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New record of the feather star Palaeocomatella hiwia(echinodermata:Crinoidea:Comatulida)from Zhenbei Seamount in South China Sea:new insights into the taxonomic position of Palaeocomatella

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Journal of Oceanology and Limnology 2024年第1期42卷 244-251页

作者： Shao’e SUN Zijie MeI Zhongli SHA Jing WANG Nansheng CHeN Department of Marine Organism Taxonomy and Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Marine ecology and environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China Shandong Province Key Laboratory of experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean mega.Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

One specimen belonging to the family Comatellinae was collected from the Zhenbei Seamount(332.5–478.2 m)in the South China Sea in July *** on the morphological characters,the specimen was identified as Palaeocomatella hiwia McKnight,*** is first recorded from China Sea and redescribed in *** specimen differs from the original description from New Zealand for never showing syzygy at br4+5 or br5+6 on interior and br1+2 on exterior ***,it is much conform to the redescription to specimens from Indonesia,with only differences in position of the second syzygy and distalmost pinnule *** is deposited in the Institute of Oceanology,Chinese Academy of *** analyses based on the mitochondrial c oxidase subunit I(COI)and 16S rRNA genes indicated that *** was nested within the tribe Phanogeniini and clustered with Aphanocomaster ***,*** showed same morphological features in terms of mouth placement,comb location,and number of comb teeth rows as other genera of ***,we suggest that the genus Palaeocomatella should be put in the tribe Phanogeniini.

关键词： new record Palaeocomatella hiwia McKnight 1977 South China Sea phylogenetic relationship taxonomy

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Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring

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Neural Regeneration Research 2019年第3期14卷 491-500页

作者： Christiano Spindler ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe mega.Gabriela dos Santos Salvalaggio Matilde Achaval Viviane Rostirola elsner Simone Marcuzzo Programa de Pos-Graduacao em Neurociencias Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Laboratorio de Histofisiologia Comparada Departamento de Ciencias Morfologicas Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Programa de Pos-Graduacao em Biociências e Reabilitacao Centro Universitario Metodista-IPA

It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear.

关键词： epigenetics preconception methylation learning treadmill running fetal programming inheritance sperm nerve regeneration

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The Impact of Multidisciplinary Care in a Large Volume Robot-Assisted Radical Prostatectomy Program: A Paradoxical Stage Migration toward More Aggressive Disease

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Open Journal of Internal Medicine 2014年第4期4卷 108-114页

作者： Jospeh F. Renzulli II Michael M. Maddox Omar Nadeem Simone Thavaseelan Gyan Pareek Anthony e. mega Warren Alpert Medical School Brown University Providence USA

Introduction: With the widespread use of robot-assisted radical prostatectomy (RARP), a stage migration to less aggressive prostate cancer (CaP) may be expected in pathological specimens due to over-treatment of low risk disease. It is unclear whether implementation of a multidisciplinary clinic (MDC) model would offset this phenomenon. We sought to analyze our database for possible stage migration in prostatectomy specimens in the setting of MDC. Methods: A total of 262 patients who underwent open prostatectomy (OP) from 2004 to 2006 and 757 patients who underwent RARP from 2007 to 2011 were identified from our prospective database. The implementation of MDC occurred concurrently at the time of RARP initiation. Demographic data, pathology, positive margin rates along with standard CaP reporting data were recorded. The two groups were compared with regards to percentage of cases stratified by Gleason grade. Results: The number of CaP cases managed at our institution increased considerably after the introduction of robotics and MDC. There was a significant decrease in the patients with Gleason 6 CaP undergoing RARP as compared with OP (p = 0.001). Additionally, RARP was performed on a significantly greater percentage of Gleason 7 disease (p en comparing pathological stage, there was a significant increase in the incidence of pT3 disease following RARP (p e introduction of a MDC and minimally invasive radical prostatectomy did not result in an increased application of surgery for the treatment of low risk prostate cancer. This highlights the importance of MDC in a large volume RARP program.

