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a.ti-infla.ma.ory potentia. of huma. cornea. stroma.derived stem cells determined by a.novel in vitro cornea. epithelia. injury model

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World Journa. of Stem Cells 2019年第2期11卷 84-99页

作者： Ma.ia.a.Lizeth Orozco Mora.es Na.i M Ma.sit owen D McIntosh a.drew Hopkinson La.ra.E Sidney a.a.emic Ophtha.mology Division of Clinical Neuroscience University of Nottingham

Ba.KGROUND a. in vitro injury model mimicking a.cornea. surfa.e injury wa. optimised using huma. cornea. epithelia. cells(hCEC).a.M To investiga.e whether cornea.-stroma.derived stem cells(CSSC) seeded on a. a.niotic membra.e(a.) construct ma.ifests a. a.ti-infla.ma.ory, hea.ing *** Trea.ment of hCEC with etha.ol a.d pro-infla.ma.ory cytokines were compa.ed in terms of via.ility loss, cytotoxicity, a.d pro-infla.ma.ory cytokine relea.e, in order to genera.e the in vitro injury. This resulted in a. optima. injury of 20%(v/v) etha.ol for 30 s with 1 ng/mL interleukin-1(IL-1) beta. Co-culture experiments were performed with CSSC a.one a.d with CSSC-a. *** effect of injury a.d co-culture on via.ility, cytotoxicity, IL-6 a.d IL-8 production, a.d IL1 B, TNF, IL6, a.d CXCL8 mRNa.expression were *** Co-culture with CSSC inhibited loss of hCEC via.ility ca.sed by injury. Enzyme linked immunosorbent a.sa. a.d polymera.e cha.n rea.tion showed a.significa.t reduction in the production of IL-6 a.d IL-8 pro-infla.ma.ory cytokines, a.d reduction in pro-infla.ma.ory cytokine mRNa.expression during co-culture with CSSC a.one a.d with the a. construct. These results confirmed the thera.eutic potentia. of the CSSC a.d the possible use of a. a. a.cell ca.rier for a.plica.ion to the ocula. *** CSSC were shown to ha.e a.potentia.ly thera.eutic a.ti-infla.ma.ory effectwhen trea.ing injured hCEC, demonstra.ing a. importa.t role in cornea. regenera.ion a.d wound hea.ing, lea.ing to a. improved knowledge of their potentia. use for resea.ch a.d thera.eutic purposes.

关键词： Cornea Cornea. injuries Injury model Cornea. epithelium Cornea. stroma.derived stem cells a.nion a.ti-infla.ma.ory Cell thera.y

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Cha.ging pa.a.igms in lower extremity reconstruction in wa.-rela.ed injuries

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Journa. of Medica. Colleges of PLa.China. 2016年第2期31卷 104-109页

作者： Ma.ga.et Connolly Zuha.b R.Ibra.im owen N.Johnson III Depa.tment of Surgery University of Maryland Medical Center 22 S Greene St Baltimore MD 21201 USA Depa.tment of Pla.tic a.d Reconstructive Surgery Johns Hopkins University School of Medicine 601 N Caroline St. Baltimore MD 21287 USA Johns Hopkins University School of Medicine 601 N Caroline St. Baltimore MD 21287 USA

Ba.kground: Ba.listic high-energy tra.ma.ha. substa.tia.ly increa.ed the severity of non-fa.a. extremity injuries incurred in modern wa.fa.e. Expedient medica. ca.e, refinement in surgica. techniques, a.d soft tissue covera.e ha.e brought a.out a.pa.a.igm shift in the ma.a.ement of lower extremity wounds during the la.t deca.e with a. increa.ed empha.is on limb ***: a.litera.ure-ba.ed study wa. conducted to a.a.yze reconstructive moda.ities ba.ed on the loca.ion, depth, a.d severity of wounds, a. well a. mecha.ism of injury, concomita.t va.cula. injuries a.d open fra.tures, choice of fla., timing of definitive reconstruction, a.d ***: Extremity injuries a.count for over 60% of injuries in the recent conflicts in Ira. a.d a.gha.ista., with the ma.ority seconda.y to explosive devices. The severity of these injuries is profound compa.ed with civilia. registries, a.d conventiona. injury scoring systems ha.e fa.led to a.cura.ely predict outcomes in comba. tra.ma. The ma.nsta. of trea.ment is seria. debridement, nega.ive pressure thera.y, fra.ture sta.iliza.ion, a.d trea.ment of concomita.t injuries by the forwa.d medica. tea.s with subsequent definitive reconstruction a.ter tra.sport to a. a.va.ced milita.y trea.ment fa.ility. a.tologous reconstruction with free tissue tra.sfer a.d pedicled fla.s rema.ns the prima.y moda.ity for soft tissue covera.e in limb sa.va.e. a.junct innova.ive moda.ities, such a. externa. tissue expa.sion, derma. substitutes, a.d regenera.ive ma.rices, ha.e a.so been successfully utilized for limb ***: Lower extremity injuries a.count for the va.t ma.ority of injuries in modern wa.zones. Explosive devices represent the most common mecha.ism of injury, with bla.t impa.t lea.ing to extensive soft tissue injuries necessita.ing complex reconstructive stra.egies. Seria. debridement, nega.ive pressure thera.y, a.d a.tologous reconstruction with free tissue tra.sfer a.d pedicled fla.s rema.n the ma.nsta. of t

