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First complete genome sequence in Arborophila and comparative genomics reveals the evolutionary adaptation of Hainan Partridge(Arborophila ardens)

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Avian Research 2019年第1期10卷 63-70页

作者： Chuang Zhou Shuai Zheng Xue Jiang Wei Liang megan price Zhenxin Fan Yang Meng Bisong Yue Key Laboratory of Bioresources and Ecoenvironment(Ministry of Education) College of Life SciencesSichuan University Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife College of Life SciencesSichuan University Ministry of Education Key Laboratory for Ecology of Tropical Islands College of Life SciencesHainan Normal University

Background:The Hainan Partridge(Arborophila ardens,Phasianidae,Galliformes) is an endemic species of Hainan Island,China,and it is classified as globally vulnerable *** are at least 16 species in genus Arborophila and no genome sequence is ***:The whole genome of Hainan Partridge was de novo sequenced(with shotgun approach on the Illumina 2000 platform) and ***:The genome size of Arborophila ardens is about 1.05 Gb with a high N50 scaffold length of 8.28 Mb and it is the first high quality genome announced in Arborophila *** 9.19% of the genome was identified as repeat sequences and about 5.88 million heterozygous SNPs were detected.A total of 17,376 protein-coding genes were predicted and their functions were *** genome comparison between Hainan Partridge and Red Junglefowl(Gallus gallus) demonstrated a conserved genome *** phylogenetic analysis indicated that the Hainan Partridge possessed a basal phylogenetic position in Phasianidae and it was most likely derived from a common ancestor approximately 36.8 million years ago(Mya).We found that the Hainan Partridge population had experienced bottleneck and its effective population decreased from about 1,040,000 individuals 1.5 Mya to about 200,000 individuals 0.2 Mya,and then recovered to about 460,000 *** number of 1:1 orthologous genes that were predicted to have undergone positive selection in the Hainan Partridge was 504 and some environmental adaptation related categories,such as response to ultraviolet radiation were represented in GO distribution ***:We announced the first high quality genome in Arborophila genus and it will be a valuable genomic resource for the further studies such as evolution,adaption,conservation,not only on Hainan Partridge but also on Arborophila or Phasianidae species.

关键词： Hainan Partridge Arborophila ardens Comparative genomics Positive selection

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Genome-wide analysis reveals signatures of complex introgressive gene flow in macaques(genus Macaca)

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Zoological Research 2021年第4期42卷 433-449页

作者： Yang Song Cong Jiang Kun-Hua Li Jing Li Hong Qiu megan price Zhen-Xin Fan Jing Li Key Laboratory of Bio-resources and Eco-environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuan 610064China Institute of Animal Genetics and Breeding College of Animal Science and TechnologySichuan Agricultural UniversityChengduSichuan 611130China Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife College of Life SciencesSichuan UniversityChengduSichuan 610064China

The genus Macaca serves as an ideal research model for speciation and introgressive gene flow due to its short period of diversification(about five million years ago)and rapid radiation of constituent *** understand evolutionary gene flow in macaques,we sequenced four whole genomes(two *** and two ***)and combined them with publicly available macaque genome data for genome-wide *** analyzed 14 individuals from nine Macaca species covering all Asian macaque species groups and detected extensive gene flow signals,with the strongest signals between the fascicularis and silenus species ***,we detected bidirectional gene flow between *** and *** estimated proportion of the genome inherited via gene flow between the two species was 6.19%.However,the introgression signals found among studied island species,such as Sulawesi macaques and ***,and other species were largely attributed to the genomic similarity of closely related species or ancestral ***,gene flow signals varied in individuals of the same species(***,***,***,*** and ***),suggesting very recent gene flow after the populations *** sequentially Markovian coalescence(PSMC)analysis showed all macaques experienced a bottleneck five million years ago,after which different species exhibited different fluctuations in demographic history trajectories,implying they have experienced complicated environmental variation and climate *** results should help improve our understanding of the complicated evolutionary history of macaques,particularly introgressive gene flow.

