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Effect of high shear homogenization on quality characteristics of bael fruit pulp

Food Quality and Safety 2022年第1期6卷 81-92页

作者： meenatai g.kamble Anurag Singh Pramod Kumar Prabhakar Murlidhar Meghwal Sukh Veer Singh Ajay V.Chinchkar Department of Food Science and Technology National Institute of Food Technology Entrepreneurship and Management(NIFTEM)SonipatHaryana-131028India

Response surface methodology was used to investigate the influence of high shear homogenization speed(A:3000-12000 r/min)and processing time(B:30-120 min)on bael fruit pulp quality *** experimental results were best fitted in the suggested quadratic model to delineate and envision the responses in terms of color(values of L^(*),meaning brightness to blackness,1oo-0;a^(*),meaning green-a^(*)to red+a^(*);and b^(*),meaning blue-b^(*)to yellow+b),total soluble solids,ascorbic acid,viscosity,andβ-carotene content with the highest coefficients of determination(R2)ranging from 0.80 to ***(Pge in the L^(*)value,total soluble solids,ascorbic acid,andβ-carotene content was found with change in homogenization *** interaction effect of homogenization showed a significant difference in a^(*)value and total soluble solid content of the *** best homogenization conditions were determined via multiple response optimization as 10682 r/min speed and 43.18 min process *** quality parameters of the pulp at optimized conditions were observed as L^(*)15.35,a^(*)4.51,b^(*)10.25,ascorbic acid 18.64 mg/100 g,viscosity 5349 cP,andβ-carotene 4.14μg/100 *** addition,total phenolic content,flavonoid content,and antioxidant content of homogenized bael fruit pulp was found to significantly(Pg gallic acid equivalent(gAE)/100 mL,(147.39±0.69)to(156.10±1.11)mg quercetin equivalent(QE)/100 mL,and(41.77%±0.60%)to(66.53%±0.41%),***,this strategy could be used in fruit processing industries to process highly fibrous fruits and nonuniform-textured fruit pulptoavoid sedimentation whileretaining functionality.

关键词： Aegle marmelos L. underutilized fruit viscosity bioactive compounds color values

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Quieting the neonatal intensive care unit:A quality improvement initiative

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World Journal of Clinical Pediatrics 2024年第3期13卷 53-60页

作者： Darshan Rajatadri Rangaswamy Niranjan kamble Amulya Veeramachaneni Department of Pediatrics Subbaiah Institute of Medical SciencesShimoga 577222KarnatakaIndia

BACKgROUND The neonatal intensive care unit(NICU)is vital for preterm infants but is often plagued by harmful noise *** noise,ranging from medical equipment to conversations,poses significant health risks,including hearing impairment and neurodevelopmental *** American Academy of Pediatrics recommends strict sound limits to safeguard neonatal *** such as education,environmental modifications,and quiet hours have shown to reduce noise ***,up to 60%of the noises remain *** noise exposure exacerbates physiological disturbances,impacting vital functions and long-term neurological *** noise reduction in the NICU is crucial for promoting optimal neonatal *** To measure the sound levels in a NICU and reduce ambient sound levels by at least 10%from *** A quasi-experimental quality improvement project was conducted over 4 mo in a 20-bed level 3 NICU in a tertiary care medical *** noise levels were recorded continuously using a sound level *** interventions included targeted education,environmental modifications,and organizational changes,and were implemented through three rapid Plan-Do-Study-Act(PDSA)*** feedback and monitoring were conducted,and statistical process control charts were used for *** mean noise values were compared using the paired *** The baseline mean ambient noise level in the NICU was 67.8 dB,which decreased to 50.5 dB after the first cycle,and further decreased to 47.4 dB and 51.2 dB after subsequent *** reduction in noise levels was 21%during the day and 28%PDSA cycle(mean difference of−17.3 dB,Pgy reduced noise in the NICU by 25%over 4 *** success of this initiative emphasizes the significance of comprehensive interventions for noise reduction.

