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Severe acute respiratory syndrome coronavirus 2 may cause liver injury via Na^(+)/H^(+) exchanger

World Journal of Virology 2023年第1期12卷 12-21页

作者： medine cumhur cure Erkan cure Department of Biochemistry Private Tanfer HospitalIstanbul 34394Turkey Department of Internal Medicine Bagcilar Medilife HospitalIstanbul 34200Turkey

The liver has many significant functions,such as detoxification,the urea cycle,gluconeogenesis,and protein synthesis.Systemic diseases,hypoxia,infections,drugs,and toxins can easily affect the liver,which is extremely sensitive to injury.Systemic infection of severe acute respiratory syndrome coronavirus 2 can cause liver damage.The primary regulator of intracellular pH in the liver is the Na+/H+exchanger(NHE).Physiologically,NHE protects hepatocytes from apoptosis by making the intracellular pH alkaline.Severe acute respiratory syndrome coronavirus 2 increases local angiotensin II levels by binding to angiotensinconverting enzyme 2.In severe cases of coronavirus disease 2019,high angiotensin II levels may cause NHE overstimulation and lipid accumulation in the liver.NHE overstimulation can lead to hepatocyte death.NHE overstimulation may trigger a cytokine storm by increasing proinflammatory cytokines in the liver.Since the release of proinflammatory cytokines such as interleukin-6 increases with NHE activation,the virus may indirectly cause an increase in fibrinogen and D-dimer levels.NHE overstimulation may cause thrombotic events and systemic damage by increasing fibrinogen levels and cytokine release.Also,NHE overstimulation causes an increase in the urea cycle while inhibiting vitamin D synthesis and gluconeogenesis in the liver.Increasing NHE3 activity leads to Na+loading,which impairs the containment and fluidity of bile acid.NHE overstimulation can change the gut microbiota composition by disrupting the structure and fluidity of bile acid,thus triggering systemic damage.Unlike other tissues,tumor necrosis factor-alpha and angiotensin II decrease NHE3 activity in the intestine.Thus,increased luminal Na+leads to diarrhea and cytokine release.Severe acute respiratory syndrome coronavirus 2-induced local and systemic damage can be improved by preventing virus-induced NHE overstimulation in the liver.

关键词： Liver Hepatocyte Severe acute respiratory syndrome coronavirus 2 COVID-19 Na+/H+exchanger Sodium-proton pump

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Discuss public hospital performance salary calculation

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中国国际财经（中英文版） 2015年第11期 25-27页

作者： Ren Jun cure

in our country, the public hospital shoulders on the responsibility of protecting people＇s health, the public hospital （hereinafter referred to as hospitals） is the people＇s health guardian, whole-hearted service for patients, everything for the patient,in order to all patients.Hospital performance wage accounting, involving the performance salary distribution policy implementation to the hospital, is to maintain a good hospital benefit and the benefit to do earnestly safeguard department arouse the enthusiasm ofdepartment employees, so as to maximize the arouse the enthusiasm of medical personnelservice patient, the patient to feel the warmth of the hospital, let patients feel the superiorityof medical and health care system in our country.To hospital performance salary allocationreouest pavroll accounting orocess of scientific and reasonable, the correct understanding and use of accounting oolicv, accounting oersonnel, a strong sense of resoonsibility and highsense of responsibility.

关键词：工资计算医院绩效医疗保健系统人民健康分配政策责任感科学性

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A Study on Strategic Management for Paparusso——How to Build Competitive Capacity for the Firm Paparusso?

A Study on Strategic Management for Paparusso——How to Buil...

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作者： Laura Porziela Bernadette cure 上海交通大学

