dementia MCI ANS Hand Care Prevention COVID-19

Pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion from an aortic intramural hematoma

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World Journal of Gastroenterology 2016年第16期22卷 4259-4263页

作者： Akihiko Sakatani Yoshinori Doi Toshiaki Kitayama Takaaki Matsuda Yasutaka Sasai Naohiro Nishida megumi Sakamoto Naoto Uenoyama Kazuo Kinoshita Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine Department of Gastroenterology Otemae Hospital Department of Radiology Otemae Hospital

Pancreaticoduodenal artery aneurysms are a rare type of visceral artery aneurysm, whose rupture is associated with high mortality. These aneurysms are of particular interest because local haemodynamic change caused by coeliac artery obstruction plays an important role in their development. However, the pathophysiological mechanism of coeliac artery obstruction is not completely understood. Pressure from the median arcuate ligament is most frequently reported cause. Although it is well-known that stenosis or occlusion of the visceral vessels may be caused by aortic syndrome, reports of pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion due to aortic syndrome are extremely rare. Our case indicates a new aetiology for a pancreaticoduodenal artery aneurysm and demonstrates the rapid deterioration of the patient affected.

关键词： Pancreaticoduodenal artery Coeliac artery Visceral artery aneurysm Aortic dissection

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甲基汞暴露对普通狨猴肾脏蛋白组的影响

甲基汞暴露对普通狨猴肾脏蛋白组的影响

Protracted anaphylaxis developed after peginterferon α-2a administration for chronic hepatitis C

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者：邵月婷蒋义国董薇 megumi Yamamoto Gleb Mironov Laurie H.MChan 广州医科大学公共卫生学院预防医学系加拿大渥太华大学生物系日本国家水俣病研究中心基础医学系

目的研究甲基汞暴露下普通狨猴肾脏蛋白组的变化特点,以及肾脏生物功能、细胞组分、信号转导通路及其相关蛋白的变化。方法普通狨猴(Callithrix jacchus)分别暴露于氯化甲基汞(1.5mg/kg,L-半胱氨酸),和非暴露组(给予同样体积的L-半胱氨... 详细信息

目的研究甲基汞暴露下普通狨猴肾脏蛋白组的变化特点,以及肾脏生物功能、细胞组分、信号转导通路及其相关蛋白的变化。方法普通狨猴(Callithrix jacchus)分别暴露于氯化甲基汞(1.5mg/kg,L-半胱氨酸),和非暴露组(给予同样体积的L-半胱氨酸)2周。继而停止给药2周,麻醉取材狨猴肾脏。LC-ESI-MS/MS鉴定蛋白质,两种生物信息学工具(Cytoscape与Webgestalt)对MeHg暴露和非暴露的狨猴肾脏蛋白组进行比较分析,通过搜索人源性数据库对显著变化的蛋白质进行分析。Immuno blot用于核实液相质谱结果。结果 MeHg暴露与非暴露组间蛋白质表达差异显著。共筛选出914个蛋白质,155个蛋白发生显著变化p<0.05(60个上调,29个下调)。Gene Ontology(GO)富集分析显示普通狨猴肾脏受MeHg影响的生物过程主要涉及甘油三酯生物合成过程,谷氨酰胺氨基酸生物合成、跨膜运输功能蛋白及蛋白水解(p<0.05);组分分析结果显示内吞小泡、液泡腔、质膜组分及内质网伴侣复合体为受MeHg影响的细胞器;转运蛋白活性、肽酶活性、特别是作用于L-氨基酸肽的肽酶活性、丝氨酸型内肽酶活性为受MeHg影响的分子功能(p<0.05)。KEGG信号通路富集分析结果显示肾脏受MeHg影响的主要信号通路分别为脂肪细胞因子信号通路、甘油脂代谢、维生素代谢及精氨酸生物合成(p<0.05)。Immunoblot结果显示与脂类代谢相关的ACLY蛋白,及抗氧化应激GPX-1蛋白含量的变化与质谱预测结果一致。结论 MeHg主要通过诱导氧化应激、引起脂质过氧化的形式损伤肾脏。甲基汞靶向肾脏的转运系统如囊泡、质膜、内膜系统。ACLY及ACSL1蛋白为受甲基汞暴露后肾脏损伤的重要蛋白。