关键词： Prostate Cancer Robotics Multidisciplinary Care

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巨桉GRF基因家族生物信息学分析及其在不同氮水平下的组织表达模式

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西北农林科技大学学报（自然科学版） 2024年第3期52卷 62-72页

作者：杨雪芮陈少雄王建忠何沙娥中国林业科学研究院速生树木研究所广东湛江524022 南京林业大学林学院江苏南京210037 广西国有东门林场广西崇左532108

【目的】从全基因组水平上鉴定巨桉生长调节因子(growth-regulating factor,GRF)基因家族成员,分析其在不同氮素水平下的组织表达模式,为巨桉GRF基因功能研究及氮高效利用桉树品种的培育奠定基础。【方法】在NCBI网站中选择巨桉基因组,... 详细信息

【目的】从全基因组水平上鉴定巨桉生长调节因子(growth-regulating factor,GRF)基因家族成员,分析其在不同氮素水平下的组织表达模式,为巨桉GRF基因功能研究及氮高效利用桉树品种的培育奠定基础。【方法】在NCBI网站中选择巨桉基因组,用拟南芥和毛果杨的GRF蛋白序列与巨桉基因组数据库进行BLAST蛋白序列同源比对,并通过InterPro和SMART数据库进行保守结构域分析,获得巨桉GRF基因。利用在线网站ex-pasy protparam、SignalP-5.0、WoLF PSORT和SOPMA,对巨桉GRF蛋白进行基本理化性质分析、信号肽预测、亚细胞定位及二级结构预测。利用mega..0软件构建系统进化树,使用MeMe在线平台分析egrGRF蛋白的保守结构域和基序,用Plant CARe预测基因上游的顺式作用元件,并使用TBtools软件将结果可视化。以2年生巨桉苗为供试材料,浇灌氮素浓度分别为45(高氮)、15(常规氮)和1.5(低氮)mmol/L的营养液,4 d后取样,采用实时荧光定量PCR技术检测egrGRF基因在3种氮素水平下的叶片、茎和根中的表达情况。【结果】鉴定得到6个巨桉GRF基因家族成员(egrGRF1~egrGRF6),分布于4条染色体上;6个egrGRF蛋白的氨基酸数目为296~605个,分子质量为33415.86~64630.89 u,理论等电点为7.29~8.85,脂溶指数为39.93~64.79,均为亲水性蛋白;无规则卷曲和α-螺旋为主要二级结构元件,均定位于细胞核上,未检测到信号肽存在。系统进化树分析表明,巨桉、毛果杨和拟南芥的GRF家族成员可分为4组,各组中egrGRF蛋白数量分别为0,3,1和2个,多数egrGRF成员与毛果杨亲缘关系较近。基因结构及蛋白基序分析结果显示,巨桉GRF基因家族成员具有2~4个内含子;6个egrGRF蛋白均具有CX_(9)CX_(10)CX_(2)H和QX_(3)LX_(2)Q保守基序。顺式作用元件分析表明,egrGRF基因启动子区含有茉莉酸甲酯、脱落酸、分生组织表达及低温等响应元件。实时荧光定量PCR结果显示,egrGRF2和egrGRF6基因在低氮处理的巨桉叶片中优势表达,egrGRF2、egrGRF3、egrGRF5和egrGRF6基因在低氮处理根中的表达量较高氮和常规氮处理显著升高,egrGRF4基因在常规氮处理茎中的表达量最高。【结论】鉴定获得6个巨桉GRF基因家族成员,其中egrGRF4基因可能参与茎生长发育的调控,egrGRF2、egrGRF3、egrGRF5和egrGRF6基因可能参与了巨桉对低氮胁迫的响应。

关键词：巨桉 GRF基因家族生物信息学分析基因表达氮响应

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Mitochondrial phylogenomics reveal the origin and adaptive evolution of the deep-sea caridean shrimps(Decapoda:Caridea)

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Journal of Oceanology and Limnology 2021年第5期39卷 1948-1960页

作者： Shao’e SUN Zhongli SHA Yanrong WANG Deep Sea Research Center Institute of OceanologyChinese Academy ofSciencesQingdao 266071China Laboratory for Marine Biology and Biotechnology Pilot NationalLaboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Center for Ocean mega.Science Chinese Academy of SciencesQingdao266071China University of Chinese Academy of Sciences Beijing 100049China

The deep-sea is considered as the most extensive ecosystem on the *** is meaningful for elucidating the life origins by exploring the origin and adaptive genetic mechanisms of the large deepsea *** shrimps have colonized and successfully adapted to deep-sea *** provide an ideal model to analyze the origin and adaptive evolution of modern deep-sea ***,we conducted the phylogenetic analyses of mitocho ndrial genomes(mitogenomes)from carideans,including 11 newly sequences reported in this investigation to explore the habitat origins,divergence times,and adaptive evolution of deep-sea(seamounts and hydrothermal vents)caridean *** results showed that the species of deep-sea Caridea formed a monophyletic *** analysis supported that the deepsea caridean shrimps may originated from shallow *** hydrothermal vents alvinocaridid shrimps and Lebbeus shinkaiae from Thoridae underwent a second range expansion from seamounts to vent *** of divergence time showed that the caridean shrimps invaded into deep-sea at 147.75 *** divergence of most of the modern seamount and hydrothermal vent species are in the late Cretaceous/early *** may associate with the geological events of the Western Pacific,the climate change,and the global deep-water anoxic/dysoxic events during this ***-two potentially important adaptive residues were detected in the deep-sea shrimp lineage,which were located in atp6,atp8,cox1,cox3,cytb,nad2,nad4 l,and *** investigation adds our understanding of the evolutionary history of deep-sea caridean shrimps,and provides insights into the mitochondrial genetic basis of deep-sea adaptation in this group.