学位级别：硕士

Purpose and significane of the research: Understanding the luxury fashion industry is a significant factor to implement a robust competitive strategy for the new firm Paparusso.This master thesis contributes to the strategic management area by researching the Chinese’s purchase incentives concerning ready-to-wear and made-to-measure clothes.Paparusso is a fashion firm that registered a business license in Shanghai,named“巴巴红瑟.”Starting from the beginning,Paparusso is a fashion firm adopting two business models.The first one is to sell ready-to-wear clothes（RTW）and the second one is that customers may have the possibility to order their size,through the made-to-measure（MTM）product and service.Literature review: The literature review contains prescriptive guidance about the strategic management field and Chinese luxury fashion market.The luxury fashion market has been expanding in China for a few years,much helped by the arising middle-class and the improved buying power of Chinese,especially Millennials that provide a tremendous contribution.Methodologies: Different tools support academic research for the thesis.Firstly,the PEST model is necessary when starting to analyze the environment.These four elements appear to be positive to set up a fashion business in Shanghai.The following tool is the Five Forces that scan the external environment as well.The first most potent force that represents a threat for Paparusso firm is the existing competitors because there are too many players in the market.Thirdly,the methodology lean startup is engaged in the thesis to support the business plan.Eric Ries defends the idea of experimentation when starting a business.Fourthly,the Value Chain is one of the main tools used in this master thesis.The first and support activities are defined to create value for customers and therefore create a competitive advantage.The more value an organization creates,the more profitable it is likely to be.Fifthly,the VRIO framework is a primary tool for creating the strategic management of the fir

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Intracranial hematoma development following thrombolysis inpatients suffering with acute myocardial infarction: Management strategy

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Journal of Acute Disease 2018年第5期7卷 217-219页

作者： Luis Rafael Moscote Salazar Amit Agrawal Guru Dutta Satyarthee George Chater cure Alfonso Pacheco-Hernandez Universidad de Cartagena Cartagena de IndiasColombia Department of Neurosurgery Narayna Medical College HospitalChinthareddypalemNellore-524003Andhra PradeshIndia All India Institute of Medical Sciences New DelhiIndia Clinica General de Norte BarranquillaColombia

Intracerebral hemorrhage secondary to thrombolysis in patients with acute myocardial infarction is a catastrophic condition.Several factors predispose to intracranial bleeding including low body weight,female sex,advanced age,use of oral anticoagulants prior to the administration of fibrinolytic therapy,diastolic blood pressure (greater than 110 mm Hg),among others.Optimal medical management involves multidisciplinary roles of hematology,neurosurgery and critical medicine.In this illustrative case,a classification and management algorithm were proposed for patients with complications hemorrhage associated with thrombolysis after myocardial infarction.

关键词： Acute myocardial infarction Thrombolysis Intracranial hematoma Management Outcome

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水产养殖水体好氧同时硝化—反硝化脱氮的研究

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山西大学学报(自然科学版) 2005年第3期28卷 328-332页

作者：连晋山西省鱼病防治中心山西太原030002

利用筛选和分离的7株脱氮微生物,在好氧条件下将氨氮转化为亚硝酸氮,随即在好氧反硝化菌的作用下还原为氮气排放.将上述菌株固定在PVA凝胶膜中,研究了水产养殖水体中氨氮、硝酸氮和亚硝酸氮在PVA凝胶膜中的扩散性能和转化脱氮过程.结果... 详细信息

利用筛选和分离的7株脱氮微生物,在好氧条件下将氨氮转化为亚硝酸氮,随即在好氧反硝化菌的作用下还原为氮气排放.将上述菌株固定在PVA凝胶膜中,研究了水产养殖水体中氨氮、硝酸氮和亚硝酸氮在PVA凝胶膜中的扩散性能和转化脱氮过程.结果表明,氨氮、硝酸氮和亚硝酸氮在PVA浓度为15%,细胞浓度为40g/L凝胶膜中,扩散系数分别为0.55m2/s,0.46m2/s,0.45m2/s.整个生物脱氮过程历时较短,36h内对200mg/L的氨氮去除率达99%,而且无中间产物亚硝酸氮的积累,固定化微生物生长的适宜pH范围为7~9,最适温度为30℃;与游离的硝化细菌和反硝化细菌相比,固定化硝化菌是游离硝化菌对氨氧化速率的70%,固定化反硝化菌是游离反硝化菌对亚硝酸氮还原速率的74%.经过20d的连续处理,固定化微生物的稳定性远大于游离微生物,28d后,游离微生物在反应器内的浓度几乎为零,而固定化微生物的浓度和活性几乎不变.