关键词： Quality improvement Noise pollution Preterm care Sound measurement Plan-Do-Study-Act

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Bethanechol Remains the Preferred Drug in Suspected Underactive Bladder: Findings from Nation-Wide Prescription Analysis

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Open Journal of Urology 2024年第5期14卷 301-311页

作者： Sanjay Vasant kamble Anjana Kalpesh Yadav Maneesha Tarkeshwar Sharma Radha Ratnadeep Bhosle Department of Medical Services Samarth Life Sciences Pvt. Ltd. Mumbai India

Background: Bethanechol chloride, a cholinergic agonist, is often prescribed in suspected underactive bladders to improve detrusor contractility, despite its limited clinical efficacy. We investigated the usage pattern of bethanechol in actual practice with the understanding that it would enable the physicians to make an informed decision on the coherent use of bethanechol. Methods: A nation-wide survey was carried out to obtain the responses of the urologists. Out of the 755 urologists approached, 630 survey responses were considered for analysis. Results: Usage of bethanechol was advocated as very common [318 (50.48%)], common [200 (31.75%)], not so common [107 (16.98%)], and rare [5 (0.79%)] in postoperative urinary retention, where it was preferred either exclusively [255 (40.48%)] or along with alpha blockers [247 (39.21%)]. Predilection to use alpha-blocker [247 (39.21%)], alpha-blocker plus naloxone [4 (0.64%)], naloxone [1 (0.16%)], alpha-blocker plus bethanechol plus naloxone [1 (0.16%)] was also observed. It was also preferred individually in pathologies causing urinary retention such as benign prostatic hyperplasia [125 (19.84%)], diabetic neuropathy [82 (13.02%)], neurological diseases [69 (10.95%)], senile bladder [14 (2.22%)], drugs [13 (2.06%)], and infective/inflammatory conditions [6 (0.95%)]. Other [321 (50.95%)] physicians opted to prescribe bethanechol in two or more of the enumerated indications. Bethanechol was prescribed orally as 25 mg thrice daily [441 (70.00%)], 50 mg thrice daily [86 (13.65%)], 25 mg four times daily [59 (9.37%)], and many “strongly agree” and “agree” that its sustained release formulation may offer better treatment compliance [565 (89.68%)], safety [548 (86.99%)], and efficacy [544 (86.35%)]. Conclusion: Bethanechol was the most prescribed drug for the management of postoperative urinary retention and other pathologies suspected to cause underactive bladder.

关键词： Bethanechol Benign Prostatic Hyperplasia Detrusor Underactivity Urinary Retention Underactive Bladder

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Effect of KiwiBiotic on functional constipation and related symptoms:A prospective,single-center,randomized,comparative,crossover study

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World Journal of gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 40-49页

作者： Ashwin D Porwal Paresh M gandhi Deepak K Kulkarni gajanan B Bhagwat Pravin P kamble Department of Proctology Healing Hands ClinicMahārāshtraPune 411001India R&D Center Healing Hands and Herbs Pvt.Ltd.MahārāshtraPune 411002India

BACKgROUND Functional constipation(FC)is a common gastrointestinal disorder characterized by abdominal pain and bloating,which can greatly affect the quality of life of *** treatments often yield suboptimal results,leading to the exploration of alternative therapeutic *** To evaluate the efficacy of KiwiBiotic in the management of FC and related *** This prospective,interventional,single-center,crossover study compared the safety and effectiveness of KiwiBiotic®vs psyllium husk in managing FC,abdominal pain,and *** diagnosed with FC were randomly assigned to receive KiwiBiotic or psyllium husk during the two treatment periods,with a 14-day washout period between *** Seventy participants were enrolled,32 of whom received KiwiBiotic followed by psyllium husk,and 33 received *** showed superiority over psyllium husk in alleviating abdominal pain and bloating,as evidenced by significantly lower mean ***,KiwiBiotic resulted in more than 90.0%of patients experiencing relief from various constipation symptoms,while psyllium husk showed comparatively lower *** KiwiBiotic is an effective treatment option for FC,abdominal pain,and bloating,highlighting its potential as a promising alternative therapy for patients with FC and its associated symptoms.

