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A Systematic Review of Cannabidiol Effects in Coronary Syndromes: Challenges to Clinical Translation

Journal of Biosciences and Medicines 2024年第4期12卷 246-263页

作者： Mario E. Zuñiga-Ayala Alejandra meaney-Martínez Alejandro Alcocer-Chauvet Vidal Gonzalez-Coronado Nestor Rubio-Infante Gerardo Garcia-Rivas Department of Cardiology Instituto de Seguridad Social and Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Department of Interventional Cardiology Instituto de Seguridad Social y Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Instituto Tecnó logico de Monerrey Escuela de Medicina and Ciencias de la Salud C&#225tedra de Cardiolog&#237a and Medicina Vascular Monterrey Mexico

Background: Myocardial ischemia in addition to other several cardiac syndromes represent a pathological proinflammatory state alongside a complex cellular microenvironment that can be modified by using cannabinoids. Cannabidiol (CBD), a non-psychoactive compound of cannabis has been recently proposed as an immudomodulatory and cardioprotective drug. Objectives: In this systematic review we sought to clarify and summarize the clinical and preclinical evidence of potential benefit of the use of CBD in coronary syndromes. Methods: We conducted a systematic search and review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Review of Animal Data from Experimental Studies (CAMARADES) guidelines, in the electronic database from PubMed, Web of Science and Scopus up to April 2022 using predefined search terms. Pre-specified exclusion and inclusion criteria were considered, finally 11 articles were chosen to be included for this peer review. Results: Currently there are no good-quality clinical trials with the use of CBD in acute or chronic coronary syndromes. A total of 11 preclinical studies where prescreened and 5 demonstrated reproducible positive cardiovascular outcomes on in-vivo models treated with CBD. Mechanisms of CBD cardioprotection observed: 1) reduction in oxidative stress and inflammation, 2) activation of adenosine receptors and 3) increased expression of angiotensin type 2-receptor. Experimental models included ischemia/reperfusion injury, myocardial infarction, arrhythmias, and metabolic syndrome-like conditions. Conclusion: No clinical recommendation can be issued with the current evidence, on the use of CBD in acute and chronic coronary syndromes. Based on preclinical evidence, we considered there is enough evidence to propose the development of well-designed clinical trials that include CBD in the management of coronary syndromes.

关键词： Cannabis Cannabidiol Acute Coronary Syndromes Myocardial Infarction Myocardial Ischemia and Oxidative Stress

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Lessons from a Marine Spatial Planning data management process for Ireland

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International Journal of Digital Earth 2021年第2期14卷 139-157页

作者： Sarah Flynn Will meaney Adam M.Leadbetter Jeffrey P.Fisher Caitriona Nic Aonghusa Marine Institute RinvilleOranmoreCounty GalwayH91 R673Ireland

This paper presents a framework containing ten components to deliver a data management process for the storage and management of data used for Marine Spatial Planning(MSP)in *** work includes a data process flow and a recommended solution *** architecture includes a central data catalogue and a spatial storage *** components of the process are presented to maximise the reuse potential of any dataset within an MSP *** terms‘Suitability’and‘Readiness’in the MSP context are offered as both formal and considered assessments of data,as is the applicability of a data stewardship maturity *** data contained in such a storage system can be published externally to potential consumers of these data is also *** process presents a means of managing data and metadata to ensure data lineage is optimised by carrying information about the origin of and the processing applied to the data;to evaluate the quality and relevance of geospatial datasets for use in MSP decisions in *** process was piloted in the National Marine Planning Framework for Ireland in the development of draft map products;feedback from the public consultation is ongoing and not presented.

