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P_(4k-1)-factorization of bipartite multigraphs

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Science China Mathematics 2006年第7期49卷 961-970页

作者： WANG Jian & DU Beiliang nantong Vocational College, nantong 226007, China Department of Mathematics, Suzhou university, Suzhou 215006, China 1. Vocational College Nantong 226007 China 2. Department of Mathematics Suzhou University Suzhou 215006 China

LetλKm,n be a bipartite multigraph with two partite sets having m and n vertices, respectively. A Pν-factorization ofλKm,n is a set of edge-disjoint Pν-factors ofλKm,n which partition the set of edges ofλKm,n. Whenνis an even number, Ushio, Wang and the second author of the paper gave a necessary and sufficient condition for the existence of a Pν-factorization ofλKm,n. When v is an odd number, we proposed a conjecture. However, up to now we only know that the conjecture is true forν= 3. In this paper we will show that the conjecture is true whenν= 4k-1. That is, we shall prove that a necessary and sufficient condition for the existence of a P4k-1-factorization ofλKm,n is (1) (2k-1)m≤2kn, (2) (2k-1)n≤2km, (3)m + n = 0 (mod 4k-1), (4)λ(4k-1)mn/[2(2k-1)(m + n)] is an integer.

关键词： bipartite multigraph, factor, factorization.

Abnormal expression of HSP gp96 associated with HBV replication in human hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 381-386页

作者： Deng-Fu Yao,Xin-Hua Wu,Xiao-Qin Su,Min Yao, Wei Wu, Li-Wei Qiu, Li Zou and Xian-Yong Meng The Institute of Clinical Medicine, nantong university, and Department of Gastroenterology,Affiliated Hospital of nantong university, nantong 226001, China and Nanjing medical university, Nanjing 210009, China The Institute of Clinical Medicine Nantong University Nantong 226001 China. yaodf@***

BACKGROUND: Heat shock protein (HSP) gp96 is a member of the HSP90 family and presumably overexpresses as a result of stimulation by mutated or abnormal proteins. Its abnormal expression correlates with carcinogenesis, progression and prognosis of hepatocellular carcinoma (HCC). In this study, we investigated the pathological characteristics of liver gp96 expression and its relationship with hepatitis B virus (HBV) replication in HCC patients. METHODS: Tumor specimens were prospectively collected from 30 HCC patients undergoing liver resection. Total RNAs were extracted from HCC or their noncancerous tissues. The distribution of gp96 expression in hepatocytes was investigated by streptavidin peroxidase (S-P) immunohistochemistry and tissue HBV-DNA was detected by the in situ molecular hybridization technique. The association of gp96 expression with HBV replication, and the histopathological characteristics of HCC were analyzed. RESULTS: The gp96 was strongly expressed in HCC (73.3%, 22 of 30) and weakly (46.7%, 14 of 30) in non-cancerous tissues. The gp96 expression in HCC tissues was correlated with degree of tumor differentiation and tumor size, but not with tumor number (P>0.05). Immunohistochemical analysis showed that 17 of 19 HCC patients with HBVDNA -positive were strongly expressed for gp96, whereas only 5 of 11 patients with HBV-DNA-negative were positive for gp96. A significant difference was found between the two groups (89.5% vs. 45.5%, P<0.05). CONCLUSIONS: The abnormal expressions of HSP gp96 in HCC tissues are associated with HBV replication. This finding indicates that HBV infection plays an important role in the development of HCC.

关键词： hepatocellular carcinoma heat shock protein gp96 immunohistochemistry HBV-replication

An output delay approach to fault estimation for sampled-data systems

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Science China(Information Sciences) 2012年第9期55卷 2128-2138页

作者： WEN ChengLin 1,QIU AiBing 2 & JIANG Bin 3 1 Institute of Information and Control,Hangzhou Dianzi university,Hangzhou 310018,China 2 school of Electrical Engineering,nantong university,nantong 226019,China 3 College of Automation Engineering,Nanjing university of Aeronautics and Astronautics,Nanjing 210016,China 1. Institute of Information and Control Hangzhou Dianzi University Hangzhou 310018 China2. School of Electrical Engineering Nantong University Nantong 226019 China3. College of Automation Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The problem of fault estimation for a class of non-uniformly sampled-data systems is investigated from the time delay point of view in this ***,the output delay approach is employed to model the sampled-data system as a continuous-time one with time-varying delay ***,based on the analysis of the inapplicability of the adaptive fault diagnosis observer in such class of time-delay systems,a novel augmented fault estimation observer design method is proposed to guarantee the exponential convergence of the estimation ***,an extension to the case of time varying fault estimation for the noisy sampled-data systems is ***,simulation results of a flight control system are presented to demonstrate the effectiveness of the proposed method.