关键词：甲基汞肾毒性普通狨猴 LC-ESI-MS/MS(液相色谱-电喷雾串联质谱)

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World Journal of Gastroenterology 2015年第9期21卷 2826-2829页

作者： Akihiko Sakatani Yoshinori Doi Takaaki Matsuda Yasutaka Sasai Naohiro Nishida megumi Sakamoto Naoto Uenoyama Yoshiya Matsumoto Kazuo Kinoshita Department of Gastroenterology and Hepatology Osaka University Graduate School of MedicineSuitaOsaka 565-0871Japan Department of Gastroenterology Otemae HospitalOsaka 540-0008Japan Department of Respiratory Medicine Otemae HospitalOsaka 540-0008Japan

Peginterferon is a key drug used to treat chronic viral hepatitis that is known for causing various side *** effects occurring immediately after administration include headache, nausea, and influenza-like symptoms, such as fever and joint ***, reports of anaphylactic shock are extremely *** we report a patient with protracted anaphylaxis who suffered shock symptoms after peginterferon α-2a administration for chronic hepatitis *** the patient improved temporarily with shock treatment, symptoms of anaphylaxis *** peginterferon is often administered on an outpatient basis, it is important to recognize life-threatening side effects that may develop in a protracted manner.

关键词： Peginterferon α-2a Anaphylaxis Anaphylactic shock

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表土中天然放射性核素含量与矿物组成的关系

辐射防护通讯 1991年第4期11卷 59-61页

作者： K.megumi 潘三铭

引言土壤中天然放射性核素的分布知识不仅对保健物理研究,而且对地质科学研究也是非常重要的。通常认为环境天然放射性主要取决于地质和地理条件,岩石中天然放射性主要取决于地质和地理条件。关于岩石中天然放射性核素浓度的地质特性有... 详细信息

引言土壤中天然放射性核素的分布知识不仅对保健物理研究,而且对地质科学研究也是非常重要的。通常认为环境天然放射性主要取决于地质和地理条件,岩石中天然放射性主要取决于地质和地理条件。关于岩石中天然放射性核素浓度的地质特性有许多报告,

关键词：土壤放射性核素矿物组成浓度

Regulation of Respiratory and Ligninolytic Enzyme Activity of Lentinula edodes by Selenium

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Advances in Microbiology 2013年第8期3卷 31-36页

作者： Regiane Goncalves Feitosa Leal Nunes Jose Maria Rodrigues da Luz Elizabete Fantuzzi Maria Catarina megumi Kasuya Maria Cristina Dantas Vanetti Instituto Federal de Educacao Ciência e Tecnologia do PiauíCampus Teresina CentralCentroTeresinaBrazil Department of Microbiology Federal University of VicosaVicosaBrazil Federal University of Alegre AlegreBrazil

The production of mushrooms enriched with essential elements, e.g. selenium, for human health is an interesting strategy to improve the functional foods supply. The selenium is an essential mineral and makes part of structure of enzymes involved in the oxidative metabolism. However, the selenium effect on the activity of respiratory and lignocellulolytic enzymes has not been considered. The understanding of this effect is important to determine the selenium concentration that increases the mushroom productivity and the degradation rate of the substrate. In this study, it was observed reduction of the respiratory activity of Lentinula edodes (Berk.) Pegler, the shiitake mushroom, in function of the increasing of the sodium selenite concentration in the substrate (p < 0.05). Selenium did not inhibit the activity of the hydrolytic enzymes (cellulase and xylanase), but it increased the activity of the oxidative enzyme (laccase). Respiratory activity of L. edodes has a negative correlation with sodium selenite concentration added in substrate. Thus is important to define the ideal dose of selenium to be added to the substrate for increasing lignocellulosic residues degradation and, consequently, guarantee a higher production of Se-enriched mushrooms.

