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Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1

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World Journal of Gastroenterology 2013年第10期19卷 1551-1562页

作者： Il-Joo Jo Gi-Sang Bae Kyoung-Chel Park Sun Bok choi Won-Seok Jung Su-Young Jung Jung-Hee Cho mee-ok choi Ho-Joon Song Sung-Joo Park Department of Herbology School of Oriental MedicineWonkwang UniversityIksanJeonbuk 540-749South Korea Department of Beauty Science Kwangju women's UniversityKwangju 506-713South Korea Hanbang Body-fluid Research Center Wonkwang UniversityIksanJeonbuk 540-749South Korea Jeollanamdo Development Institute for Korean Traditional Medicine JangheungJeollanamdo 529-851South Korea

AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse ***:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of *** AP developed,the stable cholecystokinin analogue,cerulein was injected hourly,over a 6 h *** samples were taken 6 h later to determine serum amylase,lipase,and cytokine *** pancreas and lungs were rapidly removed for morphological examination,myeloperoxidase assay,and real-time reverse transcription polymerase chain *** specify the role of SSM in pancreatitis,the pancreatic acinar cells were isolated using collagenase *** the cells were pre-treated with SSM,then stimulated with *** cell viability,cytokine productions and high-mobility group box protein-1(HMGB-1) were ***,the regulating mechanisms of SSM action were ***:The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury,as was shown by the reduction in pancreatic edema,neutrophil infiltration,vacuolization and *** treatment also reduced pancreatic weight/body weight ratio,serum amylase,lipase and cytokine levels,and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β.In addition,treatment with SSM inhibited HMGB-1 expression in the pancreas during *** accordance with in vivo data,SSM inhibited the cerulein-induced acinar cell death,cytokine,and HMGB-1 *** also inhibited the activation of c-Jun NH2-terminal kinase,p38 and nuclear factor(NF)-κ***:These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun NH2-terminal kinase,p38 and NF-κB.

关键词： Scolopendra subspinipes mutilans Cytokines Acute pancreatitis High-mobility group box protein-1

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Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer

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World Journal of Gastroenterology 2011年第9期17卷 1167-1173页

作者： Youngmin choi mee-Sook Roh Young-Seoub Hong Hyung-Sik Lee Won-Joo Hur Department of Radiation Oncology Dong-A University School of Medicine Department of Pathology Dong-A University School of Medicine Department of Preventive Medicine Dong-A University School of Medicine

AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with lymph node involvement were *** patients received radical surgery and postoperative pelvic chemoradiotherapy of 50.4-54.0 *** of 5-fluorouracil and leucovorin or levamisole was given intravenously during the first and last week of radiotherapy,and then monthly for about 6 *** of IL-24 and VEGF was evaluated by immunohistochemical staining of surgical specimens, and their relations with patient characteristics and survival were *** median follow-up of surviving patients was 73 mo(range:52-122 mo). RESULTS:IL-24 expression was found in 81 out of 90 patients;31 showed weak intensity and 50 showedstrong *** expression was found in 64 out of 90 *** and weak intensities of IL-24 expression were classified as negative expression for ***-24 expression was significantly reduced in poorly differentiated tumors in comparison with well or moderately differentiated tumors(P=0.004),N2b to earlier N stages(P=0.016),and stageⅢc to stageⅢ a orⅢb(P=0.028).The number of involved lymph nodes was also significantly reduced in IL-24-positive patients in comparison with IL-24-negative ones. There was no correlation between VEGF expression and patient *** of IL-24 and VEGF was not correlated with survival,but N stage and stages were significantly correlated with survival. CONCLUSION:IL-24 expression was significantly correlated with histological differentiation,and inversely correlated with the degree of lymph node involvement in stageⅢrectal cancer.