关键词： KiwiBiotic Psyllium husk Constipation Abdominal pain Bloating

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Experimental investigation on the effects of process parameters of gMAW and transient thermal analysis of AISI321 steel

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Advances in Manufacturing 2013年第4期1卷 362-377页

作者： A.g.kamble R.Venkata Rao Department of Mechanical Engineering Sardar Vallabhbhai National Institute of Technology

gas metal arc welding （gMAW） develops an arc by controlling the metal from the wire rod and the input pro- cess parameters. The deposited metal forms a weld bead and the mechanical properties depend upon the quality of the weld bead. Proper control of the process parameters which affect the bead geometry, the microstructures of the weldments and the mechanical properties like hardness, is necessary. This experimental study aims at developing mathematical models for bead height （HB）, bead width （WB） and bead penetration （PB） and investigating the effects of four process parameters viz： welding voltage, welding speed, wire feed rate and gas flow rate on bead geometry, hardness and microstructure of AISI321 steel with 10 mm thickness. The transient thermal analysis shows temperature and residual stress distributions at different conduction and convection conditions.

关键词： gas metalMathematical modelingthermal analysisarc welding (gMAW)Microstructure ~ Transient

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Triheterocyclic Thiadiazepine Derivatives of Pharmacological Interest： Synthesis of 2-Aryl-4-[ρ-（2,3-dihydro-5-methyl-2-oxo-1,3,4-oxadiazol-3-yl）phenyl]-6-（u n）su bstituent-1 ＂,2＂ ,4＂- triazolo[3＂,4＂-b]-1 ＇,3＇,4＇-thiadiazepine

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Chinese Journal of Chemistry 2006年第1期24卷 129-134页

作者： kamble, Ravindre SUDHA, Belagur Department of Chemistry and Food Science Yuvaraja' s College University of Mysore Mysore 570005 India

Synthesis of novel thiadiazepine derivatives based on the reactivity of 4-acetylphenylsydnone （1） was reported. The structures of the newly synthesized compounds have been proved by their physical, analytical, IR, 1... 详细信息

关键词： 4-acetylphenylsydnone 1,3-dipolar cycloaddition 1,3,4-thiadiazepine 1,2,4-triazole 1,3,4-oxadiazoline triheterocycle ring closure condensation Michael addition cardiovascular agent

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Carbon and Nitrogen Amendments Lead to Differential growth of Bacterial and Fungal Communities in a High-pH Soil

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Pedosphere 2018年第2期28卷 255-260页

作者： Pramod N. kamble Erland BAATH Microbial Ecology Department of Biology Ecology Building Lund University Lund SE-223 62 (Sweden) Department of Environmental Sciences Savitribai Phule Pune University Pune 411007 (India)

Microbial growth in soil is mostly limited by lack of carbon (C). However, adding fresh, C-rich litter can induce nitrogen (N) limitation. We studied the effect of alleviating C and N limitation in high-pH (> 8) soils, soils expected to favor bacterial over fungal growth. Nitrogen limitation was induced by incubating soils amended with C-rich substrate (starch or straw) for 4 weeks. Limiting nutrients and the effects of alleviating limitation were then studied by adding C (as glucose) or N (as NH_4NO_3) and measuring microbial growth and respiration after 4 d. In non-amended, C-limited soils, adding C but not N increased both microbial respiration and bacterial growth. In N-limited, substrate-amended soils, adding C increased respiration, whereas adding N increased both microbial respiration and growth. Inducing N limitation by amending with straw was most easily detected in increased fungal growth after the addition of N, whereas with starch, only bacterial growth responded to alleviating N limitation. Compared to earlier results using a low-pH soil, the effect of substrate used to induce N limitation was more important than pH for inducing bacterial or fungal growth after alleviating N limitation. Furthermore, we found no evidence that alleviating N limitation resulted in decreased respiration concomitant with increased microbial growth in soil, suggesting no drastic changes in C use efficiency.