关键词： Shiitake Laccase Se-Enriched Mushrooms Eucalypt Sawdust Lignocellulosic Residues

Healthcare Needs of the Elderly People over 85 Years Living Alone on the Island Area in Japan: A Descriptive Study

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Health 2018年第4期10卷 516-530页

作者： Osamu Hiramitsu Michiko Moriyama Kanae Osaki Ritsuko Sakamoto megumi Sakamoto Shoko Maeno Hidemi Sasaki Katm Ehsanul Huq Md Moshiur Rahman Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Health and Social Welfare Kure City Municipality Hiroshima Japan Graduate School of Nursing Hiroshima Bunka Gakuen University Hiroshima Japan

Background: Japan has the highest aging people accounting 33.8 million with the rate of 26.7% in 2015. Although, public long-term care insurance services support people age 40 years and above, most of the users are 85 years and over due to their more vulnerability for getting sick. This study describes the physical, mental and social status of the elderly people aged 85 years and over, who were living alone at home. Method: A cross-sectional study was conducted between November 2016 and March 2017 in the island of Kure city, Hiroshima, Japan. A structured questionnaire and scales were used for data collection and documentation of physical measurements. Descriptive analysis was used. Result: A total of 190 subjects were participated, and the data were analyzed. The age range of the subjects was 85 to 98 years, and 68.4% of them were 85 to 89 years old. Male and female ratio was 21.6% vs 78.4%. Subjects of 17.4% continued their occupation at the time of the study period and most of them involved in agricultural work (93.9%). A certain percentage of the subjects had abnormal physical, mental and social difficulties and need additional support from family, friends, relatives, and community. Conclusion: Early detection and intervention such as disease management, nutritional support, and human support are required. The findings suggested policy makers to predict the burden and provide necessary care for these elderly people. It is necessary to aware family, friends, relatives, community and government supporting staff to provide information on correct recognition and usages of long-term care insurance services for these elder people.

关键词： Elderly Living Alone Long-Term Care Insurance Japan

Oncofertility in Gynecologic Malignant Tumors

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Journal of Cancer Therapy 2015年第14期6卷 1176-1191页

作者： Masataka Adachi Kouji Banno Iori Kisu megumi Yanokura Moito Iijima Takashi Takeda Kiyoko Umene Yuya Nogami Eiichiro Tominaga Daisuke Aoki Department of Obstetrics and Gynecology Keio University School of Medicine Tokyo Japan

Long-term survival is the priority in treatment of patients with malignant tumors. In the field of gynecology, fertility preservation has also recently become an important objective due to improved treatment outcomes and different needs of patients. Methods for fertility preservation include cervical conization, ovarian protection against radiation or chemotherapy for ovarian cancer since the ovary is hypersensitive to cancer therapies, treatment of gynecological cancer during pregnancy, and cryopreservation of oocytes, embryos or ovarian tissue before treatment of malignant tumors. Radical trachelectomy for early cervical cancer and treatment with medroxy progesterone acetate for early endometrial carcinoma are also options for fertility preservation, but the efficacy and risk of recurrence have yet to be fully evaluated. The first childbirth following uterine transplantation was also achieved last year and this success has expanded the potential for pregnancy and delivery among cancer survivors.

关键词： Gynecological Cancer Fertility Preservation Cryopreservation Uterine Transplantation Pregnancy

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圣诞之星是否存在

Newton-科学世界 2004年第12期 36-41页

作者： megumi Hara Pier Andrea Canei 曹金刚

圣诞夜最明亮的同时也是最神秘的象征——《马太福音》叙述过它，乔托画过它，天文学家开普勒研究过它。它将帮助人们揭开耶稣诞生目的秘密。

关键词：存在耶稣《马太福音》秘密帮助目的圣诞诞生天文学家叙述