关键词： hydrothermal vents seamounts Caridea mitochondrial genome phylogenetic analysis evolutionary history

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Making Sense of Hospital Project MisPerformance: Over Budget, Late, Time and Time Again—Why? And What Can Be Done About It?

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engineering 2022年第5期8卷 183-201页

作者： Peter e.D.Love Lavagnon A.Ika School of Civil and Mechanical engineering Curtin UniversityPerthWA 6845Australia Telfer School of Management University of OttawaOttawaON KIN 6N5Canada

Hospital projects worldwide often experience misperformance,showing a tendency to exceed their estimated cost,miss their deadline,suffer quality problems,and yield benefit *** this ubiquitous problem,this paper aims to make sense of this phenomenon by addressing the following research question:How can we make sense of hospital project misperformance,and what can be done to mitigate its occurrence?We use an illustrative case study approach and the analytical lens of sense-making to examine the misperformance of three mega.hospital *** research reveals issues such as scope changes,an inability to adapt and respond to risk and uncertainty,ineffectual project management and governance,and optimism bias,which combine to impact project performance *** suggest that the two prominent theoretical perspectives dominating the literature in this field fall short of adequately explaining hospital project *** provide suggestions for improving the procurement process of hospitals and submit there is a need to develop a robust and balanced theory of project misperformance.

关键词： Cost Hospital Optimism bias Procurement Project management Performance Sense-making

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 16-17页

作者： mega.M.S. Dinov I.D. Porter V. 高中宝 Alzheimer's Disease Center and Center on Aging Providence Health System 10150 SE 32nd Ave. Portland OR 97222 United States Dr.

Background: Regional brain correlates of treatment with cholinesterase inhibit ors in those with Alzheimer disease are unknown. Objective: To map brain metabol ism associated with the treatment response to galantamine with fludeoxyglucose F 18 positron emission tomography in patients with Alzheimer disease. Design: Thi s is a hypothesis-driven, prospective, open-label study of 19 patients with mi ld to moderate Alzheimer disease examined before and after treatment with the ch olinesterase inhibitor galantamine. Clinical examinations included the cognitive portion of the Alzheimer Disease Assessment Scale, the Mini-Mental State exami nation, and the Neuropsychiatric Inventory. Imaging was performed using fludeoxy glucose F 18 positron emission tomography. The positron emission tomographic dat a, registered to a probabilistic anatomical atlas, were subjected to a voxel-ba sed analysis of 3 subgroups: total patient analysis, cognitive analysis, and beh avioral analysis. Subvolume thresholding corrected random lobar noise to produce 3-dimensional significance maps. Results: The total group analysis showed an i ncrease in left caudate metabolism with no significant change in clinical outcom es for the total group with treatment. Subgroup analysis of cognitive and behavi oral responders demonstrated a significant activation of a striatal-thalamofr- ontal network with galantamine treatment that was not present in patients whos e condition worsened or was unchanged by therapy. In cognitive subgroups, change in left anterior cingulate metabolism significantly correlated with change in t he cognitive portion of the Alzheimer Disease Assessment Scale (r=0.70, P=.02); in behavioral subgroups, right cingulate metabolic change significantly correl ated with improve ment in depression and right ventral putamen metabolic change with improvement i n apathy (r=0.63, P e and behavioral respon ders to galantamine therapy show clinically related impr

关键词：脱氧葡萄糖 PeT 临床反应加兰他敏认知功能胆碱酯酶抑制剂阿尔茨海默病亚组神经心理扣带回

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Study of photometric phase curve:assuming a cellinoid ellipsoid shape for asteroid(106)Dione

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Research in Astronomy and Astrophysics 2017年第9期17卷 61-70页

作者： Yi-Bo Wang Xiao-Bin Wang Donald e Pray Ao Wang Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for the Structure and evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Center for Astronomical mega.Science Chinese Academy of SciencesBeijing 100012China Sugarloaf Mountain Observatory South DeerfieldMA 01373USA