关键词： Interleukin-24 Rectal cancer Lymph node Histological differentiation Vascular endothelial growth factor

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Synchronous triple occurrence of MALT lymphoma, schwannoma, and adenocarcinoma of the stomach

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World Journal of Gastroenterology 2017年第22期23卷 4127-4131页

作者： Kyeong W choi mee Joo Han S Kim Woo Y Lee Department of Surgery Seoul Paik Hospital Inje University College of Medicine Department of Pathology Ilsan Paik Hospital Inje University College of Medicine

We present a case of a 56-year-old man with 3 synchronous gastric tumors. The patient presented with melena, and 3 gastric abnormalities were detected on gastroduodenoscopic examination, including a small ulcerative lesion in the gastric antrum, a submucosal mass in the gastric body, and severe erosion in the fundus. Histological examination of biopsy samples yielded respective diagnoses of gastric adenocarcinoma, gastritis, and mucosa-associated lymphoid tissue(MALT) lymphoma. The patient first received medication to eradicate any underlying Helicobacter pylori infection, which might have been a cause of the MALT lymphoma. Four weeks later, after examination of repeat biopsy samples revealed that the MALT lymphoma had resolved, the patient underwent subtotal gastrectomy. Further histological examination of resected tissue confirmed the antrum lesion as adenocarcinoma and the body lesion as schwannoma. To our knowledge, this is the first reported case of synchronous triple primary gastric adenocarcinoma, MALT lymphoma, and schwannoma.

关键词： Gastric cancer Synchronous Mucosa-associated lymphoid tissue lymphoma Schwannoma Triple

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Spontaneous liver rupture in a patient with peliosis hepatis:A case report

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World Journal of Gastroenterology 2009年第43期15卷 5493-5497页

作者： Sun-Keun choi Jun-Shuo Jin Soon-Gu Cho Suk-Jin choi Chul-Soo Kim Yun-mee Choe Keon-Young Lee Department of Surgery Inha University School of MedicineIncheon 400-711South Korea Department of Radiology Inha University School of MedicineIncheon 400-711South Korea Department of Pathology Inha University School of MedicineIncheon 400-711South Korea Department of Internal Medicine Inha University School of MedicineIncheon 400-711South Korea

Peliosis hepatis is a rare pathological entity and may cause fatal hepatic hemorrhage and liver ***, we present a young male patient with aplastic anemia,who had received long-term treatment with *** patient suffered from sudden onset of intra-abdominal hemorrhage with profuse *** patient was treated successfully with a right hemihepatectomy and is in good health after 13 postoperative *** suggest that peliosis hepatis be considered in patients with hepatic parenchymal hematoma,especially in patients under prolonged synthetic anabolic steroid *** possibility of a potentially life-threatening complication of massive intra-abdominal bleeding should also be considered.

关键词： Peliosis hepatis Spontaneous rupture Liver

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Controlling the contact levels of details for fast and precise haptic collision detection

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Frontiers of Information Technology & Electronic Engineering 2017年第8期18卷 1117-1130页

作者： A Ram choi Sung Min KIM mee Young SUNG Department of Computer Science and Engineering lncheon National University lncheon Korea

For accurate and stable haptic rendering, collision detection for interactive haptic applications has to be done by filling in or covering target objects as tightly as possible with bounding volumes （spheres, axis-aligned bounding boxes, oriented bounding boxes, or polytopes）. In this paper, we propose a method for creating bounding spheres with respect to the contact levels of details （CLOD）, which can fit objects while maintaining the balance between high speed and precision of collision detection. Our method is composed mainly of two parts： bounding sphere formation and two-level collision detection. To specify further, bounding sphere formation can be divided into two steps： creating spheres and clustering spheres. Two-level collision detection has two stages as well： fast detection of spheres and precise detection in spheres. First, bounding spheres are created for initial fast probing to detect collisions of spheres. Once a collision is probed, a more precise detection is executed by examining the distance between a haptie pointer and each mesh inside the colliding boundaries. To achieve this refmed level of detection, a special data structure of a bounding volume needs to be defined to include all mesh information in the sphere. After performing a number of experiments to examine the usefulness and performance of our method, we have concluded that our algorithm is fast and precise enough for haptic simulations. The high speed detection is achieved through the clustering of spheres, while detection precision is realized by voxel-based direct collision detection. Our method retains its originality through the CLOD by distance-based clustering.

