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Ambient synthesis, characterization, and electrochemical activity of LiFePO4 nanomaterials derived from iron phosphate intermediates

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Nano Research 2015年第8期8卷 2573-2594页

作者： Jonathan M. Patete megan E. Scofield Vyacheslav Volkov Christopher Koenigsmann Yiman Zhang Amy C. Marschilok Xiaoya Wang Jianming Bai Jinkyu Han Lei Wang Feng Wang Yimei Zhu Jason A. Graetz Stanislaus S. Wong Department of Chemistry State University of New York at Stony Brook Stony Brook NY 77794-3400 USA Condensed Matter Physics and Materials Sciences Department Building 480 Brookhaven National Laboratory Upton NY 11973 USA Department of Materials Science and Engineering State University of New York at Stony Brook Stony Brook NY 11794-2275 USA Sustainable Energy Technologies Department Building 815 Brookhaven National Laboratory Upton NY 11973 USA National Synchrotron Light Source II Building 741 Brookhaven National Laboratory Upton NY 11973 USA

LiFePO4 materials have become increasingly popular as a cathode material due to the many benefits they possess including thermal stability, durability, low cost, and long life span. Nevertheless, to broaden the general appeal of this material for practical electrochemical applications, it would be useful to develop a relatively mild, reasonably simple synthesis method of this cathode material. Herein, we describe a generalizable, 2-step methodology of sustainably synthesizing LiFePO4 by incorporating a template-based, ambient, surfactantless, seedless, U-tube protocol in order to generate size and morphologically tailored, crystalline, phase-pure nanowires. The purity, composition, crystallinity, and intrinsic quality of these wires were systematically assessed using transmission electron microscopy （TEM）, high-resolution TEM （HRTEM）, scanning electron microscopy （SEM）, X-ray diffraction （XRD）, selected area electron diffraction （SAED）, energy dispersive analysis of X-rays （EDAX）, and high-resolution synchrotron XRD. From these techniques, we were able to determine that there is an absence of any obvious defects present in our wires, supporting the viability of our synthetic approach. Electrochemical analysis was also employed to assess their electrochemical activity. Although our nanowires do not contain any noticeable impurities, we attribute their less than optimal electrochemical rigor to differences in the chemical bonding between our LiFePO4 nanowires and their bulk-like counterparts. Specifically, we demonstrate for the first time experimentally that the Fe-O3 chemical bond plays an important role in determining the overall conductivity of the material, an assertion which is further supported by recent ＂first-principles＂ calculations. Nonetheless, our ambient, solution-based synthesis technique is capable of generating highly crystalline and phase-pure energy-storage-relevant nanowires that can be tailored so as to fabricate different sized materials of repro

关键词： ambient synthesis template synthesis cathode material lithium iron phosphate nanostructures

利用CRISPR/Cas9系统建立斑马鱼Morn3基因敲除模型

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重庆医科大学学报 2018年第11期43卷 1449-1452页

作者：曾婧刘晗李为 Hept megan Lister James A 张玲张志兵武汉科技大学医学院公共卫生学院"职业危害识别与控制"湖北省重点实验室武汉430065 Department of Obstetrics & Gynecology Wayne State University Departments of Human & Molecular Genetics Virginia Commonwealth University

目的:采用高效基因编辑系统CRISPR/Cas9对斑马鱼的Morn3基因进行编辑,以期建立Morn3基因敲除斑马鱼模型。方法:针对斑马鱼Morn3基因用生物信息学选取靶位点,构建gRNA表达载体并体外转录,将gRNA和Cas9mRNA混合物显微注射到斑马鱼单细胞... 详细信息

目的:采用高效基因编辑系统CRISPR/Cas9对斑马鱼的Morn3基因进行编辑,以期建立Morn3基因敲除斑马鱼模型。方法:针对斑马鱼Morn3基因用生物信息学选取靶位点,构建gRNA表达载体并体外转录,将gRNA和Cas9mRNA混合物显微注射到斑马鱼单细胞期的受精卵中,24~48 h提取基因组DNA,PCR扩增出目的片段,限制性酶切法初步检测基因打靶情况,最后进行测序分析确定编辑效果。结果:取3个靶位点(M1、M2、M3)进行试验,选择gRNA浓度较高的M2和M3进行注射。限制性酶切及测序的结果显示M3已产生基因编辑效应。结论:本研究通过CRISPR/Cas9系统成功获得Morn3基因编辑的突变体,为进一步探讨Morn3基因的作用提供研究基础。

关键词： CRISPR/Cas9 Morn3 斑马鱼基因编辑

在重症监护、急诊及围手术期情境下,非注意盲视与病情恶化患者的抢救失败:4例病案报告

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中国护理管理 2017年第7期17卷 1008-1008页