关键词： fault estimation non-uniformly sampled-data augmented observer output delay

The proof of Ushio's conjecture concerning path factorization of complete bipartite graphs

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Science China Mathematics 2006年第3期49卷 289-299页

作者： DU Beiliang & WANG Jian Department of Mathematics, Suzhou university, Suzhou 215006, China nantong Vocational College, nantong 226007, China Department of Mathematics Suzhou University Suzhou 215006 China nantong Vocational College Nantong 226007 China

Let Km,n be a complete bipartite graph with two partite sets having m and n vertices, respectively. A Pv-factorization of Km,n is a set of edge-disjoint Pv-factors of Km,n which partition the set of edges of Km,n. When v is an even number, Wang and Ushio gave a necessary and sufficient condition for existence of Pv-factorization of Km,n. When k is an odd number, Ushio in 1993 proposed a conjecture. Very recently, we have proved that Ushio's conjecture is true when v = 4k - 1. In this paper we shall show that Ushio Conjecture is true when v = 4k + 1, and then Ushio's conjecture is true. That is, we will prove that a necessary and sufficient condition for the existence of a P4k+1-factorization of Km,n is (i) 2km ≤ (2k + 1)n,(ii) 2kn ≤ (2k + 1)m, (iii) m + n ≡ 0 (mod 4k + 1), (iv) (4k + 1)mn/[4k(m + n)] is an integer.

关键词： complete bipartite graph, factorization, Ushio Conjecture.

Synthesis of Oxa-Steroidal-Estrogen Analogues

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Chinese Chemical Letters 1998年第3期9卷 249-250页

作者： Yong ZOU Ling Ling WENG Hu ZHENG(school of Pharmacy, West China university of medical Sciences, Chengdu 610041) W China Univ Med Sci Sch Pharm Chengdu 610041 Peoples R China

The total synthesis of (+/-)-6-oxa-13 beta-ethyl-3-methoxy-8 alpha-gona-1.3.5(10)-trien-17-one and (+/-)-6-oxa-13 beta-ethyl-2-methoxy-8 alpha-gona-1.3.5(10)-trien-17-one was described.

关键词： oxa-steroidal-estrogen osteoporosis total-systhesis

Synthesis on Multifunctional Groups and Multibranched Compounds Ⅷ.Synthesis of Dendritic Polyestrone

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Chinese Chemical Letters 1998年第5期9卷 451-453页

作者： Jian CHEN Ling Ling WENG Hu ZHENG(school of Pharmacy, West China university of medical Sciences, Chengdu 610041) school of Pharmacy W. China Univ. of Medical Sciences Chengdu 610041 China

In this article, using the four-directional core and quaternary carbon branching point, adendritic polyestrone with twelve estrone units was synthesized by convergent strategy. Itsstructure was confirmed by IR and NMR... 详细信息

关键词： dendrimer polyestrone synthesis

Preparation and Characterization for Bispecific Antibodies of Anti-CD3×Anti-Idiotype to BCellLym phocytic Leukem ia

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Journal of Huazhong university of Science and Technology(medical Sciences) 1999年第3期19卷 166-169页

作者： SHEN Guanxin , ZHANG Yue , ZHU Huifen , YANG Jing , WANG Xiaolin Department of Immunology, school of Basic medical Sciences, Tongji medical university, Wuhan 430030 Department of Immunology School of Basic Medical Sciences Tongji Medical University Wuhan 430030

Bispecific antibodies (BsAbs) of anti CD3×anti idiotype (Id) to B cell lymphocytic leukemia (CLL) were prepared by chemical conjugation and direct hybridization technique of hybridoma and hybridoma without screening markers. The specificity of BsAbs from culture supernatants or ascites was assayed by indirect ELISA and indirect immunoflurescence (IF). The results showed that BsAbs could specifically react with homologous serum IgM from patients with B CLL and cells carrying CD3 marker respectively. Cell combination test and LDH assay demonstrated that BsAb significantly increased the conjugate formation between lymphocyte activated kill (LAK) cells and Daudi cells, and enhanced the cytotoxic activity of LAK cells against Daudi cells.