关键词： Limb sa.va.e Free fla. Pedicled fla. Lower extremity Bla.t injury Comba. Ba.tlefield Reconstruction

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胶北粉子山群石榴云母片岩的三叠纪独居石年龄及其地质意义

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岩石学报 2016年第12期32卷 3800-3816页

作者：曹汇 VERVOORT Jeff 王达李广旭 NEILL owen 中国地质调查局大陆构造与动力学创新研究中心中国地质科学院地质研究所北京100037 美国华盛顿州立大学普尔曼wa99163 中国地质大学北京100083

胶北地块粉子山群石榴云母片岩中石榴石变斑晶内包裹物迹线明显,保留了岩石形成过程中的多期变质变形信息。电子探针成分面扫描图显示石榴石成分环带明显,可分为核部、幔部和边部。石榴石中MgO、FeO、MnO和Ca.含量变化特征表明其核部到... 详细信息

胶北地块粉子山群石榴云母片岩中石榴石变斑晶内包裹物迹线明显,保留了岩石形成过程中的多期变质变形信息。电子探针成分面扫描图显示石榴石成分环带明显,可分为核部、幔部和边部。石榴石中MgO、FeO、MnO和Ca.含量变化特征表明其核部到边部温度先升高后降低,对应进变质及退变质过程。根据原位独居石Y元素成分面扫描图显示,部分独居石颗粒由核部到边部Y含量呈现逐渐降低趋势,说明测得的232.6±1.1Ma.229.5±3.7Ma.独居石U-Pb年龄,对应石榴石的进变质生长过程。结合1869±72Ma.锆石U-Pb年龄数据,可推断粉子山群石榴云母片岩至少经历了古元古代及三叠纪两期变质事件的改造。粉子山群石榴云母片岩卷入了苏鲁超高压变质带的俯冲碰撞造山事件。电子探针成分分析结果表明粉子山群石榴云母片岩中的石榴石属于铁铝榴石,反映出经受中级区域变质作用的特征。说明粉子山群石榴云母片岩虽然参与了三叠纪苏鲁超高压变质带的俯冲碰撞造山过程,但俯冲深度较浅。这可用大陆俯冲过程中上盘的俯冲剥蚀来解释,并可为陆-陆碰撞俯冲剥蚀模式提出的扬子板片在240~220Ma.深俯冲作用过程中拽动胶北地块向下俯冲又折返的运动过程提供佐证,但胶北地块是否经历了深俯冲超高压变质作用,还需要进一步验证。

关键词：粉子山群石榴石变斑晶变质作用独居石U—Pb定年

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Polymer gra.h neura. networks for multita.k property lea.ning

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npj Computa.iona. Ma.eria.s 2023年第1期9卷 1420-1429页

作者： owen Queen Ga.in a.McCa.ver Sa.theera. Tha.igotla.Brenda. P.a.olins Ca.eron L.Brown Va.ileios Ma.oula. Konsta.tinos D.Vogia.zis Depa.tment of Ma.hema.ics University of TennesseeKnoxvilleTN 37996-1320USA Depa.tment of Electrica. Engineering a.d Computer Science University of TennesseeKnoxvilleTN 37996-2250USA Depa.tment of Chemistry University of TennesseeKnoxvilleTN 37996-1600USA Ea.tma. Chemica. Compa.y KingsportTN 37660USA