作者： Angela Jones megan-Jane Johnstone 迪肯大学护理和助产学院

背景:对临床恶化的识别和应对失败,是考核患者安全、医院绩效和护理质量的重要标准。虽然已有研究明确了患者、医院系统和人为因素在抢救失败的病案中的作用,但作为一个可能的影响因素,非注意盲视的作用被忽视了。目的:在重症护理、急... 详细信息

背景:对临床恶化的识别和应对失败,是考核患者安全、医院绩效和护理质量的重要标准。虽然已有研究明确了患者、医院系统和人为因素在抢救失败的病案中的作用,但作为一个可能的影响因素,非注意盲视的作用被忽视了。目的:在重症护理、急诊和围手术期护理情境下,探讨非注意盲视的特性和对患者安全的影响。方法:从自然调研中选择了4例病案,分析护士如何识别和管理护理间隙(不连续性)。通过深入访谈采集数据,访谈的目标样本为71名护士,其中20名为重症护理护士,19名为急诊护士,16名为围手术期护士。以非注意盲视的角度,完成病案的鉴别、选择和分析。结果 :本文报告的4例病案提示,当患者的观测指标已提示临床恶化时,未能识别和处理,这可以用非注意盲视来解释。对本文报道的全部病案(1例除外),所有生命体征都进行了定期测量和记录。但是,医护团队未能"看到"临床恶化的早期征象。这些病案发生的临床环境极具压力和复杂性,伴随着高认知工作负荷、噪音和频繁干扰,为非注意盲视创造了条件。结论 :本报告涉及的病案提出了在危重医疗范围内,对抢救失败的病例来说,非注意盲视是一个突出的但被忽视的人为因素的可能性。进一步的学科交叉比较研究,可以确保更好地理解非注意盲视在重症监护情境下的特性及其对患者安全的可能的影响。

关键词：重症监护室急诊科卫生保健抢救失败人因工程非注意盲视护士患者安全围手术期

Evaluation of Insulin Infusion Rates for the Treatment of Diabetic Ketoacidosis in the Emergency Department

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Journal of Biosciences and Medicines 2022年第3期10卷 203-211页

作者： megan E. Bass Nicole Paavola Tyree H. Kiser Garth Wright Gabrielle Jacknin Department of Clinical Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Aurora CO USA Department of Pharmacy UCHealth University of Colorado Hospital Aurora CO USA

Introduction: There is minimal literature to support the appropriate dosing for the initiation of IV regular insulin therapy in DKA patients. A 0.1 unit/kg bolus followed by 0.1 units/kg/hour or 0.14 units/kg/hour is commonly utilized and recommended in guidelines. Objective: We sought to assess clinical and safety outcomes associated with various insulin infusion starting doses in patients diagnosed with DKA in the emergency department in an effort to help guide prescribing. Methods: A retrospective cohort study was conducted within an academic emergency department and included patients who received continuous infusion regular insulin with an ICD-10 code for DKA between January 2016 and January 2019. A predictive regression model was applied to test if predefined lab values influenced the starting insulin infusion rates. Clinical and safety outcomes were evaluated by starting insulin infusion rate. Data was analyzed based on starting insulin infusion rates. Results: 347 patients met inclusion criteria with 92 (26.5%) patients receiving Conclusion: Glucose levels significantly influenced the insulin starting infusion rate, with no identified differences in adverse effects or clinical outcomes.

关键词： Diabetic Ketoacidosis Regular Insulin Intravenous Insulin Dose Infusion Rates

Neither autophagy nor exercise training mode affect exercise-induced beneficial adaptations in high fat-fed mice

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Sports Medicine and Health Science 2020年第1期2卷 44-53页

作者： megan E.Rosa-Caldwell Lisa T.Jansen Seongkyun Lim Kirsten R.Dunlap Wesley S.Haynie Tyrone A.Washington Nicholas P.Greene Integrative Muscle Metabolism Laboratory Exercise Science Research CenterDepartment of Human Health Performance and RecreationUniversity of ArkansasUSA Exercise Muscle Biology Laboratory Exercise Science Research CenterDepartment of Human Health Performance and RecreationUniversity of ArkansasUSA

Exercise mitigates obesity-associated pathologies;however,there is controversy regarding optimal exercise ***,is known to decrease during obesity and is an important moderator for exercise ***:To investigate individual and combined effects of different exercise interventions and autophagy inhibition on exercise adaptations during ***:C57BL/6J mice initiated 45%high fat diet at 8 weeks of *** 6 weeks of diet,animals were divided into moderate(MOD)or high intensity interval training interventions(HIIT),animals were further divided into autophagy inhibition or vehicle conditions(n=10/group).Animals exercised and autophagy was inhibited 3X/week by NSC185058 injections,thereby blocking autophagosome *** continued for 4 ***:High fat diet impaired glucose handling~17%;exercise interventions normalized glucoregulation to prehigh fat diet levels,without differences between any *** fat diet induced~25%decrease in aerobic capacity,which returned to baseline after exercise interventions,with no differences between any *** effects of autophagy inhibition were ***:HIIT and MOD training confer similar health-related adaptations.

