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Journal of Huazhong university of Science and Technology(medical Sciences) 2009年第3期29卷 313-317页

作者：周健黄元成田德英许东陈淼吴会玲 Department of Infectious Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

The aim of the present study was to investigate the expression of toll-like receptors （TLR） 9 in peripheral blood mononuclear cells （PBMC） of patients with chronic hepatitis B and C with different virus copies. The study group included 90 patients （60 with chronic hepatitis B, and 30 with chronic hepatitis C）, and 20 healthy people served as control group. The protein and mRNA levels of TLR9 were detected by using flow cytometry and real-time PCR. The serum viral copies of HBV and HCV were measured in all patients, and the correlation between HBV-DNA copies or HCV-RNA copies and the TLR9 expression was analyzed. Our results demonstrated that HBV or HCV infection led to a decreased expression of TLR9 mRNA and protein compared to the control group （P〈0.05）. The TLR9 protein and mRNA levels were negatively correlated with serum viral copies of HBV and HCV （r=-0.632, r=-0.909, P〈0.01）. It was concluded that TLR9 mRNA and protein are down-regulated in PBMC of HBV-infected or HCV-infected patients, and they are negatively correlated with serum viral copies and play an important role in detecting viral replication of HBV and HCV.

关键词： peripheral blood mononuclear cells innate immunity toll-like receptor 9

Identification of the Wave-Particles Interaction in Space Plasma Using Higher-Order Statistics

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Wuhan university Journal of Natural Sciences 1998年第1期3卷 41-45页

作者： Zhao Zhengyu, Shi Xianqing, F. Lefeuvre, A. Masson(college of Electronic Information, Wuhan university, Wuhan 430072, China)(LPCE/CNRS, 45100 Orleans Cedex 02, France) Wuhan university College of Electronic Information Wuhan China (GRID:grid.49470.3e) (ISNI:***) LPCE/CNRS Orleans Cedex 02 France (GRID:grid.49470.3e)

The interaction of wave-particles and wave-wave in the space plasmas are essentially non-linear or non-Gaussian processes. Using the higher-order statistical analyses methods (higher-order moments and bi-tri correlation or bi-tri spectrum), its physical properties can be described. The question addressed in this paper is that of the usefulness of higher-order statistical analysis for identification of the wave-particles interaction in space plasmas. The signals handled are from the ARCAD-3 ISOPROBE experiment on ELF frequency range, then strong electrostatic turbulence and electron density irregularities. Second and third order statistical analyses are applied: first, on time series associated with each type of measurement, then, on the two types. All results are presented for one typical case. Correlation functions estimated over the corresponding time intervals point out the existence of a, non-linear interaction between these fluctuations and electrostatic filed.

关键词： Key words wave particles interaction space plasmas higher order statistics

Application of ensemble kalman filter to geophysical parameters retrieval in remote sensing:A case study of kernel-driven BRDF model inversion

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Science China Earth Sciences 2006年第6期49卷 632-640页

作者： QIN Jun1, YAN Guangjian1, LIU Shaomin1, LIANG Shunlin2, ZHANG Hao1, WANG Jindi1 & LI Xiaowen1 1. State Key Laboratory of Remote Sensing Science, School of Geography and Remote Sensing, Research Center for RS&GIS, Beijing Normal university, Beijing 100875, China 2. Department of Geography, 2181 Lefrak Hall, university of Maryland, college Park, MD20742, USA State Key Laboratory of Remote Sensing Science School of Geography and Remote Sensing Research Center for RS&GIS Beijing Normal University Beijing China Department of Geography 2181 Lefrak Hall University of Maryland College Park USA

The use of a priori knowledge in remote sensing inversion has great implications for ensuring the stability of inversion process and reducing uncertainties in retrieved results, especially under the condition of insufficient observations. Common optimization algorithms have difficulties in providing posterior distribution and thus cannot directly acquire uncertainties in inversion results, which is of no benefit to remote sensing application. In this article, ensemble Kalman filter (EnKF) has been introduced to retrieve surface geophysical parameters from remote sensing observations, which has the capability of not merely obtaining inversion results but also giving its posterior distribution. To show the advantage of EnKF, it is compared to standard MODIS AMBRALS algorithm and highly effi-cient global optimization method SCE-UA. The inversion abilities of kernel-driven BRDF models with different kernel combinations at several main cover types are emphatically discussed when observa-tions are deficient and a priori knowledge is introduced into inversion.

关键词： remote sensing inversion, a priori knowledge, posterior distribution, ensemble kalman filter, BRDF, kernel-driven model, albedo.

Effects of resveratrol on vascular endothelial cells in high glucose medium

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Effects of resveratrol on vascular endothelial cells in high...