关键词： B chronic lymphocytic leukemia bispecific antibody quadruma chemical conjugation

Effects of the CNTF-collagen gel-controlled delivery system on rat neural stem/progenitor cells behavior

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Science China(Life Sciences) 2010年第4期53卷 504-510页

作者： YANG ZhaoYang1, QIAO Hui2 & LI XiaoGuang1,3 1school of Biological Science and medical Engineering, Beihang university, Beijing 100191, China 2Public Heath school, Ningxia medical university, Yinchuan 750004, China 3Beijing Institute for Neuroscience, Capital medical university, Beijing 100069, China 1. school of Biological Science and medical Engineering Beihang University Beijing 100191 China2. Public Heath School Ningxia Medical University Yinchuan 750004 China3. Beijing Institute for Neuroscience Capital Medical University Beijing 100069 China

The injury of central nervous system (CNS) usually causes the cavity formation. Although transplantation of neural stem/precursor cells (NSPCs) into the lesioned area of CNS has been shown to be implicated in the functional restoration, the therapeutic result is limited by the poor survival of NSPCs as well as their insufficient proliferation and differentiation abilities. Type-1 collagen is considered as a candidate scaffold or drug delivery system to overcome the aforementioned obstacle. This study observed the effects of the CNTF (ciliary neurotrophic factor)-collagen gel-controlled delivery system and daily addition of soluble-form CNTF on the NSPC survival, migration, proliferation and differentiation. The results showed that, within 12 h of the initial co-culture, CNTF was released in a burst pattern, then the CNTF-collagen gel-controlled delivery system stably released CNTF for up to 12 d. The cell viability test, together with immunohistochemistry, RT-PCR and Western blotting, showed that the CNTF-collagen gel-controlled delivery system supported the NSPCs seeded on the surface of collagen gel survival and facilitated their migration and proliferation. The daily addition of soluble-form CNTF to the medium had similar effects to the CNTF-collagen gel-controlled delivery system, but large quantities of soluble-form CNTF were consumed during the entire process. Taken together, the CNTF-collagen gel-controlled delivery system not only provides a physical scaffold for the transplanted NSPCs to adhere and migrate, but also facilitates the NSPC survival, growth and proliferation, simultaneously reducing the consumption of the expensive growth factors. This system may be used to enhance the microenvironment in the lesioned area of CNS.

关键词： spinal cord neural stem/progenitor cells control release type-1 collagen CNTF

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智能全科医生中国专家共识

中国全科医学 2025年第2期28卷 135-142页

作者：清华大学万科公共卫生与健康学院北京大学公共卫生学院中国医师协会全科医师分会梁万年刘民路孝琴刘珏不详清华大学万科公共卫生与健康学院中国医师协会全科医师分会北京大学公共卫生学院首都医科大学全科医学与继续教育学院

人工智能大语言模型等新技术的飞速发展给医学临床实践带来了新的变革。国内外已开始了智能全科医生系统的研究及实践探索,但尚未形成共识。在此背景下,清华大学万科公共卫生与健康学院、北京大学公共卫生学院联合中国医师协会全科医师... 详细信息

人工智能大语言模型等新技术的飞速发展给医学临床实践带来了新的变革。国内外已开始了智能全科医生系统的研究及实践探索,但尚未形成共识。在此背景下,清华大学万科公共卫生与健康学院、北京大学公共卫生学院联合中国医师协会全科医师分会及来自国内多家单位的全科医学、公共卫生、人工智能、循证医学等多学科领域的专家学者,在广泛检索国内外文献的基础上,经过多轮专家研讨,最终形成《智能全科医生中国专家共识》,从智能全科医生的定义、特点、应用、挑战与建议等方面形成17条专家共识,为促进智能科技赋能全科医生临床实践、提升基层卫生智慧化服务水平提供科学参考。

关键词：人工智能大语言模型全科医生专家共识