We carried out new photometric observations of asteroid （106） Dione at three apparitions （2004, 2012 and 2015） to understand its basic physical properties. Based on a new brightness model, new photometric observational data and published data of （106） Dione were analyzed to characterize the morphology of Dione＇s photometric phase curve. In this brightness model, a cellinoid ellipsoid shape and three-parameter （H, G1, G2） magnitude phase function system were involved. Such a model can not only solve the phase function system parameters of （106） Dione by considering an asymmetric shape of an asteroid, but also can be applied to more asteroids, especially those without enough photometric data to solve the convex shape. Using a Markov Chain Monte Carlo （MCMC） method, Dione＇s absolute magnitude of H = 7.66＋0.03-0.03 mag, and phase function parameters G1 = 0.682＋0.077-0.077 and G2 = 0.081＋0.042-0.042 were obtained. Simultaneously, Dione＇s simplistic shape, orientation of pole and rotation period were also determined preliminarily.

关键词： asteroids general photometric phase curve -- asteroids individual (106) Dione - techniques: photometric - Markov Chain Monte Carlo method

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重大建设工程技术创新合作关系与风险防控能力研究

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铁道科学与工程学报 2024年第9期21卷 3854-3863页

作者：郭珍旭王青娥彭春艳彭玉珍蔡超勋中南大学土木工程学院湖南长沙410075 中国铁道科学研究院集团有限公司北京100081

技术创新合作是破解重大建设工程难题的关键手段,但合作关系的建立和管理也带来了新风险。为有效降低技术创新合作风险,技术创新合作关系对风险防控能力的作用值得深入思考。基于“结构—行为—绩效”范式和风险管理理论,结合已有研究,... 详细信息

技术创新合作是破解重大建设工程难题的关键手段,但合作关系的建立和管理也带来了新风险。为有效降低技术创新合作风险,技术创新合作关系对风险防控能力的作用值得深入思考。基于“结构—行为—绩效”范式和风险管理理论,结合已有研究,构建“合作关系—合作行为—合作绩效—风险防控能力”的链式中介模型,采用问卷调查法得到235份有效样本,采用回归分析和中介效应分析进行假设检验。回归分析结果显示,合作关系、合作行为、合作绩效均对风险防控能力有显著正向影响,且影响程度依次减弱。良好的合作关系显著提高合作行为的执行效果,提升合作绩效,进而对风险防控能力产生积极影响。中介效应检验结果表明,合作行为、合作绩效在合作关系与风险防控能力之间起链式中介作用,合作关系不仅直接影响风险防控能力,还通过合作行为和合作绩效对风险防控能力产生间接影响。在此基础上,为提高重大建设工程技术创新合作能力,提出重视合作关系的建立与维护、强化合作行为的执行与管理、关注合作绩效的评估与提升及构建良好的风险防控机制等对策建议。研究揭示了重大建设工程技术创新合作主体通过合作路径影响风险防控能力的内在机理,为重大建设工程技术创新合作提供参考。

关键词：重大建设工程技术创新合作合作关系合作行为合作绩效风险防控能力

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PI3K/Akt pathway is involved in the activation of RAW 264.7 cells induced by hydroxypropyltrimethyl ammonium chloride chitosan

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Journal of Oceanology and Limnology 2020年第3期38卷 834-840页

作者： YANG Yue XING Rong’e LIU Song QIN Yukun LI Kecheng YU Huahua LI Pengcheng Key Laboratory of experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

We previously demonstrated that 2-hydroxypropyltrimethyl ammonium chloride chitosan(HACC)promoted the production of nitric oxide(NO)and proinflammatory cytokines by activating the mitogen-activated protein kinases(MAPK)and Janus kinase(JAK)/STAT pathways in RAW 264.7 cells,indicating good immunomodulatory activity of *** this study,to further investigate the immunomodulatory mechanisms of HACC,we determined the roles of phosphatidylinositol 3-kinase(PI3K)/Akt,activating protein(AP-1)and nuclear factor kappa B(NF-κB)in HACC-induced activation of RAW 264.7 cells by the western *** results suggest that HACC promoted the phosphorylation of p85 and ***,c-Jun and p65 were also increased after the treatment of RAW 264.7 cells with HACC,indicating the translocation of NF-κB and AP-1 from cytoplasm to *** addition,as scanning electron microscopy(SeM)analysis shows,the cell morphology changed after HACC *** findings indicate that HACC activated MAPK,JAK/STAT,and PI3K/Akt signaling pathways dependent on AP-1 and NF-κB activation in RAW 264.7 cells,ultimately leading to the increase of NO and cytokines.

关键词： hydroxypropyltrimethyl ammonium chloride chitosan RAW 264.7 cells PI3K/Akt pathway nuclear factor-κB activating protein 1

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