关键词： Insulin resistance Exercise capacity Glucose tolerance Obesity

The essential cosmic perspective 3rd ed.

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2005年

作者： Jeffrey Bennett megan Donahue Nicholas Schneider Mark Voit. Bennett Jeffrey. Donahue megan. Schneider Nicholas. Voit Mark.

来源：畅想之星图书光盘版（南... 评论

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脑创伤

生物技术世界 2010年第5期7卷 32-39页

作者： megan Scudellari 钟欣（翻译）

每天都有成千上万的人在经受着脑外伤的折磨，然而目前却没有什么有效的治疗手段。相关研究所获得的资金投入仅仅是其他疾病的九牛一毛。现在，研究脑创伤的科学家们不得不穷则思变，尝试改变这一领域的现状。

关键词：创伤脑资金投入研究所科学家牛

Correlation of rapid point-of-care vs send-out fecal calprotectin monitoring in pediatric inflammatory bowel disease

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 127-130页

作者： Alexis Rodriguez Lauren Yokomizo megan Christofferson Danielle Barnes Nasim Khavari KT Park Stanford University School of Medicine Stanford University Division of Gastroenterology De-partment of Pediatrics Stanford University

AIM To assess the correlation between the send-out enzymelinked immuno sorbent assay(ELISA) and the point-ofcare(POC) calprotectin test in pediatric inflammatory bowel disease(IBD) *** We prospectively collected stool samples in pediatric IBD patients for concomitant send-out ELISA analysis and POC calprotectin testing using the Quantum Blue?(QB) Extended immunoassay. Continuous results between 17 to 1000 μg/g were considered for comparison. Agreement between the two tests was measured by a Bland-Altman plot and statistical significance was determined using Pitman's *** Forty-nine stool samples were collected from 31 pediatric IBD patients. The overall means for the rapid and ELISA tests were 580.5 and 522.87 μg/g respectively. Among the 49 samples, 18(37.5%) had POC calprotectin levelsof ≤ 250 μg/g and 31(62.5%) had levels > 250 μg/*** levels ≤ 250 μg/g show good correlation between the two assays. Less correlation was observed at quantitatively higher calprotectin levels. CONCLUSION In pediatric IBD patients, there is better correlation of between ELISA and POC calprotectin measurements at clinically meaningful, low-range levels. Future adoption of POC calprotectin testing in the United States may have utility for guiding clinical decision making in real time.

关键词： Calprotectin Stool biomarker Inflammatory bowel disease Crohn’s disease Ulcerative colitis Pointof-care test

Adolescent Exposure of JWH-018 “Spice” Produces Subtle Effects on Learning and Memory Performance in Adulthood

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Journal of Behavioral and Brain Science 2012年第2期2卷 146-155页

作者： David M. Compton megan Seeds Grant Pottash Brian Gradwohl Chris Welton Ross Davids Department of Psychology Donnelley Behavioral Neuroscience Laboratory Palm Beach Atlantic University West Palm Beach USA

The active components associated with the bio-designer drugs known variously as “Spice” or “K2” have rapidly gained in popularity among recreational users, forcing the United States Drug Enforcement Administration to classify these compounds as Schedule I drugs in the Spring of 2011. However, although there is some information about many of the synthetic cannabinoids used in Spice products, little is known about the consequences of the main constituent, (1-pentyl-3-(1-naphthoyl)indole;JWH-018), on neuropsychological development or behavior. In the present experiment, adolescent rats were given repeated injections of either saline or 100 μg/kg of JWH-018. Once the animals were 75 days of age, they were trained using tasks with spatial components of various levels of difficulty and a spatial learning set task. On early trials with water maze tasks of varying difficulty, the JWH-018 treated rats were impaired relative to controls. However, by the end of each phase of testing, drug and control animals were comparable, although on probe trials the drug-treated animals spent significantly less time in the target quadrant. In addition, the performance of the drug-treated rats was inferior to that of the control animals on a learning set task, suggesting some difficulty in adapting their responses to changing task demands. The results suggest that chronic exposure to this potent cannabinoid CB1 receptor agonist during adolescence is capable of producing a variety of subtle changes affecting spatial learning and memory performance in adulthood, well after the drug exposure period.

关键词： 1-Pentyl-3-(1-naphthoyl)indole JWH-018 K2 Spice Spatial Learning Morris Water Maze Development Memory