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Sick Neighborhood Syndrome: Population with Multiple Chemical Sensitivity Adjacent to Bioethanol Distillery

Journal of Biosciences and Medicines 2022年第4期10卷 87-98页

作者： Eduardo Maturano Bryan Mac Lean Flavia Silvina Difilippo Juan Manuel Laino medardo avila-vazquez Nacional University of Córdoba Córdoba Argentina

The population of a neighborhood in the city of Córdoba presents general irritant symptoms since a bioethanol distillery began to operate there, from which formaldehyde, toluene, xylene mainly emanate. At the request of the community, collective environmental health was evaluated with a cross-sectional study of prevalence of these conditions. 53% of the residents reported respiratory disorders, conjunctivitis 31%, headaches 27%, dermatitis 23% and dyspepsia 22%. 57% of children aged 6 - 7 use bronchodilators (an indicator of asthma). 66% of the population has one of these conditions, 46% has two and 26% has three;children are the most affected. The results coincide with the Consensus on Multiple Chemical Sensitivity Syndrome in that it is reproducible by repeated chemical exposure, is chronic and does not improve without eliminating exposure, affecting multiple organs and systems. 14.8% of newborns feature malformations, while in the rest of the city, only 1.7% did. Similar to the Sick Building Syndrome, the collective health picture found suggests a “Sick Neighborhood Syndrome”.

关键词： Multiple Chemical Sensitivity Environmental Exposure Air Pollution Environmental Health Formaldehyde

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Association between Cancer and Environmental Exposure to Glyphosate

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International Journal of Clinical Medicine 2017年第2期8卷 73-85页

作者： medardo avila vazquez Eduardo Maturano Agustina Etchegoyen Flavia Silvina Difilippo Bryan Maclean Faculty of Medical Sciences National University of Cordoba Cordoba City Argentina Epidemiology Committee of Virology Institute Jose Maria Vanella Faculty of Medical Sciences National University of Cordoba Cordoba City Argentina Center for Environmental Research Faculty of Exact Sciences National University of La Plata La Plata City Argentina

Background: Argentina, Brazil, Paraguay and Uruguay farm transgenic seeds glyphosate resistant. Argentina annually utilizes 240,000 tonnes of glyphosate in agriculture. A change in the profile of morbidity and mortality is perceived in agricultural areas;cancer seems to prevail. Monte Maíz is a typical argentine agricultural town with 8000 inhabitants;the Mayor and residents of Monte Maiz requested an environmental health study due to perceived increase in cancer frequencies. Methods: An exploratory ecological study was developed to assess the urban environmental contamination and the frequencies and distribution of cancer through an environmental analysis of pollution sources including measurements of pesticides in water, soil and grain dust, and a cross-sectional study of cancer patients that explore associations with different variables. Results: Glyphosate was detected in soil and grain dust and was found to be at an even higher concentration in the village soil than in the rural area. 650 tonnes are used annually in the region and manipulated inner town. We do not find other relevant sources of pollution. Cancer incidence, prevalence, and mortality are between two and three times higher than the reference values (Globocan 2012, WHO) for the entire nation (706/100,000 persons vs. 217/100,000;2123/100,000 persons vs. 883.82/100,000 and 383/100,000 persons vs. 115.13/100,000, respectively). Conclusion: This study detects high glyphosate pollution in association with increased frequencies of cancer in a typical argentine agricultural village, and by design, cannot make claims of causality. Other study designs are required, but if we corroborate the concrescence of high exposure to glyphosate and cancer.

关键词： Glyphosate Pesticides Cancer Environmental Health Environmental Exposure

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Environmental Exposure to Glyphosate and Reproductive Health Impacts in Agricultural Population of Argentina

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Journal of Environmental Protection 2018年第3期9卷 241-253页

作者： medardo avila-vazquez Flavia S. Difilippo Bryan Mac Lean Eduardo Maturano Agustina Etchegoyen Chair of Pediatric Clinic Faculty of Medical Sciences National University of Cordoba Cordoba Argentina Epidemiology Committee of Virology Institute Jose Maria Vanella Faculty of Medical Sciences National University of Cordo-ba Cordoba Argentina Center for Environmental Research Faculty of Exact Sciences National University of La Plata La Plata Argentina

Argentina annually utilizes 240,000 tones of glyphosate in industrial agriculture and a change in the profile of morbidity is perceived for physicians of agricultural areas;now reproductive disorders seem to prevail. The objective of this study is to determine concurrence of glyphosate exposure and reproductive disorders in a typical argentine agricultural town (Monte Maíz). An ecological study was developed with an environmental analysis of pollution sources including measurements of glyphosate and other pesticides and a cross-sectional study of spontaneous abortions and congenital abnormalities prevalence. Glyphosate was detected in soil and grain dust and was found to be at an even higher concentration in the village soil than in the rural area;650 tonnes of glyphosate are used annually in the region and manipulated inner town contaminating the soil and dust in suspension of the town creating an burden of environmental exposure to glyphosate of 79 kg per person per year. We do not find other relevant sources of pollution. The spontaneous abortion and congenital abnormalities rates are three and two times higher than the national average reported by the national health (10% vs. 3% and 3% - 4.3% vs 1.4% respectively). Our study verified high environmental exposure to glyphosate in association with increased frequencies of reproductive disorders (spontaneous abortion and congenital abnormalities) in argentine agricultural village, but is unable to make assertions cause-effect. Further studies are required with designs for such purposes.

关键词： Glyphosate Spontaneous Abortions Congenital Abnormalities Environmental Exposure Environmental Health

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