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A parameter uniform essentially firsorder convergent numerical method for a parabolic system of singularly perturbed differential equations of reaction—diffusion type with initial and Robin boundary conditions

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International Journal of Biomathematics 2019年第1期12卷 1-31页

作者： R.Ishwariya J.J.H.miller s.Valarmathi Department of Mathematics Bishop Heber College TiruchirappalliTamil NaduIndia Institute for Numerical Computation and A nalysis Dublin Ireland

In this paper,a class of linear parabolic systems of singularly perturbed second-order differential equations of reaction-diffusion type with initial and Robin boundary conditions is *** components of the solution u→ of this system are smooth,whereas the components of αu→/αx exhibit parabolic boundary layers.A numerical method composed of a classical finite difference scheme on a piecewise uniform shishkin mesh is *** method is proved to be first-order convergent in time and essentially first-order convergent in the space variable in the maximum norm uniformly in the perturbation parameters.

关键词： singular perturbations boundary layers linear parabolic differential equations Robin boundary conditions finite difference schemes shishkin meshes parameter uniform convergence

Phytochemical constituents and antibacterial efficacy of the flowers of Peltophomm pterocarpum(DC.) Baker ex Heyne

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Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 735-738页

作者： sukumaran s Kiruba s Mahesh M Nisha sR miller Paul Z Ben CP Jeeva s Centre for Biodiversity and Biotechnology Department of BotanyN.M.Christian College.Marthandam.Kanyakumari-629 165.Tamilnadu.India Department of Zoology Scott Christian College(Autonomous)NagercoilKanyakumari - 629 003.TamilnaduIndia Centre for Biodiversity and Biotechnology Department of BotanyN.M.Christian College.MarthandumKanyakumari - 629 165.TomilnaduIndia

Objective:To investigate the preliminary phytochemistry and antibacterial activity of the flower extract of Peltophorum ***:Phytochemical analysis was done by using the standard methods given by *** methanolic flower extract were tested against Escherichia coli,Klebsiella pneumonia,Pseudomonas *** aureus. Bacillus cereus,salmonella typhi,serratia marsecens,Acinetobacter *** sp., Proteus *** faecalis and streptococcus pyogenes by the agar disc diffusion ***:Preliminary phytochemical screening of flower extract showed the presence of phenolic compounds,***,steroids,tannins,xanthoproteic,carboxylic acids, coumarins and *** flower extract of Peltophorum pteroearpum showed significant activity against four gram positive(staphylococcus *** *** faecalis and streptococcus pyogenes) and three gram negative bacteria(Proteus mirabilis,Acinetohacter baumannii and serratia marsecens).out of 12 pathogenic bacteria ***:The findings of the present study confirm the presence of significant antibacterial activity against human pathogens in the flowers of Peltophorum pleracarpum.

关键词： Antibacterial activity Human pathogens Peltophorum pterocarpum Phytochemical screening

The Future of Artificial Intelligence for Alzheimer’s Disease Diagnostics

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Advances in Alzheimer's Disease 2021年第4期10卷 53-59页

作者： Robert Logan sabrina s. Zerbey sean J. miller Pluripotent Diagnostics Molecular Medicine Research Institute Sunnyvale CA USA Department of Biology Eastern Nazarene College Quincy MA USA

Alzheimer’s disease (AD) is a leading cause of death, yet there is no disease-modifying drug therapy currently available. It is critical to establish a diagnosis of AD before clinical system onset so that drug therapies can start earlier. Unfortunately, this is not the current standard practice. Artificial intelligence (AI) holds tremendous promise for identifying AD related structural changes in brain scan images. This paper discusses the recent applications and potential future directions for AI in AD diagnostics. Annual brain scanning and computer vision-assisted early diagnosis is encouraged, so that disease-modifying drug therapy could begin earlier in the progressive pathology.

关键词： Artificial Intelligence Convolutional Neural Network Disease Detection Neu-rodegeneration Alzheimer’s Disease

Islands of misfit buildings: Detecting uncharacteristic electricity use behavior using load shape clustering

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Building simulation 2021年第1期14卷 119-130页

作者： Matias Quintana Pandarasamy Arjunan Clayton miller National University of singapore SingaporeSingapore Berkeley Education Alliance for Research in singapore(BEARs) SingaporeSingapore

Many energy performance analysis methodologies assign buildings a descriptive label that represents their main activity,often known as the primary space usage(PsU).This attribute comes from the intent of the design team based on assumptions of how the majority of the spaces in the building will be *** reality,the way a building’s occupants use the spaces can be different than what was *** the recent growth of hourly electricity meter data from the built environment,there is the opportunity to create unsupervised methods to analyze electricity consumption behavior to understand whether the PsU assigned is *** or oversimplification of the use of the building is possible using these labels when applied to simulation inputs or benchmarking *** work towards accurate characterization of a building’s utilization,we propose a modular methodology for identifying potentially mislabeled buildings using distance-based clustering analysis based on hourly electricity consumption *** method seeks to segment buildings according to their daily behavior and predict which ones are misfits according to their assigned PsU *** process finds potentially uncharacteristic behavior that could be an indication of mixed-use or a misclassified *** results on two public data sets,from the Building Data Genome(BDG)Project and Washington DC(DGs),with 507 and 322 buildings respectively,show that 26%and 33%of these buildings are potentially mislabelled based on their load shape *** information provides a more realistic insight into their true consumption characteristics,enabling more accurate simulation *** of this process and a discussion of limitations and reproducibility are included.