关键词： Collision detection Haptic rendering Bounding sphere Clustering Contact levels of details (CLOD)

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Transmural penetration of sigmoid colon and rectum by retained surgical sponge after hysterectomy

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World Journal of Gastroenterology 2016年第10期22卷 3052-3055页

作者： Woo Young Shin Chan Hyuk Im Sun Keun choi Yun-mee Choe Kyung Rae Kim Department of Surgery Inha University HospitalInha University College of Medicine

Gossypiboma is a surgical sponge that is retained in the body after the operation. A 39-year-old female presented with vague lower abdominal pain, fever, and rectal discharge 15 mo after hysterectomy. The sponge remaining in the abdomen had no radiopaque marker. Therefore a series of radiographic evaluations was fruitless. The surgical sponge was found in the rectosigmoid colon on colonoscopy. The sponge penetrated the sigmoid colon and rectum transmurally, forming an opening on both sides. The patient underwent low anterior resection and was discharged without postoperative complications.

关键词： Gossypiboma Textiloma Retained foreign object Surgical sponge Radiopaque marker

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Simulation of the extreme waves generated by typhoon Bolaven (1215) in the East China Sea and Yellow Sea

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Acta Oceanologica Sinica 2015年第12期34卷 19-28页

作者： JUN Ki Cheon JEONG Weon Mu choi Jin Yong PARK Kwang Soon JUNG Kyung Tae KIM mee Kyung CHAE Jang Won QIAO Fangli Coastal Disaster Research Center Korea Institute of Ocean Science and Technology Coastal & Environmental Engineering Division Korea Institute of Ocean Science and Technology Marine Radionuclide Research Center Korea Institute of Ocean Science and Technology First Institute of Oceanography State Oceanic Administration

Record-breaking high waves occurred during the passage of the typhoon Bolaven（1215）（TYB） in the East China Sea（ECS） and Yellow Sea（YS） although its intensity did not reach the level of a super *** and directional wave measurements were made using a range of in-situ instruments mounted on an ocean tower and *** order to understand how such high waves with long duration occurred,analyses have been made through measurement and numerical *** winds were generated using the TC96 typhoon wind model with the best track data calibrated with the *** then the wind fields were blended with the reanalyzed synoptic-scale wind fields for a wave *** fields were simulated using WAM4.5 with adjustment of C_d for gust of winds and bottom friction for the study *** the accuracy of simulations is considerably enhanced,and the computed results are also in better agreement with measured data than *** is found that the extremely high waves evolved as a result of the superposition of distant large swells and high wind seas generated by strong winds from the front/right quadrant of the typhoon *** the typhoon moved at a speed a little slower than the dominant wave group velocity in a consistent direction for two days,the wave growth was significantly enhanced by strong wind input in an extended fetch and non-linear interaction.

关键词： extreme waves typhoon measurements numerical simulation East China Sea

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Efficacy of cap-assisted endoscopy for routine examining the ampulla of Vater

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World Journal of Gastroenterology 2013年第13期19卷 2037-2043页

作者： Young Rak choi Joung-Ho Han Young Shim Cho Hye-Suk Han Hee Bok Chae Seon mee Park Sei Jin Youn Department of Internal Medicine College of MedicineChungbuk National University

AIM: To determine the efficacy of a cap-assisted endoscopy (CAE) to completely visualize the ampulla of Vater (AV) in patients failed by conventional endoscopy. METHODS: A prospective study was conducted on 120 patients > 20 years of ages who visited the Health Promotion Center of Chungbuk National University Hospital for conscious sedation esophagogastroduodenoscopy (EGD) as a screening test from July to October, 2011. First, forward-viewing endoscopy was performed with reasonable effort using a push and pull method. We considered complete visualization of the AV when we could observe the entire AV including the orifice clearly, and reported the observation as complete or incomplete (partial or not found at all). Second, in cases of complete failure of the observation, an additional AV examination was conducted by attaching a short cap (D-201-10704, Olympus Medical Systems, Tokyo, Japan) to the tip of a forward-viewing endoscope. Third, if the second method failed, we replaced the short cap with a long cap (MH-593, Olympus Medical Systems) and performed a re-examination of the AV. RESULTS: Conventional endoscopy achieved complete visualization of the AV in 97 of the 120 patients (80.8%) but was not achieved in 23 patients (19.2%). Age (mean ± SD) and gender [male (%)] were not significantly different between the complete observation and the incomplete observation groups. Additional short CAE was performed in patients in whom we could not completely visualize the AV. This group included 13 patients (10.9%) with partial observation of the AV and 10 (8.3%) in which the AV was not found. Short CAE permitted a complete observation of the AV in 21 of the 23 patients (91.3%). Patients in whom visualization of the AV failed with short CAE had satisfactory outcomes by replacing the short cap with a long cap. The additional time for CAE took an average of 141 ± 88 s. There were no complications and no significant mucosal trauma. CONCLUSION: CAE is safe to use as a salvage me