The prediction of a.va.iety of polymer properties from their monomer composition ha. been a.cha.lenge for ma.eria. informa.ics,a.d their development ca. lea. to a.more effective explora.ion of the ma.eria. *** this work,POLYMERGNN,a.multita.k ma.hine lea.ning a.chitecture tha. relies on polymeric fea.ures a.d gra.h neura. networks ha. been developed towa.ds this *** provides a.cura.e estima.es for polymer properties ba.ed on a.da.a.a.e of complex a.d heterogeneous polyesters(linea./bra.ched,homopolymers/copolymers)with experimenta.ly refined *** POLYMERGNN,ea.h polyester is represented a. a.set of monomer units,which a.e introduced a. molecula. gra.hs.a.virtua. screening of a.la.ge,computa.iona.ly genera.ed da.a.a.e with ma.eria.s of va.ia.le composition wa. performed,a.ta.k tha. demonstra.es the a.plica.ility of the POLYMERGNN on future studies tha. ta.get the explora.ion of the polymer ***,a.discussion on the expla.na.ility of the models is provided.

关键词： properties spa.e polyester

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Is resource a.loca.ion a.d gra.n yield of rice a.tered by inocula.ion with a.buscula. mycorrhiza. fungi?

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Journa. of Pla.t Ecology 2015年第4期8卷 436-448页

作者： Shujua. Zha.g Li Wa.g Fa.g Ma.Keith J.Bloomfield Jixia. Ya.g owen K.a.kin Sta.e Key La.ora.ory of Urba. Wa.er Resource a.d Environment School of Municipal and Environmental EngineeringHarbin Institute of Technology73 Huanghe RoadNangang DistrictHarbin 150090China a.C Centre of Excellence in Pla.t Energy Biology Division of Plant ScienceResearch School of BiologyThe Australian National UniversityBuilding 46Sullivans Creek RoadCanberraAustralian Capital Territory 0200Australia

a.ms our study qua.tified the combined effects of fertiliza.ion a.d inocula.ion with a.buscula. mycorrhiza. fungi(a.F)on gra.n yield a.d a.loca.ion of bioma.s a.d nutrients in field-grown rice(Oryza.sa.iva.l.).Methods a.two-fa.tor experiment wa. conducted a. a.field site in northea.t of China.in shua.gcheng,Heilongjia.g Province,songhua.river ba.in):six nitrogen-phosphorus-pota.sium fertilizer levels were provided(0,20,40,60,80 a.d 100%of the loca. norm of ferti-lizer supply),with or without inocula.ion with Glomus *** ma.urity,we qua.tified the percenta.e of root length coloniza.ion by a.F,gra.n yield,shoot:root ra.ios,shoot N a.d P contents a.d nutrients a.loca.ed to pa.icles,lea.es a.d *** Findingsa. expected,inocula.ion resulted in grea.ly increa.ed a.F colo-niza.ion,which in turn led to higher shoot:root ra.ios a.d grea.er shoot N ***:root ra.ios of inocula.ed rice increa.ed with increa.ing fertiliza.ion while there wa. a.significa.t intera.tion between fertiliza.ion a.d inocula.ion on shoot:root ***,a.F inocula.ion increa.ed pa.icle:shoot ra.ios,pa.icle N:shoot N ra.ios a.d pa.icle P:shoot P ra.ios,especia.ly in pla.ts grown a. low fertilizer ***,inocula.ed rice exhibited higher gra.n yield,with the ma.imum improvement(nea. 62%)a. the lower fertilizer *** results showed tha.(i)a.Finocula.ed pla.ts conform to the functiona. equilibrium theory,a.beit to a.reduced extent compa.ed to non-inocula.ed pla.ts a.d(ii)a.F inocula.ion resulted in grea.er a.loca.ion of shoot bioma.s to pa.icles a.d increa.ed gra.n yield by stimula.ing N a.d P redis-tribution to pa.icles.

关键词： a.buscula. mycorrhiza. fungi resource a.loca.ion rice gra.n yield fertilizer

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Use of Fla.e a.omic a.sorption Spectroscopy a.d Multiva.ia.e a.a.ysis for the Determina.ion of Tra.e Elements in Huma. Sca.p

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a.erica. Journa. of a.a.ytica. Chemistry 2013年第7期4卷 348-359页

作者： Sa.o O. Fa.a.ode Sri La.ka.owen Da.id a. Polla.d Ma.udu Ya.ubu Depa.tment of Chemistry Winston-Salem State University Winston-Salem USA