关键词： uncharasteristic behaviour building energy use building energy benchmarking building performance rating primary-use-type analysis load profile clustering

Analysis of roof and pillar failure associated with weak floor at a limestone mine

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International Journal of Mining science and Technology 2016年第3期26卷 471-476页

作者： Murphy Michael M. Ellenberger John L. Esterhuizen Gabriel s. miller Tim Office of Mine safety and Health Research National Institute of Occupational Safety and Health East Fairfield Company

A limestone mine in Ohio has had instability problems that have led to massive roof falls extending to the surface. This study focuses on the role that weak, moisture-sensitive floor has in the instability *** NIOsH research related to this subject did not include analysis for weak floor or weak bands and recommended that when such issues arise they should be investigated further using a more advanced analysis. Therefore, to further investigate the observed instability occurring on a large scale at the Ohio mine, FLAC3 D numerical models were employed to demonstrate the effect that a weak floor has on roof and pillar stability. This case study will provide important information to limestone mine operators regarding the impact of weak floor causing the potential for roof collapse, pillar failure, and subsequent subsidence of the ground surface.

关键词： Underground limestone Ground control Case study Weak floor Instability

Highly Fluorescent Dye-Doped silica Nanoparticles Increase Flow Cytometry sensitivity for Cancer Cell Monitoring

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Nano Research 2009年第6期2卷 448-461页

作者： M.-Carmen Estévez meghan B.OʼDonoghue Xiaolan Chen Weihong Tan Center for Research at the Bio/Nano Interface Departments of Chemistry and Department of Physiology and Functional GenomicsShands Cancer Center and UF Genetics InstituteMcKnight Brain InstituteUniversity of FloridaGainesvilleFlorida 32611-7200USA

Early and accurate diagnosis and treatment of cancer depend on rapid,sensitive,and selective detection of tumor *** diagnosis of cancers,especially leukemia,relies on histology and fl ow cytometry using single dye-labeled ***,this combination may not lead to high signal output,which can hinder detection,especially when the probes have relatively weak affi nities or when the receptor is expressed in a low concentration on the target cell *** solve these problems,we have developed a novel method for sensitive and rapid detection of cancer cells using dye-doped silica nanoparticles(NPs)which increases detection sensitivity in fl ow cytometry analyses between 10-and 100-fold compared to standard *** NPs are~60 nm in size and can encapsulate thousands of individual dye molecules within their *** have extensively investigated surface modifi cation strategies in order to make the NPs suitable for selective detection of cancer cells using fl ow *** NPs are functionalized with polyethylene glycol(PEG)to prevent nonspecifi c interactions and with neutravidin to allow universal binding with biotinylated *** virtue of their reliable and selective detection of target cancer cells,these NPs have demonstrated their promising usefulness in conventional fl ow ***,they have shown low background signal,high signal enhancement,and effi cient functionalization,either with antibody-or aptamer-targeting moieties.

关键词： silica nanoparticle flow cytometry aptamer cell detection polyethylene glycol fl uorophore

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António J.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

International Collaborations In Geodesy Advance Geoscience Research

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Acta Geologica sinica(English Edition) 2017年第S1期91卷 23-页

作者： M.meghan miller UNAVCO BoulderCOUnited States of America

UNAVCO supports geoscience research at 113 Us academic Member institutions,and another 104 Associate Member institutions include international universities,laboratories,observatories,academies of science,and a *** diverse membership shares UNAVCO’s purpose at home and abroad,giving UNAVCO global reach in advancing *** the mid-1980s,modern geodesy has evolved into a cutting-edge,multi-faceted toolbox with remarkably diverse research and real-world applications,including studies and observation or forecasting of solid-Earth hazards,the dynamics of the atmosphere,climate,near-Earth space environment,and of key environmental parameters such as water storage,soil moisture,and seaand lake-level *** operates facilities on behalf of the *** science Foundation to support investigators who use geodetic tools across all of these Earth and atmospheric *** has built a number of large dense regional networks of GPs stations,including the Earth scope Plate Boundary Observatory in North America,the COCONetCaribbean network,TLALOCNet in Mexico,GNET in Greenland,and ANET in *** forward,UNAVCO plans to federate the Plate Boundary Observatory(UsA),TLALOCNet(Mexico),and COCONet(Caribbean)GPs networks as the Network of the Americas,with upgrades to state-of-the-art,multi-sensor,multi-GNss *** UNAVCO community scientists actively engage in using space and terrestrial geodetic techniques to study geodynamics at all scales,this proliferation of continuous networks is the basis for a suite of recent contributions that focus on improved daily positioning to sense Earth’s elastic response and other perturbations to loading by atmospheric and surface water,oceans,and ***-to-day and sub-daily variations in the GPs vertical and horizontal correlate to increasingly well-understood short-term mass variability,such as monsoonal flooding in Bangladesh,sub-daily changes in tidal loading at continent scales,day-to-day surf

关键词： International Collaborations In Geodesy Advance Geoscience Research

systematic review of periprosthetic tibia fracture after total knee arthroplasties

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World Journal of Orthopedics 2015年第8期6卷 649-654页

作者： Nabil A Ebraheim Joseph R Ray meghan E Wandtke Grant s Buchanan Chris G sanford Jiayong LiuZ Department of Orthopaedic surgery University of Toledo Medical Center

AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODs: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall ***: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUsION: Type 1 fractures were the most common. subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively.

关键词： Periprosthetic fractures Literature review Tibia fractures