关键词： Marine Spatial Planning MSP marine data storage&management data governance reuse&integration

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Exercises for Parkinson＇s disease

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中华物理医学与康复杂志 2017年第7期39卷 528-528页

作者： Collett J Franssen M meaney a

BACKGROUND AND OBJECTIVE While short-term exercise may improve health,well-being and function in patients with Parkinson’s disease(PD),there is a lack of evidence of long-term *** study was designed to better understand these *** This phaseⅡ,randomized,controlled trial included patients with idiopathic PD,who were able to walk at least 100 *** subjects were randomized to perform exercises or receive handwriting training,twice per week for six *** included 30minutes of aerobic training followed by 30 minutes of resistance training.A control group underwent handwriting exercises,using workbooks at *** measures were performed at baseline,and at three,six and 12 *** primary outcome measure was the two-minute

关键词：帕金森病运动随机对照试验测试评估功能评估功能评定训练对照组

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PAI-1 genetic polymorphisms influence septic patients’outcomes by regulating neutrophil activity

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Chinese Medical Journal 2023年第16期136卷 1959-1966页

作者： Shaowei Jiang Yang Wang Liang Chen Honghua Mu Connor meaney Yiwen Fan Janesh Pillay Hairong Wang Jincheng Zhang Shuming Pan Chengjin Gao Department of Emergency Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Division of Rheumatology Department of Internal MedicineUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Pathology Medicine Biology University Medical Center GroningenThe Netherlands Department of Critical Care University Medical Center GroningenThe Netherlands Department of Critical Care Medicine Zhongshan HospitalFudan UniversityShanghai 200032China

Background:Plasminogen activator inhibitor-1(PAI-1)plays an important role in the pathophysiology of sepsis,but the exact mechanism remains *** this study,we investigated the associations among the serum levels of PAI-1,the incidence of 4G/5G promoter PAI-1 gene polymorphisms,immunological indicators,and clinical outcomes in septic ***:A total of 181 patients aged 18-80 years with sepsis between November 2016 and August 2018 in the intensive care unit in the Xinhua Hospital were recruited in this retrospective study,with 28-day mortality as the primary *** initial serum level of PAI-1 and the presence of rs1799768 single nucleotide polymorphisms(SNPs)were *** logistic regression and multivariate analyses were performed to determine the factors associated with different genotypes of PAI-1,serum level of PAI-1,and 28-day ***:The logistic analysis suggested that a high serum level of PAI-1 was associated with the rs1799768 SNP of PAI-1(4G/4G and 4G/5G)(Odds ratio[OR]:2.49;95%confidence interval[CI]:1.09,5.68).Furthermore,a high serum level of PAI-1 strongly influenced 28-day mortality(OR 3.36;95%CI 1.51,7.49).The expression and activation of neutrophils(OR 0.96;95%CI 0.93,0.99),as well as the changes in the expression patterns of cytokines and chemokine-associated neutrophils(OR:1.00;95%CI:1.00,1.00),were both regulated by the genotype of ***:Genetic polymorphisms of PAI-1 can influence the serum levels of PAI-1,which might contribute to mortality by affecting neutrophil ***,patients with severe sepsis might clinically benefit from enhanced neutrophil clearance and the resolution of inflammation via the regulation of PAI-1 expression and activity.

关键词： Gene polymorphism Neutrophil Plasminogen activator inhibitor-1 PAI-1 Sepsis Single nucleotide polymorphism

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如何提高转型成功率

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商学院 2009年第7期 76-78页

作者： Josep Isern Mary C.meaney Sarah Wilson 麦肯锡马德里分公司麦肯锡伦敦分公司

Jala出任CEO时,马来西亚航空公司现金仅够支撑三个多月。Jala将重心全部放在损益表上,并据此制定了公司危机扭转计划。Jala说:"我们设立了一个小组来考查吉隆坡与曼彻斯特之间的航线。最终,该小组无法解决该航线的问题。乘客数量必须超... 详细信息

Jala出任CEO时,马来西亚航空公司现金仅够支撑三个多月。Jala将重心全部放在损益表上,并据此制定了公司危机扭转计划。Jala说:"我们设立了一个小组来考查吉隆坡与曼彻斯特之间的航线。最终,该小组无法解决该航线的问题。乘客数量必须超出现有运载能力的40%才能获得利润。我们该怎么办?难道将乘客绑在机翼上?经过全面分析后,该小组的每个人都意识到,这条航线已经无药可救。这些员工也都清楚,他们将失去那份工作。"在员工及其他利益相关方的全力支持下,该公司依然拯救了足够的航线,也实施了足够的变革措施,最终让自己绝处逢生。在困境下,即使是壮士断臂,大多数企业也发现很难实现自身的转型。有哪些经过验证的策略能够帮助企业显著地提高成功转型几率呢?