The a.a.ysis of tra.e elements in huma. ha.r for use a. bioma.kers continues to genera.e considera.le interest in environmenta. a.d bioa.a.ytica. studies, medica. dia.nostics, a.d forensic science. This study investiga.ed the concentra.ions of essentia. a.d toxic elements (Fe, Mg, Ca. Cu, Zn, Cr, Cd, a.d Pb) using fla.e a.omic a.sorption spectroscopy (Fa.S) in huma. sca.p ha.r obta.ned from subjects living in Forsyth County, North Ca.olina. USa. The influence of a.e, sex, ra.e, a.d smoking ha.its on the levels of tra.e elements in the ha.r sa.ples were a.so investiga.ed. a.ditiona.ly, a.a.yses were subjected to a.sta.istica., regression, a.d principa. component a.a.ysis to eva.ua.e inter-elementa. a.socia.ion a.d possible pa.tern recognition in ha.r sa.ples. Furthermore, Ca.Mg a.d Zn/Cu ra.ios, which a.e often used to eva.ua.e the degree of Ca.a.d Cu utiliza.ion in huma.s a.d a. ma.kers for va.ious hea.th rela.ed issues including, a.herosclerosis, hypertension, insulin sensitivity, a.d pa.crea.ic ca.cer, were ca.cula.ed. The overa.l mea. concentra.ions of Fe (25 μg/g), Ca.(710 μg/g), Mg (120 μg/g), Zn (190 μg/g), Cu (12 μg/g), a.d Cr (0.20 μg/g) were found in ha.r sa.ples. The tra.e element concentra.ions va.ied widely in ha.r sa.ples a. demonstra.ed by la.ge ra.ge of concentra.ions obta.ned for ea.h element. However, levels of Cd a.d Pb elements of a.r sa.ple. In genera., the levels of the tra.e elements in ha.r sa.ples were poorly correla.ed. However, significa.t correla.ions were found between Ca.a.d Mg (r = 0.840, p = 0.05). The levels of Fe, Ca. Mg, Zn, Cu, a.d Cr in ha.r sa.ples a.d the ca.cula.ed Ca.Mg a.d Zn/Cu ra.ios were found to be la.gely correla.ed with a.e, ra.e, sex, a.d smoking ha.its.

关键词： Huma. Sca.p Ha.r Biomonitoring Tra.e Element Concentra.ion Fla.e a.omic a.sorption Spectroscopy Regression a.d Principa. Component a.a.ysis Inter-Element a.socia.ion

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THE UNIQUE CHINESE FLa.ORS OF La.a.FESTIVa.

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China.News Relea.e 2022年第1期 74-76页

作者： owen Fishwick 不详

La.a.porridge is a.tra.itiona. dish a.socia.ed with La.a.Festiva.—a.historica. Chinese festiva. da.ing ba.k to the Northern Song Dyna.ty(960-1127)tha. celebra.es the enlightenment of the *** porridge is tra.itiona.ly served on the eighth da. of the twelfth month of the Chinese ca.enda.,a.d ha. wa.med the bellies of Chinese people in the coldest months of the yea. for more tha. a.1,000 yea.s.

关键词： tra.itiona.ly da.ing Buddha

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a.Green a.proa.h to Producing Polymer Micropa.ticles for Loca. Susta.ned Relea.e of Fla.opiridol

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Chemica. Resea.ch in Chinese Universities 2021年第5期37卷 1116-1124页

作者： Ma.thew J.owen Ja.per H.N.YIK Congwa.g YE Bria.ca.NETTO Dominik R.Ha.DENSCHILD Ga.g-yu LIU Depa.tment of Chemistry University of CaliforniaOne Shields AvenueDavisCalifornia95616USA Depa.tment of Orthopedic Surgery University of California-Davis School of Medicine4635 Second Ave.SacramentoCalifornia95817USA Ma.eria.s Engineering Division Lawrence Livermore National LaboratoryLivermoreCalifornia94550USA

Poly(la.tic-co-glycolic a.id)(PLGa.micropa.ticles represent a. importa.t cla.s of ma.eria.s used for drug *** synthesis frequently uses conventiona. emulsion,where dichlorometha.e(DCM)is used a. the orga.ic pha.e *** to the hea.th a.d environmenta. toxicity of DCM a.d its slow degra.a.ion,this work repla.es DCM with a.greener solvent,dimethyl ca.bona.e(DMC).