关键词：水产养殖同时硝化-反硝化脱氮微生物

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Myofascial Foot Pain Following Uneventful Epidural Analgesia for Labor and Delivery

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Open Journal of Anesthesiology 2012年第1期2卷 11-13页

作者： Badie S. Mansour Gretchen M. Wienecke Jorge A. cure Jeremy T. Almon Alberto J. de Armendi 不详

Following an uneventful delivery under epidural analgesia, a 17 year old female patient was referred to the Pain Clinic because of numbness and pain of the left big toe for 2 and a half Months. An Orthopedic consultation had ruled out foot injury and concluded that the pain was radicular and secondary to nerve damage from the epidural analgesia. A Pain Clinic evaluation made the diagnosis of myofascial pain which was successfully treated with trigger pint block using normal saline.

关键词： Myofascial Pain Trigger Point Epidural Analgesia Delivery in Adolescent Local Infiltration Chronic Foot Pain

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Use of antiepileptic drugs in children with brain tumors: A review for acute management

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Journal of Acute Disease 2018年第5期7卷 181-185页

作者： Jennifer Herrera-Bejarano Amit Agrawal Claudia Marcela Navas Valbuena Guru Dutta Satyarthee Chandramouli Balasubramanian Andrei F.Joaquim George Chater cure Luis Rafael Moscote-Salazar Physician Universidad del RosarioBogotaColombia Professor of Neurosurgery MM Institute of Medical Sciences&ResearchMaharishi Markandesh(w)ar UniversityMullana-Ambala133-207.HaryanaIndia Physician Universidad Industrial de SantanderUISBucaramangaColombia Assistant Professor of Neurosurgery All India Institute of Medical SciencesNew DelhiIndia Department of Neurosurgery Birmingham Children's HospitalBirminghamUK Department of Neurology Neurosurgery DivisionUniversity of Campinas(UNICAMP)Campinas-SPBrazil Neurosurgeon Clinica General del NorteBarranquillaColombia Neurosurgeon-Critical Care University of CartagenaCartagena de IndiasColombia

Patients with primary or secondary tumors in the central nervous system may have seizures resulting from direct tissue damage,metabolic abnormalities,infection,or toxic side effects of medications.In pediatric patients,it is more frequent to use drugs to control secondary epilepsy.In this article,we discuss the main nuances of antiepileptic drugs for the proper management of children with central nervous system tumors.

关键词： Antiepileptic drugs Brain tumors Neuro oncology Seizures

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甘精胰岛素或中效胰岛素联合二甲双胍治疗2型糖尿病患者的比较

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生物医学工程学杂志 2010年第3期27卷 622-625页

作者：胡茂清罗玉张林杨雪张洪茂成都中医药大学第三附属医院四川省糖尿病防治中心成都610041

了解甘精胰岛素或中效胰岛素联合二甲双胍治疗对口服降糖药血糖控制不佳的2型糖尿病患者的疗效和安全性。符合纳入标准的60例2型糖尿病患者分成A、B两组,每组各30例。A组用甘精胰岛素联合二甲双胍治疗,B组用中效胰岛素联合二甲双胍治疗,... 详细信息

了解甘精胰岛素或中效胰岛素联合二甲双胍治疗对口服降糖药血糖控制不佳的2型糖尿病患者的疗效和安全性。符合纳入标准的60例2型糖尿病患者分成A、B两组,每组各30例。A组用甘精胰岛素联合二甲双胍治疗,B组用中效胰岛素联合二甲双胍治疗,共12周。治疗前后分别测空腹血糖(FPG)、餐后2h血糖(PPG)以及糖化血红蛋白(HbA1c)水平,了解治疗期间两组低血糖的发生情况。两组治疗后较治疗前的FPG、PPG和HbA1c水平降低,差异有统计学意义(P0.05),两组治疗前HbA1c水平≥7%～0.05)。两组的轻微低血糖发生率相似(P>0.05)。甘精胰岛素或中效胰岛素联合二甲双胍治疗对口服降糖药控制不佳的2型糖尿病患者可以进一步降低血糖和糖化血红蛋白水平,低血糖发生率低。甘精胰岛素或中效胰岛素联合二甲双胍治疗是口服降糖药控制不佳的2型糖尿病患者安全有效的治疗方案,而中效胰岛素作为基础胰岛素治疗更是廉价而有效的选择。

关键词： 2型糖尿病甘精胰岛素中效胰岛素二甲双胍血糖控制安全性

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