关键词：功率转型航空公司马来西亚公司危机曼彻斯特 CEO 损益表

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职场重用女性的商业理由

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经济管理文摘 2008年第22期 30-31页

作者： Georges Desvaux Sandrine Devillard-Hoellinger Mary C. meaney

性别不平等不仅仅是一个形象的问题：我们的研究发现，它对企业业绩有着切实的影响。有些企业已经采取了有效的步骤以获得更大的性别平等。最近几十年里，发达经济体中的女性在职场上取得了重大进步。然而，现在仍不可否认，越是到企业... 详细信息

性别不平等不仅仅是一个形象的问题：我们的研究发现，它对企业业绩有着切实的影响。有些企业已经采取了有效的步骤以获得更大的性别平等。最近几十年里，发达经济体中的女性在职场上取得了重大进步。然而，现在仍不可否认，越是到企业的高层．女性所占的比例越低。

关键词：女性职场商业企业业绩性别不平等发达经济体性别平等

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Persistent Zika Virus Infection Associated with Early Fetal Demise: A Case Report

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Open Journal of Obstetrics and Gynecology 2019年第5期9卷 698-706页

作者： Janice Pérez-Padilla Gabriela Paz-Bailey Dana meaney-Delman Kate Doyle Joy Gary Dania M. Rodriguez Julu Bhatnagar Nicole M. Pérez-Rodriguez Sara Montalvo Luisa Alvarado Tyler M. Sharp Centers for Disease Control and Prevention (CDC) Dengue Branch San Juan Puerto Rico CDC National Center for Emerging and Zoonotic Infectious Diseases Atlanta GA USA CDC Division of HIV/AIDS Prevention Atlanta GA USA CDC Division of HIV/AIDS Prevention Atlanta GA USA Ponce Health Sciences University/Saint Luke’s Episcopal Hospital Ponce Puerto Rico

Background: Infection with Zika virus (ZIKV) during pregnancy is known to cause birth defects and could also be linked to pregnancy loss. Case: A pregnant woman in Puerto Rico contracted ZIKV at 16 weeks gestation. ZIKV RNA persisted in serum from her initial test at 16 weeks through 24 weeks gestation, when fetal demise occurred, and was detected in placental tissue. Conclusion: Prolonged detection of ZIKV RNA in maternal serum was associated with ZIKV RNA detection in the placenta of a patient who experienced fetal demise. While detection of placenta ZIKV RNA does not establish that ZIKV conclusively caused the demise, these findings support emerging evidence that the placenta may serve as a reservoir for ZIKV, which may be associated with prolonged detection of ZIKV RNA in serum.

关键词： Zika Pregnancy Outcomes ZIKV Persistence

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世界家庭医生组织(WONCA)研究论文摘要汇编——中度精神疾病可作为慢性病预防和筛查的预测因子

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中国全科医学 2017年第23期20卷 2918-2918页

作者：本刊编辑部 SALVALAGGIO G meaney C MOINEDDIN R

背景初级保健在提供精神保健和慢性病预防和筛查(CDPS)方面发挥关键作用。中度精神疾病(MMI)与较差的健康状态相关。而MMI可能是由于CDPS减少引起。改善初级保健的慢性病预防试验(BETTER)招募了来自32个全科医疗组的777例40~65岁参与者... 详细信息

背景初级保健在提供精神保健和慢性病预防和筛查(CDPS)方面发挥关键作用。中度精神疾病(MMI)与较差的健康状态相关。而MMI可能是由于CDPS减少引起。改善初级保健的慢性病预防试验(BETTER)招募了来自32个全科医疗组的777例40~65岁参与者,其中135例(18.2%)广泛性焦虑障碍(GAD)评分较高,118例(16.4%)抑郁自评量表(PHQ)评分较高,264例(34.0%)有电子病历(EMR)记录MMI。假设检测为阳性或有图表记录的MMI患者:(1)符合更多的CDPS条件;(2)比未受MMI影响的患者完成CDPS的比例小。方法本研究是对BETTER数据的二次分析。参与者以EMR记录的MMI和检测为阳性的MMI进行分层(分别使用GAD-7和PHQ-9进行焦虑和抑郁症筛查)。主要结果使用综合指数分析患者在随访期间完成CDPS的比例。结果经年龄、性别和社会支持调整后,有MMI证据的患者的复合指数低于无MMI证据的患者(P<0.05)。较低的复合指数主要是由于CDPS的基准线资格较高,而能够完成CDPS的能力无统计学意义。结论受MMI影响的患者比无MMI者更符合CDPS条件。尽管均能够完成CDPS,但是MMI患者存在CDPS基线差距。初级保健小组需要意识到MMI患者符合CDPS的数量增加,并确保提供给该患者可获得的最佳CDPS防治条件。需要进一步研究确定理想的有针对性的治疗条件。

