检索结果-南通市图书馆

Effect of long-term synaptic plasticity on spatial cognition of Wistar rats

在线全文

学校读者我要写书评

暂无评论

Effect of long-term synaptic plasticity on spatial cognition...

Application of memantine hydrochloride in depression-model rats

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhuo YANG~*,Da-Dong HAN medical school of nankai university,tianjin 300071,china

＜正＞Objective Long-term synaptic plasticity,including long term potentiation（LTP）and long term depression （LTD）,was an eventful pattern to modulate efficiency of synaptic transmission in nervous system,and LTP was regarded as the underlying mechanism in learning and *** and LTD switched enhancement or attenuation of neural signal via adjustment the ratio of NR2A/*** study focused on the relationship between the alteration of long-term synaptic plasticity and the performance of Morris water maze（MWM）,attempted to interpret the mechanism,which electrophysiological effects on the *** Rats were randomly divided into 3 groups,MK-801（n=16）,AP-V（n=16）and control group（n=16）.MK-801（10μg,1μg/μL）,AP-V（10μg,1μg/μL） and artificial cerebrospinal fluid（ACSF,10μL）were administered in dentate gyrus（DG）of *** was carried,and LTP and LTD were recorded *** LTP was significantly attenuated（P＜0.01）,while LTD was barely influenced（P＞0.05）in DG region of MK-801 group compared with *** the contrary,LTP was barely influenced（P＞0.05）,while LTD was significantly attenuated（P＜0.01）in DG region of AP-V group compared with *** acquisition and retention tests,the escape latency and path length were prolonged（P＜0.05;P＜0.01）in MK-801 group,and were cut down（P＜0.05;P＜0.01）in AP-V group compared with control *** the contrary, in reacquisition phase,the escape latency（P＜0.05）was cut down in MK-801 group,and was prolonged（P＜0.05）in AP-V compared with control *** The unbalance of long-term synaptic plasticity results in the spatial cognitive impairment in rats.

关键词： long-term synaptic plasticity LTP LTD spatial learning and memory

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Application of memantine hydrochloride in depression-model r...

MAXIMUM INFORMATION AND OPTIMUM ESTIMATING FUNCTION

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Mei-Na QUAN~1,Shuang LIANG~2,Tao ZHANG~2,Zhuo YANG~(1,*) 1 Laboratory of Neurophysiology,medical school,nankai university,tianjin 300071,china 2 Laboratory of Bioinformatics,Life Science Institude,nankai university,tianjin 300071,china

＜正＞Objective This study was designed to establish an animal model of depression,and using physiological, behavioral and electrophysiological methods to explore the pathogenesis of depression and to assess possible antidepressant effects of Memantine hydrochloride（HCL）,a selective N-methyl-D-aspartate（NMD A） antagonist,in this animal *** The animal model of depression was established in male Wistar rats by combining isolation rearing with chronic unpredictable mild stress（CUMS）.Memantine HCL（20 mg/kg） was administered intraperitoneally from the second day of establishing depression model,for 21 d,until the first day of water maze *** rats’ physiological status was observed by their weights and sucrose *** change was observed by water maze *** change was tested by recording long-term potentiation（LTP） from thalamus to prefrontal *** （1） Compared with normal group,rats’ weight increase and sucrose consumption was statistically lower in CUMS model group and Memantine HCL-treated group.（2） In the water maze test,the mean escape latency（EL） of the first period of Oriented Navigation Training（ONT） was significantly prolonged in CUMS model group and Memantine HCL-treated group as compared with that of normal *** of the second and third periods of ONT was significantly prolonged in Memantine HCL-treated group as compared with those of normal group and CUMS model group.（3） LTP test showed that excitatory postsynaptic potential（PSP） slopes were statistically different among three *** model group had the lowest slopes and normal group had the highest *** Animal model of depression can be established successfully by isolation rearing combined with chronic unpredicted mild *** a 21-d trial,Memantine in the dose of 20 mg/kg was not effective in the treatment of depression,but it could improve synaptic plasticity in prefrontal cortex in model rats.

关键词： depression Memantine HCL isolation rearing CUMS water maze LTP

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2003年第3期24卷 349-358页

作者： LIN Lu Department of Statistics, school of Mathematical Sciences, nankai university, tianjin 300071, china. Department of Statistics School of Mathematical Sciences Nankai University Tianjin 300071 China

In order to construct estimating functions in some parametric models, this paper introducestwo classes of information matrices. Some necessary and sufficient conditions for the informationmatrices achieving their upper bounds are given. For the problem of estimating the median,some optimum estimating functions based on the information matrices are acquired. Undersome regularity conditions, an approach to carrying out the best basis function is introduced. Innonlinear regression models, an optimum estimating function based on the information matricesis obtained. Some examples are given to illustrate the results. Finally, the concept of optimumestimating function and the methods of constructing optimum estimating function are developedin more general statistical models.

关键词： Quasi (pseudo) Fisher information Estimating function Quasi score Nonlinear regression model Median regression model

On isometric extension problem between two unit spheres

在线全文

学校读者我要写书评

暂无评论

Science china Mathematics 2009年第10期52卷 2069-2083页

作者： Ding GuangGui school of Mathematical Sciences and LPMC, nankai university, tianjin 300071, china school of Mathematical Sciences and LPMC Nankai University Tianjin China

In this paper we introduce the isometric extension problem of isometric mappings between two unit spheres. Some important results of the related problems are outlined and the recent progress is mentioned.