关键词： Macaca Whole genome Introgression Gene flow Demographic history

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Genomics and morphometrics reveal the adaptive evolution of pikas

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Zoological Research 2022年第5期43卷 813-826页

作者： Rui-Xiang Tang Jiao Wang Yi-Fei Li Cheng-Ran Zhou Guan-Liang Meng Feng-Jun Li Yue Lan megan price Lars Podsiadlowski Yan Yu Xu-Ming Wang Yin-Xun Liu Bi-Song Yue Shan-Lin Liu Zhen-Xin Fan Shao-Ying Liu Key Laboratory of Bioresources and Ecoenvironment(Ministry of Education) College of Life SciencesSichuan UniversityChengduSichuan 610065China Sichuan Academy of Forestry ChengduSichuan 610081China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of PediatricsWest China Second University HospitalSichuan UniversityChengduSichuan 610041China BGI-Shenzhen ShenzhenGuangdong 518083China Zoological Research Museum Alexander Koenig Bonn D-53113Germany Department of Entomology China Agriculture UniversityBeijing 100193China Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife College of Life SciencesSichuan UniversityChengduSichuan 610065China

Pikas(Lagomorpha: Ochotonidae) are small mouselike lagomorphs. To investigate their adaptation to different ecological environments during their dispersal from the Qinghai-Xizang(Tibet) Plateau(QTP), we collected 226 pikas and measured 20 morphological characteristics and recorded habitat information. We also sequenced the genome of 81specimens, representing 27 putative pika *** genome-wide tree based on 4?090 coding genes identified five subgenera, i.e., Alienauroa, Conothoa,Lagotona, Ochotona, and Pika, consistent with morphometric data. Morphologically, Alienauroa and Ochotona had similar traits, including smaller size and earlier divergence time compared to other ***, the habitats of Alienauroa and Ochotona differed from those of the remaining subgenera. Phylogenetic signal analysis detected 83 genes significantly related to morphological characteristics, including several visual and hearingrelated genes. Analysis of shared amino acid substitutions and positively selected genes(PSGs) in Alienauroa and Ochotona identified two genes, i.e.,mitochondrial function-related TSFM(p.Q155E) and low-light visual sensitivity-related PROM1(p.H419Y).Functional experiments demonstrated that TSFM-155E significantly enhanced mitochondrial function compared to TSFM-155Q in other pikas, and PROM1-419Y decreased the modeling of dynamic intracellular chloride efflux upon calcium uptake. Alienauroa and Ochotona individuals mostly inhabit different environments(e.g., subtropical forests) than other pikas, suggesting that a shift from the larger ancestral type and changes in sensory acuity and energy enhancement may have been required in their new environments. This study increases our understanding of the evolutionary history of pikas.

关键词： Pikas Genomics Morphometrics Adaptive evolution Sensory and energy functions

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Effects of aging on gene expression in blood of captive Tibetan macaques (Macaca thibetana) and comparisons with expression in humans

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Zoological Research 2020年第5期41卷 557-563页

作者： Chao-Chao Yan Xin-Shang Zhang Liang Zhou Qiao Yang Min Zhou Lin-Wan Zhang Jin-Chuan Xing Zhi-Feng Yan megan price Jing Li Bi-Song Yue Zhen-Xin Fan Key Laboratory of Bioresources and Eco-environment(Ministry of Education) College of Life SciencesSichuan UniversityChengduSichuan 610065China Institute of Laboratory Animal Sciences Sichuan Academy of Medical Sciences&Sichuan Provincial People's HospitalChengduSichuan 610212China Department of Genetics RutgersState University of New JerseyPiscatawayNew Jersey 08854USA

DEAR EDITOR,Changes in gene expression occur as animals,including primates,*** have long been used as a model species for primate evolution and biomedical ***,to study gene expression in Tibetan macaques (Macaca thibe... 详细信息

关键词： Tibetan blood aging

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Acetabular cup size trends in total hip arthroplasty

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World Journal of Orthopedics 2024年第1期15卷 39-44页

作者： Daniel Patrick McKenna Alex price Timothy McAleese Darren Dahly Paul McKenna May Cleary Department of Trauma and Orthopaedics University Hospital WaterfordWaterford X91 ER8EIreland Department of Epidemiology and Public Health University College CorkCork T12 XF62Ireland