关键词：世界家庭医生组织预防试验精神疾病慢性病预测因子筛查论文摘要广泛性焦虑障碍

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院内心室颤动患儿的预后

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 7-8页

作者： Samson R.A. Nadkarni V.M. meaney P.A. R.A. Berg 吴晓燕 Steele Children's Research Center College of Medicine University of Arizona 1501 N. Campbell Ave. Tucson AZ 85724-5073 United States Dr.

Background: Ventricular fibrillation and ventricular tachycardia are less common causes of cardiac arrest in children than in adults. These tachyarrhythmias can also begin during cardiopulmonary resuscitation(CPR), presumably as reperfusion arrhythmias. We determined whether the outcome is better for initial than for subsequent ventricular fibrillation or tachycardia. Methods: All cardiac arrests in persons under 18 years of age were identified from a large, multicenter, in-hospital cardiac-arrest registry. The results from children with initial ventricular fibrillation or tachycardia, children in whom ventricular fibrillation or tachycardia developed during CPR, and children with no ventricular fibrillation or tachycardia were compared by chi-square and multivariable logistic-regression analysis. Results: Of 1005 index patients with in-hospital cardiac arrest, 272(27 percent) had documented ventricular fibrillation or tachycardia during the arrest. In 104 patients(10 percent), ventricular fibrillation or tachycardia was the initial pulseless rhythm; in 149 patients(15 percent), it developed during the arrest. The time of initiation of ventricular fibrillation or tachycardia was not documented in 19 patients. Thirty-five percent of patients with initial ventricular fibrillation or tachycardia survived to hospital discharge, as compared with 11 percent of patients with subsequent ventricular fibrillation or tachycardia(odds ratio, 2.6; 95 percent con-fidence interval, 1.2 to 5.8). Twenty-seven percent of patients with no ventricular fibrillation or tachycardia survived to hospital discharge, as compared with 11 percent of patients with subsequent ventricular fibrillation or tachycardia(odds ratio, 3.8; 95 percent confidence interval, 1.8 to 7.6). Conclusions: In pediatric patients with in-hospital cardiac arrests, survival outcomes were highest among patients in whom ventricular fibrillation or tachycardia was present initially than among those in whom it developed s

关键词：心室颤动心脏停搏快速型心律失常心肺复苏术再灌注心律失常儿科患者心搏停止试验结果继发者

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利用近场成像改进乳腺癌检测技术

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真空电子技术 2003年第5期16卷 5-11页

作者： Elise C.Fear Susan C.Hagness Paul M.meaney Michal Okoniewski Maria A.Stuchly 梁友焕

长时间以来,人们梦想用非电离电磁波的人体成像技术检测癌症,如今乳腺癌的检测已取得重大进展,使这一梦想成为现实.在今后的十年里,微波系统将成为许多妇女疾病的一种可行的诊断方法.与其它癌症不同的是,乳腺肿瘤在微波波段与健康的乳... 详细信息

长时间以来,人们梦想用非电离电磁波的人体成像技术检测癌症,如今乳腺癌的检测已取得重大进展,使这一梦想成为现实.在今后的十年里,微波系统将成为许多妇女疾病的一种可行的诊断方法.与其它癌症不同的是,乳腺肿瘤在微波波段与健康的乳房组织有着明显不同的电学特性.微波很容易穿透乳房,而对其他器官则相差很多.与其他的组织如肌肉和脑组织相比,正常的乳房组织对微波具有更高的透明度.

关键词：近场成像乳腺癌检测技术微波系统微波肿瘤检测无源微波成像乳房组织电特性

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