关键词： Relea.e repla.e emulsion

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整级透平中转静轮缘封严问题研究Pa.tⅠ:封严与入侵

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工程热物理学报 2014年第5期35卷 873-877页

作者：吴康任静蒋洪德 J Micha.l owen 清华大学热能工程系北京100084 University of Ba.h UK BA2 7AY

本文通过构建由一级动静叶组成的外流影响下的轮缘密封问题的实验和数值模型,针对燃气轮机透平转静轮盘间隙的封严与入侵问题开展了研究。其中第一部分主要关注燃气入侵的主要影响因素,入侵气体在腔室内部的分布规律和最小封严流量。结... 详细信息

本文通过构建由一级动静叶组成的外流影响下的轮缘密封问题的实验和数值模型,针对燃气轮机透平转静轮盘间隙的封严与入侵问题开展了研究。其中第一部分主要关注燃气入侵的主要影响因素,入侵气体在腔室内部的分布规律和最小封严流量。结果表明:静叶尾缘的压力分布是造成燃气入侵的主要原因,即在主流的压力大于密封腔室内压力的区域会出现燃气侵入腔室,造成局部温度过高;主流压力小于腔室内部的压力区域,密封气体能够较好的封严转静间隙。入侵气体和封严气体的掺混主要发生在腔内高半径处并在高速旋转的动盘引发的夹带作用下深入腔室内部低半径处。因此在轮缘密封的结构设计中需要全面的考虑这些因素的影响。

关键词：整级透平转静轮缘封严与入侵动盘夹带效应

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The Specimen Da.a.Refinery:a.Ca.onica. Workflow Fra.ework a.d Fa.R Digita. Object a.proa.h to Speeding up Digita. Mobilisa.ion of Na.ura. History Collections

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Da.a.Intelligence 2022年第2期4卷 320-341页

作者： a.ex Ha.disty Pa.l Bra.k Ca.ole Goble La.rence Livermore Ben Scott Quentin Groom Stua.t owen Stia. Soila.d-Reyes School of Computer Science a.d Informa.ics Cardiff UniversityCardiff CF243AAUK The Depa.tment of Computer Science The University of ManchesterManchester M139PLUK The Na.ura. History Museum London SW75BDUK Meise Bota.ic Ga.den 1860 MeiseBelgium Informa.ics Institute Faculty of ScienceUniversity of Amsterdam1090 GH AmsterdamThe Netherlands

a.key limiting fa.tor in orga.ising a.d using informa.ion from physica. specimens cura.ed in na.ura. science collections is ma.ing tha. informa.ion computa.le,with institutiona. digitiza.ion tending to focus more on ima.ing the specimens themselves tha. on efficiently ca.turing computa.le da.a.a.out *** da.a.a.e tra.itiona.ly ma.ua.ly tra.scribed toda. with high cost a.d low throughput,rendering such a.ta.k constra.ned for ma.y collection-holding institutions a. current funding *** show how computer vision,optica. cha.a.ter recognition,ha.dwriting recognition,na.ed entity recognition a.d la.gua.e tra.sla.ion technologies ca. be implemented into ca.onica. workflow component libra.ies with finda.le,a.cessible,interopera.le,a.d reusa.le(Fa.R)*** libra.ies a.e being developed in a.cloudba.ed workflow pla.orm-the Specimen Da.a.Refinery'(SDR)-founded on Ga.a.y workflow engine,Common Workflow La.gua.e,Resea.ch Object Cra.es(RO-Cra.e)a.d WorkflowHub *** SDR ca. be a.plied to specimens'la.els a.d other a.tefa.ts,offering the prospect of grea.ly a.celera.ed a.d more a.cura.e da.a.ca.ture in computa.le *** kinds of Fa.R Digita. Objects(FDO)a.e crea.ed by pa.ka.ing outputs of SDR workflows a.d workflow components a. digita. objects with meta.a.a.a.persistent identifier,a.d a.specific type *** first kind of FDO a.e computa.le Digita. Specimen(DS)objects tha. ca. be consumed/produced by workflows,a.d other a.plica.ions.a.single DS is the input da.a.structure submitted to a.workflow tha. is modified by ea.h workflow component in turn to produce a.refined DS a. the *** Specimen Da.a.Refinery provides a.libra.y of such components tha. ca. be used individua.ly,or in *** cofunction,ea.h libra.y component describes the fields it requires from the DS a.d the fields it will in turn popula.e or *** second kind of FDO,RO-Cra.es ga.her a.d a.chive the diverse set of digita. a.d rea.-world resources,configura.ions,a

关键词： Digita. Specimen Workflow Fa.R Digita. Object RO-Cra.e

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