关键词： normed space isometric extension isometric mapping 1-Lipschitz mapping 46A22 46B02 46B04 46B20 46B22

Search for B_c (ns) via the B_c (ns) → B_c (ms) π^+ π^- transition at LHCb and Z^0 factory

在线全文

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2010年第11期53卷 2019-2024页

作者： KE HongWei 1 & LI XueQian 2 1 school of Science,tianjin university,tianjin 300072,china 2 school of Physics,nankai university,tianjin 300071,china school of Science Tianjin University Tianjin China school of Physics Nankai University Tianjin China

It is interesting to study the characteristics of the whole family of B c which contains two different heavy *** and the proposed Z 0 factory provide an opportunity because a large database of the B c family will be achieved.B c and its excited states can be identified via their decay *** suggested by experimentalists,B-c (ns) → B c +γ is not easy to be clearly measured,instead,the trajectories of π + and π- occurring in the decay of B c (ns) → B c (ms) + π + π( n > m ) can be unambiguously identified,thus the measurement seems easier and more reliable;therefore this mode is more favorable at the early running stage of LHCb and the proposed Z 0 *** this work,we calculate the rate of B c (ns) → B c (ms) + π + π-in terms of the QCD multipole-expansion and the numerical results indicate that the experimental measurements with the luminosity of LHC and Z 0 factory are feasible.

关键词： meson hadronic decay QCD multipole-expansion

SOME RESULTS ON INFINITE DIMENSIONAL NOVIKOV ALGEBRAS

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2003年第3期24卷 309-314页

作者： ZHAO YUFENG MENG DAOJI Department of Mathematics, nankai university, tianjin 300071, china. Department of Mathematics, nankai university, tianjin 300071, china. Department of Mathematics Nankai University Tianjin 300071 China

This paper gives some sufficient conditions for determining the simplicity of infinite di-mensional Novikov algebras of characteristic 0, and also constructs a class of simple Novikovalgebras by extending the base fie... 详细信息

关键词： Novikov algebra Novikov-Poisson Algebra Algebraic deformation

Another solution of Yang-Baxter equation on set and "metahomomorphisms on groups

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1997年第22期42卷 1852-1855页

作者： GU PeiDepartment of Mathematics, nankai university, tianjin 300071, china Department of Mathematics Nankai University Tianjin China

1 Another solution of Yang-Baxter equation on setIN ref [1], Drinfeld said that up to now there exist just two examples on the solution R of theYang-Baxter

关键词： Yang-Baxter equation solution metahomomorphism finite simple group.

Principle of limitation of physical quantities and cyclic universe

在线全文

学校读者我要写书评

暂无评论

Science china(Physics,Mechanics & Astronomy) 2008年第5期51卷 451-458页

作者： HE GuoZhu Department of Physics,nankai university,tianjin 300071,china Department of Physics Nankai University Tianjin China

A close study of Heisenberg uncertainty principles reveals many significant facts,and all four major physical quantities,energy,time,momentum and length,have both lower and upper ***,many questions come *** are these limits?Some answers may lead to the understanding of the development of our *** is the shortest limit of time?At the beginning of big bang,there exists a tre-mendously short time,the Planck *** may be just the shortest time limit in our *** longest time limit might be the lifetime of our *** longest length might be the final diameter of our expanding *** these lead to a finite *** more coupling formulae are formed for the other two pairs of physical quantities,mass and speed,thermal energy and *** four physical quantities must also have *** already knew that speed has upper limit and temperature has lower *** these two formulae,Planck and Einstein equations are derived *** most other physical quantities are somewhat related to these major physical quantities,it seems that there exists a principle of limitation of physical quantities.A quantitative sketch of big bang is *** also shows that our universe will contract back to another big *** principle of limitation opens up some fields of *** may bring nature back to the harmony and determined world described by classical physics.

关键词： principle of limitation of physical quantities limits coupling formulae cyclic universe extension of conven-tional quantum mechanics no uncertainty for physical quantities quantitative evaluation of big bang

Tunneling Through Black Rings

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2007年第5期47卷 835-842页

作者： ZHAO Liu Department of Physics,nankai university,tianjin 300071,china Department of Physics Nankai University Tianjin 300071 China

Hawking radiation of black ring solutions to 5-dimensional Einstein-Maxwell-dilaton theory is analyzedby use of the Parikh-Wilczek tunneling *** get the correct tunneling amplitude and emission rate,we adoptand develop the Angheben-Nadalini-Vanzo-Zerbini covariant approach to cover the effects of rotation and electronicdischarge all at once,and the effect of back reaction is also taken into *** constitutes a unified approach tothe tunneling *** the first law of thermodynamics for black rings holds,the emission rate is proportionalto the exponential of the change of Bekenstein-Hawking *** calculation for black ring temperatures agreesexactly with the results obtained via the classical surface gravity method and the quasi-local formalism.

关键词： black ring radiation tunneling method