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Hepatoprotective evaluation of Anogeissus latifolia:In vitro and in vivo studies

World Journal of Gastroenterology 2009年第38期15卷 4816-4822页

作者： Hulikere Ananth Pradeep Saleemullah Khan Karamkonda Ravikumar Mohammed Fazil Ahmed meesala srinivasa rao Mandava Kiranmai Dachani Sudhershan Reddy Shaik Rasheed Ahamed Mohammed Ibrahim Department of Pharmacology and Biotechnology Nizam Institute of Pharmacy JSS College of Pharmacy OotyTamilnaduIndia and Manipal College of Pharmaceutical Sciences Centre for Liver Research and Diagno-stics Deccan College of Medical Sciences and Allied Hospitals

AIM： To evaluate the hepatoprotective activity of a hydroalcoholic extract of the bark of Anogeissus latifolia; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride （CCl4）. METHODS： In the in vitro study, a primary hepatocyte monolayer culture was treated with CCh and extract of Anogeissus latifolia. Hepatoprotective activity was demonstrated in the CCh damaged primary monolayer culture. In the in vivo study, the hepatoprotective activity of a hydroalcoholic extract ofAnogeissus latifolia was analyzed in liver injured CCh-treated rats. Biochemical parameters including serum transaminases [aspartate aminotransferase （AST） and alanine aminotransferase （ALT）] and alkaline phosphatase （ALP） in serum wereanalyzed. The biochemical findings were supplemented with histopathological examination of rat liver sections. RESULTS： In vitro： primary hepatocyte monolayer cultures were treated with CCh and extract of Anogeissus latifolia. A protective activity could be demonstrated in the CCh damaged primary monolayer cultUre. In vivo： Hydroalcoholic extract of Anogeissus latifolia （300 mg/kg） was found to have protective activity in rats with CCh-induced liver damage as judged from serum marker enzyme activity. CONCLUSION： The above findings lead to the conclusion that the hydroalcoholic extract of Anogeissus latifol/a is hepatoprotective. Hence, we suggest that the inclusion of this plant in the management of liver disorders is justified.

关键词： Anogeissus latifolial Hepatoprotective Carbon tetrachloride

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Electrical Properties of Cadmium Substitution in Nickel Ferrites

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World Journal of Condensed Matter Physics 2012年第4期2卷 257-266页

作者： Ande Ashok Thatikonda Somaiah Dachepalli Ravinder Chinnala Venkateshwarlu Chandiri Sudhakar Reddy Kappera Nageshwar rao meesala Prasad Department of Chemistry University College of Science Osmania University Hyderabad India Department of Physics Nizam College Basheerbagh Osmania University Hyderabad India Department of Physics Osmania University Hyderabad India Department of Physics University College of Science Osmania University Hyderabad India

Electrical transport properties such as conductivity (σ) and thermo electric power (S) of Cadmium substituted Nickel Ferrites, forming chemical formula Ni1–xCdxFe2O4, where x = 0.0, 0.2, 0.4 have been investigated from room temperature to well beyond the Curie temperature. Plots of log (σT) versus 103/T are linear and show a transition near the Curie temperature. The transition temperature is found to decrease with increase of Cd content. On the basis of Seebeck coefficient (S), the ferrites under investigation have been classified as n-type and p-type semiconductors. The values of charge carrier concentration and mobility have been computed from experimental values of Seebeck coefficient and electrical conductivity. The activation energy in the ferrimagnetic region is in general less than that in the paramagnetic region. An attempt is made to explain the conduction mechanism in these ferrites.

关键词： Ni-Cd Ferrite Thermo Electric Power Seebeck Coefficient Charge Carrier Concentration Electrical Conductivity

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