BACKGROUND Total hip arthroplasty(THA)is a common procedure for end stage *** learning curve for THA is complex and *** of the most difficult skills to master is acetabular *** wish to identify if experience in arthroplasty leads to preservation of more bone *** To investigate if increasing surgeon experience will predict an ever decreasing acetabular cup *** A retrospective case series of four attending orthopaedic surgeons was *** uncemented elective total hip arthroplasties since appointment were selected for *** size of acetabular cup used was noted and logistic regression was used to identify if a trend to smaller cups *** A total of 1614 subjects were included with a mean age of 64 *** cups were on average 0.18mm smaller per year(95%confidence interval-0.25 to-0.11,P<0.001).Individual surgeon trends showed cup sizes to decrease 0.27 mm/year for surgeon A,0.02 mm/year for surgeon B,0.15 mm/year for surgeon C and 0.29 mm/year for surgeon *** of the four surgeons had a more pronounced trend to smaller cups for male subjects than their female *** We found increasing surgeon experience to be associated with an ever-decreasing acetabular cup *** acetabular cup size may act as a surrogate marker of surgical proficiency by virtue of decreased acetabular reaming.

关键词： Hip Arthroplasty Acetabulum Cup Learning

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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen Maria price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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乐趣是健康生活的秘诀（英文）

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英语画刊(高中版) 2024年第1期 3-5页

作者： Catherine price

你每天都有在享受快乐吗?科学记者凯瑟琳·普莱斯认为:享乐不仅是一种快乐的体验,而且对你的健康和幸福也至关重要。在下面的演讲中,她提出了一个新的关于享乐的定义,并分享了一些简单而又可靠的将乐趣融入日常生活的方法。So in realit...

你每天都有在享受快乐吗?科学记者凯瑟琳·普莱斯认为:享乐不仅是一种快乐的体验,而且对你的健康和幸福也至关重要。在下面的演讲中,她提出了一个新的关于享乐的定义,并分享了一些简单而又可靠的将乐趣融入日常生活的方法。So in reality,fun is not just lighthearted pleasure.

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霉菌毒素如何威胁家禽健康和生产性能

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国外畜牧学（猪与禽） 2024年第1期44卷 41-43页

作者： Kayla price Alexandra Weaver 蔡霞(译) 范美红(校) 李红(审) 不详

霉菌毒素是霉菌在受到应激或环境刺激时产生的代谢物。霉菌毒素一旦产生,就会非常稳定,在作物的整个收获、储存、加工和饲喂过程中都会残留在饲料中,对蛋鸡、种鸡和肉鸡都会造成危害。不同的霉菌会产生不同的霉菌毒素,这些霉菌毒素会影... 详细信息

霉菌毒素是霉菌在受到应激或环境刺激时产生的代谢物。霉菌毒素一旦产生,就会非常稳定,在作物的整个收获、储存、加工和饲喂过程中都会残留在饲料中,对蛋鸡、种鸡和肉鸡都会造成危害。不同的霉菌会产生不同的霉菌毒素,这些霉菌毒素会影响家禽的健康和生产性能。霉菌毒素污染是可控的,但必须采取从田间到农场的综合方法。

关键词：霉菌霉菌毒素家禽生产性能控制

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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Secondary steady-state and time-periodic flows from a basic flow with square array of odd number of vortices

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Applied Mathematics and Mechanics(English Edition) 2023年第3期44卷 447-458页

作者： Zhimin CHEN W.G.price School of Mathematics and Statistics Shenzhen UniversityShenzhen 518060Guangdong ProvinceChina Ship Science University of SouthamptonSouthampton SO171BJU.K.

In a magnetohydrodynamic(MHD)driven fluid cell,a plane non-parallel flow in a square domain satisfying a free-slip boundary condition is *** energy dissipation of the flow is controlled by the viscosity and linear *** latter arises from the influence of the Hartmann bottom boundary layer in a three-dimensional(3D)MHD experiment in a square bottomed *** basic flow in this fluid system is a square eddy flow exhibiting a network of N~2 vortices rotating alternately in clockwise and anticlockwise *** N is odd,the instability of the flow gives rise to secondary steady-state flows and secondary time-periodic flows,exhibiting similar characteristics to those observed when N=*** this reason,this study focuses on the instability of the square eddy flow of nine *** is shown that there exist eight bi-critical values corresponding to the existence of eight neutral eigenfunction ***,there exist non-real neutral eigenfunctions,which produce secondary time-periodic flows exhibiting vortices merging in an oscillatory *** Hopf bifurcation phenomenon has not been observed in earlier investigations.

关键词： two-dimensional(2D)Navier-Stokes equation non-parallel square vortex flow primary bifurcation secondary steady-state flow secondary time-periodic flow

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