检索结果-南通市图书馆

Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第8期27卷 966-970页

作者： Sheng-nan WU~(2,3,5,6) Rui GAO~(2,3,6) Qing-he XING~(2,3,6) Hua-fang LI~4 Yi-feng SHEN~4 Niu-fan GU~4 Guo-yin FENG~4 Lin HE~(2,3,7)2 Bio-X Life Science Research Center,shanghai jiaotong university,shanghai 200030,China 3 Institute of Nutritional Sciences,SIBS,Chinese Academy of Sciences,shanghai 200031,China 4 shanghai Institute of Mental Health,shanghai 200030,China 5 shanghai Institute of Hypertension,Ruijin Hospital,medical school of shanghai jiaotong university,shanghai 200025,China Bio-X Life Science Research Center Shanghai Jiaotong University Shanghai China Institute of Nutritional Sciences SIBS Chinese Academy of Sciences Shanghai China shanghai Institute of Hypertension Ruijin Hospital Medical School of Shanghai Jiaotong University Shanghai China shanghai Institute of Mental Health Shanghai China

Aim:Extrapyramidal syndrome (EPS) is most commonly affected by typical antip-sychotic drugs that have a high affinity with the D2 ***,manyresearch groups have reported on the positive relationship between the geneticvariations in the DRD2 gene and the therapeutic response in schizophrenia pa-tients as a result of the role of variations in the receptor in modulating *** this study,we evaluate the role DRD2 plays in chlorpromazine-induced EPS in schizophrenic ***:We identified seven SNP(singlenucleotide polymorphism) (-141Cins>del,TaqIB,TaqID,Ser311Cys,rs6275,rs6277and TaqIA) in the DRD2 gene in 146 schizophrenic inpatients (59 with EPS and 87without EPS according to the Simpson-Angus Scale) treated with chlorpromazineafter 8 *** alleles of all loci were determined by PCR (polymerase chainreaction).Results:Polymorphisms TaqlD,Ser311Cys and rs6277 were not poly-morphic in the population recruited in the present *** statistical signifi-cance was found in the allele distribution of-141Cins>del,TaqIB,rs6275 andTaqIA or in the estimated haplotypes (constituted by TaqIB,rs6275 and TaqIA) inlinkage disequilibrium between the two ***:Our results did notlend strong support to the view that the genetic variation of the DRD2 gene playsa major role in the individually variable adverse effect induced by chlorpromazine,at least in Chinese patients with *** results confirmed a previousstudy on the relationship between DRD2 and EPS in Caucasians.

关键词： dopamine receptors basal ganglia disease polymorphism chlorpromazine schizophrenia

Protective and destructive autoimmunity are concomitant in trauma spinal cord injury in adult rats

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protective and destructive autoimmunity are concomitant in t...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： He-Zuo LV,Pei-Hua LU Department of Neurobiology,medical school of shanghai jiaotong university,shanghai 200025

＜正＞The central nervous system（CNS） is an immune-privileged *** a long time,inflammation induced by autoimmunity had been viewed as an important mediator of secondary damage in CNS ***,Schwartz and colleagues recently provided "protective autoimmunity" *** believed that autoimmunity is the body’s endogenous response to a CNS injury,and that its purpose is *** verify if "protective autoimmunity" really exist in spinal cord injury（SCI）,we used neonatally thymectomied（Tx） rats,contusive SCI model,and passive immunization with myelin basic protein（MBP） or spinal cord homogenate（SCH） activated T cells,we found that the MBP activated T cells （MBP-T） and SCH activated T cells（SCH-T） are all CD3+CD4+ phenotype,but they produce different pattern of cytokines. We also found similar CD4+T cells infiltration in the injured spinal cords of MBP-T or SCH-T transferred rats,but without the similar neuroprotective *** immunization with MBP-T could reduce post-injury neuronal losses and exert immune neuroprotection,but SCH-T could not exert any *** were no differences in histology and behavioral assessments among normal,sham-Tx（sTx） and Tx *** results hint that some but not all CNS autoantigens induced autoimmunity might have neuroprotective effect,protection and damage of autoimmunity might be concomitant in SCI under spontaneous condition.

关键词： myelin basic protein protective autoimmunity neuroprotection spinal cord injury

Data analysis of Prsotate cancer with PSA in grey zone

在线全文

cnki会议

学校读者我要写书评

暂无评论

Data analysis of Prsotate cancer with PSA in grey zone

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： Qijun, Kangjian, Baiqiang, Chenfang Department of Urology, Xinhua Hospital, medical school of shanghai jiaotong university

Purpose To analysis the clinical data of prostate cancer whose PSA lies between 4 and 10 ng/ml(Grey zone). Materials and Methods From Mar. 2004 to Mar. 2005, totally 72 patients whose PSA lies in grey zone were underw... 详细信息

关键词： prostate cancer grey zone PSAD F/T

Clear cell carcinoma of the lung:a case report and literature review

在线全文

cnki会议

学校读者我要写书评

暂无评论

Clear cell carcinoma of the lung:a case report and literatur...