关键词： Ampulla of Vater Conventional endoscopy Cap-assisted endoscopy Screening test Complete observation

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Metachronous bile duct cancer nine years after resection of gallbladder cancer

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World Journal of Gastroenterology 2009年第27期15卷 3440-3444页

作者： Hye Jin Joo Gi Hyun Kim Won Joong Jeon Hee Bok Chae Seon mee Par Sei Jin Youn Jae Woon choi Rohyun Sung Department of Internal Medicine College of Medicine Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea Department of General Surgery Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea Department of Pathology College of Medicine Chungbuk National UniversityGaeshindong 62 Heungdukgu Cheongju 361-711 South Korea

We report a rare case of a 74-year-old man with metachronous gallbladder cancer and bile duct cancer who underwent curative resection twice, with the operations nine years apart. At the age of 65 years, the patient underwent a cholecystectomy and resection of the liver bed for gallbladder cancer. This was a welldifferentiated adenocarcinoma, with negative resection margins （T2NOM0, stage Ⅰ B）. Nine years later, during a follow-up examination, abdominal computed tomography and MRCP showed an enhanced 1.7 cm mass in the hilum that extended to the second branch of the right intrahepatic bile duct. We diagnosed this lesion as a perihilar bile duct cancer, Bismuth type Ⅲ a, and performed bile duct excision, right hepatic Iobectomy and Roux-en-Y hepaticojejunostomy. The histological diagnosis was a well-differentiated adenocarcinoma with one regional lymph node metastasis （TINIM0, stage Ⅱ B）. Twelve months after the second operation, the patient is well, with no signs of recurrence. This case is compared with 11 other cases of metachronous biliary tract cancer published in the world medical literature.

关键词： Biliary tree Metachronous double cancer Gallbladder cancer Hilar bile duct cancer

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Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn’s disease

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World Journal of Gastroenterology 2010年第20期16卷 2496-2503页

作者： Joon mee Kim Hyung Kil Kim Lucia Kim Suk Jin choi In Suh Park Jee Young Han Young Chae Chu Kye Sook Kwon Eun Joo Kim Department of Pathology College of Medicine Inha University7-206 Shin-heung-Dong 3 GaJoong-GuIncheon 400-711South Korea Gastroenterology College of Medicine Inha University7-206 Shinheung-Dong 3 GaJoong-GuIncheon 400-711South Korea Department of Nano and Bio Research Daegu Gyeongbuk Institute of Science and TechnologyDeocksan-dong 110Daegu 700-742South Korea

AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and ***: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic *** features of ITB and CD were reviewed,and eight pathologic parameters were *** cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test,*** assays were done using two commercial kits: kit detected IS6110 and MPB64,and kit detected IS6110 only;a manual in-house PCR method was also performed on formalin-fi xed,paraffi n-embedded colonoscopic biopsy ***: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000),giant cells (P = 0.015),caseation necrosis (P = 0.003),confluent granulomas (P = 0.001),discrete granulomas (P = 0.000),and granulomas with lymphoid cuffs (P = 0.037).However,29 cases (52.7%) of ITB showed less than fi ve kinds of pathologic parameters,resulting in confusion with *** sensitivities and specificities of the TB-PCR test by kit ,kit ,and the in-house PCR method were 88.9% and 100%,88.9% and 100%,and 66.7% and 100% in positive and negative controls,*** PCR test done on endoscopic biopsy specimens of ITB and CD were signifi cantly different with kit (P = 0.000) and kit (P = 0.000).The sensitivities and specifi cities of TB-PCR were 45.5% and 88.1%,36.4% and 100%,and 5.8% and 100%,for kit and kit and inhouse PCR method on endoscopic biopsy *** the 29 cases of histopathologically confusing CD,10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive.A combi

关键词： Intestine Tuberculosis Crohn’s disease Histopathology Polymerase chain reaction Kit IS6110 MPB64

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