关键词： acetate incorporation into ergosterol carbon use efficiency leucine incorporation limiting nutrient microbial growth microbial respiration N limitation

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A Rapid and Convenient Synthetic Route to Novel 1,5-Benzodiazepine Derivatives of 5-Methyl-3-phenyl-2-oxo-△^4-1,3,4-oxadiazolines from ρ-Acetylphenylsydnone and Their Pharmacological Activity

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Chinese Journal of Chemistry 2006年第1期24卷 79-84页

作者： kamble,Ravindra R. SUDHA, Belagur S. Department of Chemistry and Food Science Yuvaraja's College University of Mysore Mysore-570 005 India

A simple and high yielding method for the integration of 1,5-benzodiazepines integrated with 5-methyl- 2-oxo-3-phenyl-△^4-1,3,4-oxadiazolines in 75%-90% yield by microwave irradiation is devised. Microwave-accelerated reaction was compared with thermal method. All the compounds were characterized by physical, analytical and spectral （IR, 1^H NMR, MS） data. Title compounds were screened for preliminary pharmacological activities.

关键词： ρ-acetylphenylsydnone 1,3-dipolar cycloaddition 1,5-diazepine Michael addition microwave irradiation thermal method

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Fabrication of plasmonic nanopyramidal array as flexible SERS substrate for biosensing application

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Nano Research 2023年第1期16卷 1132-1140页

作者： Anindita Das Udit Pant Cuong Cao Rakesh SMoirangthem Hitesh Bhanudas kamble Nanophotonics Lab Department of PhysicsIndian Institute of Technology(Indian School of Mines)Dhanbad-826004India Institute for global Food Security School of Biological SciencesQueen’s University of Belfast19 Chlorine GardensBelfastBT95DLUK Material and Advanced Technologies for Healthcare Queen’s University of Belfast18-30 Malone RoadBelfastBT95BNUK IITB Nanofabrication Facility Department of Electrical EngineeringIndian Institute of TechnologyBombay-400076India

The proposed work aims to develop a sensitive surface-enhanced Raman spectroscopy(SERS)*** inverted nano pyramid array on silicon substrate fabricated using electron beam lithography(EBL)was utilised as a master template and the mold was later replicated via nanoimprinting process to prepare gold-coated polymer nanopyramid three-dimensional(3D)SERS *** fast and versatile replication process using nanoimprinting lithography(NIL)can produce polymer nanopyramids in a low-cost and reproducible ***,the proposed fabrication protocol can be easily upscale for large scale *** intense electric field confinement at nanotips and four edges of gold-coated polymer nanopyramid enhanced the Raman signal of probe molecules,i.e.,Rhodamine 6g with a limit of detection down to 3.277×10−9 M was *** work also underlines the efficiency of gold-coated polymer nanopyramid arrays in the spectral detection of hemoglobin proteins at low *** Raman signal enhancement mechanism was further studied through the electromagnetic simulation using COMSOL *** addition,bending test experiments were performed to understand the effect of flexibility on SERS signal *** fabricated gold-coated polymer nanopyramids arrays could pave the way for the development of low-cost SERS platforms for the detection of hazardous biological and chemical compounds at ultra-low concentrations in practical applications.

关键词： nanopyramids surface-enhanced Raman spectroscopy(SERS) flexible hemoglobin protein nanoimprinting replica molding

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Bethanechol Remains the Preferred Drug in Suspected Underactive Bladder: Findings from Nation-Wide Prescription Analysis

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Open Journal of Urology（泌尿学期刊） 2024年第5期 301页

作者： Sanjay Vasant kamble Anjana Kalpesh Yadav Maneesha Tarkeshwar Sharma Radha Ratnadeep Bhosle

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