Photocatalytic degradation kinetics of Rhodamine B cata- lyzed by nanosized TiO_2 film

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Yun GAO,Shang-Dong LIANG,Gui-Lin LI,Guo-Dong LI~* Department of Physiology,Basic medical college of Nanchang university,Nanchang 330006,China

＜正＞Introduction:Diabetes is a severe metabolic disease resulting in a host of cardiovascular complications. Hyperglycemia is an obvious disorder in diabetes,and the endothelial cytotoxicity of hyperglycemia is widely *** study aimed to examine the potential effects of resveratrol on endothelial cytotoxicity caused by ***:Human umbilical vein endothelial cells（HUVECs） were cultured for 5 days in medium containing control（5.5 mmol/L） or high concentrations of glucose（22.2 or 44.4 mmol/L） in the presence or absence of 3μmol/L ***,the cells were subject to following assays.（1） The cytotoxicity and protective effects of resveratrol were assessed by MTS assays.（2） Cellular DNA contents were measured with the fluorescence dye Hoechst 33258 using a microplate ***:Assessment of cytotoxicity by MTS assay revealed no change in viability of HUVECs after culture with resveratrol alone at 3μmol/L for 5 *** of HUVECs to high glucose significantly reduced formation of formazan products in MTS assay and decreased DNA contents as measured with the fluorescence dye Hoechst ***-treatment with resveratrol completely reversed these alterations and showed the protective effects on HUVECs from high glucose-induced ***: In summary,our data demonstrated that culture with high concentrations of glucose resulted in damage to HUVECs and resveratrol could protect the cells from the impairments.

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Chinese Science Bulletin 2003年第1期48卷 49-52页

作者： WEI Gang, ZHANG Yuanjing & XIONG Rongchun college of Material Science and Engineering, Beijing university of Chemical Technology, Beijing 100029, China Correspondence should be addressed to Xiong Rongchun (e-mail: xiongrongchun@***) college of Material Science and Engineering Beijing University of Chemical Technology Beijing 100029 China

A fixed bed photocatalytic reactor was de-signed, and dynamic fast scan of UV-Vis adsorption spec-trum was adopted to study the photocatalytic degradation dynamic behavior of Rhodamine B, a kind of dye generally recognized as to be degraded difficultly, on the surface of nanosized TiO2 thin film. The results indicate that the photocatalytic degradation process of Rhodamine B does not comply with the first-order reaction kinetic process. As a result, a kinetic model of Rhodamine B photocatalytic deg-radation reaction is brought forward, and the model is proved by the theoretical deduction and experiment.

关键词：若丹明B 光催化降解动力学含染料废水固定床光催化反应器纳米级二氧化钛薄膜 TiO2

ALMOST PERIODIC SOLUTIONS TO SOME NONLINEAR DELAY DIFFERENTIAL EQUATION

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Annals of Differential Equations 2009年第4期25卷 385-390页

作者： Chunhua Feng (college of Mathematical Science, Guangxi Normal university, Guilin 541004, Guangxi)

The existence of an almost periodic solutions to a nonlinear delay diffierential equation is considered in this paper. A set of sufficient conditions for the existence and uniqueness of almost periodic solutions to so... 详细信息

关键词： delay diffierential equation almost periodic solution existence and uniqueness

Darrieus-Savonius组合风轮气动性能的研究

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太阳能学报 1992年第3期13卷 239-244页

作者：何宗敬南京农业大学农业工程学院南京210032

分析了Darrieus风轮串加Savonius风轮后对气动性能的影响,并导出了两轮合理匹配的条件和气动性能数学模型。风洞试验结果表明,该数学模型稍加修正即可满足组合风轮的设计要求。

关键词：组合风轮气动性能数学模型

The Role of Propeptide in the Refolding of Human Group IB Phospholipase A2

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Acta Biochimica et Biophysica Sinica 2004年第9期36卷 583-588页

作者： Hong-Qiang CHENG1 and Gen-Jun XU1,2*Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2college of Life Science, Zhejiang university of Sciences, Hangzhou 310033, China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China college of Life Science Zhejiang University of SciencesHangzhou 310033 China

Human group IB phospholipase A2 (IB-PLA2) and its zymogen (proIB-PLA2) were purified from E. coli. Refolding was carried out by diluting the denatured forms of both IB-PLA2 and proIB-PLA2 with renaturation buffer in which the disulfide bonds were completely reduced. The refolding yield of proIB-PLA2 was increased by about 50% over that of the mature enzyme. The refolding of IB-PLA2 usually produced aggregates under normal conditions, as determined by light scattering. In addition, the unfolding experiments showed that the mature enzyme was more stable than the proenzyme toward denaturants in the presence of DTT. Results suggested that the N-terminal sequence rather than its conformation of human proIB-PLA2 played an important role in the refolding process.

关键词： human group IB phospholipase A2 (IB-PLA2) refolding first disulfide bond propeptide

Effects of 5 kinds of atypical antipsychotic drugs in patients with schizophrenia under the age of 16

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Effects of 5 kinds of atypical antipsychotic drugs in patien...

Low-dose-fractionated irradiation attenuates astrogliosis-mediated inhibition of axonal regeneration and facilitates recovery of motor function after spinal cord hemi-section in Beagle dogs

第十九届世界儿童及青少年精神卫生与相关学科学术会议

作者： MA Jun XIE Jun LI Yi-shen and WANG Ji-zhong Mental Health Centre of Tongji medical college of Huazhong university of Science and Technology China

＜正＞Background Discuss effects of five kinds of atypical antipsychotic drugs on schizophrenic patients under the age of 16. Methods A total of 183 patients under the age of 16,according to their treatment of patients with schizophrenia were divided into five groups, namely,the 1st group risperidone group（53 persons）,the 2nd group quetiapine group（36 persons）,the 3rd group olanzapine group（47 persons）,the 4th group of aripiprazole group（25 persons）,the 5th group paliperidone group（22 persons）,were given risperidone（2.5 to 4.5 mg/day）,quetiapine

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Low-dose-fractionated irradiation attenuates astrogliosis-me...