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： Chenjuan Gu,Yi Xiang,Min Li Department of Respiratory Medicine,shanghai Ruijin Hospital,medical school of shanghai jiaotong university

The objective of this study was to determine the clinical,imaging and pathological features of primary lung clear cell carcinoma. A case of primary lung clear cell carcinoma confirmed by video-assisted thoracoscopic lung biopsy was reported and literature was reviewed. A 45 year-old female was referred to our hospital with complaints of two months of ***

关键词：

Glucose metabolism and pancreatic beta cell function in patients with obstructive sleep apnea-hypopnea syndrome

在线全文

cnki会议

学校读者我要写书评

暂无评论

Glucose metabolism and pancreatic beta cell function in pati...

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： Chenjuan Gu,Qingyun Li,Min Li Department of Respiratory Medicine,shanghai Ruijin Hospital,medical school of shanghai jiaotong university

The objective of this study was to determine the impact of obstructive sleep apnea hypopnea syndrome(OSAHS) on glucose metabolism and pancreatic beta cell function. A total of 179 subjects who recorded all-night polysomnography in our sleep laboratory during the period from January 2005 to December 2010 were enrolled in this study and were divided into

关键词：

在线全文

cnki会议

学校读者我要写书评

暂无评论

瑞舒伐他汀的临床研究进展

中国新药与临床杂志 2010年第11期29卷 813-816页

作者：叶瑛贾楠上海交通大学医学院附属瑞金医院高血压科上海200025

瑞舒伐他汀作为目前最新且最具潜力的一类他汀类药物,与同类药物相比能更有效地降低血浆中低密度脂蛋白,同时降低胆固醇、载脂蛋白B,并且显著增加高密度脂蛋白胆固醇。不仅如此,在心血管疾病的二级预防和一级预防中,有研究显示瑞舒伐他... 详细信息

瑞舒伐他汀作为目前最新且最具潜力的一类他汀类药物,与同类药物相比能更有效地降低血浆中低密度脂蛋白,同时降低胆固醇、载脂蛋白B,并且显著增加高密度脂蛋白胆固醇。不仅如此,在心血管疾病的二级预防和一级预防中,有研究显示瑞舒伐他汀的长期使用能够逆转动脉粥样斑块负荷,减少心血管事件发生率和死亡率,降低动脉粥样硬化炎性指标,使存在不同程度心血管疾病风险的患者在其调脂治疗中获益。本文就瑞舒伐他汀的临床研究进展做一综述。

关键词：瑞舒伐他汀心血管疾病脂蛋白类 LDL 脂蛋白类 HDL

维普期刊数据库

Chronic intermittent hypoxia increases beta cell mass and activates mTOR/HIF1/VEGF-A pathway in mice islet

在线全文

学校读者我要写书评

暂无评论

Chronic intermittent hypoxia increases beta cell mass and ac...

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： Chenjuan Gu,Min Li,Qingyun Li,Ning Li Department of Respiratory Medicine,shanghai Ruijin Hospital,medical school of shanghai jiaotong university

The objective of this study was to determine changes in pancreatic beta cell mass and islet mTOR/HIF1/VEGF-A pathway in mice subjected to chronic intermittent hypoxia,which was probably related to CIH-induced impaired glucose metabolism and beta cell dysfunction. A gas control delivery system was designed to regulate the flow of nitrogen and oxygen into a customized

关键词：

对贵刊《乌灵胶囊治疗老年失眠症》一文的临床验证

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国新药与临床杂志 2010年第8期29卷 639-640页

作者：郑岚卞晓岚上海交通大学医学院附属瑞金医院中医科上海200025 上海交通大学医学院附属瑞金医院卢湾分院药剂科上海200020

失眠症是以入睡及睡眠维持困难为特征的一种最常见的睡眠障碍，患病率逐年增高。长期的失眠严重影响了老年人的生活质量，加重和诱发老年人的躯体疾病。因此老年失眠症的治疗备受人们的关注。笔者阅读了贵刊2006年第4期《乌灵胶囊治疗... 详细信息

失眠症是以入睡及睡眠维持困难为特征的一种最常见的睡眠障碍，患病率逐年增高。长期的失眠严重影响了老年人的生活质量，加重和诱发老年人的躯体疾病。因此老年失眠症的治疗备受人们的关注。笔者阅读了贵刊2006年第4期《乌灵胶囊治疗老年失眠症》一文，深受启发，采用此法治疗老年失眠症44例进行临床验证，结果报道如下。

关键词：老年人失眠症药物疗法乌灵胶囊

维普期刊数据库

Subtoxic concentration of Doxorubicin enhances TRAIL-induced apoptosis in Human prostate cancer cell line LNCaP

在线全文

学校读者我要写书评

暂无评论

Subtoxic concentration of Doxorubicin enhances TRAIL-induced...

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： Jian Kang, Liang Zhang, Jun Qi, Fang Chen Department of Urology, Xinhua Hospital, medical school of shanghai jiaotong university

Most tumor cells are sensitive to TRAIL-induced apoptosis but sparing to normal cells, thus providing therapeutic potential for clinical use. Some tumor cells are resistant to TRAIL-induced cell death while the sensit... 详细信息

关键词： TRAIL Doxorubicin LNCaP Apoptosis